Student: _Zeena Rose S.

Llanes Block:_261 - BBB (Group G)

DRUG STUDY

Brand Name: none indicated Generic Name: Salbutamol or Albuterol Pharmacologic Classification: bronchodilators; adrenergics

Dosage, Route & Frequency Drug-Drug &

Side Adverse
Drug Action Drug-Food Indications Contraindications
Recommended Prescribe Effects Reactions
Interactions
d (By (By
System) System)
Inhalation (Adults Salbutamol neb Binds to beta2-adrenergic receptors in Concurrent use with Treatment or Hypersensitivity to CNS: nervousness, Respi: Paradoxical
and Children 4 yr): 1 respoule q airway smooth muscle, leading to other adrenergic agents prevention of adrenergic amines. restlessness, tremor, bronchospasm
Via metered-dose 6hrs activation of adenyl cyclase and will have increased bronchospasm in headache, insomnia,
inhaler or dry powder increased levels of cyclic-3, 5-adenosine adrenergic side effects. asthma or chronic Use Cautiously in: hyperactivity in
inhaler—2 inhalations monophosphate (cAMP). Increases in Use with MAO inhibitors obstructive Cardiac disease; children.
every 4– 6 hr (some cAMP activate kinases, which inhibit the may lead to hypertensive pulmonary disease Hypertension;
patients may respond phosphorylation of myosin and decrease crisis. Beta-blockers may (COPD). Hyperthyroidism; Diabetes; CV: chest pain,
to 1 inhalation) or 2 intracellular calcium. Decreased negate the therapeutic Inhalation: Glaucoma; Seizure palpitations, angina,
inhalations 15 min intracellular calcium relaxes smooth effect. May decrease Prevention of disorders; Excess inhaler arrhythmias,
before exercise; NIH muscle airways. Relaxation of airway serum digoxin levels. exercise-induced use may lead to tolerance hypertension.
Guidelines for acute smooth muscle with subsequent Cardiovascular effects bronchospasm. and paradoxical
asthma exacerbation: bronchodilation. Relatively selective for are potentiated in bronchospasm; GI: nausea, vomiting.
Children—4– 8 puffs beta2 (pulmonary) receptors. patients receiving Endo:
every 20 min for 3 tricyclic antidepressants. hyperglycemia.
doses then every 1– 4 Therapeutic Effects: Bronchodilation. Risk of hypokalemia
hr; increases concurrent use F and E:
Pharmacokinetics of potassium-losing hypokalemia. Neuro:
Absorption: Well absorbed after oral diuretics. Hypokalemia tremor.
administration but rapidly undergoes increases the risk of
extensive metabolism. digoxin toxicity.
Distribution: Small amounts appear in
breast milk. Drug-Natural Products:
Metabolism and Excretion: Use with caffeine-
Extensively metabolized by the liver and containing herbs (cola
other tissues. nut, guarana, tea, coffee)
Half-life: Oral 2.7– 5 hr; Inhalation: 3.8 increases stimulant
hr effect.

Pharmacodynamics:
O: 5 - 15 mins
P: 60 -90 mins
D: 3-6 hrs
 Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)
ASSESSMENT IMPLEMENTATION
● Assess lung sounds, pulse, and BP before administration and during peak of medication. Note amount, ● For nebulization or IPPB, the 0.5-, 0.83-, 1-, and 2- mg/mL solutions do not require dilution
color, and character of sputum produced. before administration. The 5 mg/mL (0.5%) solution must be diluted with 1– 2.5 mL of
● Monitor pulmonary function tests before initiating therapy and periodically during therapy. 0.9% NaCl for inhalation. Diluted solutions are stable for 24 hr at room temperature or 48
● Observe for paradoxical bronchospasm (wheezing). If condition occurs, withhold medication and notify hr if refrigerated.
health care professional immediately ● For nebulizer, compressed air or oxygen flow should be 6– 10 L/min; a single treatment of
3 mL lasts about 10 min. IPPB usually lasts 5– 20 min
POTENTIAL NURSING DIAGNOSES
● Ineffective airway clearance EVALUATION/DESIRED OUTCOMES
● Prevention or relief of bronchospasm.

References (6th Ed. APA Format)

Sanoski and Vallerand (2019). Davis’s drug guide for nurses. 16th Edition. Philadelphia, Pennsylvania: F.A. Davis Company