Lebanese International University

School of Pharmacy
Beirut – Bekaa Campuses
Fall Semester 2021-2022
PHAR620 – Pharmacotherapeutics VI (Hematology/Oncology)
3 credits

Course Syllabus

Instructor Campus Sect Room Offered Time Office hours Address

Dr. Mariam Dabbous Beirut A 504-E MW: 8:00-9:30 MW 11:00-12:00 Mariam.dabbous@liu.edu.lb
Dr. Mariam Dabbous Beirut B 504-E MW: 9:30-10:45 MW 11:00-12:00 Mariam.dabbous@liu.edu.lb
Dr. Etwal Bou Raad Beirut C 403-E MW: 9:30-10:45 MW 08:00-9:30 Etwal.bouraad@liu.edu.lb
Dr. Etwal Bou Raad Beirut D 403-E MW: 11:00-12:15 MW 08:00-9:30 Etwal.bouraad@liu.edu.lb
Dr. Israa Al Sayed Bekaa A 116-C MW: 12:30-1:45 MW: 11:00 - 12:00 Israa.sayed@liu.edu.lb
Dr. Israa Al Sayed Bekaa B 011-C MW: 11:00-12:15 MW: 11:00 - 12:00 Israa.sayed@liu.edu.lb

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Course Coordinator: Dr. Etwal Bou Raad

Department: Biomedical sciences

Office: Pharmacy School-Block A Beirut Campus/ Block C Bekaa Campus

COURSE PREREQUISITE:
 4th year courses

REQUIRED BOOKS:

 Pharmacotherapy: A Pathophysiologic Approach, 10th : Joseph T. DiPiro, Robert

L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey
 Pharmacotherapy Casebook: A Patient-Focused Approach, 9e
 Harrison's Principles of Internal Medicine, 19e
 NCCN guidelines. www.nccn.org , FREE

COURSE DESCRIPTION:

This 3-credit course enables the students to develop knowledge regarding the
pathophysiology of the most common cancer diseases, risk factors, prevention, and
treatment approaches based on updated guidelines.

COURSE OBJECTIVES:

This course aims to prepare the students to:

1. Identify the pathophysiology of the most common types of solid and liquid
tumors.
2. Review the general prevention and management for chemotherapeutic
induced adverse drug reactions and oncological emergencies.
3. Discuss the assessment and management of major solid tumors and liquid
tumors based on updated guidelines.

INTENDED LEARNING OUTCOMES:

Upon the completion of the course, the student will be able to:

Domain 1: Foundational Knowledge

PLO ILOs
1.1.1  Describe the pathophysiology of cancer including the hallmarks of

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 cancer, the metastatic process, tumor markers, and mechanisms of
resistance.
 Distinguish between the different types of tumors (benign vs.
carcinogenic, solid vs. liquid, leukemia vs. lymphoma…).
1.1.2  Indicate the prevention and management of chemotherapeutic induced
adverse drug reactions.
1.1.3  Assess the patients’ laboratory tests, staging, and factors that indicate
the best prevention and treatment modalities.
 Recognize the various screening methods for several cancer types.
1.1.4  Distinguish the main treatment modalities of cancer (surgery, radiation
and systemic therapy) including their mechanisms of action, role, and
use at various stages of the disease process.
 Develop prevention and management strategies for common
hematological, gastrointestinal, and organ toxicities induced by
anticancer treatments, as well as for oncological emergencies.
1.1.6  Identify the appropriate oncological interventions and treatment
modalities including neoadjuvant, adjuvant and palliative treatment.

Domain 2: Pharmaceutical Care

PLO ILOs
2.1.2  Recognize the importance of the different drug-drug, drug-disease and
drug-food interactions that may affect therapeutic decisions among
cancer patients, along with chemotherapeutic induced adverse drug
reactions.
2.2.2  Calculate accurately the doses of chemotherapeutic drugs (i.e. based on
body surface area or weight).
 Calculate accurately the doses of opiates and opioid analogs for pain
management.

