Streptococci, meningococci, gram

Penicillin G
Narrow spectrum positive bacilli, spirochetes Resistant strains: PRSP, aureus,
penicillin-susceptible Penicillin G + aminoglycosides Syphilis gonorrhea
Penicillin V Oropharyngeal infections
Methicillin
Very narrow spectrum
Oxacillin Staphylococci infections Resistant strains: MRSA, MRSE
penicillin-resistant
Nafcillin
Ampicillin + aminoglycosides
Wide spectrum Ampicillin, amoxicillin Hemophilus, enterococci, listeria, proteus, Moraxella, E.coli
penicillin-susceptible
Piperacillin, ticarcillin Pseudomonas, gram negative rods, Enterobacter, Klebsiella
 Cefazolin (parenteral) Staphylococci, common streptococci, E coli, K
First generation
cephalexin (oral) pneumoniae, surgical prophylaxis
cefotetan, cefoxitin Anaerobe Bacteroides fragilis
Second generation sinus, ear, and respiratory infections caused by H
cefamandole, cefuroxime, cefaclor
influenzae or M catarrhalis
Ceftriaxone (parenteral, excreted in bile) PRSP, gonorrhea
Cefixime (oral, cant cross BBB) Gonorrhea
Cefotaxime PRSP
Thirds generation
Ceftizoxime B fragilis
Ceftazidime Pseudomonas
Cefoparazome (cant cross BBB, excreted in bile) Pseudomonas
Cefepime (more resistant to beta-lactamases) Enterobacter, Hemophilus, Neisseria, PRSP
Fourth generation
Ceftaroline methicillin-resistant staphylococci