The first Oral Solution

supporting from the inside the skin’s

defenses against pollution
THE IMPACT OF POLLUTION ON THE SKIN
Air pollution is a major problem in recent decades, with a
serious toxicological impact on human health. The skin is the VOC NOx O3
PM
organ that is most exposed to air pollutants. Experts have
found that aside from UV radiation, the ongoing, daily expo-
+ = 10
PM
2.5

sure to contaminants such as polycyclic aromatic hydro-

carbons (PAHs), volatile organic compounds (VOCs), UV O3 PM PM Carbon particles
oxides, particulate matter (PM), ozone (O 3) and smoking, 10 2.5 & PAHs
play a key role in accelerating extrinsic aging and aggravate
inflammatory skin disorders. In addition, pollution-derived SKIN BARRIER ALTERATION
dermatological hazards are amplified by the deleterious EPIDERMIS OXIDATIVE STRESS & INFLAMMATION
synergy of pollution and sun, particularly by UVA radiation.
AhR ACTIVATION
DERMIS COLLAGEN DEGRADATION
Epidemiological studies have shown that traffic-related air HEALTHY DAMAGED SKIN
pollution and O 3 positively correlate with the presence of SKIN BARRIER
PIGMENTATION
coarse wrinkles and with increased pigmented spots. Also,
people living in polluted areas have significantly drier skin Pollution-induced skin damage representation
and a more delicate skin barrier function. (adapted from J. of Dermatol Science 76 (2014)

Additionally, air pollution aggravates inflammatory and aller-

gic skin conditions, such as atopic dermatitis, eczema,
psoriasis, and even skin cancer. Furthermore, during peak
periods of pollution, the formation of spots in normal and
acne-prone skin is favoured. PIGMENTATION
DRYNESS
PROBLEMS
The main mechanisms by which ambient pollutants cause FINE LINES
the deleterious effects on the skin are: the increased CLOGGED
& WRINKLES
production of free radicals, induction of cutaneous inflam- PORES & ACNE PREMATURE
matory cascades, skin barrier disruption and activation of AGING
the Aryl hydrocarbon receptor (AhR), which lead to gene SKIN RASHES
expression alteration that cause skin aging, pigmentation
and increased oxidative stress, the latter resulting in skin
inflammation.

HOW TO PROTECT
THE SKIN FROM POLLUTION
Since it is difficult to minimize skin exposure from air pollutants
For a more efficient pollution protection,
particularly in urban areas, strategies to protect the skin from
it is important to complement the
air pollution is essential.The main strategies of antipollution
topical solutions with an efficient
cosmetics can be divided into three different categories:
dietary ingredient through the endoge-
· Cosmetics including ingredients that limit the adhesion of pollu- nous delivery to the skin, protecting
tants to the skin. the deeper skin layers that even the
· Enhance pollution elimination when cleansing. best serums cannot access. For these
· Incorporating ingredients, e.g. powerful antioxidants, to mini- reasons, Monteloeder has developed
mize the damaging effect of pollutants. Zeropollution ®

Why antipollution cosmetics are not sufficient, and a more

holistic approach is needed:

· Cosmetics can only protect the most external layers of the

skin. Yet the smallest particulate matters (< 2.5μm) can pass
through the clothes and pores, penetrating into deeper layers
of the skin, where cosmetic ingredients cannot reach.
· Pollutants have an inside-outside effect. The systemic exposure
to ultrafine particles (UFP) and PHAs also induce skin damage,
since they are capable of passing from the lungs to the
bloods tream and reaching the skin from within.
WHAT IS ZEROPOLLUTION®?
Zeropollution ® is the unique proven efficacy natural ingredient
dedicated to protect and repair the visible and invisible skin
damage caused by pollution and amplified by UV exposure, from
Lemon Verbena Olive extract
the inside.
extract
Zeropollution ®, is a patented multi-component active ingredient
based on 4 herbal extracts; rosemary, olive leaf, Lippia citriodora
and Sophora japonica, that act synergistically and complemen-
tarily to manage the negative effects of pollution. The antipollu-
tion effectiveness of Zeropollution ® has been proven through in
vitro (keratinocytes and melanocytes) and ex vivo (human skin
explants) studies and in a large-scale clinical trial performed by Rosemary Sophora japonica
well recognized Clinical Research Organization. extract extract

Zeropollution ® offers a new way to take care of our skin from

external agressions with full body coverage.

