Systemic Procain Therapy BOGOTA 2016

systemic procain therapy 07.10.
16
Systemic Procain Therapy

- Twenty years experience with
Procain infusion -
Dr.med. R. Oettmeier
Tel +41
+41 71
71335
33571715757 • Fax
• Fax +41
+41 71 71
335335 71•56
71 56 • Mail
Mail academy@paracelsus.ch
academy@paracelsus.ch • www.paracelsus.ch
• www.paracelsus.ch
Procain –
the innovative Classic
PROCAIN
The royal
Remedy ...
Prof. Aslan, 1954
Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com
Dr. Oettmeier, Paracelsus Academy 2016 1

systemic procain therapy 07.10.16
Procain: natural remedy with a

big palette of action
Pharmacological Effects of Procain
– Poor of side effects

– Low half life period acceptance
– Low toxicity
– Local anesthesia
– Endo anesthesia Neural Therapy
– sympathicolytic Pain Therapy
– Vascular dilatation RR - regulation
– bronchospasmolytic Lung function
Increase of coronary perfusion
– negative inotrop and antiarhythmic heart effects
– Anti-inflammatory chron. inflammation
– Anti-rheumatic pcP, Kollagenossis
– Anti-cancerous Tumor Therapy
– Vitalization Well-Aging
Procain –
the royal remedy
Feature of Procain
• Increase of Microangio-
perfusion (Glusa et al. 1999, Huang et al. 2009)
• Inhibition of Inflammation
(Donaldson et al. 1994, Levine et al. 1985, Niederau et al. 2003)

Procain –
the royal remedy
Feature of Procain
• Antioxidative Effect (Rusu et al.
1996, Dolganiuc et al. 1998, Kasch 2000)
• Antirheumatic and Joint

protective Effect (Bräuer et al 2000,
Krause et al 2000, Kasch et al 2001)
Procain –
the royal remedy
Feature of Procain
• Reduction of Side Effects

from Chemotherapy and
Radiation (von Yau et al. 1980, Hidvegi et al.
1982, Chlebovski et al. 1982, Esposito et al. 1990, Viale
et al. 1998)

Procain –
the royal remedy
Feature of Procain
Cancer Inhibition and

Prevention
Procaine is a DNA-demethylating
Agent with Growth-inhibitory Effects
in Human Cancer Cells (Villar-Garea,
Fraga, Espada & Esteller , [Cancer Research
63, 4984-4989, August 15, 2003]
Procain –
the royal remedy
Feature of Procain
brightened mood, anxiety loss,

emotional relaxing
Balancing of neurotransmitter metabolism in limbic
system (e.g. CRH), HAHN-GODEFFROY, Schweiz. Z.
Ganzheitsmed. 23, 291-296 (2011)

Procain – fields of application

(parenteral)
Effect Amount
local anesthesia
local small
wheal- and trigger point application
Nerve root blockades
regional Ganglion blockades middle
Anesthesia oversegmental
systemic large
Procain-(Base)-Infusion
History of systemic Procain

Therapy
1996
• Infusionsneuraltherapie (Reuter &
Oettmeier, NaturaMed 7, 20-25)
1999
• Die hochdosierte Procain-Basen-
Therapie (Reuter & Oettmeier, Ärztezeitschrift
Naturheilverfahren 40, 776 - 782)
2000
• Die kontinuierliche Procain-Basen-
Dauerinfusion/-perfusion (Oettmeier &
Reuter, Erfahrungsheilkunde 2, 75-84
2012
• Die systemische Procaintherapie
(Oettmeier & Reuter, Arzt – Zahnarzt –
Naturheilverfahren 2, 5-10)

Procain-Base-Infusion
The effective Synthesis ...
PROCAIN Sodium-bicarbonate
- analgetic - alkalizing
- anti- inflammative - mineralized
- anti-oxidative - Retardation of
- vasodilative Procain - degradation
systemic use of 200 – 500

mg Procain
as infusion
over 30-60 min.

• short infusion (30-60 Min.) with
– Procain Actavis 1% od. 2% (100-500 mg) no preservatives
added
– Natriumbikarbonat 8,4 % (20 - 120 ml)
– physiologic sodium chloride solution (250 – 500 ml)
• dosage at beginning: 50 - 200 mg Procain
• ECG recording and oxymetry up to mean dose and in risk
patients recommended
Titration of optimal dose
• at the beginning: 50-100 mg Procain & 20-