Domain 3: Essentials for Practice and Care

PLO ILOs
3.1.1  Interpret relevant cancer patients' history and their clinical and
laboratory findings.
3.1.2  Select the appropriate management based on the patients’ disease
stage, cumulative chemotherapeutic dose, and previous diseases or
manifestations.
3.1.3  Develop a patient-specific treatment plan including nonpharmacological
measures, pain management, supportive and antineoplastic therapies.
3.1.5  Interpret various diagnostic, prognostic, patient and disease related
factors to propose the most effective therapeutic options for cancer
patients.
 Develop prevention and management strategies for chemotherapeutic
induced adverse drug reactions including hematological, gastrointestinal,

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 and other organs.
 State and justify antiemetic regimens for high, moderate, low and
minimal emetogenic regimens.

Domain 4: Approach to Practice and Care

PLO ILOs
4.1.1  Identify the primary oncological problem and accordingly define the
appropriate treatment goals.
4.1.2  Explore the various modalities and regimens available for the
management of different cancer types and associated toxicities.

TEACHING AND ASSESSMENT METHODS:

ILOs Learning Methods Assessment Methods
1.1.1, 1.1.2, 1.1.3, 1.1.4,  Lectures as PowerPoint  Exams I, II, and Final
1.1.6, 2.1.2, 2.2.2 presentations (MCQ’s)

3.1.1, 3.1.2, 3.1.3, 3.1.5,  Lectures as PowerPoint  Exams I, II, and Final
4.1.1, 4.1.2, presentations (MCQ’s)
 Group Case Discussions  Graded rubric for group
case discussions

COURSE DELIVERY METHODS:

1. The learning platform for this course is Google Classroom.
2. The instructor will post course material as PDF, Microsoft Word, or Microsoft
PowerPoint to students on Google Classroom stream. All material for
assignments, homework, or other course details will be posted as well.
3. The course will be delivered remotely using synchronous (live sessions according
to course schedule) and asynchronous (recordings by voice-over-PowerPoint
[VOPP]) methods.
4. Live sessions will be scheduled according to the time slot when the course is
offered. VOPP recordings will be shared prior to class time to allow students to
watch them at their own pace before live sessions.

COURSE ATTENDANCE REGULATIONS:

1. Attendance of live sessions is HIGHLY RECOMMENDED. Please try to join them to
get maximal benefit from the course.

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 2. During live sessions, instructors will summarize recordings and highlight essential
concepts to help you understand the material. They will also answer questions,
create discussions, and perhaps do quizzes online.

ONLINE ETIQUETTE:
A code of conduct should be applied in remote education. Please note the following
important etiquette for live sessions:
1. You are expected to join class on time.
2. Reduce noise by using earphones and the mute button, and minimize
distractions from the surroundings as much as you can.
3. Please remember that the virtual class replaces the normal (physical) class.
Accordingly, make sure to professionally join the class (adequate dress code,
adequate seating, avoid eating, drinking, and disrupting activities).
4. The instructor will try to create an engaging, respectful, and meaningful learning
environment. Please acknowledge that by participating in discussions, asking
questions, and properly interacting in the session. Be ready to share, connect
and engage with the class.
5. If you choose to communicate with the instructor via chat boxes, please use
appropriate, professional, English language and double check your text for
mistakes before posting it.
6. If assignments or homework are posted on Google Classroom, please make sure
to post your work prior to deadlines.

CHEATING REGULATIONS:
1. Exams will be conducted on campus in a computerized format.
2. Cheating during online exams in any way or form, will not be tolerated and
will be considered as evidence of academic dishonesty. Students will be
referred to the grievance committee and an F will be posted on the exam.
3. Plagiarism: It is unacceptable to copy and pass off, as one's own the ideas or
words of another without properly crediting the source. Turnitin, the
university’s designated plagiarism checker, may be used on any submitted
written work. Instances of inappropriate or unacceptable academic behavior
will be treated on a case-by-case basis with the consequences ranging from
no credit on the assignment for those involved to automatic failure of or
removal from the course. In addition, university administration may be
notified.

MAKE-UP EXAMS:
 Makeup exams are not allowed and attending exams is obligatory.
 Make up exams are ONLY allowed in cases of:

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 a. Death of a first degree relative ONLY
b. Hospitalization with a valid hospital medical report: only hospital
records are allowed.

