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Anatomy & Physiology Midterm
Anatomy & Physiology Midterm
Anatomy & Physiology Midterm
normally.
o We must consume them in the foods that we eat because generally they can’t be
made by our bodies
28. What is a metabolite?
o Metabolites are chemicals involved in or byproducts of normal metabolism
29. What is a hydrophilic molecule?
o a molecule that loves water - readily interact with water
30. What is a hydrophobic molecule?
o molecule that fears water - does not readily interact with water
EX: Fats, oils
31. Examples of inorganic compounds
o carbon dioxide or CO2,
o oxygen or O2
o water or H2O
o inorganic acids
o bases
o salts
32. Organic compounds: classifications and functions of each of them
o Organic molecules always have C & H -
carbs
lipids
proteins
nucleic acids
33. Examples of organic compounds.
34. What is a protein?
o Proteins are very large molecules assembled from carbon, hydrogen, oxygen and
nitrogen. CHON.
sometimes have sulfur
o Functions of proteins:
Support: structural proteins
Movement: contractile proteins
Transport: carrier proteins
Buffering: regulation of pH
Metabolic regulation: enzymes
Coordination and control: hormones
Defense: antibodies
35. Name the protein shapes
36. Name the examples of protein structures (4)
o Primary structure
This is the sequence of amino acids that form the protein. Ex. glycine-
glycine-leucine-tryptophane-glycine.
o Secondary structure
beta sheet
The developing chain of amino acids form either an alpha helix or a
pleated sheet structure.
o Tertiary structure
has a single heme unit
alpha helix
Reaction of the side groups of the amino acids with each other and with
the surrounding medium may lead to the formation of a globular protein.
o Quarternary structure
multiple alpha helixes
This occurs when several peptide chains are needed to form a functioning
protein (i.e. hemoglobin)
2. Function of the proteins?
o DNA
forms the inherited genetic material inside each human cell
T-A, C-G
o RNA
is involved in the synthesis of proteins.
there are 3 types of RNA: ribosomal RNA, transfer RNA, and messenger
RNA each with a specific role in the process of protein synthesis
T-U, C-G
o plasma membrane
o phospholipid bilayer
2. Membrane lipids.
o phospholipids
o glycolipids
o cholesterol
2. Characteristics of the phospholipids bilayer
o hydrophilic heads
o hydrophobic tails
o cholesterol
3. Membrane proteins and Variety of specialized functions
o Receptor protein
in plasma membrane, are sensitive to presence of extracellular ions or
molecules called ligands; ligand binds to receptor
o Carrier protein
bind solutes and transport them across plasma membrane
o Integral protein (part of membrane itself)
channel proteins are integral proteins that allow water, ions & small water
soluble solutes through plasma membrane
o Peripheral protein (attached to membrane)
are attached to, but can separate from, the membrane
4. Glycocalyx. Functions
o the sugar coat on the cell
o protects cell membrane
o serves as mediator for cell-to-cell interactions
5. Nucleus function
o control metabolism
o storage and processing of genetic info
o control of protein synthesis
6. Contents of the nucleus
o DNA
o RNA
o Enzymes
o Proteins
7. Nuclear envelope.
o membrane that surrounds the nucleus
8. Location of the DNA
o Inside the nucleus
9. Location of the chromosomes and # of chromosomes.
o Located inside the nucleus
o 23 pairs of chromosomes - 46 total
10. What is chromatin?
o In nondividing cells, DNA is loosely coiled & organized called chromatin
11. What is the function of the nucleoli?
o Synthesize ribosomal RNA; appear as dark-staining areas in nuclei
12. What is protein synthesis?
o occurs in ribosomes
13. What is transcription?
o Production of RNA from DNA template
14. What is translation?
o The assembling of functional polypeptides in the cytoplasm
15. How is the movement of materials across the cell membrane?
o A selectively permeable membrane allows the passage of some substances and
restricts the passage of others
16. What is diffusion?
o Is a passive process that does not require the energy of ATP: however molecules
can only move down the concentration gradient from high to low concentration.
17. What is osmosis?
o is a special case of diffusion. It is the diffusion of water across a selectively
permeable membrane from an area of high water concentration to an area of low
water concentration.
