Oral Contraceptive

REVIEw QUESTIONNS
SHORT QUESTIONS
1 What are oral contraceptives?
2. Why we need oral contraceptives2
What are Combination hormonal
.
contraceptives
Write names of combination oral
.
contraceptives (COCs), formulations
. What is mechanism for oral contraceptives
. Write in short for Mifepristone
7. Write in short for norgestrel

LONG QUESTIONS
. Explain oral contraceptives with their mechanism, how they control unwanted
2. Highlight medical uses of Mifepristone with their structure and IUPAC name. pregnancy?
3. Explain Choosing a Pill flow chart
4. Enumerate importance of Combination hormonal
contraceptives.
MULTIPLE CHOICE QUESTIONS
1. Mifepristone is
a) 11-(2-Dimethylaminophenyl-17p-hydroxy-17a-prop-1-ynylestra-4,9-dien-3-one
b)
118-(3-Dimethylaminophenyl)-17p-hydroxy-17a-prop-1-ynylestra-4,9-dien-3-one.
d) 11-4-Dimethylaminophenyl)-17p-hydroxy-17a-prop-1-ynylestra-4,9-dien-3-one.
11p-6-Dimethylaminophenyl)-17p-hydroxy-17a-prop-1-ynylestra4,9-dien-3-one.
2. Mifepristone is used for
a) Mifepristone is also used for labour induction after intrauterine fetal death
b) Mifepristone is used in postcoital contraception.
c) Mifepristone is used in treatment for uterine fibroids (leiomyomas)
d) All of above
. Identify the given structure

a) Norgestrel b) Levonorgestrol
c)Mifepristone d) Nonel of above
GnRH is
a)b) Gonadotropin releasing hormone
Gonadotropin relaxing hormone
c) Gonadotropin refreshing hormone
d) Gonadotropin resting hormone

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 U A Toxt Book of Modlcinal Choms
180 mistry-l
5. POP is
a) Pepsin-only pill
b) Pregnane-only pil
c)Progestin-only pill
d) Postoperative-only pill
Choosing a Pill health chart has recommended by
a) World Healeh Organization only
b) World Health Organization and the Food and Drug Administration
Indian Health Organization and the Food and Drug Administration
c)
d Pharmacy council of India and the Food and Drug Administration
7. Progestin prevents ovulation by
a) Suppressing luteinizing hormone secretion
b)Suppressing estrogen receptors
Suppressing gonadotropin releasing hormone
d) Suppressing androgen receptor complex
8. PMDD is
a) Postmenstrual dysphorie disorder
b) Premenstrual dysphoric disorder
c)Premature dysphoric disorder
d) Premenstrual dysphoric
9.
depression
COCs also contain following progestin's except
a) Drospirenone
b) Levonorgestrel
Cortisone
d) Norethindrone acetate
10. IUD is
a) Intrauterine Device
intrauterine system
c) intrauterine development
d) Intrauterine pregnancy detector

ANSWERS
1.C 2.D
7. A
3.B 4.A
8. B
9.C 10. A
5.C 6. B

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EXPLANATION TYPE QUESTIONS
1. Write in details of Glucocorticolds
nnd thelr drug.
Corticosterolds with detalln of Prednisolone ns dru8
Classify relationshlp of
Cortlcosteroids

Enumerate structure activlty

Corticosterolds
Highlights importance of for Corticosterolds
Give details of Blosynthesls process for Cortisone.
mechanism of action
Explain G-Protein Coupled receptor

MULTIPLE CHOICE QUESTIONS

Is
1. Long acting corticosteroid
a) Tricenolone
b) Betamethasone
cHydrocortisone
d) Prednisolone
mineralocorticoids is
Most potent

a) Aldosterone
b)DOCA
c)Fludrocortisone

d) Triamcelone
3. Steroid with max mineralocorticoid activity
a) Fludrocortisone

b) Prednisone
Trimcenolone

d) DOCA
4. In Addison's disease drug to be given is
a) Hydrocortisone
b) Prednisone
cDOCA

d)Betamethasone
Corticosteroid with max sodium retaining potential
a) Dexamethasone
b)Prednisone

c)Aldosterone
d)Betamethasone
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Corticosteroid which is given by inhalatlon

route
a) Prednisolone
Beclomethasone b) Dexamethasone
c)
d) Hydrocortisone
Oc-fluoro-16a-methyl-11p, 21-trihydroxypregna- 1, 4-dlen-3,20-dlone
a) Prednisolone
17,
b) Dexamethason
Beclomethasone
d) Hydrocortlsone
Cortisoneis
8.
17a, 21-dihydroxypregn-4-en-3,11,20-trione
b)9a-fluoro-16a-methyl-11ß, 17,21-trihydroxypregna- 1, 4-dien-3,20-dione
9a
floro-16 -hydroxy prednisolone
d) 17a, 21-dihydroxypregn-4-en-3,11,dione
9. In the steroid nucleus, there are
a) 6 chiral centres with nucleus 13,8,9,10, 11 &e 12]
b) 6 chiral centres with nucleus
5,79,10,13, & 161
7 chiral centres with nucleus
13,8,9,10, 11, 12, & 14]
d)6 chiral centres with nucleus [ 5,79,10,13 &e 14]
10. 19-Nor steroids means
a) Lackmethyl group at C-19 position
b) Have methyl group at C-19 position
c) Lack chloro group at C-19 position
d) Have chloro group at C-19
position
. Choose the correct statement about estrogen
a)Ring D is benzenoid &-OH gp at C7 is phenolie
b) Ring A is quinonoid & -OH gp at C3 is alcoholic
Ring A is benzenoid &-OH gp at C3is phenolic
d Ring D is quinonoid & - OH at C17 is alcoholic

