RESPIRATORY DRUGS: PHARMACOLOGY

DECONGESTANTS
November 02, 2020
Transcribers: Celada, Kyrriel J.
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PHARMACOTHERAPEUTICS

⎯ Allergic rhinitis IMPLEMENTATION

⎯ Vasomotor rhinitis
⎯ Report ineffectiveness of the drug to
⎯ Acute coryza
the prescriber; also report if the
⎯ Sinusitis patient’s cough persists or if signs
and symptoms worsen.
⎯ Encourage the patient to perform
PHARMACOKINETICS deep-breathing exercises.
⎯ Oral ⎯ Advise the patient not to take other
medications, OTC products, or
herbal remedies until talking with
PHARMACODYNAMICS the prescriber or a pharmacist.
⎯ Identify and correct hypoxia,
⎯ Cause vasoconstriction by directly hypercapnia, and acidosis, which
stimulating alpha-adrenergic may reduce drug effectiveness or
receptors in the blood vessels of the increase adverse reactions, before or
body during ephedrine administration.
⎯ Don’t crush or break extended-
release forms of the drug.
DRUG INTERACTIONS ⎯ Give the last dose at least 2 hours
⎯ Epinephrine and norepinephrine before bedtime to minimize
⎯ Dopamine insomnia.
⎯ Dobutamine ⎯ Instruct the patient to limit his use of
⎯ Isoproterenol intranasal forms to 3 to 5 days to
prevent rebound congestion.
⎯ MAO inhibitors

ADVERSE REACTIONS

⎯ Nervousness
⎯ Restlessness and insomnia
⎯ Nausea
⎯ Palpitations and tachycardia
⎯ Difficulty urinating
⎯ Elevated blood pressure

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