HEALTH WORKING GROUP (ENVI)

Public Webinar on Complementary Integrative Medicine

Monday, 11 October 2021, 12.00 - 13.30

INTEGRATIVE ONCOLOGY
COMPLEMENTARY MEDICINE IN THE
PREVENTION AND SUPPORT OF THE
ONCOLOGICAL PATIENT

Dr Jorge Pérez-Calvo Soler

Director of the Centre for Biological Medicine and Integrative
Oncology Unit, Barcelona

1
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

Cancer is responsible for more than of 25%

total deaths in Europe and is the leading 1 IN 2 MEN
cause of death between the ages of 45 and 1 IN 3 WOMEN
WILL GET CANCER
65, a number increasing every year (1)
(2)

CANCER CASES (3)

Diagnosed:
4,398,443
Deaths:
1,955,231

2040: projected to increase 70% (4)

Vican5 study : 5 years after cancer :

 The total cost of cancer was €199
-. 63.5% OF PATIENTS SUFFER FROM SEQUELAE
billion in Europe in 2018 (5)
-. 50% ARE LIMTED IN THEIR PHYSICAL ACTIVITY
(6)
I-. 48.7% SUFFERS FROM FATIGUE

(1) EUROSTAT – Statistics Explained. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Causes_of_death_statistics/es&oldid=505766

(2) Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2016, National Cancer Institute. Bethesda, MD,
https://seer.cancer.gov/csr/1975_2016/, based on November 2018 SEER data submission, posted to the SEER web site, April 2019.
(3) International Agency of Research on Cancer. https://gco.iarc.fr/today/home
(4) WHO report on cancer: setting priorities, investing wisely and providing care for all. Geneva: World Health Organization; 2020. Licence: CC BY-NC-SA 3.0 IGO.
(5) Hofmarcher T., et al. The cost of cancer in Europe 2018; 2020. DOI: https://doi.org/10.1016/j.ejca.2020.01.011
(6) « La vie cinq ans après un diagnostic de cancer », INCa, June 2018. 2
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

MULTIFACTORIAL CANCER CAUSES

• CHRONIC INFLAMMATION
• OBESITY
• ALCOHOL, RED MEAT, REFINED SUGARS
• UNAPPROPRIATED FOOD-NUTRITION
• HEAVY METALS, ARSENIC,..
• ENVIRONMENTAL POLLUTANTS, TOXINS
• SEDENTARY LIFESTYLE
• SOME ELECTROMAGNETIC RADIATION
• TOBACCO
• SOME VIRUS
• STRONG EMOTIONAL STRESS
(7)
Greater resilience to diseases
and cancer treatment
IMPROVING
LIFESTYLE Better clinical results
Greater Well-being
COMPLEMENTARY
Longer life expectancy
MEDICINES
Decrease in relapses
(7) World Cancer Research Fund / American Institute for Cancer Research. 3
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

51% of cancer patients used INTEGRATIVE ONCOLOGY

CONVENCIONAL COMPLEMENTARY
complementary treatment (8) THERAPIES
TREATMENT:
• Surgery • Nutritional medicine and food
In pediatric oncology, of 80% • Radiation therapy • Chinese traditional medicine
• Chemotherapy • Acupuncture
families with a child with cancer (9) • Intravenous Vitamin C
• Hormone therapy
• Immunotherapy Infusions
• Ozone therapy
• Oncothermia
• Psychological stress support
• Homeopathy
• Yoga y Meditation
SCIENTIFIC • Physical exercise
EVIDENCE • Phytotherapy
• Aromatherapy
SANT JOAN DE DÉU HOSPITAL
Complementary treatment in Children's Oncology

Integrative Oncology seeks to optimize health,

biological condition, quality of life, and clinical
outcomes, throughout the cancer process,
supporting and respecting conventional treatment.