18. What is a hypotonic solution?
o the water flows into the cell. The swelling may continue until the plasma
membrane ruptures, or lyses.
o Solute concentration higher in the cell cause water to rush in
o Makes cells swell
19. What is a hypertonic solution?
o water moves out of the cell. The red blood cells crenate (shrivel).
o Solute concentration is lower in the cell causing water to leave cell
o Makes cells shrivel up
20. What is an isotonic solution?
o no osmotic flow occurs, and the red blood cells appear normal in size and shape.
o Stable cell, normal shape
21. What is Crenation?
o The shrinking of cells
22. What is facilitated diffusion?
o is the movement of materials across a membrane by a carrier protein.
o Movement follows the concentration gradient.
23. What is active transport?
o Requires carrier proteins that move specific substances across a membrane against
their concentration gradient.
o If the carrier moves one solute in one direction and another solute in the opposite
direction, it is called an exchange pump.
24. What is Vesicular transport?
o The cell forms small membrane surrounded sacs called vesicles to move
substances into or out of the cell.
Two basic types of vesicular transport are endocytosis and exocytosis.
o Energy is required for this type of transport
25. What is Exocytosis?
o This is the movement of substances from the cell to the outside.
26. What is Endocytosis?
o is the packaging of extracellular materials into a vesicle for transport into the cell.
27. What is Pinocytosis?
o vesicles form at the plasma membrane and bring fluids and small molecules into
the cell. This process is often called “cell drinking.”
28. What is Phagocytosis?
o vesicles called phagosomes form at the plasma membrane to bring particles into
the cell. This process is often called “cell eating.”
29. What is Mitosis?
o the essential step in cell division in which a single cell nucleus divides to produce
two identical daughter cell nuclei
30. What is Meiosis?
o production of sex cells
31. What is the Interphase?
o A stage in a cell’s life when it performs all its normal functions and, if necessary,
prepares for cell division. Most somatic cells spend the majority of their time in
interphase, which
o Following sub-phases
G1
S (DNA replication)
G2 phases
32. What is Prophase?
o Chromatin condenses and chromosomes become visible; centrioles migrate to
opposite poles of the cell and spindle fibers develop; and the nuclear membrane
disintegrates
33. What is Metaphase?
o Chromatids attach to spindle fibers and line up along the metaphase plate
34. What is Anaphase?
o Chromatids separate and migrate toward opposite poles of the cell
35. What is Telophase?
o The nuclear membrane forms; chromosomes disappear as they uncoil back to
chromatin; and nucleoli appear
36. What is cytokinesis?
o The cytoplasmic movement that separates two daughter cells; cytokinesis
completes the process of cell division
1. What is histology?
o The study of tissues
2. Name the 4 basic tissue types.
o Connective, Epithelial, Nervous, Muscle
3. What is the procedure used by the Pap test? What is exfoliating cytology?
o The Pap Smear
o Exfoliating Cytology is study of cells that have been shed from the body
4. Epithelial T is specialized for:
o covers exposed surfaces
o lines internal passageways and chambers
o produces glandular secretions
5. Connective tissue is specialized for:
o filling internal spaces
o providing structural support
o storing energy
6. Muscle T is specialized for:
o contracting to produce movement
7. Neural T is specialized for:
o propagating electrical impulses
o carrying information
8. Epithelial Tissue includes epithelia and glands
o True
9. Where is found the epithelia?
o exposed surfaces
o lining of internal organs
10. Name characteristics of the epithelia.
o What is cellularity?
composed of cells bound closely together by interconnections known as
cell junctions
o What is Polarity?
the presence of structural and functional differences between the exposed
and attached surfaces
o What is avascularity?
lacking blood vessels
o What is regeneration?
cells that are damaged are continually replaced through stem cell division
o What is attachment?
the base of the epithelium is bound to a thin basement membrane or basal
lamina
2. Name the two functional regions of an epithelial cell?
o gland cells
2. Name the specializations of the epithelial cells.
o The movement of fluids over the epithelial surface, providing protection and
lubrication.
