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Connections Among Symptoms of Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder: A Case Series
Connections Among Symptoms of Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder: A Case Series
Connections Among Symptoms of Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder: A Case Series
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Abstract
Theoretical, clinical, and empirical implications of the functional connections between symptoms of
obsessive–compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) are abundant. As such,
four cases are presented here of men and women who met criteria for comorbid OCD and PTSD. All had
been diagnosed with treatment-resistant OCD and were seeking treatment from an OCD specialty clinic
or institute, all reported a history of traumatic experiences prior to the onset of OCD, and all appeared to
demonstrate negative treatment outcomes. Upon examination, it appeared that symptoms of OCD and PTSD
were connected such that decreases in OCD-specific symptoms related to increases in PTSD-specific symp-
toms, and increases in OCD-specific symptoms related to decreases in PTSD-specific symptoms. Specu-
lations about the function of OCD symptoms in relation to post-traumatic psychopathology are put forth;
and theoretical, research, and treatment implications are discussed.
2003 Elsevier Science Ltd. All rights reserved.
Recently, a sparse literature has begun to emerge that describes a relation between traumatic
events and the development and maintenance of obsessive–compulsive disorder (OCD). This
literature, composed of case studies illustrating the role of traumatic events in the etiology of
OCD, indicates that in a subset of OCD sufferers, psychological trauma may play a role in the
∗
Corresponding Author.
E-mail address: gershuny@psych.mgh.harvard.edu (B.S. Gershuny).
0005-7967/03/$ - see front matter 2003 Elsevier Science Ltd. All rights reserved.
doi:10.1016/S0005-7967(02)00178-X
1030 B.S. Gershuny et al. / Behaviour Research and Therapy 41 (2003) 1029–1041
development of OCD and co-exist as a comorbid disorder with posttraumatic stress disorder
(PTSD) (de Silva & Marks, 1999, 2001; Pitman, 1993).
Though behavior therapy and pharmacotherapy are usually effective in reducing OCD symp-
toms, a significant minority of patients do not benefit from such treatments (e.g., Franklin, Abra-
mowitz, Kozak, Levitt, & Foa, 2000; Marks, 1981). Prior studies investigating comorbid psychi-
atric disorders that may impede treatment effectiveness have to date proven inconclusive. Some
found that major depressive disorder adversely affected treatment outcome for OCD (e.g., Stek-
etee, Chambless, & Tran, 2001) while others found that major depressive disorder did not have
an adverse affect (e.g., Zitterl et al., 2000). Similarly, some studies demonstrated that a comorbid
Axis II diagnosis (particularly Cluster A personality disorders) predicted poorer treatment outcome
for OCD (e.g., AuBuchon & Malatesta, 1994; Minichiello, Baer, & Jenike, 1987), while other
studies demonstrated no such impact (e.g., Steketee et al., 2001).
A recent study indicated that a diagnosis of comorbid PTSD impeded successful treatment of
OCD (Gershuny, Baer, Jenike, Minichiello, & Wilhelm, 2002): patients without comorbid PTSD
improved significantly with behavior therapy (i.e., exposure and response prevention) on measures
of OCD and depression, but those with comorbid PTSD did not improve (indeed, some with
PTSD reported an increase in OCD and depression symptoms). Similarly, a case study reported
by Pitman (1993) demonstrated that a diagnosis of comorbid PTSD and OCD was a negative
predictor of treatment outcome. The question remains as to why such impediments occurred.
It has been posited elsewhere that the study of comorbid disorders would increase in value if
more attention were paid to the connectedness between disorders (Rachman, 1991). For example,
understanding whether the connection between disorders is static or dynamic (e.g., increases or
decreases in symptoms of one disorder impact the symptoms of the other disorder) may aid in
the development of more fruitful treatment approaches and allow us to make better prognoses
(de Silva & Marks, 1999; Rachman, 1991); examining the connection between symptoms may
also increase our understanding of the impact of comorbid disorders on treatment outcome.
In some cases, connections between PTSD and OCD symptoms may appear quite straightfor-
ward, such as a person who reports feeling “unsafe” following a household robbery and sub-
sequently engages in compulsive checking behaviors involving his or her doors and locks. In
other cases, however, connections between symptoms may be less obvious and require more in-
depth scrutiny and assessment.
