LMUSM 2.

8 Hazardous and Dangerous Substances Risk Assessment (COSHH/DSEAR)

1. Location of Process      Laboratory 2. Department       3. Assessment Ref.      
      Synthesis of Antimalarial based on the
4. Process (What is being done) Amino-quinoline Nucleus 5. Frequency of use      High

     Researchers performing the experiments 7. Any special risk      Not in particular apart from those available in
6. Who is/are at risk? lab
groups?
8. Substances and microbiological materials (include mixtures and products)
8a. Name 8b. Physical 8c. Quantity 8d. Hazard pictograms 8e. Workplace 8f. Control measures 8g. Disposal route
form handled (chemical, see foot of last Exposure Limit
page) and signal word (WEL) from
(warning, danger or none) EH40 / mg m-3,
or Hazard Group - HG1 or long (l) or
HG2 (microbiological) short term (s)

1      Di-chloromethane      Liquid                              

2      Trimethylamine      Gas                              

3      Propane -1,3-diol      Liquid                              

4      Chloromethylphosphonic
                                   
dichloride
5                                          
6                                          
7                                          
8                                          
9                                          
10                                         
11                                         
12                                         
13                                         
14                                         

1
LMUSM 2.8 Issue 1 Uncontrolled when printed Issued on 09/11/2012
LMUSM 2.8 Hazardous and Dangerous Substances Risk Assessment (COSHH/DSEAR)
9. Key Message       Trimethylamine is the most dangerous substance from above all.
From the list above, what is the most
dangerous/ hazardous substance and why?

10. Instruction, training and supervision

10a. What special instructions are needed
to carry out the process safely?
10b. What special training is required to
carry out the process safely?
10c. What supervision is required to carry
out the process safely?
     Special instruction that are needed to carry out the experiment safely are to handle all the chemicals with precaution and wear a
safety mask, lab apron and gloves etc while handling the chemicals in the laboratory.
     A particular person who works in a laboratory has to be train in a particular method that “How to take precautionary measures, know
how about the chemical hazardness of chemicals handled or being used in the laboratory etc”
     A lab instructor is necessary to look after the students or researchers performing the experiment in the laboratory, so that all the
process is carried out safely without any hindrance, and all the chemicals are handled with precaution.

11. Emergency measures for the process

11a. Minor spillage or release procedure
11b. Major spillage or release procedure
11c. Fire precautions and procedures
11d. First aid precautions and procedures
     If there is a minor spillage in the laboratory, it’s the work of Lab instructor or in-charge be ready for any mis-conduct so different
apparatus must be available in the lab to stop the damage before it becomes a big issue.
     If there is a major spillage, it can cause a hindrance in the lab, but it should be handled with precaution.
      If it can cause fire problem, sprinklers must be installed in the lab avoid the fire as well and fire extinguishers should be placed in range
so they can be easily reached and used in case of emergency.
First aid kit should always be available in the lab in case of any mis-conduct happening to avoid making it a big issue.

12. Statement of approval (the process must only be approved if the estimated risk is trivial, low or moderate using the matrix at the end of this document)
Likelihood of harm occurring (L)       Severity of harm (S)      
The risk arising from the process after applying the controls stated is (R = L x
     
S)
12a. Assessed by [name(s) & signature(s)] 12b. Date 12c. Approved by (name and signature) 12d. Date
                       

2
LMUSM 2.8 Issue 1 Uncontrolled when printed Issued on 09/11/2012
LMUSM 2.8 Hazardous and Dangerous Substances Risk Assessment (COSHH/DSEAR)
13. Is health surveillance required for personnel engaged in this
      If yes, approver must notify Human Resources
process?

3
LMUSM 2.8 Issue 1 Uncontrolled when printed Issued on 09/11/2012
LMUSM 2.8 Hazardous and Dangerous Substances Risk Assessment (COSHH/DSEAR)

Do not print this page, use only for completing the assessment

Risk estimation matrix (for information only, not necessary to print)

Likelihood of harm occurring (L)

Use this grid to work out the
risk rating (R = L x S) RARE UNLIKELY MODERATE LIKELY ALMOST CERTAIN
1 2 3 4 5
NEGLIGIBLE TRIVIAL TRIVIAL LOW MODERATE SIGNIFICANT
1 1 2 3 4 5

LOW TRIVIAL LOW MODERATE SIGNIFICANT MAJOR

Severity of harm (S)

2 2 4 6 8 10

MEDIUM LOW MODERATE SIGNIFICANT MAJOR HIGH

3 3 6 9 12 15

VERY HIGH MODERATE SIGNIFICANT MAJOR HIGH SEVERE

4 4 8 12 16 20

EXTREME SIGNIFICANT MAJOR HIGH SEVERE SEVERE

5 5 10 15 20 25

For each substance, copy the relevant pictograms below and paste into the table at 8d.

4
LMUSM 2.8 Issue 1 Uncontrolled when printed Issued on 09/11/2012