12. Which is natural steroid

a) Oestradiol
6) Halotestin
Testosterone
d) Betamethasone

ANSWERS
1. B 2. A 3. A . A 5. C 6. C
7.B 8. A 9.D 10 A 11.C 12. A

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 MULTIPLE CHOICE QUESTIONS
. TSH is
a) Thyroid stimulating hormone
b) Thyroid stop hormone
cThyroid standard hormone
d) None of the above
TSH consist of amino acld
a) 310
b) 210
c) 410
d) 510
Tick the correct serial order of the
a)
biosynthesis of thyroid hormone
lodide uptake oxidation and ,
iodination, coupling, storage and release , peripheral conversion
of Ta to Ta
b) oxidation and iodination, lodide uptake, coupling, storage and release, peripheral
T to T conversion of
c)peripheral conversion of Ta to T, oxidation and iodination, lodide uptake, coupling,
and release storage
d) None of Above
Thyroxine hormone is used in
a) Hyperthyroidism
b) Hypothyroidism

c)Heart
d) None
burn
of the above
5. IUPAC name of
a) L-Thyroxine is
(S-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-4,5-diiodopheny)propanoic acid
b) (R-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-4,5-diodophenyl)propanoic acid

6. c)(S)-2-amino-3-(4-(4-hydroxy-3,5-di odophenoxy)-3,5-di odopheny)propanoic acid

d)
TUPAC
(R-2-amino-3-44-(4-hydroxy-3,5-diiodophenoxy-3,5-diiodophenyl)propanoic acid
name of given structure is

a) 2,4-Dihydro-6-propyl-2-thioxopyrimidin-4(1H)-one
b) 2,3-Dihydro-6-propyl-2-thioxopyrimidin4(1H)-one

c2,3-Dihydro-6-propyl-2-thioxopyrimidin-2(1H-one
d) 3,3-Dihydro-6-propyl-2-thioxopyrimidin-2(1H)-one
hyroidandAntithyroid Drugs 205

Levothyroxine having physical properties like

White or slightly brownish-white fine, crystalline hygroscopic powder
b) White or slightly blackish-yellow fine, crystalline hygroscopic powder
c)
White or slightly greenish-yellow fine, crystaline hygroscopic powder
d) White or slightly brownish-yellow fine, crystalline hygroscopie powder
Deficiency of thyroid hormone in the body is known as

a) Hyperthyroidismn
b) Hypothyroidism
cHeart burn
None of the above
d)

9.
1-Methylimidazole-2-thiol drug is used in
Hyperthyroidism conditions
b) Hypothyroidism conditions
Both a andb

d) None of above

10. TRH mean

a)
Thyrotropin-releasing hormone
Thyroid-releasing hormone
b) Thyroxine -releasing hormone
d) Thyroid-stimulating hormone

ANSWERS
9.A 10.A
6.B 7.D 8.B
4.B 5.D
2.B 3.A
1.A
 Review Questions

MULTIPLE CHOICE QUESTIONS

Clinical use of clonidine:

Q.1

a)Analgesic
b) Antihypertensive

c)Both
d) Neigther
Q.2 p-blockers adverse effects:

a)Bronchoconstriction

b)Bradycardia
c)Depression
d) Mask hypoglycemia
 Jame of the drug contraindicated with digoxin.
a)Captopril
c)Furosemide
b) Atenolol d) Laartan
.hich one will cause heart failure when combined with verapamil?
Q.4 Which

a)Captopril cAllskiren
b) Atenolol d) Furosemide

This hypertension drug is the first choice for diabetic and renal failure pts.
a) Ksparing diuretics

b) ACE inhibitors

Loop diuretics
d) Calcium channel blockers
06 Impotence is most commonly caused by which antihypertensive agent.

a) Calcium channel blocker

b) ACE inhibitors

c)AT1 receptor antagonist

d) Beta blockers

Q.7 Which drug

inactivates bradykinin.
a) Lisinopril
b) Losartan

c)Gaunethedin

d) Reserpine
Q.8 Hydralazine works on hypertension by:
a) Decrease in sympathetic response
b) Peripheral vasodilation

)Directly inhibits renin

wall
d) Block Cat* from stimulating muscle

Answers
Q6-d, Q7-a, Q8-b.
Q.1-c,Q2-a, Q.3-c, Q4-b, Q.5-c,