GRADE DISTRIBUTION AND EXAM SCHEDULE:

Exam Date Time Grade
distribution
Midterm Friday , November 19th 1:00-2:00 pm 40% (Automated
, 2021 Exam ON
CAMPUS”

Case Discussion Tuesday, January 3, 7:00- 8:00 pm 5 % (Online quiz-

2021 Google form)
Final Exam Set by the university TBA 55 %

COURSE OUTLINE:

Recording (before the live Program Learning

Week Dates Chapter title
session)/Comments Outcomes

Syllabus Principles of cancer treatment

Principles of cancer treatment
(indicated slides)
Mon 4/10/2021 - Fri
1 Prevention and treatment of
8/10/2021 chemotherapy related ADR-
Hematology ( At least discuss
till Neutropenia)
Prevention and treatment of
chemotherapy related ADR-
Hematology (Continue the
Mon 11/10/2021 – Fri
2 Anemia part)
15/10/2021 Prevention and treatment of
chemotherapy related ADR- GI
Prevention and treatment of
Mon 18/10/2021 – Fri chemotherapy related ADR- GI
3
22/10/2021 (continue if not finished)
Prevention and treatment of
(indicated slides only)
Prevention and treatment of
chemotherapy related ADR-
Hematology
Prevention and treatment of
chemotherapy related ADR- GI ( Full
recording)
1.1.1, 1.1.2, 1.1.3, 1.1.4,
1.1.6, 2.1.2, 2.2.2, 3.1.1,
3.1.2, 3.1.3, 3.1.5, 4.1.1,
4.1.2
Prevention and treatment of
chemotherapy related ADR-
Dermatology
“Follow up if all instructors is on

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 chemotherapy related ADR-
Dermatology
Prevention and treatment of
Mon 25/10/2021 – Fri chemotherapy related ADR-
4
29/10/2020 Specific Organ Toxicity One
the timeline and decision pertaining
if dermatological reactions will be
included in the midterm shall be
disseminated”
Prevention and treatment of
chemotherapy related ADR- Specific
Organ Toxicity One

Prevention and treatment of

Prevention and treatment of chemotherapy related ADR- Specific
Mon 1/11/2021 – Fri chemotherapy related ADR- Organ Toxicity Two
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5/11/2021 Specific Organ Toxicity Two

Antiemetic treatment Antiemetic treatment( recoding for

Mon 8/11/2021 – Fri (Antiemetic is included in the the indicated slides only)
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12/11/2021 midterm)
Pain management in cancer Pain management
patients for TTH sections Midterm Nov 19th from 1:00 am to
Mon 15/11/2021 – Fri
7 No classes For MW Sections 2:00 PM
19/11/2020 “ON CAMPUS AUTOMATED
EXAM”
Pain management in cancer Colon cancer
Mon 22/11/2021 – Fri patients for MW sections
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26/11/2021 No classes for TTH sections
Colon Cancer Breast Cancer
Mon 29/11/2021 – Fri
9
3/12/2021

Mon 6/12/2021 – Fri Non Small Lung Cancer (NSCLC)

10 Breast Cancer
10/12/2021

Mon 13/12/2021 – Fri NSCLC

11 Small Cell lung Cancer (SCLC)
17/12/2021

Prostate Cancer
NSCLC (recordings for Lymphoma +/-
Mon 20/12/2021 –Th
12 SCLC dermatological will be sent to all
23/12/2021 students before the Christmas
vacation)

13 Christmas Vacation 24/12/2021 to 1/1/2022

Online Quiz on Tuesday Jan 3 from

Mon 2/1/2022 – For TTH sections, the live session will
7:00 PM till 8:00 PM on lymphoma
Wed 5 /1/2022 be held on Tuesday instead of
14 +/- dermatological reactions
Armenian Christmas Thursday
Wed 6/1/2022 Prostate Cancer
Leukemia (AML, APL, ALL)
Leukemia (CML, CLL)
Mon 9/1/2022 – Fri
15 Leukemia (AML, APL, ALL)
13/1/2022

Monday 17th, 2022-

Leukemia (CML, CLL)
16 Wednesday 20th, End of the Fall Semester 
2022