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SPECIAL ISSUE ARTICLE

Diagnosis and Evaluation of Eating


Disorders in the Pediatric Patient
Briana Sacco, MD; and Urszula Kelley, MD, CEDS

tally normal mouthing of objects by


ABSTRACT infants that result in ingestion. Gener-
Recognizing eating disorders in the pediatric population can be challenging for outpa- ally, those with pica are not averse to
tient providers. With the high prevalence of these disorders in children and adolescents, ingesting food. Pica can be diagnosed
it is critical that pediatricians recognize these disorders and connect these children and with another mental condition (such as
families with available treatments. This article provides a review of the current diagnostic intellectual disability, autism spectrum
criteria for pica, rumination disorder, anorexia nervosa, bulimia nervosa, avoidant restric- disorder, or schizophrenia) or medical
tive food intake disorder, binge-eating disorder, other specified feeding or eating disorder, condition if it is sufficiently severe to
and unspecified feeding or eating disorder as described in The Diagnostic and Statistical warrant additional independent clinical
Manual of Mental Disorders, fifth edition. Recommendations for initial medical evaluation attention (such as pregnancy or iron de-
and helpful screening measures are discussed. [Pediatr Ann. 2018;47(6):e244-e249.] ficiency anemia).1
Pica can result in severe medical

E
ating disorders are challeng- screening recommendations for these complications such as gastrointestinal
ing to diagnose in the pediatric disorders. obstruction by formation of bezoar or
population, as these disorders perforation of the stomach or intestines,
can have an insidious onset and those PICA heavy metal poisoning caused by the
suffering can have limited insight into Pica is an eating disorder that in- ingestion of metal-based substances, or
their illness. Due to the high prevalence volves eating items over a period of infections such as toxoplasmosis and
of these disorders and the associated at least 1 month that are not typical- toxocariasis.2,3 Although pica is more
morbidity and mortality, it is critical ly thought of as food and that do not common in pregnant women and chil-
that pediatricians accurately diagnose contain significant nutritional value. dren, prevalence in the general popula-
these conditions as early as possible. Non-nutritive foods could include pa- tion is unknown.4
This article provides a review of the per, soap, cloth, hair, string, wool,
current diagnostic criteria for eating soil, chalk, talcum powder, paint, gum,
disorders included in the Feeding and metal, pebbles, charcoal, ash, clay, RUMINATION DISORDER
Eating Disorders section of The Diag- starch, or ice. Pica can occur at any Rumination disorder (RD) involves
nostic and Statistical Manual of Men- age and gender, although the diagnosis the regular regurgitation of food that oc-
tal Disorders, fifth edition (DSM-5),1 is not made in children younger than curs for at least 1 month. Regurgitated
and discusses initial evaluation and age 2 years to exclude developmen- food can be re-chewed, re-swallowed,
or spit out. When someone regurgitates
Briana Sacco, MD, is an Assistant Professor of Psychiatry, Division of Child and Adolescent Psychiatry, their food, they do not appear to be try-
University of Texas Southwestern Medical Center; and the Medical Director, Center for Pediatric Eating ing to do so, nor do they appear to be
Disorders, Children’s Medical Center Plano, Children’s Health. Urszula Kelley, MD, CEDS, is a Professor of stressed, upset, or disgusted. Medical
Psychiatry, Division of Child and Adolescent Psychiatry, University of Texas Southwestern Medical Cen- etiologies, including gastrointestinal
ter; a Child Psychiatrist, Center for Pediatric Eating Disorders, Children’s Medical Center Plano, Children’s conditions, must be excluded before
Health; and the Director of Psychiatric Services, Children’s Medical Center Plano, Children’s Health. this diagnosis is made, and a child can-
Address correspondence to Briana Sacco, MD, Children’s Medical Center Plano, Children’s Health, not have this diagnosis concurrently
7601 Preston Road, Suite P4300, Plano, TX, 75024; email: briana.sacco@utsouthwestern.edu. with another eating disorder diagnosis
Disclosure: The authors have no relevant financial relationships to disclose. (such as avoidant restrictive food intake
doi:10.3928/19382359-20180523-02 disorder [ARFID], anorexia nervosa

