Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)

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Document #: msds-102 -EN

Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 7 of 15
BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 8 of 15
BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 9 of 15
BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 10 of 15
BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 8/20/2012
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 8/20/2012


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 4/20/2018
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Version: B
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 4/20/2018
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Version: B
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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Version: B
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 10 of 15
BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
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Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

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BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

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BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
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BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
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MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

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Version: B
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BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

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Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
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BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


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BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

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Version: B
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BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
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BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 4/20/2018
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Version: B
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 8 of 15
BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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Version: B
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
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Version: B
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BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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Version: B
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BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


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Version: B
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BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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Version: B
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 10 of 15
BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
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Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

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BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

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Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
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BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
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PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

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BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

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Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 7 of 15
BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
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BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 4/20/2018
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Version: B
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BSE-Scrapie 99-08600 Page: 7 of 15
BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 8 of 15
BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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Version: B
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BSE-Scrapie 99-08600 Page: 9 of 15
BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
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Version: B
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BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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Version: B
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BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


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Version: B
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BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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Version: B
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 10 of 15
BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 1 of 15
BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 2 of 15
BSE 99-09437

Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 3 of 15
BSE 99-09437

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
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BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
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BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
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Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

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BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

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Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
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BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
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PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

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BSE 99-09437

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name(s) Bovine Spongiform Encephalopathy-Scrapie Antigen Test Kit (BSE-Scrapie)


Bovine Spongiform Encephalopathy Antigen Test Kit (BSE)
Product code(s) 99-08600, 99-09437
Identified uses For veterinary use only.

Company IDEXX Laboratories, Inc. IDEXX Laboratories Pty Ltd. IDEXX Europe B.V.
One IDEXX Drive Metro Centre Scorpius 60 Building F
Westbrook, ME 04092 Unit 20, 38-46 South Street Hoofddorp 2132 LR
United States Rydalmere, NSW 2116 Australia The Netherlands
Telephone 1-800-548-6733 1-800-655-978 00800 727 43399
Fax 1-207-556-4346 1-800-634-409 00800 433 99329

Substrate solution Conjugate concentrate, SRB CC


Company Moss Inc. SurModics (StabilZyme HRP)
P.O. Box 189 9924 West 74th Street
Pasadena, MD 21123-0189 Eden Prairie, MN 55344-3523
United States United States
Telephone 1-800-932-6677 1-800-755-7793
+00-1-410-768-3442 +00-1-952-500-7200
Fax +00-1-410-768-3971 +00-1-952-500-7201

24 hour Emergency Phone # CHEMTREC 1-800-424-9300


Outside U.S +(00)-1-703-527-3887
Australia +(61)-290372994
2. HAZARDS IDENTIFICATION

GHS Classification, Classification according to Regulation (EC) No 1272/2008

Conditioning buffer
Acute Toxicity, Oral, Category 4
Chronic Aquatic Toxicity, Category 3
Pictogram

Signal Word Warning


Hazard statement(s) H302 Harmful if swallowed.
H412 Harmful to aquatic life with long lasting effects.
EUH032 Contact with acids liberates very toxic gas.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel
unwell.
P330 Rinse mouth.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Conjugate diluent
Hazard statement(s) EUH208 Contains ProClin 150. May produce an allergic reaction.

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Negative control
Skin Irritation, Category 2
Serious Eye Damage, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H315 Causes skin irritation.
H318 Causes serious eye damage.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
Plate diluent 1, Substrate solution
Skin Irritation, Category 2
Eye Irritation, Category 2
Pictogram

Signal Word Warning


Hazard statement(s) H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s) P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Plate diluent 2
Skin Irritation, Category 3
Respiratory Sensitization, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H316 Causes mild skin irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if
inhaled.
Precautionary statement(s) P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P285 In case of inadequate ventilation wear respiratory protection.
P332+P313 If skin irritation occurs: Get medical advice/attention.

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P304+P340 IF INHALED: Remove person to fresh air and keep comfortable


for breathing.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER
/doctor.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Positive control
Acute Toxicity, Oral, Category 4
Skin Corrosion, Category 1B
Acute Aquatic Toxicity, Category 1
Chronic Aquatic Toxicity, Category 1
Pictogram

Signal Word Danger


Hazard statement(s) H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s) P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face
protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/shower.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable
for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage.
P501 Dispose of contents in accordance with local/regional/
national/international regulations.
Wash solution 1
Skin Irritation, Category 3
Pictogram No symbol
Signal Word Warning
Hazard statement(s) H316 Causes mild skin irritation.
Precautionary statement(s) P332+P313 If skin irritation occurs: Get medical advice/attention.

