RHESUS FACTOR

-Rhesus factor is an antigen present on the surface of RBC

-result in agglutination when it reacts with the antibodies from individual without the antigen.

 If an individual has the Rhesus factor, he is known as Rh-positive (Rh+)

 The genotype of a Rh-positive individual can be either homozygous dominant (Rh-Rh) or
heterozygous (Rh-rh)
 If he does not have Rhesus factor, he is known as Rh-negative (Rh-)
 Rh-negative individuals are homozygous recessive (rh-rh)

Question 1:
A man who is homozygous Rh-positive maries a woman who is Rh-negative. What are the chances of
their children being Rh-negative?
Question 2:
A man who is heterozygous Rh-positive maries a woman who is Rh-negative. What are the chances of
their children being Rh-negative?
Question 3:
A married couple has different Rhesus factors. Their first child is Rh-positive. However, the second
pregnancy ends with a miscarriage. What is the Rhesus factor of the couple and the miscarried foetus?
Question 4:
A mother has a second child who suffers from erythroblastosis fetails during the foetal stage. What are
the genotypes of the Rhesus factor of the parents?

SEX-LINKED INHERITANCE
-refers to the genes carried on the X-chromosome.
-example: haemophilia & colour blindness
-bothdisorders are caused by resessive genes that are linked to the sex chromosome X.

 Haemophilia
-Condition in which blood cannot clot normally.
-Individuals who suffer from haemophilia are called haemophiliacs.
-lack of protein needed for normal blood clotting→ability to produce protein from a dominant
gene.
-result in excessive bleeding
-inability to produce protein cause by recessive allele on X chromosomes.

females males Dominant homozygote

XHXH XHY
normal normal Questionhomozygote
Recessive 5:
XhXh XhY Explain how haemophilia is inherited
when haemophiliac haemophiliac a heterozygous female for blood clotting
heterozygote
(female carrier) marries a normal male.
XHXh -
carrier

 Colour blindness
-Condition in which a person cannot differentiate between certain colours. The most common
form of colour blindness is red-green colour blindness.
-caused by recessive allele on the X chromosome.
Dominant homozygote
 females males
XBXB XBY
normal normal Recessive homozygote
XbXb XbY
colour blind colour blind
heterozygote
XBXB -
carrier
Question 6:
A man with normal vision marries a woman with normal vision. The woman carries the colour blindness
allele. How colour blindness is inherited?

Question 7:
A colour-blind man marries a homozygous normal vision woman. How colour blindness is inherited?

Question 8:
A man with normal vision marries a colour-blind woman. How colour blindness is inherited?

Question 9:
The allele for normal colour vision is represented by the capital letter B (dominant) while the allele for
colour blindness is represented by the capital letter b (recessive). Which cross produces all colour-blind
male progeny?