LORMA COLLEGES CON TEMPLATE

DRUG STUDY
RELATED LEARNING EXPERIENCE

STUDENT NAME GARCIA, ERIN R. ROTATION 4th Rotation AREA Intermedicate Medical Care Unit
(IMCU)
YR. LEVEL AND BSN IV DATES CLINICAL INSTRUCTOR MRS. Maria Rosario Corpuz
SECTION JEANWATSON HEAD NURSE: MS. Rillera, Diana

DRUG NAME CLASSIFICATION MECHANISM INDICATION CONTRAINDICATIO SIDE EFFECTS NURSING

OF ACTION N RESPONSIBILITIES
GENERIC AUTONOMIC NERVOUS Indirect-acting Differential Hypersensitivity to Body as a - Monitor vital signs.
NAME: SYSTEM AGENT; cholinesterase diagnosis and anticholinesterase Whole: Severe Observe for signs of
EDROPHONIUM CHOLINERGIC inhibitor similar as adjunct in agents; intestinal and adverse effects respiratory distress.
BRAND NAME: (PARASYMPATHOMIMETIC) to neostigmine evaluation of urinary obstruction. uncommon with Patients >50 y are
Enlon, Reversol, CHOLINESTERASE that is rapidly treatment Safety during usual doses. particularly likely to
Tensilon INHIBITOR reversible. Acts requirements of pregnancy (category CNS: develop bradycardia,
DOSAGE: as antidote to myasthenia C) or lactation is not Weakness, hypotension, and
10 mg/mL curariform drugs gravis, for established. muscle cramps, cardiac arrest.
injection (Adult: by displacing differentiating dysphoria, - Edrophonium test for
IV Prepare 10 them from myasthenic from fasciculations, myasthenia gravis:
mg in a syringe; muscle cell cholinergic incoordination, All cholinesterase
inject 2 mg over receptor sites, crisis, and to dysarthria, inhibitors
15–30 sec, if no thus permitting reverse dysphagia, (anticholinesterases)
reaction after 45 resumption of neuromuscular convulsions, should be
sec, inject the normal blockade respiratory discontinued for at
remaining 8 mg, transmission of produced by paralysis. least 8 h before test.
may repeat test neuromuscular overdosage of CV: Positive response to
after 30 min IM impulses. Like nondepolarizing Bradycardia, edrophonium test
Inject 10 mg, if neostigmine, it skeletal muscle irregular pulse, consists of brief
cholinergic prolongs relaxants, e.g., hypotension, improvement in
reaction occurs, skeletal muscle tubocurarine, pulmonary muscle strength
retest after 30 relaxant action gallamine. Not edema. unaccompanied by
min with 2 mg to of recommended Special lingual or skeletal
rule out false- succinylcholine for maintenance Senses: Miosis, muscle
negative chloride and therapy in blurred vision, fasciculations.
reaction) decamethonium myasthenia diplopia, - Evaluation of
ROUTE: bromide. gravis because lacrimation. myasthenic
IV/IM of its short GI: Diarrhea, treatment:
FREQUENCY duration of abdominal Myasthenic
action. cramps, response (immediate
nausea, subjective
vomiting, improvement with
excessive increased muscle
salivation. strength, absence of
Respiratory: fasciculations;
Increased generally indicates
bronchial that patient requires
secretions, larger dose of
bronchospasm, anticholinesterase
laryngospasm, agent or longer-
pulmonary acting drug);
edema. Cholinergic response
Other: [muscarinic adverse
Excessive effects (lacrimation,
sweating, diaphoresis,
urinary salivation, abdominal
frequency, cramps, diarrhea,
incontinence. nausea, vomiting;
accompanied by
decrease in muscle
strength; usually
indicates over-
treatment with
cholinesterase
inhibitor)]; Adequate
response [no change
in muscle strength;
fasciculations may
be present or
absent; minimal
cholinergic adverse
effects (observed in
patients at or near
optimal dosage
level)].