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SPECIAL ISSUE ARTICLE

[AN] or bulimia nervosa [BN]). RD, if type is general food aversion. These experience. This type can present in
severe enough to warrant independent children typically eat a small amount of a child of any age, from infancy into
clinical attention, can be diagnosed in food, and this is a pattern that develops adulthood.1,5,6
the presence of another mental disor- by age 3 years. These children may not
der, including intellectual disability.1 recognize hunger sensations, frequent- Concurrent Medical Condition
Prevalence of RD in the general popu- ly demonstrate a lack of interest in food The fourth and final type is a concur-
lation is unknown.4 or eating, and often they would rather rent medical condition. These children
play or talk than eat. Given reduced can develop food refusal or inadequate
AVOIDANT RESTRICTIVE FOOD nutritional intake, these children are at intake at any age, and these behaviors
INTAKE DISORDER risk for significant growth deficiency, may come and go depending on the
Children suffering from ARFID often exhibiting both weight and height medical condition contributing to the
present with avoidance or restriction deficiencies. For some children, these symptoms. These children will typi-
of food intake resulting in clinically restrictive eating behaviors will persist cally initiate feeding but may become
significant failure to meet nutritional into adulthood.1,5,6 distressed or refuse to continue eating.
requirements. To meet DSM-51 criteria, Based on the child’s medical experience
children present with at least one of the Sensory Food Aversion (eg, constipation causing cramping ab-
following features: weight loss (or lack The second type is sensory food dominal pains, gastroesophageal reflux
of expected weight and height gains for aversion, in which a child may refuse to causing sharp stomach pains), these
age and gender), significant nutritional eat foods due to specific taste, texture, children associate discomfort with food
deficiency or health impact, depen- temperature, or smell experiences that and eating, and this is thought to con-
dence on enteral feeding or oral nutri- are aversive to the child. These children tribute to the development of avoidant
tional supplements for growth, and/or will demonstrate food refusal after in- eating behaviors. Medical management
marked interference with psychosocial troduction of a new or different type of of these children may improve their
functioning. The children do not ex- food that is aversive to the child, and symptoms but will not fully resolve
press concerns about body weight or subsequently that child may general- their avoidant eating behaviors, and as
shape. Exclusion criteria include devel- ize this aversion and refuse other foods a result they will continue to struggle
opmentally normal picky eating behav- with similar color, appearance, or smell. with adequate weight gain.1,5,6
iors and culturally or religiously sanc- These children will eat preferred foods Although ARFID has been observed
tioned practices. Before the diagnosis without difficulty, so they may dem- by medical and mental health providers
can be made, medical etiologies must onstrate specific dietary deficiencies for years, the diagnosis was formalized
be excluded.1 depending on their eating preferences, in DSM-51 in 2013, so epidemiological
but may not show any signs of overall data are limited. Prevalence of ARFID
General Food Aversion growth deficiency. These children tend in children treated for eating disorders
The DSM-51 diagnostic criteria for to present in the first decade of life, al- in the tertiary care setting ranges from
ARFID is quite broad, but character- though their symptoms may also persist 5% to 22%.6-8 One cohort of 13-year-
istic subtypes have been described and into adulthood.1,5,6 old adolescents screened for ARFID
are helpful to keep in mind in the con- in Switzerland had 3% prevalence of
text of clinical presentation and diag- Posttraumatic Feeding Disorder ARFID symptoms. Of these children
nostic formulation. In considering the The third type is posttraumatic feed- with ARFID symptoms, 39% reported
most common clinical presentations ing disorder, in which a child demon- general food aversion, 61% sensory
and based on Chatoor’s work in infant strates acute onset of food refusal. This food aversion, and 15% posttraumatic
psychiatry,5 children and adolescents typically presents after a traumatic feeding disorder, with 15% reporting 2
presenting with ARFID can be further event (eg, choking) or repeated trau- or more ARFID symptom types. Medi-
described by 1 of 4 subtypes (Table 1).6 matic insults to the oropharynx or gas- cal comorbidities were not assessed
Although these children usually have trointestinal tract (eg, intubation or up- in this sample.9 In a psychiatrically
one prominent presenting type, they per endoscopy). The child’s consistent based eating disorder program, ARFID
can meet criteria for more than one type refusal to eat can present in a variety prompting presentation to clinical care
based on their clinical history. The first of ways based on the child’s traumatic was 43% sensory food aversion, 22%

PEDIATRIC ANNALS • Vol. 47, No. 6, 2018 e245


SPECIAL ISSUE ARTICLE

TABLE 1. TABLE 2.

