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The Genetics Revolution
The Genetics Revolution
In the modern world genetics plays a part in more dramatic breakthroughs than any other field of
biological study. These breakthroughs have an impact in a wide variety of areas, from curing diseases to
growing better vegetables to catching criminals. The field of genetics is in the midst of a revolution, and
at the center of this exciting (and, to some minds, terrifying) phenomenon is the realm of genetic
engineering: the alteration of genetic material by direct intervention in genetic processes. In agriculture,
for instance, genes are transplanted from one organism to another to produce what are known
as transgenic animals or plants. This approach has been used to reduce the amount of fat in cattle raised
for meat or to increase proteins in the milk p roduced by dairy cattle. Fruits and vegetables also have
been genetically engineered so that they do not bruise easily or have a longer shelf life.
Not all of the work in genetics is genetic engineering per se; in the realm of law, for instance, the most
important application of genetics is genetic fingerprinting. A genetic fingerprint is a sample of a person's
DNA that is detailed enough to distinguish it from the DNA of all others. The genetic fingerprint can be
used to identify whether a man is the father of a particular child (i.e., to determine paternity), and it can
be applied in the solving of crimes. If biological samples can be obtained from a crime scene—for
example, skin under the fingernails of a murder victim, presumably the result of fighting against the
assailant in the last few moments of life—it is possible to determine with a high degree of accuracy
whether that sample came from a particular suspect. The use of DNA in forensic science is discussed
near the conclusion of this essay.
THE REVOLUTION IN MEDICINE.
Some of the biggest strides in genetic engineering and related fields are taking place, not surprisingly, in
the realm of medicine. Genetic engineering in the area of health is aimed at understanding the causes of
disease and developing treatments for them: for example, recombinant DNA (a DNA sequence from one
species that is combined with the DNA of another species) is being used to develop antibiotics,
hormones, and other disease-preventing agents. Vaccines also have been genetically re-engineered to
trigger an immune response that will protect against specific diseases. One approach is to remove
genetic material from a diseased organism, thus making the material weaker and initiating an immune
response without causing the disease. (See Immunity and Immunology for more about how vaccines
work.)
Gene therapy is another outgrowth of genetics. The idea behind gene therapy is to introduce specific
genes into the body either to correct a genetic defect or to enhance the body's capabilities to fight off
disease and repair itself. Since many inherited or genetic diseases are caused by the lack of an enzyme
or protein, scientists hope one day to treat the unborn child by inserting genes to provide the missing
enzyme. (For more about inherited disorders, see the essays Disease, Noninfectious Diseases, and
Mutation.)
THE HUMAN GENOME PROJECT.
One of the most exciting developments in genetics is the initiation of the Human Genome Project,
designed to provide a complete genetic map outlining the location and function of the 40,000 or so
genes that are found in human cells. (A genome is all of the genetic material in the chromosomes of a
particular organism.) With the completion of this map, genetic researchers will have easy access to
specific genes, to study how the human body works and to develop therapies for diseases. Gene maps
for other species of animals also are being developed.
The project had its origins in the 1990s, with the efforts of the United States Department of Energy
(DOE) and the National Institutes of Health (NIH). The NIH connection is probably clear enough, but the
DOE's involvement at first might seem strange. What, exactly, does genetics have to do with electricity,
petroleum, and other concerns of the DOE? The answer is that the DOE grew out of agencies, among
them the Atomic Energy Commission (AEC), established soon after the explosion of the two atomic
bombs over Japan in 1945. Even at that early date, educated nonscientists understood that the
radioactive fallout produced from nuclear weaponry can act as a mutagen; therefore, Congress
instructed the AEC to undertake a broad study of genetics and mutation and the possible consequences
of exposure to radiation and the chemical by-products of energy production.
Eventually, scientists in the AEC and, later, the DOE recognized that the best way to undertake such a
study was to analyze the entire scope of the human genome. The project formally commenced on
October 1, 1990, and is scheduled for completion in the middle of the first decade of the twenty-first
century. Upon completion, the Human Genome Project will provide a vast store of knowledge and no
doubt will lead to the curing of many diseases.
Still, there are many who question the Human Genome Project in particular, and genetic engineering in
general, on ethical grounds, fearing that it could give scientists or governments