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    Ntheaia & Bepornbion: Pypimicline

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    Runa Levie
    Pyrimidine is a heterocyclic organic compound similar to purine. It consists of two nitrogen atoms at positions 1 and 3 in a six-membered ring with carbon atoms. Pyrimidine can be prepared through various synthetic routes, including the condensation of barbituric acid with urea or through reactions between amidines and α-haloketones. It undergoes substitution reactions at position 2 and 6 of the ring. Pyrimidine derivatives have applications as pharmaceuticals and in agrochemicals.

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    Ntheaia & Bepornbion: Pypimicline

    Uploaded by

    Runa Levie
    8 views7 pages
    Pyrimidine is a heterocyclic organic compound similar to purine. It consists of two nitrogen atoms at positions 1 and 3 in a six-membered ring with carbon atoms. Pyrimidine can be prepared through various synthetic routes, including the condensation of barbituric acid with urea or through reactions between amidines and α-haloketones. It undergoes substitution reactions at position 2 and 6 of the ring. Pyrimidine derivatives have applications as pharmaceuticals and in agrochemicals.

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    Pyrimidine

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    Pyrimidine is a heterocyclic organic compound similar to purine. It consists of two nitrogen atoms at positions 1 and 3 in a six-membered ring with carbon atoms. Pyrimidine can be prepared through various synthetic routes, including the condensation of barbituric acid with urea or through reactions between amidines and α-haloketones. It undergoes substitution reactions at position 2 and 6 of the ring. Pyrimidine derivatives have applications as pharmaceuticals and in agrochemicals.

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    8 views7 pages

    Ntheaia & Bepornbion: Pypimicline

    Uploaded by

    Runa Levie
    Pyrimidine is a heterocyclic organic compound similar to purine. It consists of two nitrogen atoms at positions 1 and 3 in a six-membered ring with carbon atoms. Pyrimidine can be prepared through various synthetic routes, including the condensation of barbituric acid with urea or through reactions between amidines and α-haloketones. It undergoes substitution reactions at position 2 and 6 of the ring. Pyrimidine derivatives have applications as pharmaceuticals and in agrochemicals.

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    of 7

    ntheaia & Bepornbion

    Pypimicline
    uimidaine us a n aiomaie heteoce
    olganic cowpun Sumilas fe pyuidne
    One o e thue cluazinesthas a
    itlesen atms at postens 1&3 in

    un e Caben arel hdtngem cueCBnhectrd


    via allenating dpure anel Airgle eols
    Th
    Ag system is phnt n many
    natiua pioduks ike huceic auol Cune
    Suntibe dungs ike balbituuate

    Pyiwmione
    Supthesis
    meuy be pAepaied o
    ()Ryumidine
    le Corclonsatíon e
    boitutic acid ounf by
    malee esteu Gnel ula.

    CoOH CHONVa
    H,C + HN
    CoOC,Hs H,N C4OH

    H OH
    O
    N
    Taut s
    HC
    C-N
    C =0
    LCH C=N
    c-OH

    H OH

    C
    POC >
    o HI N

    ficine
    Comdensatien 3-dicabon Cempeud uith
    weA in pALne 2HONa givs boubitiuuic ced
    i
    whic o etd -ehe tutomewm
    is
    pyinidne 24,6--tn'ol huther it on tuatmt
    with Pougleue by tuatnet with zinc dust
    gi PyAmidine
    () dkom amdine
    O HN
    p MeonaMoH
    -R
    +
    e
    N

    (ii) m 24-cichleiepynidune
    C

    H2-PalC
    -2HU
    24 Pyumone

    amoune
    24-dichloiepyumucdure

    em Pyumiolunes

    CI CooH
    deobunyehen
    co)
    Co 2
    imudune -4-cakoye idise
    4-mtpyuimdune acid
    Recaon o imduno.
    a) (Reacteons ith audl ( Pastor athon)
    a)
    ves P i d u r i u n salks

    H
    C

    H
    imdine u n d m u m clotirle

    bQuotesnizaen /N-alkylatn

    N CH
    TO
    A

    fyvudine CHa
    et puimioli naie
    iedide.
    C)lthopk.ie asendie ustituton
    Renctons Ri'mdhe

    Less
    ess active due u r itiogen
    pAesent in He skeletonPcte poible
    ot stiongy electuon
    an Case o PAesenCe
    te ig
    3oup (-wu2)-oH)
    on
    clevt
    Subsbtuben aku place at s positon.
    HNO3 H2504
    Nitrab
    oN
    6 NH2

    Has0 olwg
    Sulphendin

    NH2
    s t a elton
    doci B-2CH&eoH
    3

    Halogeaba,
    d) Oxidatven

    N
    alkune kMn
    CoOH

    Nudeopiie subrtithon Reactior

    imidine uncdegecs hudesphli


    Subtuten eactens at 2he peatem
    NanH2

    icy NH
    NH2

    KOH
    6 OH
    5r

    s
    With oxiclizin agents

    mcPBA

    N CHCa
    CI

    m-Chletepeioaybenzeic aud

    O
    O OH

    Ca with uduci agens CoBn

    Na3CCNDE
    CIco,B n, Me ODH -
    co,Bn
    Benzyfhletsiate
    Socuuw
    jansbomohydnd

    O Nat

    N BH

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