Common Clinical Questions for Children with a Possible Eating Disorder


Presentations of Avoidant
Topic Question
Restrictive Food Intake
Weight What is your current, highest, and lowest weight (include dates)?
Disorder
Body image How do you feel about your body? If you could wave a magic wand and
• General food aversion
change something about your body, what would you change? Have
• Sensory food aversion you ever felt afraid of gaining weight or being fat? What is your goal
• Posttraumatic feeding weight?
disorder
Restrictive eating How do you decide what you are going to eat? Do you have a goal for
• Concurrent medical condition the number of calories per food item, per meal, or per day? Do you keep
Adapted from Chatoor5 and Sacco and Schwalen.6 track of calories that you eat? How much time do you spend reading
food labels or counting calories?
Exercise How often do you exercise? What do you do for exercise and how
much time do you spend exercising? Do you take days of rest between
general food aversion, 22% posttrau- days of exercising? Why do you like to exercise? Do you think about
matic feeding disorder, and 13% con- burning calories or losing weight while exercising? Do you keep track of
current medical condition.6 Compared the calories that you burn from exercising?
to children diagnosed with AN or BN, Purging Have you ever made yourself throw up? Have you ever taken diet pills
children with ARFID diagnosis often to lose weight or not get fat? Have you ever taken laxatives more
present at younger ages, more likely than prescribed by your doctor to lose weight or not get fat (include
frequency, first/most recent episodes)?
to be boys, with longer hospital stays,
Diet Tell me about a typical day and what you eat for breakfast, lunch, and
increased used of enteral feeding meth-
dinner. What snacks do you have between meals? What fluids are you
ods, and greater likelihood of comorbid drinking?
mental health conditions.7,10,11
Menstruation When did you first start your periods? When was your last period?
Have your periods ever become irregular, lighter, or stopped (include
ANOREXIA NERVOSA dates, duration)?
Children diagnosed with AN present
with persistent energy intake restriction
combined with disturbance in self-per- in binge eating or purging behaviors at of any psychiatric disorder.1,13 Adoles-
ceived weight or shape. These children least once weekly for 3 months would cents diagnosed with AN report rates
demonstrate intense fear of gaining be considered the binge eating/purging of attempted suicide as high as 10% to
weight or becoming fat, or persistent type.1 Distinguishing between these 20%.14
behaviors that interfere with weight subtypes is important, as children with
gain. Behaviors can include restrictive binge eating/purging type of AN can be BULIMIA NERVOSA
eating, overexercising, binge eating, misdiagnosed with BN. Children with BN present with recur-
purging, and diet pill/laxative abuse. AN is the third most common chron- rent episodes of binge eating followed
DSM-51 eliminated specific weight cut ic disease among teenage girls and by inappropriate compensatory behav-
off and amenorrhea as diagnostic crite- young women age 14 to 21 years, with iors to prevent weight gain. Classically
ria, although irregular menses are sup- a 12-month prevalence of 0.4% among these behaviors include purging (self-
portive of AN diagnosis. young women. AN has a bimodal peak induced vomiting, diet pill abuse, laxa-
incidence at age 13 and 18 years.1 AN tive abuse), but these children can also
Restrictive Eating and Binge is highly comorbid with other psychi- demonstrate restriction and overexercis-
Eating/Purging atric illnesses, including mood disor- ing behaviors. These children have con-
If a child has been demonstrating ders (depression, bipolar), anxiety dis- cerns about their body shape and weight,
persistent restrictive eating and/or over- orders, substance abuse/dependence, which drives these compensatory be-
exercising behaviors for a period of 3 and obsessive-compulsive disorder.13 haviors. To meet DSM-51 criteria, the
months, this would be considered the Patients diagnosed with AN have a frequency of binge eating and compen-
restrictive type. Children who engage mortality rate of 5% to 6%, the highest satory behaviors must occur at a mini-

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SPECIAL ISSUE ARTICLE

TABLE 3. TABLE 4. TABLE 5.