o The movement of fluids through the epithelium, to control permeability
o The production of secretions that provide physical protection or act as chemical
messenger
2. What is a ciliated epithelium?
o epithelial cells covered in cilia that are tiny little fingers that help move
substances
2. Function of the ciliated epithelium that lines the respiratory tract.
o move mucus from the lungs and towards the throat
o this mucus traps particles and pathogens and is then carried to the throat for
expulsion or to be swallowed
3. Name the specializations adapted for absorption.
o Microvilli are are where absorption and secretion take place
4. Epithelium is avascular
o True
5. The epithelium is connected to the underlying connective tissues by the --------
o Hemidesmosomes
6. What is the neuroepithelia?
o an epithelium with the specialization to perform sensory functions, smell, taste,
sight, equilibrium and hearing
7. What is the function of the secretions discharged on the body surface?
o provide physical protection or act as a chemical messenger
8. Name the intercellular connections.
o Cell Adhesion Module (CAM)
o Cell Junction
o Gap Junction
o Tight Junction
o Desmosome
9. What is a CAM
o Tie two cells together through filaments attached to discs on each cell
10. Name the three most common types of cell junctions.
o Tight junctions
o Gap junctions
o Desmosomes
11. What is a desmosome?
o CAMs and proteoglycans link the opposing plasma membranes; very strong and
can resist stretching and twisting
12. Name the different types of desmosomes and their function.
o Spot desmosome
stabilize the shape of the cells
o Hemidesmosomes
stabilize the position of the cell and anchor it to underlying tissue
13. Why can we find gap junction in the tissue that requires rapid intercellular
communication.
o Because at a gap junction, two cells are held together by two interlocking
transmembrane proteins called connexons. These are channel proteins, and they
form a narrow passageway that lets small molecules and ions pass from cell to
cell.
14. In the tight junction the lipid portion of the cell membranes are tightly bound
together by interlocking membrane proteins:
o True
15. Function of the tight junctions.
o prevent the passage of water and solutes between cells
16. Name the strong intercellular connections that hold together the cells.
o desmosomes
o spot desmosomes
o hemidesmosomes
17. Name the basic shapes of the epithelial cells.
o Squamous
o Columnar
o Cuboidal
2. Classify epithelia according to the number of layers.
o Cardiac
o Skeletal
o Type of muscle tissue that shows no striations.
o Smooth
o Neural tissue is specialized for:
o conducting electrical impulses
o Name the two basic types of cells of the neural or nervous tissue.
o Neurons
o Neuroglia
o The bone is avascular (T/F):
o False
o The epithelium is avascular (T/F):
o True
o The cartilage is avascular (T/F):
o True
o What is the antiangiogenesis factor?
o Chemical produced by chondrocytes that discourages the formation of blood
vessels
o What is the inflammatory response?
o The tissue's first response to injury, isolates the injured area while damaged cells,
tissue and any dangerous microorganisms are cleaned up.
o What is a membrane?
o Epithelia and connective tissues unite to form membranes that line, cover, or
surround surfaces of the body and organs and cavities in the body. Together they
form a functional whole structure and a physical barrier.
o Function of the membranes.
o Physical barriers
o Line or cover portions of the body
o Consist of:
o An epithelium
o Supported by connective tissue
o Types of membrane?
o Serous membrane
o Mucous membrane
o Synovial membrane
o Cutaneous membrane
2. Location of the mucous membranes, serous membranes. Synovial
membranes and cutaneous membranes.
o Mucous Membrane:
digestive, respiratory, urinary, and reproductive tracts
o Serous Membrane:
pleura, peritoneum, pericardium
o Synovial Membrane:
line moving, articulating joint cavities; protect the ends of bones
o Cutaneous Membrane:
in the skin, surface of the body
o What is dysplasia?
o A reversible change in the normal shape, size, and organization of the tissue
o What are the tissue changes with age?
o repair process is slower due to poorer circulation
o speed and effectiveness of tissue regeneration decreases
o hormonal changes take places
1. avascular
2. oxygen and nutrients defuse from the dermis
2. Where are found the epidermal cells with the highest metabolic demands?
1. closest to the underlying dermis
Why?
epidermal cells rely on diffusion of nutrients and oxygen from the
capillaries within the dermis
3. Name the most abundant epithelial cells.
1. keratinocytes
4. Where is found the thin skin?
1. most of the body
5. Where is found the thick skin?
1. palms of hands
2. soles of the feet
6. Number of layers in the thin skin.
1. 4 layers of keratinocytes
7. Number of layers in the thick skin.
1. 5 layers of keratinocytes
8. The stratum corneum has a much thicker superficial layer in the ---------------skin.
9. The stratum lucidum appears only in the:
1. thick skin
10. Name the strata in order from the basal lamina to the surface.
1. basal lamina
2. spinosum
3. granulosum
4. lucidium
5. corneum
2. The stratum germinativum is also known as --------------------------layer.
1. basale layer
3. Function of the hemidesmosomes found in the basal layer.
1. Inflammatory
2. Migratory
3. Proliferation
4. Scarring
2. What is a scab?
1. long bone
bones that are longer than they are wide. have a pole like shaft (diaphysis)
and two wide ends (epiphysis)
EX: femur, metacarpals, metatarsals, humerus, etc..
