[Pharma–TRANS] 2.

09 Geriatric Pharmacology •Discuss the general principles in pharmacotherapy

Dr. Edwin Rodriguez in the elderly
December 1, 2021 • Discuss the PK and PD changes in the elderly
•Enumerate the drug classes of concern in the
elderly population
I. The elderly •Enumerate practical aspects in geriatric
A. Aging process pharmacotherapy
B. Physiologic changes associated with • Describe the adverse reactions associated with
aging the elderly
II. Challenges in geriatric Prescribing • Enumerate Pharmacological problems in the
A. Multimorbidity and Person-Centered elderly
Care • Enumerate steps to consider for effective
B. Polypharmacy and Deprescribing pharmacologic intervention in the elderly
C. Use of potentially inappropriate
medications
D. Prescribing Cascade
E. Underuse of Medications
F. Use of Potentially Dangerous Drugs
G. Adherence
III. Age-Related Changes in PK
A. Drug Absorption
B. First-Pass Metabolism and
Bioavailability
C. Drug Distribution in the body
D. Protein binding
E. Drug Clearance   
F. Kidney
IV. Age-Related Changes in PD
A. Anticoagulants
B. Cardiovascular drugs
i. Calcium channel Blockers
ii. Beta-Blocking Agents
C. CNS-Active Drugs
D. Anesthetic Agents
V. Variability in Response to Medicines
VI. Medication use in the elderly
VII. Polypharmacy vs. Approprate
Prescribing
VIII. Medication Review
A. Prescription Optimization method
B. Sructured History to Improve
Medication Taking in elderly
IX. Adherence
X. Adverse Drug Reactions
XI. UnderTreatment
XII. Inappropriate medicines
XIII. Dose Adjustments
XIV. Improving Adherence
A. Guidelines for good prescribing in
elderly patients
B. Drugs that pose a particular for
people
C. Types of prescribing quality
indicators

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