Professional Documents
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Discussions Prescription Analysis
Discussions Prescription Analysis
OVERVIEW
Prescription
from the Latin words; prae – before; and scribe – I write
an order for medication issued by a physician, dentists, veterinarian or other properly
licensed practitioner
PARTS OF PRESCRIPTION
1. Prescriber’s information
2. Patient’s information
3. Date
4. Superscription or Rx symbol, from Latin “recipe”, “you take”
5. Inscription or Medication Prescribed – names of prescribed medications, dosage form,
dose and quantity
6. Subscription or Dispensing direction to the pharmacist
7. Transcription or Signa – direction to the patient
8. Refill, special labelling and/or other instructions
9. Prescriber’s signature
TYPES OF PRESCRIPTION
a. Simple prescription
with only one ingredient
b. Compound prescription
with more than one (1) ingredient but not more than ten (10)
c. Polypharmacal prescription
with ten (10) or more than ten (10) ingredients of the same therapeutic
use
Also called shot gun prescription
Magistral Prescription
A prescription which is prescribed very often by the same doctor, of the same
ingredients and compounded by the same pharmacists
A coded Prescription
also called blind prescription and consists of words symbols, to represent the
names of the drugs
unethical practice of same doctors and pharmacists
Other Abbreviations
ATC – around the clock BM – Bowel Movement WA – While awake
Check for incompatibilities with other drugs in the prescription and/or being taken
by the patient (drug – drug interactions; drug – disease interactions)
Medication error
Any preventable event that may cause or lead to inappropriate medication use or
patient harm while the medication is in the control of the health professional, patient or
consumer
2. NUMBERING THE PRESCRIPTION
Legal requirement
Identify the bottle or package
For reference in case of refill
In duplicate or triplicate (in Rx label and record book)
Pharmacy Compounding
is defined as the preparation, mixing, assembling, packaging, or labelling of drug or
device as a result of a practitioner’s prescription or drug order.
Fortify or reduce the strength of an active ingredient in a dermatological preparation
Reformulate adult dosage forms such as tablets or capsules, into an oral suspension for
pediatric use, or IV admixture
Most serious mistake: dispensing the incorrectly compounded or the wrong drug: follow
systematic approach in compounding;
6. PACKAGING
Main function of the container: to maintain the quality, safety, and stability of its
contents
Dropper bottles
• Examples: Opthalmic bottles for eyes and oral liquids to be
administered by drops
Applicator bottles
• for liquid medications to be applied to a wound or to skin surface
-Nasal containers
• for the nose
Prescription Bottles
•for capsules and tablets and for liquids of low viscosity
Prescription Bottles
7. RECHECKING
Ingredient and amount used must be verified by the pharmacist (other pharmacist, if
available)
All details in the labels should be rechecked against the prescription order
8. DELIVERING AND PATIENT COUNSELLING
The following information should be provided to the patient:
Dosage form and its identity
Indications or expected action
Contraindication
Dosage or amount to be used
Frequency of administration (correct/exact time of administration)
Duration of treatment
Expected side effects
ADR’s
Drug interactions (drug-drug, drug-food)
Consequences of non – compliance/compliance
Proper storage of the medication
There are different methods used in pricing the prescriptions. The most commonly used method
of pricing the prescription is the following:
1. Percentage Mark -up
Formula: Dispensing price = Cost of ingredients + ( cost of ingredients X % mark -up)
Example: The unit price of the drug is P 5.00 and the % mark up is 10%. What is the
dispensing price.
Dispensing price = P 5.00 + ( 5.00 x 10/100)
= 5.00 + 0.5
= P 5.50
Minimum fee is usually established to recover the combined cost of the container, label,
overhead expenses and professional services.
Example: The unit price of the drug is P 5.00 and the % mark-up is 40%. The minimum
fee is P 5.00. What is the dispensing price?
3. Professional fee
The true professional fee is independent of the cost of ingredients. They are all the same
in all prescriptions. The greater the cost of ingredients, the greater is the fee.
Rules and regulations to Implement Dispensing Requirements Under the Generics Act of 1988
(R.A. No. 6675)
Means dispensing the patient’s/buyer’s choice from among generic equivalents
- Finished pharmaceutical products having the same active ingredient(s), same dosage
form and strength as the prescribed drug
LIST A
1.2 * Per DDB Regulation No. 3 s. 2005 — to be prescribed thru Ordinary Rx (Personalized
Rx) with S2, 1 DDP per Rx, Partial Filling allowed, No Refill.
KETAMINE — (Vial : Ketamax. Ketazol, Ketram, Uniket)
1.3 * Per DDB Regulation No. 3 s. 2005 — to be prescribed thru Ordinary Rx (Personalized
Rx) with S2, 1 DDP per Rx, Partial Filling allowed, No Refill.
1.4. * Per DDB Resolution No. 8 s. 2004 — preparations not in injectable form i.e. capsule,
tablet or syrup, to be prescribed thru Ordinary Rx (Personalized RX) with S2, 1 DDP per
Rx, Partial Filling allowed, No Refill.
Section 32 (6), DDB Regulation No. 3 s. 2003 — The quantities that may be prescribed in a
single
applicable prescription by a licensed practitioner should not exceed the specified quantities as
follows:
LIST B MEDICINES
List B medicines include immediate release, solid oral dosage forms of multisource
(generic) pharmaceutical products that require in-vivo bioequivalence studies as
proposed
by the World Health Organization (WHO):
Pharmaceutical formulations that can be eligible for a biowaiver procedure not requiring in-vivo
bioequivalent studies show the following characteristics:
1. should contain a Class I API
2. should be rapidly dissolving (should release at least 85% of its content in 30 minutes in
media with pH 1.2, pH 4.5 and pH 6.8 at 37° Celsius)
3. should not contain excipients which could influence the absorption of the API.