Conjugate concentrate, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2


Not a hazardous substance according to GHS.
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

According to European Directive 67/548/EEC as amended.

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 4 of 15
BSE 99-09437

Conditioning buffer
Hazard symbol(s) Xn Harmful
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R32 Contact with acids liberates very toxic gas.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S45 In case of accident or if you feel unwell, seek medical advice
immediately.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Negative control
Hazard symbol(s) Xi Irritant
R-phrase(s) R38 Irritating to skin.
R41 Risk of serious damage to eyes.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.

Plate diluent 1, Substrate solution


Hazard symbol(s) Xi Irritant
R-phrase(s) R36/38 Irritating to eyes and skin.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37/39 Wear suitable gloves and eye/face protection.
Plate diluent 2
Hazard symbol(s) Xi Irritant
R-phrase(s) R42 May cause sensitization by inhalation.
S-phrase(s) S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice
immediately.
Positive control
Hazard symbol(s) Xn Harmful
C Corrosive
N Dangerous for the environment
R-phrase(s) R22 Harmful if swallowed.
R34 Causes burns.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s) S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S28 After contact with skin, wash immediately with plenty of soap and water.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S46 If swallowed, seek medical advice immediately and show this container
or label.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Conjugate concentrate, Conjugate diluent, Reconstitution buffer, Wash solution 1, Wash solution 2, SRB Conjugate
concentrate
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 5 of 15
BSE 99-09437

This substance is not classified as dangerous according to Directive 67/548/EEC.


3. COMPOSITION/INFORMATION ON INGREDIENTS

Conditioning buffer
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Alkaliine salts and alkaline earth salts - - 615-030-00-5 - < 50%
of thiocyanic acid
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Conjugate diluent
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 2%
ProClin 150 - - - - ≤ 0.5%

Negative control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trometamol 77-86-1 201-064-4 - TY2900000 < 10%
N-lauroylsarcosine 97-78-9 202-608-3 - - ≤ 5%
Triton X-100 9036-19-5 - - MD0907600 ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Plate diluent 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 5%
Zwittergent 3-14 14933-09-6 239-003-9 - - ≤ 5%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Plate diluent 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trypsin 9002-07-7 232-650-8 647-010-00-7 YN5075000 < 7%
Trometamol 77-86-1 201-064-4 - TY2900000 < 4%

Positive control
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Trade secret - - - - < 30%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.2%

Substrate solution
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Substrate solution - - - - 100%

Wash solution 1
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
N-lauroyl sarcosine 97-78-9 202-200-5 - - ≤ 1%
Sodium azide 26628-22-8 247-852-1 011-004-00-7 VY8050000 ≤ 0.1%

Wash solution 2
Substance CAS-No. EC-No. Index-No. RTECS-No. Concentration
Sodium chloride 7647-14-7 231-598-3 - VZ4725000 < 10%
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 6 of 15
BSE 99-09437

4. FIRST AID MEASURES

IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Conditioning buffer
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER or doctor/physician if you feel unwell.

Negative control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth.

Plate diluent 1, Substrate solution


IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Plate diluent 2
IF INHALED: Remove victim to fresh air and keep comfortable for breathing. If experiencing respiratory
symptoms: Call a POISON CENTER/doctor.
IF ON SKIN: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Rinse mouth.

Positive control
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair):
Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash
contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or
doctor/physician.
5. FIRE FIGHTING MEASURES

Suitable extinguishing media


Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 7 of 15
BSE 99-09437

Advice for firefighters


Wear self contained breathing apparatus for firefighting if necessary.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/ mist/vapors/spray. Take off contaminated clothing and wash
it before reuse.

Environmental precautions
Avoid release to the environment. Collect spillage.

Methods and materials for containment and cleaning up


Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Positive control
Soak up with inert absorbent material and dispose of as hazardous waste.
7. HANDLING AND STORAGE

Precautions for safe handling


Use personal protective equipment as required. Wash hands thoroughly after handling. In case of inadequate ventilation
wear respiratory protection. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this
product.

Conditions for safe storage


Store in a well-ventilated place. Keep container tightly closed. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS / PERSONNAL PROTECTION

Exposure Controls
Handle in accordance with good industrial hygiene and safety practice. Do not get in eyes, on skin, or on clothing.

Personal protective equipment


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber
Eye protection Safety glasses.
Body protection Wear protective clothing.

