10/26/2020

SINTESIS
PROTEIN :
TRANSLASI
Apt. Devika N, M. Pharm. Sci

Tipe RNA Tipe RNA

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Kodon

My Schedule The Best Grades

WHOA! 01 02
Here you can describe the Here you can describe the
topic of the section topic of the section

My Students Topics to Discuss

03 Here you can describe the

topic of the section
04 Here you can describe the
topic of the section

01 “This is a quote, words full of wisdom

that someone important said and can
make the reader get inspired.”

–Someone Famous

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Penentuan unit sedimentasi pada komponen ribosom Prokariot VS Eukariot

Do you know what helps you make

your point clear? Lists like this one:

● They’re simple

● You can organize your ideas clearly Mercury Venus

● You’ll never forget to buy milk Mercury is the closest planet to Venus has a beautiful name
the Sun and the smallest one and is the second planet from
again!
in the Solar System—it’s only a the Sun. It’s terribly hot—even
And the most important thing: the bit larger than the Moon hotter than Mercury
audience won’t miss the point!

Proses Translasi Struktur tRNA aminoasil

Wednesda
Monday Tuesday Thursday Friday
y

8:00 Religion
Math
Mars Jupiter Saturn
9:00
Despite being red, Mars It’s a gas giant and the Yes, this is the ringed
Science History English
is a cold place. Iron oxide biggest planet in our one. It’s a gas giant,
dust is what gives the Solar System. Jupiter is composed mostly of 10:00
planet its reddish cast the fourth-brightest hydrogen and helium P. E.
11:00

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1. INISIASI
Aktivasi asam amino untuk bergabung membentuk protein
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Kode Genetik
❑ kode genetic → 3 nukleotida - kodon - mengkode 1 asam
amino protein
❑ Kodon → 3 sekuens nukleotida pada mRNA yang secara
spesifik akan diubah menjadi asam amino dan selanjutnya
menjadi kode protein tertentu.
❑ Hubungan antara kodon dengan asam amino → Kode genetik
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Kode Genetik Kode Genetik

❑ Tidak semua kodon digunakan dengan frekuensi yang sama.
❑ Ada beberapa jumlah tertentu dari variasi tipe kodon yang
digunakan pada setiap organisme
❑ Masing-masing kelompok yang terdiri dari 3 nukleotida pada
mRNA disebut kodon. Karena 4 basa, kodon yang terbentuk
adalah 43 = 64, yang harus mengkode 20 asam amino yang
berbeda.
❑ Lebih dari satu kodon digunakan untuk banyak asam amino : kode
genetik bersifat “degenerate”. Hal ini berarti bahwa tidak
mungkin mengambil sekuen protein dan menterjemahkannya ke
dalam sekuen basa gen tersebut.
❑ Dalam banyak hal, basa ketiga dari kodon (the wobble base)
dapat diubah tanpa mengubah asam aminonya.
❑ AUG digunakan sebagai start kodon. Awal translasi semua
protein adalah metionin, meskipun sering dihilangkan setelah
translasi. Ada juga internal metionin yang dikode oleh kodon
AUG yang sama.
❑ Terdapat 3 stop kodon, yang disebut “nonsense” kodon. Protein
berakhir dengan stop kodon yang tidak mengkode suatu asam
amino

Kode Genetik Wobble Hypothesis

❑ Kebanyakan kode genetik bersifat universal. Digunakan baik pada
prokariot maupun eukariot
❑ Namun, beberapa varian dijumpai, terutama pada mitokondria
yang hanya memiliki sedikit gen.
❑ Contoh: CUA umumnya mengkode, tetapi pada mitokondria
yeast mengkode treonin. AGA umumnya mengkode arginin,
tetapi pada mitokondria manusia dan Drosophila merupakan
stop kodon.

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Relationships of DNA to mRNA to polypeptide chain.

1. Inisiasi Perbedaan translasi pada prokariot dan eukariot

29% 15%
Mercury is the closest Despite being red,
planet to the Sun Mars is a cold place Pencils Crayons Rulers

Mars 54.1 852 124

20% 36%
Venus is the second Yes, this is the ringed Jupiter 949 102 308
planet from the Sun one. It’s a gas giant

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2. Elongasi

Proses
elongasi

2. Elongasi 3. Terminasi

Don’t Forget! For Tomorrow’s Class

Mercury Venus Mars

● Clip board ● Watercolors

76% 21% 13%

● Marker ● Liquid corrector

● Envelope ● Notebook

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Proses Pasca-Translasi Proses Pasca-Translasi

Topic 1 Topic 2 Topic 1 Topic 2

Mercury is the closest 01 02 Despite being red, Mercury is the closest 01 02 Despite being red,
planet to the Sun Mars is a cold place planet to the Sun Mars is a cold place

Topic 3 Topic 4 Topic 3 Topic 4

It’s the biggest planet
in the Solar System
03 04 Venus is the second
planet from the Sun
It’s the biggest planet
in the Solar System
03 04 Venus is the second
planet from the Sun

Banyak obat yang bertarget pada proses translasi terutama

obat golongan antibiotik.

Obat Yang
Despite being red, Mars is a cold

Bertarget Pada place. It’s full of iron oxide dust

Translasi Saturn is composed of

hydrogen and helium

It’s a gas giant and the

biggest planet

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Perbedaan transkripsi &

translasi
eukariot vs prokariot

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Thanks!

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