LEGEND PATHOPHYSIOLOGY OF SCENARIO

F.N. is a 57-year-old housewife, happily married with grown children, and 2

Pathophysiology
Predisposing
Factors
Precipitating
Factors
BRAIN TUMOR new grandchildren. F.N. made an appointment with her optometrist to
explore a progressive OS visual loss over a 9-month period. Her eye
exam was essentially normal, and the optometrist referred her to a
Disease Signs & symptoms Definition neurologist. After workup, a 2.5 cm brain mass was found, and surgery
was scheduled. Her only past medical history (PMH) is hypertension, for
which she takes nifedipine XL 60 mg qd. Her past surgical history (PSH)
includes T&A as a child, cholecystectomy, and a TAH at age 42. She also
takes a conjugated estrogen (Premarin) 0.625 mg qd.

F.N.

Environmental Factors:
57 years old Exposure to Chemical
Immunosuppresion
Agents, Radiation &
Viruses
Exposure to
chemicals,
radiation/
viruses to
normal cell

Irritation and
damage to cell
structure

adaptive mechanism

Morphology:
Change in size,
Change in Cell morphology shape and
tructure

continued exposure
becomes irreversible

Inherited mutations in:

Gene mutation
- Genes affecting DNA repair
in DNA
- Genes affecting cell growth & apoptosis

Tumor suppressor Oncogenes:

genes: Inactivation of Activation of
Mutated gene that
tumor growth
Slows down cell contributes to the
suppressor promoting
division, repair DNA development of a
genes oncogenes
mistakes, or tell cells cancer
when to die

Apoptosis:
uncontrolled cell decreased process of
proliferation apoptosis programmed cell
death

Hyperplasia:
Enlargement of a tissue
hyperplasia of caused by an increase in
brain cells the amount of organic
tissue that results from cell
proliferation

BRAIN TUMOR

Tumor
outgrows

Disrupts blood
supply

Cerebral
ischemia

Injury to
localized brain
region

Symptoms vary depending on the location

of the brain affected

Occiptal lobe

Visual
disturbances