We present here a retrospective naturalistic review of four cases of patients who met criteria
for both OCD and PTSD upon admission to a residential treatment facility for treatment-resistant
OCD. Each patient presented here reported a history of traumatic experiences that reportedly
predated the onset of OCD. We present reported symptoms, diagnoses, and treatment outcome
for each patient. To expand the pioneering case study papers of de Silva and Marks (1999) and
Pitman (1993), we place particular emphasis on the seeming connections (Rachman, 1991)
between traumatic experiences, symptoms of PTSD, and symptoms of OCD, and the impact of
such connections on treatment outcome. We also provide impressions derived from post-treatment
contact after discharge from the facility. Because prior work has indicated that comorbid PTSD
has an adverse affect on treatment outcome for OCD (Gershuny et al, 2002), it also seems
important to systematically examine related individual cases to potentially gain greater understand-
ing of why such adverse impact may have occurred. Though exposure-based treatments are argu-
ably the treatment of choice for both OCD and PTSD, exposure-based treatment of the symptoms
B.S. Gershuny et al. / Behaviour Research and Therapy 41 (2003) 1029–1041 1031
of one disorder (e.g., OCD) may not generalize to the treatment of the symptoms of another
disorder (e.g., PTSD) and may indeed result in an increase in symptoms of the other disorder.
This will be discussed in further detail later in this paper.
1. Methods
As part of hospital-related, routine clinical procedures, each patient was administered a semi-
structured diagnostic interview at intake and self-report questionnaires at both intake and dis-
charge. For the purposes of this paper, self-report questionnaires administered at intake included:
Traumatic Events Survey—Lifetime (TES-L; Gershuny, 1999), Yale–Brown Obsessive–Compul-
sive Inventory (YBOCS; total possible score ranges from 0 to 40; Goodman, Price, Rasmussen
et al., 1989), Beck Depression Inventory (BDI; total possible score ranges from 0 to 63; Beck &
Steer, 1987), and Posttraumatic Diagnostic Scale (PDS; total possible score ranges from 0 to 51;
Foa, Cashman, Jaycox, & Perry, 1997). Questionnaires administered at discharge included:
YBOCS and BDI. A review of medical charts was used to obtain pre- (i.e., intake) and post-
(i.e., discharge) treatment scores as well as to obtain information regarding course of symptoms.
1.2. Cases
Four cases are presented of patients who met criteria for both OCD and PTSD based on inter-
view and self-report. Each patient was referred to a residential treatment program for treatment-
resistant OCD (the Massachusetts General Hospital OCD Institute) due to lack of benefit from
prior courses of treatment (e.g., psychodynamic, behavioral, pharmacological). Interestingly,
though all of the patients presented below had received a diagnosis of OCD from other treaters
prior to their referral to the OCD Institute, none had arrived at the Institute with a diagnosis of
PTSD and received this comorbid diagnosis only after a comprehensive semi-structured diagnostic
interview (validated by data also obtained from self-report questionnaires) revealed a history of
trauma(s) with associated PTSD symptoms. None of the patients included met criteria for a psy-
chotic disorder. All of the patients were taking psychotropic medications, most commonly SSRIs,
tricyclic antidepressants, neuroleptics, benzodiazepines, and/or hypnotics. Though we were unable
to ascertain quantifiable follow-up data for each of the patients included here, we were able to
gather information indicative of follow-up functioning via unsolicited post-treatment contact (or
in the cases of Ms. A. and Ms. D., continued and re-commenced outpatient treatment contact,
respectively).
some way by these numbers. Her rituals included: washing her hands and body and clothes with
industrial strength detergents immediately after contact with “unlucky” numbers, repeating some-
thing a certain number of times so that she does not say something related to any part of her
“unlucky” number, and ritualistic avoidance that includes anything which might reveal her
“unlucky” number (e.g., clocks, television, radio, driving because of seeing license plates, shop-
ping because of certain prices) or which might have come into contact with her “unlucky” number
and thus become “contaminated” (e.g., any places and situations during which she encountered
her unlucky number, clothing she was wearing when she encountered her unlucky number). Ms.
A.’s total YBOCS score at intake was 18, suggestive of “moderate” clinical OCD.
thoughts as obsessions and rituals appeared to decrease a bit. In following, these rituals re-intensi-
fied in frequency and duration. Core obsessions never seemed to lessen, habituation to fears never
seemed to take place, and rituals returned and intensified. Indeed, it seems that the moment direct
thoughts regarding past trauma emerged, OCD symptoms would flare and avoidance would
become particularly intense.
