Professional Documents
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Human Health Notes
Human Health Notes
Human Health Notes
2. Acquired immunity
The resistance that an individual acquires during his life is known as acquired
immunity or adaptive immunity.
It is a specific immune response because the antibodies are produced in response to
a specific antigen.
It is characterized by memory. I.e., our body when it encounters a pathogen for the
first time produces a response called primary response with a low intensity.
When the same pathogen enters the body for the second, the immune response is
very fast and highly intensified. This is called secondary response or anamnestic
response.
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The primary and secondary immune responses are effected with the help of two
cells namely B-lymphocytes and T-lymphocytes.
The B-lymphocytes produce an army of proteins in the blood known as antibodies in
response to pathogens.
The T-lymphocytes do not produce antibodies but help the B-cells to produce them.
ANTIBODY
The molecules which are produced in response to antigen are called antibodies
All antibodies belong to a class of plasmaglobulins called immunoglobulins (Ig).
There are five classes of antibodies. They are IgG, IgA, IgM, IgD and IgE.
IgG is the most abundant immunoglobulin in man.
The antibodies are produced by specialized cells known as lymphocytes and plasma
cells.
Antibodies are specific to antigens. I.e., a particular antibody binds only with a
particular antigen. This explains a lock and key mechanism.
Antigen-antibody reaction makes the antigen inactive.
Structure of immunoglobulin
Each immunoglobulin is formed of four polypeptide chains.
Of the 4 chains, two are long chains called heavy chains or H chains and the other
two are short chains called light chains or L chains.
The 4 chains are held together by disulphide bonds to form a ‘Y’ shaped structure.
Each antibody has two portions; - a stem and two prongs.
The two tips of the prongs bind to the specific antigens in a lock and key fashion,
forming an antigen-antibody complex.
The amino acid sequence of stem portion is similar in all antibody molecules
belonging to the same class, while the prongs show great specificity-
(Dept. of Zoology GHSS Mylachal)
ACTIVE IMMUNITY
The antibodies produced in an animal’s own body following its exposure to an
antigen are called active immunity.
This can be induced by vaccination. It involves the introduction of vaccines into the
body.
Vaccines are preparations which contain weakened or attenuated pathogens.
In order to produce adequate immunity against a disease, booster doses of the
vaccine may be required.
A dose of antigen (secondary) given after the primary dose to stimulate accelerated
production of large amounts of antibodies is called booster dose. The first dose is
called trigger dose.
The active immunity is also developed by diseases such as mumps, measles,
chicken pox etc. In this case the first attack will produce life long immunity.
PASSIVE IMMUNITY
When ready made antibodies are given to protect the body against foreign antigens
is called passive immunity.
Passive immunity is less efficient and inferior than active immunity.
It is short lived and lasts only for 3 months.
The main advantage of passive immunization is that it is immediate in its action of
producing immunity
Why mother’s milk is considered very essential for the new born infant?
The yellowish fluid colostrum secreted by mother during the initial days of
lactation has abundant antibodies (IgA) to protect the infant.
The foetus also receives some antibodies from their mother, through the placenta
during pregnancy.
This is an example for passive immunity.
VACCINATION AND IMMUNISATION
The principle of immunization or vaccination is based on the property of ‘memory’
of the immune system
In vaccination, a preparation of antigenic proteins of pathogen or
inactivated/weakened pathogen (vaccine) is introduced into the body.
The antibodies produced in the body against these antigens would neutralize the
pathogenic agents during actual infection.
The vaccines also generate memory-B and T-cells that recognize the pathogen
quickly on subsequent exposure and overwhelm the invaders with a massive
production of antibodies.
Passive immunization
If a person is infected with some deadly microbes (e.g. tetanus) to which quick
immune response is required, we need to directly inject the preformed antibodies or
antitoxins (a preparation containing antibodies to the toxin).
Similar process is also done during snake bite. This type of immunization is called
passive immunization.
(Dept. of Zoology GHSS Mylachal)
(Dept. of Zoology GHSS Mylachal)
Recombinant DNA technology is now employed in the production of vaccines in
bacteria or yeast. E.g. Hepatitis B vaccine produced from yeast.
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ALLERGIES
The exaggerated response of the immune system to certain antigens present in the
environment is called allergy.
The antibodies produced in allergies are IgE type.
Allergy is due to the release of chemicals like histamine and serotonin from the mast
cells.
Allergens
The substances to which immune response is produced are called allergens.
The common examples of allergens are dust, pollens, animal dander etc.
Symptoms
Symptoms of allergic reactions include sneezing, watery eyes, running nose and
difficulty in breathing.
Treatment
For determining the cause of allergy, the patient is exposed to or injected with very
small doses of possible antigens, and the reaction is studied.
The use of drugs like anti-histamine, adrenalin and steroids quickly reduce the
symptoms of allergy.
AUTO IMMUNITY
The humoral or cell mediated immune response against the body’s own tissues is
called auto immunity.
It is produced when the immune system recognizes an antigen of its own body as
non-self.
The diseases associated with autoimmunity are called auto immune diseases.
In man, rheumatoid arthritis is a common auto immune disease.