40 ml 8,4%ig Sodium-bicarbonate
• stepwise increase of dose with Procain (50-

100 mg) and Sodium-Bicarbonate (10-20 ml)
each
• preservation of dose in case of good

tolerance and better symptoms

Study of clinical use
Change of pain level and general condition under

procain-base infusion (n=281)
9
8
7 Reuter und Oettmeier 1999
6
VAS
5
4
3
2
1
0
0 1 2 3 4 5 6 7 8 9 10 nach nach
number of infusions 4 Wo. 12
Wo.
Belastungsschmerz
Pain at Loading Ruheschmerz
Pain at Rest Allgemeinbefinden
General condition
Study of clinical use
Change in the use of analgetics (NSAR ,

Opioids) under procain-base infusion (n=281)
100
Reuter und Oettmeier 1999
(%)
80
Verbrauch (%)
Consumption
60
40
20
0
vor before
Therapie nachafter
Therapie 3 3Mo. nach
month
Therapie
after
Opioids
Opioide NSAR Other Analgetics
sonstige Analgetika

experiences after approximately

220.000 applications (Greiz and
Lustmühle)
• heart palpitation (ca. 6%),
• RR drop (ca. 4%),
• RR rise (ca. 3%),
• headache (ca. 5%),
• sleep disorder (ca. 6%)
Important: all side effects were reversible
Procain-Basen-Infusion
experiences after approximately 220.000

applications (Greiz and Lustmühle)
Allergy ?

Results from Basic Research
ProcCluster® : the Prodrug of Procain

NaCl H
H H
H + H O O
N O
N H Cl
+
O H O NaCl
O
H2N H
O
O
O Metabolisierung Procain
H
+ O N
+ NaHCO3 N H2N
O O
O
Plasma esterase
Di-ethyl- O H O N
H pABA
amino- H2N
ProcCluster O
ethanol
Cl- Na+ (DEAE) main metabolits
Hauptmetabolite
Na+ Cl- The word ProcCluster means „Proc“ is standing

ProcH+ HCO3- for Procain and „Cluster“ is demonstrating the
Na+ Cl-
chemical procedure to embed the agent
Cl- Na+
Intermediate metabolite
ProcCluster®
the most important characteristics
• Amphiphilic (hydro- and lipophil)

Cl- Na+
• alkalic component is bound on
Cl-
Na+ procain (release retarded)
ProcH+ HCO3-
• retarded degradation from
Na+ Cl-
plasma esterase
Cl- Na+
• all application forms possible

Agent release
(ProcHHCO3 + NaCl)
NaCl 3
ProcHCl + NaHCO Procain + H2CO3 + NaCl
Cl- Na+
DEAE
DEAE Na+ Cl-
Na + pABA
Na+
HCO3- pABA ProcH+ HCO3-
HCO3- Procain
Na+ Cl-
Cl- CO32-
Procain Cl-
Cl- Na+ ProcH + HCO 3-
Use in neural therapy Capsule, Cream, High dosed Procain-Base

Injection, Infusion Infusion
Procain-HCl
100 % ProcCluster contains ca. 20%
stabilized, retarded ProcCluster
pH-Vergleich von Procain-Basen-Infusion (PBI) und

ProcCluster® (System Buffy, komstar.ch)
9
8,37
8,14
8
7,92
7,6
PBI 100/40
PBI 200/80
7
6,18 PBI 300/120
5,89
6 5,6 ProcCluster 0,1
4,84 ProcCluster 0,2
pH Wert
5
4,13
3,95 ProcCluster 0,3
4
NaBi 1,68 in NaCl 0,72
3
Procain 1%
2 Ultracain 1%
1 Lidocain 1%
Normal value blood:

0
7,35-7,45
Buffy
Proc-HCl / Actavis, Na-hydrogencarbonate 8,4% / Braun, ProcCluster / JenCluster

Procain orally und parenteral:

ProcCluster®
• agent-optimized procain - base: idea of action
1. Blood flow enhancement (dilatation of

small vessels, capillaries and lymphatic v.)
2. Reduction of pain (stabilization of
nerve membranes)
3. Alkalization (releasing of body-own base
sodium-hydrogen-bicarbonate)
4. Inhibition and prevention of cancer
(effect towards demythelization of
chromosomes into nucleus)
5. Anti-inflammatory effect (protection of
immune cells, inhibition of inflammarory
cytokines, additionaly combination effect
from points „1“ to „4“)
Procain systemic
treatment
Main indications
• All kinds of acute or chronic pain situations
• Base treatment in holistic cancer therapy
• Clinical and paraclinical hints of latent tissue acidosis
(pathol. pH-reduce pericellular)
• Inflammatory and auto-immune diseases (acut and
chronic)
• Prae- and postoperative (better wound healing,
Neuroprotection)
• Stress relief, infection, common cold, vitalisation,
rejuvenation

actual recommended
procedure
• Procain compartibility test

• Testing with1% Procain-HCl or ProcCluster®-cream
• Additionaly Acid-Base-Diagnostics
Optimal • Jörgensen-Test, Buffy, Sander, BET-A Vincent
• Procain-Base-short infusion
• 1-2x per week, before other infusions
• Start with 100 ml Procain/20-40 Na-bicarbonate
• increase of dosage till improvement of complaints
• ProcCluster®-Depot i.m. or orally