2. Discussion
For at least some patients with comorbid OCD and PTSD seemingly subsequent to traumatic
experiences, there appears to be a relation between symptoms of both disorders: when symptoms
1038 B.S. Gershuny et al. / Behaviour Research and Therapy 41 (2003) 1029–1041
of OCD lessen, symptoms of PTSD increase; when symptoms of OCD increase, symptoms of
PTSD lessen. Given this seemingly dynamic connection (Rachman, 1991), targeting OCD (and
perhaps PTSD) in isolation may impede therapy effectiveness (Gershuny et al., 2002), a conse-
quence demonstrated by the cases described in this paper.
Consistent with a behavioral theoretical perspective, obsessive–compulsive symptoms (e.g.,
excessive checking and/or cleaning, hyper-attention to obsessive thoughts) may facilitate avoid-
ance of the emotional discomfort generated by trauma cues (much as they facilitate the avoidance
of anxiety associated with OCD-related obsessions). These obsessive–compulsive behaviors may
then be negatively reinforced and strengthened by a reduction in discomfort (e.g., anxiety) if these
strategies are at least temporarily effective. Thus, OCD symptoms may be construed as serving
some type of coping or protective function against trauma-related thoughts and emotions that are
too psychologically uncomfortable for the person to bear. Note that we are not referring here to
a process of ‘symptom substitution;’ it does not seem that OCD symptoms replace PTSD or that
PTSD symptoms replace OCD. Rather, it appears that OCD symptoms serve as a form of coping
with trauma-related material (e.g., affective, cognitive) and symptoms.
Relatedly, Borkovec and Roemer (1995) found that people with GAD were more likely than
non-anxious controls to cite “distraction from more emotional topics” as a reason to worry. In a
later paper, Borkovec and his colleagues (Borkovec, Ray, & Stoeber, 1998) postulated that, for
those with GAD, worrying served as cognitive avoidance and inhibited emotional processing of
more difficult material. This process may mimic the role of obsessive–compulsive symptoms for
at least a subset of those with comorbid PTSD.
Furthermore, in his discussion of the need to assess connections among symptoms of seemingly
comorbid disorders, Rachman (1991) described the inter-relatedness of fear and related processes
(e.g., cognitive, physiological) and the necessity of evaluating such potential inter-relatedness. In
the cases described in this paper, a thorough assessment of core cognitions was not completed
and should indeed be completed with future cases (Rachman, 1991). Based on observations and
discussions of symptoms and behaviors, we can speculate that perhaps all had a fundamental
belief that “I am in danger or I might die,” and/or “I am not in control.” For people diagnosed
with OCD, it is not uncommon to hold such beliefs; it also is not uncommon for people diagnosed
with PTSD to hold such beliefs. A key difference may revolve around the “reality” of such beliefs.
During a traumatic experience, the individual is faced with danger and possible death either per-
sonally or vicariously. The individual also is faced with a situation in which he or she likely does
not have control. Thus, such core beliefs are born from reality even if over time they are main-
tained and no longer associated with current reality.
It is possible that when asked to confront what seem to be OCD-related triggers (e.g., for Ms.
A: number 54), fear is indeed elicited as are the related cognitions of “I am in danger,” and “I am
not in control.” However, rather than habituating to such fear and ameliorating such “unrealistic”
cognitions (i.e., the number 54 itself cannot actually cause harm), the individual may be enveloped
by fears related to precipitating trauma (i.e., murder of stepmother) and the associated core cog-
nitions mentioned above. Thus, rather than learning that she indeed is not in danger when con-
fronted with the number 54, she is reminded that the world is dangerous, that she does not have
total control, and that someone who was supposed to take care of her and be safe was capable
of murder and molestation. Hence, habituation to the OCD-related obsession would not occur.
In addition, some of the cases presented in this paper seem to be experiencing a phenomenon
B.S. Gershuny et al. / Behaviour Research and Therapy 41 (2003) 1029–1041 1039
previously conceptualized as “mental pollution” (Rachman, 1994). For Ms. A, Mr. B, and Ms. D
in particular, it seems that some of their contamination fears are not actually related to germs or
filth. Rather, they seem to feel “dirty from within” or tainted in some way. And such perceptions
appear triggered by “contaminants” even without physical contact to such “contaminants” (e.g.,
number, nightmare, trauma-related intrusive thought and/or flashback). Indeed, even what is per-
ceived as “contaminating” in and of itself cannot cause “contamination” per se, and again seems
to refer to a stimulus agent that was associated at some point in the individual’s history with
thoughts, images, emotions, and sensations that were, and are, horrifying, frightening, and/or
disgusting to the person, relate to a sense of helplessness, and are seemingly inextricably tied to
prior trauma(s). Because we speculate here that a process like that of “mental pollution”
(Rachman, 1994) is indeed underlying some, if not most, of the contamination fears reported by
the individual cases presented in this paper, it then follows that related obsessions and rituals
would not abate with standard exposure and response prevention treatment.