Negative control, Positive control


Respiratory protection In case of inadequate ventilation wear respiratory protection.
Skin protection Handle with gloves. Nitrile rubber.
Eye protection Face shield. Tightly fitting safety goggles.
Body protection Wear protective clothing.

Control parameters
Substance Country Value Control parameter Update
Trade Secret Australia TWA 1 mg/m3 07.2008
STEL 2 mg/m3
Belgium TWA 1 mg/m3 03.2002
STEL 2 mg/m3
Denmark TWA 0.5 mg/m3 10.2002
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 8 of 15
BSE 99-09437

Finland TWA 1 mg/m3 09.2009


France VME 1 mg/m3 02.2006
Korea TWA 1 mg/m3 2006
Mexico TWA 1 mg/m3 2004
The Netherlands MAC-TGG 1 mg/m3 2003
New Zealand TWA 1 mg/m3 01.2002
STEL 2 mg/m3
Norway TWA 1 mg/m3 01.1999
Poland TWA 1 mg/m3 01.1999
Sweden TWA 1 mg/m3 06.2005
Switzerland MAK-W 1 mg/m3 12.2006
Turkey TWA 1 mg/m3 01.1993
United Kingdom TWA 1 mg/m3 2005
STEL 2 mg/m3
United States TWA 1 mg/m3 1992
STEL 2 mg/m3
9. PHYSICAL AND CHEMICAL PROPERTIES

Conditioning buffer Conjugate concentrate Conjugate diluent


Form liquid liquid liquid
Color (Colour) colorless amber colorless
Odor (Odour) no data available no data available no data available
pH 6.0 – 8.0 6.2 – 7.2 6.0 – 8.0
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Negative Control Plate diluent 1 Plate diluent 2


Form solid liquid solid
Color (Colour) no data available colorless white
Odor (Odour) no data available no data available no data available
pH not applicable 8.0 -8.5 not applicable
Melting point no data available no data available no data available
Initial boiling point no data available no data available no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Positive Control Reconstitution buffer Substrate solution


Form solid liquid liquid
Color (Colour) no data available colorless colorless
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 9 of 15
BSE 99-09437

Odor (Odour) no data available no data available no data available


pH not applicable 6.5 – 7.5 3.0 – 5.0
Melting point no data available 0°C no data available
Initial boiling point no data available 100°C no data available
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble

Wash solution 1 Wash solution 2 SRB Conjugate concentrate


Form liquid liquid liquid
Color (Colour) colorless colorless amber
Odor (Odour) no data available no data available no data available
pH 6.0 - 8.0 7.0 – 7.5 6.2 – 7.2
Melting point no data available no data available no data available
Initial boiling point no data available no data available 100°C
Flash point not applicable not applicable not applicable
Flammability not applicable not applicable not applicable
Explosive properties not applicable not applicable not applicable
Oxidizing properties not applicable not applicable not applicable
Vapor (Vapour) pressure no data available no data available no data available
Relative density no data available no data available no data available
Water solubility soluble soluble soluble
10. STABILITY AND REACTIVITY

Chemical stability no data available


Incompatible materials Oxidizing agents.
Conditions to avoid Conditioning buffer – Contact with acids liberates very toxic gas.
Hazardous decomposition products Carbon oxides, Nitrogen oxides.
11. TOXICOLOGICAL INFORMATION

Alkaliine salts and alkaline earth salts of thiocyanic acid


Acute toxicity LD50 Oral - rat - 593 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

N-lauroylsarcosine
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 10 of 15
BSE 99-09437

Acute toxicity no data available


Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

ProClin 150
Acute toxicity LD50 Oral - rat - 2630 mg/kg
Skin corrosion/irritation Skin - rabbit - Corrosive
Serious eye damage/eye irritation Eyes - rabbit - Corrosive to eyes
Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact.
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium azide
Acute toxicity LD50 Oral - rat - 27 mg/kg
LC50 Inhalation - rat - 37 mg/m3
LD50 Dermal - rabbit - 20 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Sodium chloride

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 11 of 15
BSE 99-09437

Acute toxicity LD50 Oral - rat – 3,000 mg/kg


LC50 Inhalation - rat - 1 h - > 42,000 mg/m3
LD50 Dermal - rabbit - > 10,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trade secret
Acute toxicity LD50 Oral - rat - 350 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Triton X-100
Acute toxicity LD50 Oral - rat – 1,800 mg/kg
LD50 Dermal - rabbit – 8,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation Eyes - rabbit - Risk of serious damage to eyes.
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – no data available
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Print Date: 4/20/2018


Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 12 of 15
BSE 99-09437

Trometamol
Acute toxicity LD50 Oral - rat – 5,900 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Trypsin
Acute toxicity LD50 Oral - rat - > 5,000 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization May cause allergic respiratory and skin reactions
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available

Zwittergent 3-14
Acute toxicity no data available
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity IARC: No component of this product present at levels greater than or equal to
0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
Reproductive toxicity no data available
Specific Target Organ Toxicity – Inhalation - May cause respiratory irritation.
Single Exposure
Specific Target Organ Toxicity – no data available
Repeated Exposure
Aspiration hazard no data available
12. ECOLOGICAL INFORMATION

Alkaline salts and alkaline earth salts of thiocyanic acid


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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 13 of 15
BSE 99-09437

Toxicity to fish LC50 - Poecilia reticulata (guppy) - 89.1 mg/l - 96.0 h


Toxicity to daphnia and other aquatic EC50 - Daphnia - 42.4 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

N-lauroylsarcosine
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

ProClin 150
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium azide
Toxicity to fish LC50 - Lepomis macrochirus – 0.68 mg/l - 96 h
Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) – 4.2 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Sodium chloride
Toxicity to fish no data available
Toxicity to daphnia and other aquatic NOEC - Daphnia - 1500 mg/l - 7 d
invertebrates. LC50 - Daphnia magna (Water flea) - 1661 mg/l - 48 h
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trade secret
Print Date: 4/20/2018
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Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
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BSE-Scrapie 99-08600 Page: 14 of 15
BSE 99-09437

Toxicity to fish LC50 - Cyprinus carpio (Carp) - 0.4 - 2.2 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia magna (Water flea) - 0.2 mg/l - 48 h
invertebrates
Toxicity to algae Growth inhibition LOEC - Pseudokirchneriella subcapitata - 12.5 mg/l - 96 h
Persistence and degradability no data available
Bioaccumulative potential Bioaccumulation Pimephales promelas (fathead minnow) - 63d
Bioconcentration factor (BCF): 21.000
Mobility in soil no data available
PBT and vPvB assessment no data available

Triton X-100
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 8.9 mg/l - 96.0 h
Toxicity to daphnia and other aquatic EC50 - Daphnia - 26 mg/l - 48 h
invertebrates
Toxicity to algae no data available
Persistence and degradability Biotic/Aerobic Biochemical oxygen demand - Exposure time 28 d
Result: 36 % - Not readily biodegradable.
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available
Other adverse effects Chemical Oxygen Demand (COD) – 2.19 mg/g

Trometamol
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Trypsin
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
PBT and vPvB assessment no data available

Zwittergent 3-14
Toxicity to fish no data available
Toxicity to daphnia and other aquatic no data available
invertebrates.
Toxicity to algae no data available
Persistence and degradability no data available
Bioaccumulative potential no data available
Mobility in soil no data available
Print Date: 4/20/2018
Document #: msds-102 -EN
Version: B
MATERIAL SAFETY DATA SHEET Revision Date: 08/09/2012
CO #: 061685
BSE-Scrapie 99-08600 Page: 15 of 15
BSE 99-09437

PBT and vPvB assessment no data available


13. DISPOSAL CONSIDERATIONS

Dispose of contents in accordance with local/regional/national/international regulations.


14. TRANSPORT INFORMATION
UN-Number
USDOT: 3082 ADR/RID: 3082 IMDG: 3082 IATA: 3082

UN proper shipping name


USDOT: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S (Positive Control)
IATA: Environmentally Hazardous Substance, liquid, n.o.s (Positive Control)

Transport hazard class(es)


USDOT: 9 ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group
USDOT: III ADR/RID: III IMDG: III IATA: III

Environmental hazards
USDOT: yes ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Alkaline salts N-Lauroyl ProClin 150 Sodium Sodium Trade secret


sarcosine azide chloride
Germany (WGK) 2 1 2 2 1 3

Triton X-100 Trometamol Trypsin Zwittergent 3-14


Germany (WGK) 3 2 1 3
16. OTHER INFORMATION

HMIS Ratings

Conjugate concentrate, Conjugate diluent, Reconstitution buffer, SRB conjugate concentrate, Wash solution 2

Health hazard 0 Flammability 0 Physical hazard 0

Conditioning buffer, Negative control, Plate diluent 1, Plate diluent 2, Wash solution 1
Health hazard 1 Flammability 0 Physical hazard 0

Positive Control
Health hazard 2 Flammability 0 Physical hazard 0

Print Date: 4/20/2018

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