• i.m. 1-4x per month (2 % solution of ProcCluster 5 ml)
• Orally with Capsule (50 – 100 mg), dosage 1x1 or every other day
Metabolic alkalosis often in

chronic infections and cancer
Buffy-Test
(komstar.ch)

Metabolic acidosis often in chronic

pain and rheumatic diseases
Plasma Vollblut
Buffy-Test
(komstar.ch)
Procain-Base infusion adapted to

acid-base-balance
• Venous • Venous
Alkalosis Acidosis or
• Peripher normal pH
Acidosis • Peripher
venous
• Typic in Acidosis
venous capillary • Typic in
Cancer and
chronic capillary Rheumatism
infections and chronic
pain
Infusion with: Infusion with:

•Procain-Base with max. 0-40 ml Na-bi •Procain-Base with max. 80-120 ml Na-bi
•Essent. Amino acids (liver protection) •Base infusion (Rau, Wolitscheck)
•Antioxidants and additives •Antioxidants and additives
Additional important: Additional important:
•Reduce of protein, lactic acid products •Alkalic food, bowel cleanse
•Sanitation of heavy metals, focuses and •Orthomolecular medicine
toxins, immunotherapy •Sanitation of focuses and intoxications

examples
Systemic Procain- and ProcCluster® Therapy
SOME CASE SERIES AND

CASUISTICS
Cl- Na +
Na + Cl-
ProcH + HCO 3-
Na + Cl-
Cl- Na +
Visible effect
6 Procain PCL-Infusions, 2x pro Woche

(checked with regulation thermography, alpha system)
before treatment after treatment


Visible effect
6 Procain PCL-Infusions, 2x pro Woche

(checked with regulation thermography, alpha system)
before treatment 2 weeks after treatment
Casuistics: systemic
Procain-Therapy
• Pat. H.S., 54 y.: deep chronic Ulcer left Dorsum of the

Foot, Osteomyelitis Dig. 1, state after kidney
transplantation, cytostatic therapy,
– From 11-08 to 3-09 treatment Uni Hospital Jena, together 12 (!)
operations, multiple rejection reactions after autologeous skin
transplantations, wound healing disorders on harvesting points
– 17.4.09: CRP 98,5, large, superinflammated ulceration of the
dorsum of foot, partly extensor tendons and bones are visible
15.04.2009

Procain-Therapy
• Pat. H.S., 54 y.: (continuation)
– Therapeutical concept: 2x per week PBI, daily 60 mg ProcCluster®
cps., exposure to Ozon gas locally, homeopathic remedies
– 25.5.09: CRP 23,3, wounds on forearm and upper leg completely
healed, ulceration foot 80% closed, pain reduced from VAS 8 to 2-3,
Opioid drug (Valoron 200 ret.) discontinued
– 17.6.09: CRP 6,8, foot wound also complete dry, increase of motion
training
– 4.10.09: maintenance dose 1 Tab. ProcCluster 50 mg, very
beneficial, no recurrance till today
25.5.2009
Procain-Therapy
• Pat. Z.R., 38 J.: Multiple Sclerosis since 2003,

relapsing-remitting, at last 4-2011, 3 weeks stay in
hospital (Corticoid and Interferon-treatment)
– 3-13: reports about double vision, rotary vertigo, right side of face
with intensive dysaesthesia, general exhaustion, stress syndroma
– Wants to have biological medicine, if possible without hospital and

Cortisone

Procain-Therapy
• Pat. Z.R., 38 J.: Multiple Sklerose
– 4-13: MRT
Clear demyelinisation in white matter periventricular

right more than left. According MR-morphology clear
hints for inflammatory disease (e.g. multiple
sclerosis).
Procain-Therapy
• Pat. Z.R., 38 J.: Multiple Sclerosis (continuation)

– Therapy outpatient:
• Neuraltherapy of irritating fields (Tonsils, Sinusis) using 1%
ProcCluster
• 1st week 3x, 2nd – 3rd Infusion with ProcCluster in rising
dosage (total 7x), 1x per week, brain fresh cells (Curafaktur)
• Homeopathy: Conium D12 2x3 over 10d and Gels. C30 1x3
(1d)
– Clinical course:
• Quickly better symptoms, after two weeks already free of
complaints (!)
• Period of diability only 4 weeks (!)
• His feeling is very well and energetic, last control 11-2014
without any change