2. short bone
small box like bones with equal length and width
EX: carpals, tarsals
3. flat bone
think bones that are sandwich like.
they have an inner and outer layer of compact bone, with a spongy bone
layer in the middle
EX: skull bones, sternum, scapula
4. irregular bone
asymmetrical shape, have pointed surfaces
EX: hip bones, vertebrae
2. What is a sesamoid bone. Give an example of sesamoid bone.
1. small bones that are insides of tendons or membranes
EX: patella, hyoid
3. Name the 4 bones that contain Para nasal sinuses
1. frontal
2. ethmoid
3. sphenoid
4. maxillary
2. Name all the bone cells. Give the function of: the Osteocytes, Osteoblasts,
Osteoclasts and Osteoprogenitor cells.
1. osteocytes
mature bone cells that maintain protein and the mineral content of the
bone matrix.
they do not divide.
they are found in cavities called lacuna and have cytoplasmic extensions
that pass through canaliculi.
they also help to repair damaged bone.
2. osteoblasts
they produce new bone matrix during the process of osteogenesis
(ossification)
eventually become osteocytes
osteoid is the matrix that has not been calcified
3. osteoclasts
large multinucleated cells that produce acids and protein-digesting
enzymes that dissolve the bone matrix which is absorbed and removed to
release primarily calcium when blood calcium levels are low
break down bone
maintain homeostasis
4. osteoprogenitor cells / osteogenic cells
bone stem cells
they are mesenchymal cells that become osteoblasts
located in the inner cellular layer of the periosteum and endosteum
they assist in fracture repair.
2. List the Organic components of the matrix.
1. collagen
3. List the Inorganic Components.
1. Calcium
2. Potassium
3. Sodium
4. Magnesium
5. Carbonate
6. Phosphorus
4. Name the largest bone cells?
1. osteoclasts
5. Name the mature bone cells.
1. osteocyctes
6. Name the most abundant bone cells
1. osteocytes
7. What is a lacuna?
1. depressions in bone matrix that contain osteocytes
8. What type of cell contains the lacuna?
1. osteocyte
9. How many cells contain the lacuna?
1. one
10. Describe the canaliculi. Give the function of the canaliculi.
1. narrow like channels that form pathways for blood vessels
2. allows exchange of nutrients & waste
11. What is Osteolysis?
1. dissolve bone matrix & release stored minerals
2. think osteoclasts
12. What is Osteogenesis?
1. produce new bone matrix, also known as ossification
2. think osteoblasts
13. Name the two types of Osseous Tissue?
1. compact
2. spongy
14. What type of osseous tissue reduces the weight of the skeleton?
1. spongy
15. What type of bone is adapted to withstand stresses that arrive from a limited range
the directions?
1. compact
16. What is the periosteum?
1. covers all bones
2. isolates the bone from surrounding tissues
3. provides a route for circulatory & nervous supply
4. participates in bone growth & repair
17. What is the endosteum?
1. inner lining of the bone
2. incomplete cellular layer, lines the marrow cavity
3. lines the inner surfaces of the central canals
4. where cellular layer is incomplete, matrix is exposed; osteoblasts & osteoclasts
can remove or deposit matrix components
18. What is the location of the osteoprogenitor cells?
1. present in the bone marrow
2. periosteum
3. even adipose tissue.
19. Where are the osteoclasts more numerous?
1. sites of active bone cell activity (living bones)