(8) Martin R. Keene, Ian M. Heslop, Sabe S. Sabesan, Beverley D. Glass, Complementary and alternative medicine use in cancer: A systematic review, Complementary Therapies in Clinical Practice, Volume 35, 2019, Pages 33-47, ISSN
1744-3881, https://doi.org/10.1016/j.ctcp.2019.01.004.
(9) https://www.sjdhospitalbarcelona.org/es/oncologia-integrativa-pediatrica 4
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

IMPORTANCE OF INTEGRATIVE ONCOLOGY

In United State of America:

45 National Cancer Institutes (NCI)
Provide services:
• 60% centers have integrative medicine doctors
• 91% Offer Consultation on nutrition
• 73% Offer Acupuncture
• 84% Dietary supplements
• 67% Herbs (10)

• 69% Meditation and Yoga

Excellence care
• In Pediatric Oncology Centers
accreditation
Public Hospitals in Europe:
• Charité – Universitäts medizin, Berlin
• Pediatric Oncologic Center Sant Joan de Déu, Barcelona
(10) Hyeongjun Yun, Lingyun Sun, Jun J. Mao, Growth of Integrative Medicine at Leading Cancer Centers Between 2009 and 2016: A Systematic Analysis of NCI-Designated Comprehensive Cancer Center Websites, JNCI Monographs,
Volume 2017, Issue 52, November 2017, lgx004, https://doi.org/10.1093/jncimonographs/lgx004 5
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

51% of cancer patients used INTEGRATIVE ONCOLOGY

CONVENCIONAL COMPLEMENTARY
complementary treatment (8) THERAPIES
TREATMENT:
• Surgery • Nutritional medicine and food
In pediatric oncology, of 80% • Radiation therapy • Chinese traditional medicine
• Chemotherapy • Acupuncture
families with a child with cancer (9) • Intravenous Vitamin C
• Hormone therapy
• Immunotherapy Infusions
• Ozone therapy
• Oncothermia
• Psychological stress support
• Homeopathy
• Yoga y Meditation
SCIENTIFIC • Physical exercise
EVIDENCE • Phytotherapy
• Aromatherapy
SANT JOAN DE DÉU HOSPITAL
Complementary treatment in Children's Oncology

Integrative Oncology seeks to optimize health,

biological condition, quality of life, and clinical
outcomes, throughout the cancer process,
supporting and respecting conventional treatment.

(8) Martin R. Keene, Ian M. Heslop, Sabe S. Sabesan, Beverley D. Glass, Complementary and alternative medicine use in cancer: A systematic review, Complementary Therapies in Clinical Practice, Volume 35, 2019, Pages 33-47, ISSN
1744-3881, https://doi.org/10.1016/j.ctcp.2019.01.004.
(9) https://www.sjdhospitalbarcelona.org/es/oncologia-integrativa-pediatrica 4
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

NUTRITION IN CANCER

IMPORTANT SCIENTIFIC EVIDENCE

on foods that pose a risk of promoting cancer and foods with the
ability to fight it :

WCRF (World Cancer Research Fund)

https://www.wcrf.org (13)

AICR (American Institute for Cancer Research)

http://www.aicr.org (14)

WHO (World Health Organization)

http://www.who.int/es (15)

(13) World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Judging the evidence. Available in dietandcancerreport.org
(14) American Institute for Cancer Research, «AICR, the China Study, and Forks Over Knives», http:// www.aicr.org/ about/ advocacy/ the-china-study.html , 9 January 2015.
(15) WHO, Technical Report Series 2003. “Diet, Nutrition and the Prevention of Chronic Diseases” 6
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

Foods that pose a risk of promoting cancer

NUTRITION IN CANCER and foods with the ability to fight it.
Nutritional medicine can improve
adherence to treatment, quality of
life and chances of survival

(13)

(13) This material has been reproduced from the World Cancer Research Fund/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective. Continuous Update Project Expert Report 2018.
Available at dietandcancerreport.org. 7
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

OZONE THERAPY AS AN ONCOLOGICAL ADJUVANT TREATMENT

Improves tissues oxygenation . Powerful systemic antioxidant effect.

(18)
REFRACTORY Worst
unimaginable MODERATE THE TOXIC EFFECT
ONCOLOGICAL PAIN Pain
OF CHEMO AND RADIATION
THERAPY
(17)
SECONDARY TO:
• Radiotherapy
• Chemotherapy
• Endoscopy

REFRACTORY TO MANY TT.

• Opioid Treat.,
• Invasive Techniques in
Chronic Pain Units
HEALING DELAYS IN
IMPROVEMENT: 5 / 6 CANCER PATIENTS WOUNDS (19)

NO
Pain

BERNARDINO CLAVO MD, PHYD (16)

Ozone Therapist. Head of the Research Unit at the Hospital Universitario de G. C.
Dr. Negrín, Canary Islands Health Service, Spain.

