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  • Anesthesia: Basics

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    Mona
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    This document discusses the basics of anesthesia, including pharmacodynamics, pharmacokinetics, and therapeutic index. It outlines several classes of anesthetic drugs: propofol is an ideal induction agent with short duration and low side effects; benzodiazepines like midazolam reduce anxiety and cause amnesia; opioids like morphine, codeine and fentanyl act on brain receptors and cause respiratory depression; non-opioids like ketorolac are NSAIDs but can cause bleeding; and local anesthetics can cause CNS and cardiovascular toxicity.

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    Original Title

    ANESTHESIA

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    This document discusses the basics of anesthesia, including pharmacodynamics, pharmacokinetics, and therapeutic index. It outlines several classes of anesthetic drugs: propofol is an ideal induction agent with short duration and low side effects; benzodiazepines like midazolam reduce anxiety and cause amnesia; opioids like morphine, codeine and fentanyl act on brain receptors and cause respiratory depression; non-opioids like ketorolac are NSAIDs but can cause bleeding; and local anesthetics can cause CNS and cardiovascular toxicity.

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    © All Rights Reserved
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    2 views2 pages

    Anesthesia: Basics

    Uploaded by

    Mona
    This document discusses the basics of anesthesia, including pharmacodynamics, pharmacokinetics, and therapeutic index. It outlines several classes of anesthetic drugs: propofol is an ideal induction agent with short duration and low side effects; benzodiazepines like midazolam reduce anxiety and cause amnesia; opioids like morphine, codeine and fentanyl act on brain receptors and cause respiratory depression; non-opioids like ketorolac are NSAIDs but can cause bleeding; and local anesthetics can cause CNS and cardiovascular toxicity.

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    of 2

    Thursday, March 5, 2020

    ANESTHESIA

    BASICS

    - Pharmacodynamics is the study


    of what a drug does to the body

    - Pharmacokinetics is the study of


    what the body does to a drug.

    - ratio of the toxic dose and


    effective dose, TD50/ED50, is the
    therapeutic index

    - Propofol

    • short duration, rapid recovery,


    and low incidence of nausea
    and vomiting

    • induction agent of choice.


    - Benzodiazepines

    • Midazolam

    • reduce anxiety and produce


    amnesia

    - Opiods

    • act on μ-receptors in the brain and spinal cord

    • morphine, codeine, fentanyl

    • result in equal degrees of respiratory depression


    - Non-opiod

    1
    Thursday, March 5, 2020
    • ketorolac

    • NSAIDS

    • can cause bleeding, platelet dysfunction, and acute kidney injury

    - Local

    • can cause central nervous system (CNS)

    toxicity and cardiovascular toxicity

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