A-Oss Specification

en / 12.2014 / ver.1
· DBB (Deproteinized Bovine Bone)
· Osteoconduction
· Superior volume maintenance
· Superior biocompatibility
· Manufacturer: Osstem Implant Co., Ltd., South Korea

g Particle Size 0.25~1.0mm

0.1(0.2cc) BBS01
0.25(0.5cc) BBS02
0.5(1.0cc) BBS05
1.0(2.0cc) BBS10 Bone Graft Material
2.0(4.0cc) BBS20 Bone graft material most similar to human bone

g Particle Size 1.0~2.0mm

0.1(0.3cc) BBL01
0.25(0.75cc) BBL02
0.5(1.5cc) BBL05
1.0(3.0cc) BBL10
2.0(6.0cc) BBL20

http://www.osstem.com/
8th FL, World Meridian II, 123, Gasan digital 2-ro, Geumcheon-gu, Seoul, Korea
Tel. +82-2-2016-7000 Fax. +82-2-2016-7001
OSSTEM IMPLANT A-Oss Bone Graft Material 02 Structure 03

A-Oss is bone graft

material most similar
to human bone

Pore structure The 3D pore structure of A-Oss similar to human bone is easy to carry body fluids, Surface Bone cells can easily adhere to the A-Oss surface and proliferate on it.
suitable for the blood vessels and cells. It has a role to support during the period of structure In addition, it provides enough space to take nutrition and effective factors to
regeneration of new bone regeneration. suitable for form superior bone tissue.
bone tissue cell growth

Observation with a Observation with a

scanning electron
microscope.
A-Oss scanning electron
microscope.
A-Oss
x 50 x 3000
Human bone Human bone

Our Competitor’s Company A Company B Our Competitor’s Company A Company B

Products Products

Under the 50 times magnification, the pore structure of A-Oss is similar to those of human bone and com- Under the 3,000 times magnification, the surface structure is suitable for cell growth by virtue of the similar
pany A’s product which are great for the regeneration of bone tissue. shape with human bone and company A’s product. On the contrary, company B’s product is different from
human bone.
OSSTEM IMPLANT A-Oss Bone Graft Material 04 Ability 05

A-Oss has
optimal condition
for new bone growth

Superior A-Oss’s high porosity and wide surface area maximize the contact area with body fluids, Excellent A-Oss has superior blood permeability compared to other companies’ products

blood which allows a great amount of blood to permeate compared with other graft materials new bone so that it has superb new bone formation in the long term.
permeability in the same condition. formation
capability

Mixing the same Micro CT evaluation

amount of blood of new bone formation
with each bone graft capability for 12 weeks
materials (Immediate loading implant
(Blood 0.1ml / Graft material 0.07g) on an adult canine’s mandible) Shows superb Shows low bone formation
long-term new in the long term compared
New bone to its fast bone formation
bone formation
Graft material
in the initial stage

A-Oss Company A Company C Soft tissue

Our Competitor’s Products

Highest level A-Oss Company C

Quantitative evaluation 200 of surface area 160%

of surface area and and blood permeability 140%

blood permeability Quantitative evaluation 60%
150
137 120%
of new bone formation
Surface area
Blood permeability
100% (Immediate loading implant New bone 56
100 80%
on an adult canine’s mandible)
40% increased by

Amount of new bone formation (%)

109 60%
68% in 6 weeks
Blood permeability (%)

34
Surface Area (m2/g)

50 40%
20%
20%

0 0

A-Oss Company A Company B Company C

Our Competitor’s Products
Company D 0%

6 weeks 12 weeks 6 weeks 12 weeks 6 weeks 12 weeks

A-Oss has optimal condition for new bone growth by wide surface area and high blood permeability as A-Oss Company A Company C
Our Competitor’s Products
much as company A’s product.
A-Oss shows superb new bone formation increased by 68% in the long term between 6 weeks and 12
Permeability and wettability In general, permeability and wettablility are used interchangeably. Nevertheless, wettablility can not mean
that can contain a great amount of blood. weeks, compared with the poor record by company B’s product.
OSSTEM IMPLANT A-Oss Bone Graft Material 06 Stability 07

Successful bone grafting

with A-Oss

Stable A-Oss has excellent structural stability, Safety Oral bacteria rarely adhere to A-Oss so that it provides safety against inflammation

volume which maintain its volume while autogenous bone is being formed. against in comparison with other companies’ products.
maintenance Simultaneously, the amount of new bone keeps increasing. inflammation

Evaluation of the Fluorescent microscopy

volume of graft material observation
and the rate of change (After 15 minutes of exposure
in new bone formation Volume maintenance Unfit for maintaining to the same oral bacteria)
of A-Oss without volume due to
(Immediate loading implant
the fast absorption
on an adult canine’s mandible) getting absorbed
of graft material
in a short period
of time
A-Oss Company A

A-Oss Allograft bone

Evaluation of the 50% 50%

volume of graft material Stable volume maintenance

and the rate of change 40% 40%
Company C Company D
in new bone formation
Amount of new bone formation (%)

(Bone grafting model on 30% 30%

Quantity of bacteria adhesion (mm2)

rabbit’s calvarial defect) Quantitative evaluation 150
Volume of graft material (%)

20% 20% of bacteria adhesion

Amount of new 100
bone formation Lower quantity of bacteria
Volume of graft material 10% 10%
50
adhesion compared to
other companies’ products
0% 0%
0
6 weeks 12weeks 18 weeks 24 weeks 6 weeks 12 weeks 18 weeks 24 weeks

A-Oss Company A A-Oss Company A Company C

Our Competitor’s Products
Company D

A-Oss enables successful bone grafting with its structural stability, which maintains its volume up to 24 weeks As the results from microscopy after 15 minutes of exposure to the same oral bacteria with fluorescence
for new bone formation. staining indicate, it has been verified that A-Oss has lower bacteria adhesion compared to other companies’
products, which means safe bone grafting