(16) Clavo et al., “Ozone therapy as adjuvant for cancer treatment. Is further research Warranted?”.pag.9.Evidence based complementary and alternative medicine. https://doi.org/10.1155/2018/7931849
(17) Clavo, et al ,Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects
(18) Clavo, et al .Journal of Palliative Medicine. Jan 2021.97-102.http://doi.org/10.1089/jpm.2019.0597
(19) Clavo, et al ”OZONOTERAPIA tópica y en el tratamiento de los retardos de cicatrización en pacientes oncológicos” revista de Oncología, volumen uno, pp. 45-46. 1999 8
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

OZONE THERAPY AS AN ONCOLOGICAL ADJUVANT TREATMENT

FATIGUE and WELLBEING (20)

BREAST CANCER-RELATED LYMPHEDEMA
(21)

SINGLE BLINDED RANDOMIZED

CONTROLLED CLINICAL TRIAL
n= 60, randomized with/without O3
All patients were treated with
complex physical therapy for
lymphedema
At 12 weeks Limb volume in
both groups.

Improvement was higher in Ozone

group: p < 0.05

 More research is needed given its

great therapeutic potential

(20) Tirelli U., et al, Oxygen—ozone therapy as support and palliative therapy in 50 cancer patients with fatigue. EUROPEAN REWIEU FOR MEDICAL and farmacological science 2018;22:8030-8033.
(21) Waked, I. S., et al . (2013). A Single Blinded Randomized Controlled Clinical Trial on the Efficacy of Ozone Therapy on Breast Cancer-Related Lymphedema. Cancer and Clinical Oncology, 2(2). https://doi.org/10.5539/cco.v2n2p93 9
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

ONCOTHERMIA AS AN ONCOLOGICAL ADJUVANT TREATMENT

Reduction of tumors without side effects.
Complementary with chemo and radiotherapy, increasing effectiveness.
(22)

ONCOTHERMIA AROUND THE WORLD

(22) Oncothermia Journal https://oncotherm.com/ 10

 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

ONCOTHERMIA AS AN ONCOLOGICAL ADJUVANT TREATMENT

Some interesting results in cancer.

GLIOBLASTOMA (a) LUNG (b) PANCREAS (c)

glioblastoma multiform Lung cancer at Pancreatic cancer at

at diagnosis. Inoperable diagnosis diagnosis

Radio + Quimio therapy + Radiotherapy Oncothermia

Oncothermia + Oncothermia

AFTER FIRST DIAGNOSIS DECREASE IN TUMOR REDUCTION IN TUMOR

PATIENT SURVIVED 24 MASS, NORMALIZATION SIZE. STABLE 8 MONTHS.
MONTHS OF TUMOR MARKERS
(a) Sahinbas H, Baier JE et al. (2006) Retrospective clinical study for advanced brain-gliomas by adjuvant oncothermia (electro-hyperthermia) treatment.
(b) Szasz A. Szasz o. Case reports made by Oncothermia. Oncothermia Journal. 2013, 8:47-88
(c) Tae Sig Jeung, Sun Young Ma, Jesang Yu, and Sangwook Lim. Cases That Respond to Oncothermia Monotherapy. Conference Papers in Medicine. Volume 2013 (2013), Article ID 392480, 12 pages Szasz A. Szasz o. Case reports made
by Oncothermia. Oncothermia Journal. 2013, 8:47-88 11
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

TCM AND ACUPUNTURE

High amount of scientific evidence treatment that helps in different conditions, as
pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression
and insomnia
SANT JOAN DE DÉU HOSPITAL - PEDIATRIC CANCER CENTER, BARCELONA
(23)

(23) M. Kay Garcia, et al. Systematic Review of Acupuncture in Cancer Care: A Synthesis of the Evidence. J Clin Oncol 31:952-960. © 2013 by American Society of Clinical Oncology. DOI: 10.1200/JCO.2012.43.5818 12
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

INTEGRATIVE ONCOLOGY, ACUPUNTURE AND TCM

SANT JOAN DE DÉU HOSPITAL
CANCER CENTER, BARCELONA
- PEDIATRIC
Excellence care
accreditation

13
 HEALTH WORKING GROUP (ENVI)
Public Webinar on Complementary Integrative Medicine
Monday, 11 October 2021, 12.00 - 13.30

CONCLUSION

In an attempt to prevent the rising tide of cancer and improve the

quality of life and prognosis of the cancer patient, a framework of
support for complementary medicines / integrative oncology is
required at the level of the European Institutions.

Thanks for your attention

Dr Jorge Pérez-Calvo Soler

Director of the Centre for Biological Medicine and Integrative
Oncology Unit, Barcelona

14