WHAT DOES ZEROPOLLUTION® DO?

The various studies performed have shown that
Zeropollution® has two main effects: prevention, by coun-
teracting the major mechanisms of the pollutant´s skin
damage, and repair, ameliorating the damage caused by
pollutants. Zeropollution® proven benefits:

· Enhances resistance to oxidative stress caused by

pollution (antioxidant and radical scavenging activity).
PROTECT
& REPAIR · Reduces the skin inflammation response induced by
pollutants.

· Significantly inhibits the overactivation of the hydro-

carbonaryl receptor (AhR) induced by pollutants. One of
the main mechanisms by which ambient air pollution can
induce skin damage.

· Strengthens the skin barrier by significantly reducing the

trans-dermal water loss and increasing skin moisturization.

· Control melanogenesis, which significantly improves the

skin radiance and lightens the hyperpigmented areas.

· Improves skin aging signs: reduces wrinkle depth and

improves skin texture, skin firmness and elasticity.

· Reduces sebum secretion.

· Protects skin cells from harmful UV rays which exacer-

bate the effect of the other environmental pollutants.
 NEW
CLINICAL
TRIAL

CLINICAL EFFICACY PROVEN ON SUBJECTS WITH SUSCEPTIBLE SKIN (POLLUTED

100 volunteers · 50% sensitive skin · 50% asian 250 mg/day · Placebo Study: 3 months · Checks: 2,4,8 and 12 weeks

1 ZEROPOLLUTION® IMPROVES THE SYSTEMIC AND SKIN OXIDATIVE STATUS

Researchers have identified oxidative stress

35
35% D28 D56 D84
as a primary source of the toxic effect indu- FRAS variation compared

MDA variation compared

ced by air pollutants. to initial conditions in %

to initial confitions in %
30 -1
Subjects taking Zeropollution® showed less
25 22% -3
oxidative stress than the placebo group. The
Ferric Reducing Antioxidant of saliva (FRAS), 20 -3% -3% -3%
-5
a direct measure of the systemic reductive 15 -5%
power and an indirect index of the capability -7
to resist oxidative damage, was significantly
10 -7%
5% -9
increased in Zeropollution® group compared 5 4%
with the placebo. Also, a significantly decrea- 0 -11
se of lipid peroxides (MDA) in the skin
D28 D84 -10%
horny layer was observed in subjects taking
Zeropollution® compare to placebo. Placebo Zeropollution® Placebo Zeropollution®

2 ZEROPOLLUTION® STRENGTHENS SKIN

BARRIER AND IMPROVES SKIN MOISTURIZATION 3 ZEROPOLLUTION® PROVIDES ANTI-AGING SKIN
BENEFITS AND REGULATES THE SEBUM SECRETION

Pollution weakens the skin’s natural barrier resulting in higher and Pollution is also known to degrade the structural proteins like collagen
deeper penetration of pollutants. The damaged barrier leads to higher and elastin, and as a result, the skin firmness and elasticity is adversely
transepidermal water loss (TEWL), resulting in poor skin hydration affected resulting in extrinsic signs of aging (fine lines, wrinkles..).
causing dry and sensitive skin. The clinical trial has proven that taking Zeropollution® daily lead a
Treatment with Zeropollution® leads to an average decrease in TEWL of significant reduction in the depth of their wrinkles, smooth the skin
almost 10% (5 times more than in the placebo group) and the skin hydra- making it softer, and improves the skin elasticity and firmness compa-
tion is also increased by 15% in the Zeropollution® group. red to placebo. All these effects were significantly evident with only 15
days of Zeropollution® consumption.

