30/11/2020

INBREEDING

Dra. Tuty Arisuryanti, M.Sc.,Ph.D.

Laboratory of Genetics & Breeding
Faculty of Biology UGM

Inbreeding in a single marriage is a

marriage between individuals who have
INBREEDINGIN A close family relationships (e.g. in humans
SINGLE it is a marriage between a cousin/ a
MARRIAGE nephew and an aunt/uncle, etc.).
Inbreeding in plants for example in plants
(INBREEDING that conduct self fertilization and
PADA pollination, while inbreeding in animals
PERKAWINAN such as mother is used continuously
resulting in a decrease in the quality of
TUNGGAL) offspring produced

1
 30/11/2020

INBREEDING
COEFFICIENT
(KOEFISIEN
INBREEDING)

The inbreeding coefficient is

the possibility that the two
alleles in an individual are
identical due to offspring or
called autozygosity

Inbreeding Coefficient Formula (F)

• F = Koefisien Inbreeding (F)

• n = banyaknya jalan yang dihitung
dari orang tua individu yang
F = Σ (1/2)n (1/2) hendak diketahui koefisien
inbreedingnya menuju ke ancestor
• (jalan dari anak ke orang tua
tidak dihitung)
• Untuk menghitung F, maka
diagram silsilah dikonversi ke
diagram inbreeding

2
 30/11/2020

Pedigree that do not show close family

relationships-no inbreeding

A B C D

E F

Diagram silsilah yang dikonversi

ke diagram inbreeding
A B A B
3
6
2
5
C D C D

1 4

E F E F

X
X

Diagram Silsilah Diagram Inbreeding

3
 30/11/2020

F – ancestor A = 1 – 2 – 3 – 4 = (1/2)4(1/2)
= 1/32
How to find F – ancestor B = 1 – 5 – 6 – 4 = (1/2)4(1/2)
= 1/32
the F value
F individu X = F (x) = 1/32 + 1/32 = 2/32
of X (FX) = 1/16

Artinya bahwa 6,25% lokus individu x

bersifat autozygous

Examples of inbreeding

A B

1.Buatlah diagram
C D inbreeding dari
diagram silsilah
tersebut
E
X
2.Hitunglah koefisien
inbreeding individu x

4
 30/11/2020

U
2
Hitunglah koefisien
1 inbreeding individu Z
V
4

3
6 W 5
X
Y

U = 1 – 2 – 3 = (1/2)3(1/2) =1/16
Koefisien Inbreeding = 1–2–4–5=
individu Z (FZ) adalah : (1/2)4(1/2) = 1/32
V= 6–4–3
(1/2)3(1/2) = 1/16
• U x ….. V W= 6–5
• V x ….. W (1/2)2(1/2) = 1/8
•UxW X
•WxV Y F(Z) = 1/16 + 1/32 + 1/16 + 1/8 =
•YxX Z 9/32

10

5
 30/11/2020

J K
2 6
1
5
4
L M N
3
7
O Hitung lah koefisien
inbreeding individu I
I

11

Koefisien
J = 1 – 2 – 3 = (1/2)3(1/2) =1/16
inbreeding individu I
(FI) Adalah:
K=4–5–3=
(1/2)3(1/2) = 1/16
JxK L&M
=4–6–7=
K x ….. N
(1/2)3(1/2) = 1/16
MxN O
LxO I
F (I) = 1/16 + 1/16 + 1/16 =
3/16

12

6
 30/11/2020

A
4 Hitunglah
7
koefisien
8
B inbreeding
3 6 individu X
5

C D E F
2
9
10
11
12 Jawaban : 9/128
G H I (A ada 4 jalan, B
1 13 14 ada 3 jalan dan
D ada 1 jalan)
J K
X

13