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WB COVID19 Latest Treatment Protocol
WB COVID19 Latest Treatment Protocol
1. All asymptomatic patients. Symptomatic patientswith the following co- Symptomatic patients (irrespective of comorbid
2. Comorbid patients with no morbidities conditions) with any of the following signs:
symptoms (prioritise to control the Age > 60 yrs Fever > 100.4 F
comorbid state) DM Respiratory rate > 22/ min
3. Mild symptoms (low fever, dry HTN /IHD Systolic BP <= 100 mmHg
cough, anosmia, ageusia, COPD/Chronic lung disease SpO2 <95%
weakness, diarrhea, myalgia etc) Immuno-compromised state Respiratory distress
with Immunosuppressive drugs Chest pain
No comorbidity CKD Change in mental status
Low fever (<100.4 F) Chronic Liver Disease Cyanosis
No signs of respiratory distress Obesity
Normal SpO2
Normal mental status, systolic
BP > 100 mmHg and
No oxygen requirement or Oxygen requirement >10 L/min
Respiratory rate < 22/min
Oxygen requirement <10 L/min
MONITOR: Temp, Pulse, BP, SpO2, Pneumonia (LRTI) Pneumonia (LRTI) WITH RESPIRATORY SUPPORT
WITHOUT respiratory failure (RR> 24
Sensorium HFNC if work of breathing is HIGH
respiratory failure /min,
Preferable Investigations: CBC, (Fever/ cough/ SpO2 < 95% on room air, A cautious trial of NIV /CPAP with full face
CRP, D-Dimer dyspnea & SpO2 PaO2 < 60 mmHg) mask/ oronasal mask
ECG, CBG, Serum Creatinine: as ≥95% on room air, Consider Intubation if work of breathing is
PaO2 > 60 mmHg &
required RED FLAG SIGNS high/ NIV is not tolerated
RR< 24/min)
1. SBP<100
Lung protective ventilation strategy by
Supportive Management 2. Altered sensorium
ARDS net protocol
Mask, Hand Hygiene, Physical RED FLAG SIGNS 3. Raised Troponin-I /
distancing, droplet precaution 1. NLR > 3.13 CPK-MB Prone ventilation in refractory Hypoxemia
PARACETAMOL (if fever/bodyache) 2. CRP > 5 times of 4. P:F ratio <200
Vit C ● Laxative (if required) ULN 5. Sepsis/ Septic Shock STEROID
7. Multi Organ
Inhalational BUDESONIDE 800 3. D-Dimer > 2 times Dexamethasone 0.2 to 0.4 mg/kg for at
of ULN Dysfunction Syndrome
mcg twice daily for 5 days if fever least 5-10 days
8. Rapidly increasing
persists for more than 5 days
Oxygen Demand
and/ or distressing cough. ANTICOAGULATION
Systemic Steroids should NOT be Prophylactic dose of UFH or LMWH (e.g.
ANTIPYRETICS: Paracetamol for fever
used routinely in mild cases. Enoxaparin 0.5 mg/kg BD SC), if not at high
OXYGEN SUPPORT
Target SpO2 ≥ 95% (≥90% in pts. with COPD) risk of bleeding (consider UFH if CrCl<30)
Following therapy should be used in
high risk patients: appropriate Oxygen delivery device (cannula / Face
ANTIVIRAL
mask/ non-re-breathing face mask)
Monoclonal antibody therapy Antiviral agents are less likely to be
Conscious proning may be used in whom hypoxia
(Cocktail of Casirivimab and beneficial at this stage; use of Remdesivir
persist despite use of high flow oxygen. (position
Imdevimab): 600 mg each single to be decided on case to case basis, Not to
change at every 1-2 hours)
dose (NOT MUCH EFFECTIVE AGAINST th
start after 10 days of symptom onset
OMICRON)
STEROID
Molnupiravir: 800 mg (four 200- Dexamethasone 0.1 to 0.2 mg/kg for at least 5-10 /Test date
mg capsules) orally every 12 days
TOCILIZUMAB may be considered on a case
hours for 5 days (TO BE USED ANTICOAGULATION
WITHIN 5 DAYS) Prophylactic dose of UFH or LMWH (Enoxaparin to case basis after shared decision making
40mg/ day SC)
Warning Signs MONOCLONAL ANTIBODY THERAPY (Cocktail of
ANTIBIOTICS should be used judiciously as
Difficulty in breathing Casirivimab and Imdevimab): 600 mg each per Antibiotic protocol
Persistent Fever/ High grade fever/
ANTIVIRAL INVESTIGATIONS
Recurrence of Fever
Palpitations REMDESIVIR: to be decided on case to case basis. Not to Essential investigations along with Cultures
Chest pain/ Chest tightness start after 10th days of symptom onset /Test date
(Blood / Urine), FBS, PPBS, CBC, CRP,
Severe Cough MOLNUPIRAVIR: 800 mg (four 200-mg capsules)
Ferritin, D-Dimer, Trop-T/ Quantitative
Any new onset symptoms orally every 12 hours for 5 days (NOT TO BE USED IN
PATIENTS WITH O2 THERAPY) Troponins, Procalcitonin, Coagulation
SpO2 <95% ( Room Air) Profile, HRCT Thorax.
ANTIBIOTICS
CRP > 5 times of ULN
(Antibiotics should be used judiciously as per Antibiotic
D-Dimer > 2 times of ULN SUPPORTIVE MEASURES
NLR > 3.13
protocol)
MONITORING • Maintain euvolemia
Or, as advised by physician
specially in High-Risk Group CBC, CRP, D-Dimer: 48-72 hourly • Sepsis/septic shock: manage as per
LFT, KFT: 48-72 hourly protocol and antibiotic policy
Trop T, ECG, Coagulation Profile • Sedation and Nutrition therapy along with
HRCT Chest/ CXR - PA as per existing guidelines (FAST HUG)
Admit the patient at Covid Ward/ Change in oxygen requirement, Work of breathing,
HDU/ ICU Hemodynamic instability