20. Name the 4 tissue types.
1. epithelial
2. connective
3. muscle
4. neural
2. The Bone tissue belongs to which of the 4 tissue types?
1. connective
2. Is the bone tissue vascular or a vascular?
1. vascular
3. What is the location of the central canal? Name the structure contained within the
central canal,
1. in the middle of the osteons
2. Contains one or more blood vessels – normally a capillary & venule that carry
blood to and from the osteon
4. What is the position of the Perforating canal?
1. perpendicular to the surface of the bone
5. Which structure is characteristic of compact bone?
1. the matrix of the bone is very dense and contains deposits of calcium salts
2. the matrix of the bone contains osteocytes
3. narrow channels pass through the matrix to allow for an exchange of nutrients
6. What is the functional unit of the compact bone?
1. osteon
7. What is the Osteon?
1. structural units of mature compact bone
8. What is the Haversian system?
1. a Haversian canal along with the concentric layers of compact bone surrounding it
9. What is the position of the Osteon in relation to the diaphysis?
1. parallel
10. What are the trabeculae?
1. Open network; Interconnecting tiny arches of bone tissue found in spongy bone
11. What type of osseous tissue contains the trabeculae?
1. spongy bone
12. Describe the position of the concentric lamellae.
1. around central canal
2. surround osteon
13. Describe the position of the interstitial lamellae.
1. fill the spaces between the osteons
14. Describe the position of the circumferential lamellae.
1. wrapped around long bones & bind osteons together
2. at outer & inner bone surfaces
15. Name the different parts of the long bone.
1. The shaft of the long bone is called the diaphysis
2. The upper end of the long bone is called the epiphysis
3. The lower end of the long bone is called the epiphysis
16. The region that connects diaphysis and epiphysis is the:
1. metaphysis connects the diaphysis and epiphysis
17. What is the location of the yellow marrow?
1. medullary cavity
2. spaces within spongy bones
18. What is the location of the red marrow?
1. medullary cavity
2. spaces of the spongy bone of the epiphysis of long bones
19. Function of the yellow marrow.
1. store lipids
20. Function of the red marrow.
1. blood cell formation
21. What is Calcification?
1. process of depositing calcium salts in a tissue
22. What is Ossification?
1. process of bone formation
23. Name the different types of Ossification.
1. Intramembranous or dermal ossification.
2. Endochondral (from cartilage) ossification.
24. Concept of Intramembranous Ossification...
1. the process of bone development from fibrous membranes
25. Give examples of Intramembranous Ossification...
1. flat bones of the skull
2. mandible
3. clavicles
26. Concept of Endochondral Ossification.
1. cartilage model that is slowly replaced with bone at the metaphysis
2. most bones originate as hyaline cartilage
3. Growth and ossification of long bones occurs in 7 steps.
1. hematoma formation
2. callus formation
3. spongy
4. bone formation
5. compact bone formation
2. Give the function of Vitamin D in relation with Calcium.
1. What is an articulation?
2. What is a synarthrosis?
3. What is a diarthrosis?
4. What is an amphiarthrosis?
5. A slightly movable joint is a:
6. A freely movable joint is a:
7. A nonmovable joint is a:
8. What is a synostosis?
9. A joint formed by the fusion of two bones is a .... Give an example of synostosis.
10. A suture is an example of:
11. An epiphyseal line is an example of a:
12. Name the three types of fibrous joints.
13. Give one example of suture
14. The joint that binds the teeth to the bony socket is an example of Gomphosis.(T, F)
15. A ligamentous connection such as interosseous ligament is an example of
Syndesmosis (T, F)
16. The synovial joints are all diarthrosis. True or false?
17. Give the characteristics of the synovial joints.
18. Where is secreted the synovial fluid?
19. Give all the functions of the synovial fluid.
20. The synovial fluid resembles interstitial fluid (true or false).
21. The synovial fluid contains a higher concentration of proteoglycans (T. or F).
22. The synovial fluid is secreted by fibroblasts of the synovial membrane(T or F).
23. The synovial fluid is a lubricant? (T, F).
24. The synovial fluid is a viscous solution? (T/F)
25. The synovial fluid reduce friction? (True or false)
26. Give the characteristics of the surfaces of the articular cartilages.
27. The Articular cartilage consist of Hyaline cartilage (T or F),
28. Functions of the articular cartilages.
29. What is the meniscus? Location of the meniscus. Function of the meniscus
30. The meniscus allow variation of shapes of the articular surfaces (True or false)
31. What ligament reinforces the lateral surface of the knee?
32. What ligament reinforces the medial surface of the knee joint?
33. The ligament that limit anterior posterior movement of the femur and maintain the
alignment of the femur and the femoral and tibial condyles are the cruciate
ligaments (true or false)
34. The back of the knee joint is reinforced by popliteal ligaments, (T,F)
35. Name the ligament that attaches the patella to the tibial tuberosity.
36. Why the complete dislocation of the knee is an extremely rare event?
37. What is a bursae? Function of the bursae?