Procain-Therapy
• Pat. Z.R., 38 J.: Multiple Sklerose (continuation)

– 7-13: MRT control
Compaired with 4-2013 only rests of hyperintensities

in white matter periventricular and Pedunculus
cerebelli. Into the myelon no visible T2-Hyper-
intensities, normal conus signal.
Procain-Therapy
• Patn. R.M., 53 years, Breast cancer with lung and

bone metastasis
PBI and after a series of 12 infusions meanwhile ProcCluster®
capsule (1-2x1) within a scope of a holistic biological concept,
reached completely free of pain situation, general better
condition, stabil increased tumour marker, stabile disease over
24 months
• Patn. E.M., 57 years old, Amyotrophic Lateral

Sclerosis,
reduced ability to go, general pain in muscles, at the beginning
good effect towards Procain-Base-Infusion, meanwhile using of
1 cps. ProcCluster® (50 mg) daily over a period of 6 month, till
now good feeling, distinct reduce of pain, NO disease progress

Procain-Therapy
• Patn. H.S, 48 years, Sclerodermia

joint pain, coldness of fingers, dysaesthesia, dry eyes, very good
response to PBI, after 6 weeks changeover to ProcCluster® (50 mg)
cps., has a good effect meanwhile over a period of two years
• Patn. H.R., 34 years old, rheumatoid arthritis

had used cortisol, MTX and NSAR (ibuprofen) over three years
– Since one year in our biological treatment: change of diet,

supplementation, removal of all irritating teeth, amalgam sanitation,
probiotics for intestinal health and Procain-base infusion in the beginning
weekly, after two month reduction to twice a month, now ProcCluster
capsule (50 mg) every other day
– All pharmaceutical drugs meanwhile are stopped, very good general

condition and no more joint pain and progress of deformation
Don´t forget!
The infusion with Procain-Base, ProcCluster

and the orally use gives us more
possibilities to use this royal substance in
biological medicine. But it is not an
alternatively replacement of classic neural
therapy.

Many Thanks for Your

Attention !
Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.ch • www.paracelsus.ch
pH-comparison between Proc-HCl and

ProcCluster® using plasma titration
(System Buffy, Fa. Komstar, CH)
Titration mit
200 µl 0,1 N HCl
Proc-HCl Actavis (D), ProcCluster JenCluster (D)


Mean values concerning pH-values in various infusions

compaired with Procain-Base-infusion (PBI) (middle
dosage)
9
8,5
8
7,5
pH - Wert
7 7,4
6,5
6
5,5
5
4,5
4 0,9% Infucoll Normo- Ionosteril P B I
Ionosteril E 153
NaCl M40 fundin G5 HD5 (300/60)
pH-Wert 6,32 5,23 5,58 4,97 5,2 6,1 8,45
Oettmeier, STK Zeitung 2001


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systemic procain therapy 07.10.

Systemic Procain Therapy

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 1

Procain: natural remedy with a

Pharmacological Effects of Procain

– Poor of side effects

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 2

• Antirheumatic and Joint

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

• Reduction of Side Effects

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 3

Cancer Inhibition and

brightened mood, anxiety loss,

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 4

Procain – fields of application

Nerve root blockades

regional Ganglion blockades middle

History of systemic Procain

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 5

The effective Synthesis ...

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

systemic use of 200 – 500

Dr. Oettmeier, Paracelsus Academy 2016 6

• short infusion (30-60 Min.) with

– Procain Actavis 1% od. 2% (100-500 mg) no preservatives

– Natriumbikarbonat 8,4 % (20 - 120 ml)

– physiologic sodium chloride solution (250 – 500 ml)

• dosage at beginning: 50 - 200 mg Procain

• ECG recording and oxymetry up to mean dose and in risk

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Titration of optimal dose

• at the beginning: 50-100 mg Procain & 20-

• stepwise increase of dose with Procain (50-

• preservation of dose in case of good

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 7

Study of clinical use

Change of pain level and general condition under

Study of clinical use

Change in the use of analgetics (NSAR ,

Dr. Oettmeier, Paracelsus Academy 2016 8

experiences after approximately

experiences after approximately 220.000

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

Dr. Oettmeier, Paracelsus Academy 2016 9

Results from Basic Research

ProcCluster® : the Prodrug of Procain

Na+ Cl- The word ProcCluster means „Proc“ is standing

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com

the most important characteristics

• Amphiphilic (hydro- and lipophil)

Tel +41 71 335 71 57 • Fax +41 71 335 71 56 • Mail academy@paracelsus.com • www.paracelsus.com