Anorexia Nervosa Bulimia Nervosa SCOFF Questionnaire


Medical Admission Medical Admission • Do you make yourself Sick because you
Recommendations Recommendations feel uncomfortably full?
• Bradycardia (awake <50 beats/minute, • Syncope • Do you worry you have lost Control over
asleep <45 beats/minute) how much you eat?
• Electrolyte abnormalities (serum K
• Hypotension (systolic blood pressure <3.2 mmol/L, serum Cl <88 mmol/L) • Have you recently lost more than One
<90 mmHg) stone (14 lbs) in a 3-month period?
• Esophageal tears
• Orthostatic changes in pulse or blood • Do you believe yourself to be Fat when
• Intractable vomiting
pressure others say you are too thin?
• Hematemesis
• Cardiac arrhythmia • Would you say Food dominates your life?
• Cardiac arrhythmias
• Hypothermia (<96°F) • Hypothermia Adapted from Luck et al.21

• Malnutrition (<75% ideal body weight, • Suicide risk


body fat <10%)
• Failure to respond to outpatient
• Refusal to eat treatment
• Failure to respond to outpatient of low frequency or duration. Children
treatment
Adapted from Campbell and Peebles.15
who engage in purging behaviors with-
Adapted from Campbell and Peebles.15
out preceding binge episodes and are not
better described as having RD would be
described as having purging disorder.
mum of once per week for 3 months, de- very guilty after eating. Binge episodes Children with disordered-eating behav-
creased from twice per week according are distressing to the child experiencing iors who do not meet the criteria for any
to DSM-IV-TR12 criteria. them, and to meet DSM-51 criteria, the of the available diagnoses would fall
The prevalence of BN is 0.9% to 3% frequency of binge episodes must aver- into the category of unspecified feeding
with peak incidence between ages 17 age once per week for at least 3 months. or eating disorder.1
and 18 years.15 BN is highly comorbid The prevalence of BED is between
with other psychiatric disorders, includ- 1% and 3% with similar frequency in CLINICAL EVALUATION OF A
ing mood disorders (depression, bipo- boys and girls and average age of onset CHILD WITH SUSPECTED EATING
lar), anxiety disorders, substance abuse, is approximately age 12 to 13 years.4,16 DISORDER
and dependence.4 The mortality rate for BED among children increases risk There are many published recom-
children diagnosed with BN is 2%, and 2-fold for development of obesity and mendations to guide the clinician in
their risk of lifetime suicidality and sui- increased symptoms of depression.16 evaluating a child suspected of having
cide attempts is higher than people with Children with BED demonstrate more an eating disorder.15,17,18 When evaluat-
a diagnosis of AN.15 BN should be con- suicidal ideation and emotional distress.4 ing such a child, obtaining a thorough
sidered a risk factor for suicide when history is important. In your history, be
evaluating a child for suicidal ideation.4 SPECIFIED AND UNSPECIFIED specific in asking questions that explore
FEEDING OR EATING DISORDERS weight, body image, restrictive eating,
BINGE-EATING DISORDER With the increased prevalence of pe- exercising, and purging behaviors. Also,
Children with binge-eating disorder diatric obesity, an important presentation obtain a thorough diet history and, in
(BED) present with recurrent binge- that pediatric providers must be aware of girls, menstrual history, including any
eating episodes, associated with three is atypical AN. These are children who contraceptive use because this can mask
or more of the following: eating more would otherwise meet criteria for AN, true menstrual history (Table 2).15,19
rapidly than normal, eating until feel- but their weight is in the normal range Symptoms endorsed on review of
ing uncomfortably full, eating large despite significant weight loss. These systems and physical examination find-
amounts of food when not hungry, eat- children often have a preceding history ings will depend on the child’s nutri-
ing alone due to feeling embarrassed by of binge-eating behaviors and obesity. tional status. Children presenting with
amount one is eating, feeling disgusted Other examples include BN of low fre- menstrual changes, constipation, cold
with oneself, and/or depressed or feeling quency and/or limited duration of BED intolerance, weight loss, hypotension,