4. should not contain API with narrow therapeutic index.
5. should not be designed to be absorbed from the oral cavity.
High permeability ensures complete uptake of 85% or more of the API during its passage in the
small intestines.
The WHO noted that in some countries, products may be available at doses exceeding the highest
dose on the WHO Essential Medicines List (EML). In such cases, the WHO tables on biowaivers
may no longer be appropriate and the dose solubility ratio and permeability will have to be
reassessed at the product dose.
List B Medicines in the PNDF vol. 1, 7th edition includes the following:
1. Acetazolamide 250 mg
2. Albendazole 400 mg
3. Artemether 20 mg + lumefantrine 120 mg
4. Artesunate 50 mg
5. Azathioprine sodium 50 mg
6. Azithromycin 500 mg
7. Carbamazepine 200 mg
8. Cefixime 400 mg
9. Ciclosporin 25 mg
10. Clofazimine 100 mg
11. Dapsone 100 mg
12. Diloxanide furoate 500 mg
13. Efavirenz 200 mg
14. Erythromycin stearate and ethylsuccinate 250 mg
15. Etoposide 100 mg
16. Furosemide 40 mg
17. Glibenclamide 5 mg
18. Griseofulvin 250 mg
19. Haloperidol 2 mg
20. Indinavir sulfate 400 mg
21. Ivermectin 6 mg
22. Lopinavir 133.3 mg + ritonavir 33.3 mg
23. Mefloquine hydrochloride 250 mg
24. Mercaptopurine 50 mg
25. Nelfinavir mesilate 250 mg
26. Nevirapine 200 mg
27. Nifedipine 10 mg
28. Nitrofurantoin 100 mg
29. Phenytoin sodium
30. Praziquantel 600 mg
31. Pyrimethamine 25 mg
32. Retinol palmitate 110 mg (200,000 IU)
33. Rifampicin 300 mg and rifampicin FDC with other anti‐TB medicine
34. Ritonavir 100 mg
35. Saquinavir 200 mg
36. Spironolactone 25 mg
37. Sulfadoxine 500 mg + pyrimethamine 25 mg
38. Sulfamethoxazole + trimethoprim
400 mg + 80 mg
39 + 160 mg
39. Theophylline anhydrous
40. Verapamil hydrochloride 80 mg
Compounding is important and it requires professional skills learned by practice and you should
be able to have knowledge in the following:
Uses
Compatibilities
Incompatibilities
Dosages
Since compounding has been largely replaced by
- Methods of formulation
- Methods of processes
- Industrial Processes
As a Pharmacist, you are required to know how to formulate and understand dosage forms
Dosage Forms
Drugs
Any substance which, when ingested, elicits a pharmacological response
o Propranolol – decreases blood pressure
o Digoxin – increase myocardial contractility
o Ibuprofen – acts as pain reliever
Dose
A measured quantity of medicine to be administered either at one time or over a period
of time
o 1 tab 3x a day
o A cap OD
o Inject 30mg SC qd
Route of Administration
The way the drug is given
o PO
o IV
o IM
o SC
Dosage Range
Smallest dose which does not cause a toxic effect
o 30mg – 300mg
o 0.5mg – 300mg
o No more than 4000mg daily
o 0.05 – 0.375 mg
In making the final decision in dispensing and compounding of the prescription, numerous
factors must be considered:
Dosage size
o Peripheral vs. central infusion
o Tablets vs.suspensions
Route
o Parenteral vs. Oral
Interval
o Peak and Trough
o Adjust dose and interval to avoid toxicity
Allergies
o Penicillin allergy
Designation (Temperature)
Freezer
Refrigeration
Room Temperature
The ideal prescription analysis should be done by the clinical pharmacist and then the oncology
pharmacist, and it includes:
Dose adjustments
Should this patient have their doses adjusted? How are their exams? Is a drug of their
prescription toxic according to his/her condition evaluated by exams and evolution? A
table of a good reference containing dose adjustments for each drug and each possible
condition (such as renal or hepatic impairment, blood count decreased, and others) will
be of importance to this analysis.
Exams evaluation
Can this patient receive chemotherapy? How are their leukocytes? How are the exam
requirements of the phase in which the patient is in? Are they into these conditions?
Physical-chemical stability
Some drugs have few hours of stability and should be handled next to the time of
administration. When each drug will be administrated?
Drug-interactions
Drug-interaction analysis is not simple and should receive attention with the required time
to confer the prescribed drugs, solutions, material used, and the patient’s diet.
Support drugs
Does the protocol mention support drugs? Are they prescribed? Does the patient have the
necessity to receive more doses, or a higher dose, of a supportive drug, e.g., more doses
of mesna because the patient always has cystitis? It is necessary to confer if the physician
has not forgotten a drug, such as for nausea, pain, allergy, or others that should be
prescribed.
Patient’s evolution
Is there new information about the patient?
Patient follow-up
Was the patient checked by all the necessary teams, such as clinical pharmacy? It is very
important to be sure that the patient has their height and weight measured before
receiving this cycle. Pediatric patients have their weight and height changed quite quickly.
The body surface should be calculated again before each cycle of chemotherapy