Results after 3 months of product intake:

D14 D28 D56 D84
TEWL variation compared
to initial conditions in %

-1
-3 -2% -2% 8%
-3% -3%
-5
-4% SMOOTHNESS
-7 INCREASE
-6%
-9
-11
-9%
-10% 8% 7%
Placebo Zeropollution®
ELASTICITY SKIN FIRMNESS
INCREASE INCREASE

15%
compared to initial conditions in %

15
Moisturization variation

12.5 12%
10 9% 22%
7.5 6% 6%
11% WRINKLE DEPTH
5% REDUCTION IN THE
5 4% SEBUM
2.5 1% REDUCTION CROW’S FEET

0
D14 D28 D56 D84

Placebo Zeropollution®
 4 ZEROPOLLUTION® IMPROVES SKIN RADIANCE AND LIGHTENS HYPERPIGMENTED AREAS

Pollution affects the melanin synthesis pathways and can result in dark spots, overall skin darkening, and uneven skin tone.
Zeropollution® daily intake provides exceptional skin brightening benefits (20% more luminosity, 5 times more than placebo group) and
also significantly lightens the hyperpigmented areas on the cheekbone (16% ITA angle increase, 2.5 times more than placebo group).

18 16% 20%
Increase in ITA angle on dark spot
compare to initial conditions in %

compare to initial conditions in %

16 20 19%

Increase in skin brightness

14%
14
12% 13%
12 15
10 8%
8 7% 10 8%
6 5%
4% 4% 4%
4 3% 5
3%
2 2%
0 0
D14 D28 D56 D84 D14 D28 D56 D84
Placebo Zeropollution® Placebo Zeropollution®

5 IN SHORT: WHAT PARTICIPANTS TAKING ZEROPOLLUTION® FELT?

AGREE THEIR HAIR LOOKS

80% 82% AGREE THEIR SKIN LOOKS
HEALTHIER AND STRONGER SIGNIFICANTLY FIRMER

PERCEIVE THEIR SKIN 86% 82% NOTICE AN IMPROVEMENT OF

MORE MOISTURIZED THEIR SKIN IMPERFECTIONS
(DILATED PORES AND/OR PIMPLES)
AGREE THEIR SKIN TONE LOOKS
MORE EVEN AND HEALTHIER
84%

AGREE THEIR LINES AND WRINKLES 80% 84% NOTICE A PROTECTIVE SENSATION ON THEIR
ARE VISIBILITY REDUCED SKIN AND FEEL FEWER DISCOMFORT RELATED
TO POLLUTANTS-SENSITIVITY
EX-VIVO
STUDY

PROVEN PROTECTIVE EFFECT +60%

OF ZEROPOLLUTION® AGAINST
ENVIRONMENTAL POLLUTION IN 90
80
HUMAN SKIN EXPLANTS
%AhR positive area in

70
explant tissue

60
-87%
Zeropollution® presented antipollution properties by inhibiting 50
the main modifications induced by the mix of pollutant on
40
human skin explants:
30
· Inhibiting pollutant-induced lipid peroxidation 20
· Inhibiting the pollutant-induced inflammatory response 10 **
· Inhibiting metallothionein 1H expression, a marker indicating 0
oxidative stress and presence of heavy metals.
· Inhibiting the increase in Aryl hydrocarbon receptor (AhR) UNTREATED UNTREATED ZEROPOLLUTION®
NON POLLUTANTS POLLUTANTS POLLUTANTS
expression induced by pollutants (SEE FIGURE)

AhR is the major biological pathway of the pollutant stress

response and it is known to mediate the toxic effects of nume-
rous environmental contaminants. It induces the expression of
genes responsible for changes in the barrier function, in Human skin explants are exposed to pollutants with a camera that
melanogenesis and inflammation, in addition to inducing imitates a contaminated real urban environment. Zeropollution® is
oxidative stress in human skin. Also, air pollution, contributes incubed in the culture medium imitating a systemic administra-
tion. AhR expression induced by pollutants is detected on skin
to atopic dermatitis through AhR activation. tissue by immunostaining.
ZEROPOLLUTION® APP
UV
The Zeropollution ® App informs about Realtime
Air Quality Index (AQI) and realtime Dominant
Pollutant at your localization and with a 1-day WEATHER POLLUTION UV INDEX
forecast, allowing consumers plant their activities.

Among other features, the App also helps consu-

mers understand the risks of pollution and the
effects on their general health and skin giving %
also recommendations to protection. TEMPERATURE
HUMIDITY GEOTAG

www.monteloeder.com/zero-pollution

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