PEDIATRIC ANNALS • Vol. 47, No. 6, 2018 e247


SPECIAL ISSUE ARTICLE

hypothermia and bradycardia are sug- need for further evaluation and possibly 4. Kelly NR, Shank LM, Bakalar JL, Tanofsky-
Kraff M. Pediatric feeding and eating disor-
gestive of malnutrition processes, so af- referral for eating disorder treatment.21
ders: current state of diagnosis and treatment.
ter excluding medical causes, consider A more detailed screening tool for ado- Curr Psychiatry Rep. 2014;16(5):446-458.
a possible diagnosis of AN or ARFID. lescents with AN or BN would be the 26- doi: 10.1007/s11920-014-0446-z.
Laboratory evaluation may show leuko- item self-report Eating Attitudes Test or 5. Chatoor I. Diagnosis and Treatment of Feed-
ing Disorders in Infants, Toddlers and Young
penia, anemia, and/or thrombocytope- the modified Children’s Eating Attitude Children. Washington, DC: Zero to Three
nia, in addition to electrolyte changes Test, also a 26-item self-report measure Press; 2009.
(elevated blood urea nitrogen, hypomag- for children in third to eighth grade.22,23 6. Sacco B, Schwalen S. Treating avoidant re-
strictive food intake disorder in children and
nesemia, hypophosphatemia). These To screen for BED in children suffering adolescents. Paper presented at: Internation-
children may have sinus bradycardia from obesity, the Adolescent Binge Eat- al Association of Eating Disorders Profes-
or arrhythmias on electrocardiogram.19 ing Scale questionnaire can help identify sionals Symposium. March 2017; Las Vegas,
NV.
Young women who have demonstrated patients who may need eating-disorder
7. Fisher MM, Rosen DS, Ornstein RM,
oligomenorrhea or amenorrhea for 6 to specific treatment.24 There is no com- Mammel KA, et al. Characteristics of avoid-
12 months can show increased risk for monly used screening tool identifying ant/restrictive food intake disorder in chil-
or decreased bone mineral density for children at risk for ARFID, although dren and adolescents: a “new disorder” in
DSM-5. J Adolesc Health. 2014;55:49-52.
age.20 Children presenting with exces- the Behavioral Pediatrics Feeding As- doi:10.1016/j.jadohealth.2013.11.013.
sive weight gain should also be evalu- sessment Scale and the Child Food Neo- 8. Fisher M, Gonzalez M, Malizio J. Eating dis-
ated for BED after consideration of phobia Scale have successfully differ- orders in adolescents: how does the DSM-
5 change the diagnosis? Int J Adolesc Med
medical etiologies, and these children entiated a clinical ARFID sample from Health. 2015;27(4):437-441. doi:10.1515/
may demonstrate signs of metabolic children who are developing typically.25 ijamh-2014-0059.
syndrome.19 For children suspected of There are no screening tools specific for 9. Kurz S, van Dyck Z, Dremmel D, et al.
Early onset restrictive eating disturbances
having AN, the American Academy pica or rumination disorder.
in primary school boys and girls. Eur Child
of Pediatrics (AAP) has specific crite- Adolesc Psychiatry. 2015;24:779-785.
ria recommending medical admission CONCLUSION doi:10.1007/s00787-014-0622-z.
(Table 3).15 Eating disorders are prevalent in the 10. Norris ML, Robinson A, Obeid N, et al.
Exploring avoidant/restrictive food in-
When children have vomiting or pediatric population, so pediatricians are take disorder in eating disordered pa-
laxative abuse, metabolic changes are likely to encounter it in clinical practice. tients: a descriptive study. Int J Eat Disord.
evident on laboratory results. Addition- Familiarity with signs and symptoms 2014;47:495-499. doi:10.1002/eat.22217.
11. Norris ML, Katzman DK. Change is
ally, these children may present with of eating disorders will help pediatric never easy, but it is possible: reflections
erosion of dental enamel, dental carries, providers recognize children at risk for on avoidant/restrictive food intake disor-
and chipped teeth, in addition to parotid eating disorders, facilitating timely med- der two years after its introduction in the
DSM-5. J Adolesc Health. 2015;57:8-9.
gland enlargement or callouses on the ical evaluation and referral for eating-
doi:10.1016/j.jadohealth.2015.04.021.
dorsal aspect of the hands (from self- disorder treatment. 12. American Psychiatric Association. Diagnos-
induced vomiting).20 In these children, tic and Statistical Manual of Mental Disor-
consider a diagnosis of BN as well as REFERENCES ders [text revision]. 4th ed. Arlington, VA:
1. American Psychiatric Association. Diagnos- American Psychiatric Publishing; 2000.
ARFID and possibly RD with frequent 13. Franko DL, Keshaviah A, Eddy KT, et al.
tic and Statistical Manual of Mental Disor-
emesis. For children suspected of hav- ders. 5th ed. Arlington, VA: American Psy- A longitudinal investigation of mortality in
ing BN, the AAP has specific criteria chiatric Publishing; 2013. anorexia nervosa and bulimia nervosa. Am J
2. Sanneerappa PB, Hayes HM, Daly E, Psychiatry. 2013;170:917-925. doi:10.1176/
recommending medical hospitalization appi.ajp.2013.12070868.
Moodley n/a V. Trichobezoar: a diagno-
(Table 4).15 14. Herpertz-Dahlmann B. Adolescent eating
sis which is hard to swallow and hard-
There are several screening tools that er to digest [published online ahead of disorders: definitions, symptomatology, epi-
demiology and comorbidity. Child Adolesc
can be used in the pediatric office set- print April 30, 2014]. BMJ Case Rep.
doi:10.1136/bcr-2013-201569. Psychiatr Clin N Am. 2009;18(1):31-47.
ting for AN, BN, and BED. The SCOFF doi:10.1016/j.chc.2008.07.005.
3. Al-Rmalli SW, Jenkins RO, Watts MJ,
questions are a quick, 5-minute screen Haris PI. Risk of human exposure to arse- 15. Campbell K, Peebles R. Eating disorders
administered verbally during a patient nic and other toxic elements from geophagy: in children and adolescents: state of the
trace element analysis of baked clay us- art review. Pediatrics. 2014;134:582-592.
encounter (Table 5). If a child answers doi:10.1542/peds.2014-0194.
ing inductively coupled plasma mass spec-
with two or more “yes” responses, this trometry. Environ Health. 2010;23(9):79. 16. Field AE, Sonneville KR, Micali N, Crosby
indicates a possible eating disorder and doi:10.1186/1476-069X-9-79. RD, et al. Prospective association of common