Empirical research is needed to confirm or disconfirm the aforementioned speculations regard-
ing coping, cognitions, and mental pollution; either way, however, treatment implications abound.
While the mechanisms of the connection between PTSD and OCD are speculative, what seems
most apparent is that a treatment strategy incorporating management of symptoms of OCD and
PTSD simultaneously is necessary for patients in whom the trauma(s) seemingly preceded the
onset of OCD. For example, while engaging in CBT treatment of PTSD via prolonged imaginal
exposure and/or stress inoculation training (Foa et al., 1999) and/or imagery restructuring
(Smucker & Dancu, 1999), it is imperative to gauge the use of compulsive rituals as a means of
coping with the cognitive and affective responses related to such treatment. Not gauging and
managing rituals could result in ineffective treatment as emotional processing (Foa & Kozak,
1986; Rachman, 1980, 2001) of trauma-related material is thwarted. Conversely, while engaging
in CBT treatment for OCD via exposure and response prevention, it is imperative to gauge the
possible elicitation and exacerbation of PTSD symptoms, particularly flashbacks, nightmares,
sleep disturbances, hypervigilance, excessive startle response, emotional numbing, and social
detachment. Not gauging and managing such symptoms could again result in ineffective treatment
as habituation to feared stimuli is derailed.
It is unclear whether or not the patients described in this paper would have received greater
treatment benefit if referred to an intensive trauma/PTSD program instead of an intensive OCD
program; it is unclear whether a “dynamic connection” (Rachman, 1991) between symptoms
would be similar if PTSD symptoms were addressed first. For example, would an increase in
PTSD symptoms relate to an increase rather than a decrease in OCD symptoms? Certainly, based
on our hypothesis, one would expect this to be the case. And would a decrease in PTSD symptoms
relate to a decrease rather than an increase in OCD symptoms? Perhaps the answer is “yes,” but
these questions remain open to examination and empirical test.
Because of the complexity and severity of symptoms (and the severity of endured traumas), it
is likely that long-term therapy would be necessary regardless of the referred treatment program.
Indeed, prior research has found that comorbid PTSD negatively affects behavior therapy outcome
for OCD (Gershuny et al., 2002). Research has yet to take place that examines the impact of
OCD on CBT outcome for PTSD, and such research is necessary to piece together a more com-
plete picture of the treatment-related issues inherent in cases of comorbid OCD and PTSD.
Assessment implications also abound. If a dynamic connection (Rachman, 1991) exists in some
1040 B.S. Gershuny et al. / Behaviour Research and Therapy 41 (2003) 1029–1041
patients with comorbid OCD and PTSD, and this connection relates to negative treatment outcome
in patients seeking treatment for OCD, then how might assessments be revised at the beginning
and throughout treatment to better guide therapy approaches? This is a complex question, the
answer to which still seems elusive to us. At this point, we recommend that a thorough evaluation
that includes an assessment of trauma history and PTSD be conducted at intake for patients
referred for treatment of OCD; we recommend the same be done for patients referred for treatment
of PTSD such that a thorough assessment of OCD-related symptoms be conducted at intake. In
addition, an individualized and comprehensive functional analysis of the interplay of triggers,
cognitions, emotions, and behaviors may be helpful in generating case conceptualizations that
guide effective interventions.
Though one empirical treatment study has revealed a negative impact of comorbid PTSD on
treatment outcome for OCD (Gershuny et al., 2002), it is not yet clear if such a negative impact
exists for all, or even most, patients diagnosed with these comorbid disorders. In this paper and
in the prior study, we focused exclusively on an examination of patients who reported an onset
of OCD symptoms after experiencing trauma(s), and had failed prior courses of treatment (i.e.,
were treatment-refractory). Perhaps there are OCD/PTSD patients referred to outpatient clinics
who do just fine with treatment, particularly patients for whom trauma(s) and PTSD are sub-
sequent to OCD. This question still begs empirical investigation. It is also possible that the forms
of OCD and PTSD we are seeing in the patients presented here are more in line with Herman’s
conceptualization of Complex PTSD (Herman, 1997) that is widely regarded as difficult to treat
and requiring of long-term care. Indeed, trying to ascertain diagnostically the best way to concep-
tualize these patients is a challenge. Should they be viewed as having two separate diagnoses, or
are they better served if viewed as having Complex PTSD? Again, to date this remains unclear.
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