e248 Copyright © SLACK Incorporated


SPECIAL ISSUE ARTICLE

eating diosrders and adverse outcomes. Pedi- sity Press; 2010. 279.
atrics. 2012;130(2):e289-e295. doi:10.1542/ 20. Misra M, Aggarwal A, Miller KK, et al. Ef- 23. Maloney MJ, McGuire J, Daniels SR, Specker
peds.2011-3663. fects of anorexia nervosa on clinical, hema- B. Dieting behavior and eating attitudes in
17. American Psychiatric Association. Practice tologic, biochemical, and bone density pa- children. Pediatrics. 1989;84:482-489.
Guidelines for the Treatment of Patients with rameters in community-dwelling adolescent 24. Chamay-Weber C, Combescure C, Lanza L,
Eating Disorders. 3rd ed. Arlington, VA: girls. Pediatrics. 2004;114(6):1574-1583. et al. Screening obese adolescents for binge
American Psychiatric Publishing; 2006. doi:10.1542/peds.2004-0540. eating disorder in primary care: the adolescent
18. American Psychiatric Association. Guide- 21. Luck AJ, MorganLuck JF, Reid F, et al. The binge eating scale. J Pediatr. 2017;185:68-72.
line Watch for the Practice Guideline for the SCOFF questionnaire and clinical interview doi:10.1016/j.jpeds.2017.02.038. 
Treatment of Patients with Eating Disorders. for eating disorders in general practice: com- 25. Dovey TM, Aldridge VK, Martin CI, et
3rd ed. Arlington, VA: American Psychiatric parative study. BMJ. 2002;325(7367):755- al. Screening avoidant/restrictive food
Publishing; 2012. 756. intake disorder (ARFID) in children:
19. Mehler PS, Anderson AE. Eating Disorders: 22. Garner DM, Garfinkle PE. The Eating At- outcomes from utilitarian versus specialist
A Guide to Medical Care and Complications. titude Test: an index of the symptoms of psychometrics. Eat Behav. 2016;23:162-
Baltimore, MD: The Johns Hopkins Univer- anorexia nervosa. Psychol Med. 1979;9:273- 167. doi:10.1016/j.eatbeh.2016.10.004.

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