IMMUNE SYSTEM IN THE BODY
The human immune system consists of lymphoid organs, tissues, cells and soluble
molecules like antibodies.
The immune system also plays an important role in allergic reactions, auto-immune
diseases and organ transplantation.
Lymphoid organs
These are organs where origin, maturation and proliferation of lymphocytes occur.
There are two types of lymphoid organs such as primary lymphoid
organs and secondary lymphoid organs
Primary lymphoid organs
The organs where T and B lymphocytes mature and acquire their antigen-specific
receptors are known as primary lymphoid organs.
Bone marrow and thymus are the primary lymphoid organs.
Secondary lymphoid organs
The organs where proliferation and differentiation of lymphocytes takes place in
response to specific antigen, are called secondary lymphoid organs.
Spleen, lymph nodes, tonsils, Peyer’s patches of small intestine and appendix
etc.are the secondary lymphoid organs.
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Bone marrow
Bone marrow is the main lymphoid organ where all blood cells including
lymphocytes are produced.
Thymus
Thymus is a lobed organ located near the heart and beneath the breast bone,
Thymus is quite large at the time of birth but keeps reducing in size with age and by
the time of puberty it reduces to a very small size.
Spleen
Spleen is a large bean shaped organ.
It mainly contains lymphocytes and phagocytes.
It acts as a filter of the blood by trapping blood-borne micro-organisms.
Spleen also has a large reservoir of erythrocytes.
Lymph nodes
Lymph nodes are small solid structures located at different points along the
lymphatic system.
Lymph nodes serve to trap the micro-organisms or other antigens, which happen to
get into the lymph and tissue fluid.
Antigens trapped into the lymph nodes are responsible for the activation of
lymphocytes present there and cause the immune response
Mucosal Associated Lymphoid Tissue (MALT)
These are lymphoid tissue located within the lining of the major tracts like
respiratory, digestive and urinogenital tracts.
It constitutes about 50% of the lymphoid tissue.
ELISA -Test
A widely used diagnostic test for AIDS is Enzyme Linked Immuno Sorbent Assay
(ELISA). The confirmatory test for AIDS is Western blot test.
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Replication of Retrovirus
After getting into the body, the virus enters into the macrophages and converts its
RNA genome into DNA with the help of reverse transcriptase enzyme.
The viral DNA gets incorporated into host cell’s DNA and directs the infected cells to
produce more virus particles. i.e, the infected macrophages act like a HIV factory.
Simultaneously, HIV enters into helper T-lymphocytes (TH), replicate and produces
more viruses.
Then these viruses are released into the blood and attack other T-lymphocytes.
This will lead to the decrease in number of T-lymphocytes and the patient begins to
show the symptoms such as fever, diarrhoea, weight loss etc.
Subsequently, the immune system weakens and becomes more prone to infections of
bacteria like Mycobacterium, viruses, fungi and even parasites like Toxoplasma.
Finally he is unable to protect himself.
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Treatment
Treatment of AIDS with anti-retroviral drugs is only partially effective.
They can only prolong the life of the patient but cannot prevent death, which is
inevitable
Prevention of AIDS
No treatment is available for AIDS. Prevention is the best option.
It is due to conscious behaviour. Infection through blood transfusion may take
place due to poor monitoring.
The only excuse may be ignorance and it has been rightly said “don’t die of
ignorance”
Safe sex, only one sexual partner, avoid intercourse with unknown partner, use of
disposable needles and syringes, provide free condoms etc. are steps taken up for
preventing HIV infection.
India started a national organization (NACO-National AIDS Control Organisation)
to educate the people about the ill-effects of this disease.
A number of non-governmental agencies are also engaged in this regard.
The most important thing about AIDS is that the infected person should need help
and sympathy instead of being shunned by society.
CANCER
It is a disease characterized by the uncontrolled growth of cells resulting in the
formation of tumour.
Tumour is a tissue mass formed by abnormal cell growth and proliferation.
All tumours are not cancerous. The study of cancer is known as onchology.
Normal cells show a property called contact inhibition by virtue of which contact
with other cells inhibit their uncontrolled growth. Cancer cells appear to have lost
this property and give rise to tumours.
Types of tumour
Tumour may be of two types
1) Benign tumour
The tumours which is confined to the place of its origin is called benign
tumour. These tumours do not migrate but grow in size.
2) Malignant tumour
These tumour cells grow very rapidly, invading and damaging the
surrounding normal cells. The cells from this tumours are carried to other parts of
the body through blood and lymph and where they form secondary growth.
Metastasis
The spread of cancerous cells to other parts of the body is called metastasis.
Causes of cancer
The agents which cause cancer are called carcinogens.
Ionizing radiations like X-rays and gamma rays and non-ionizing radiations like
UV radiations can damage DNA leading to cancer.
The chemical carcinogens present in tobacco smoke have been identified as a major
cause of lung cancer.
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Cancer causing viruses are called oncogenic viruses and which have genes called
viral oncogenes.
Several genes called cellular oncogenes (c-onc) or proto oncogenes have been
identified in normal cells which when activated lead to cancer.
CANCER DETECTION AND DIAGNOSIS
1. Biopsy
In biopsy, a piece of the suspected tissue cut into thin sections and is stained and
examined for cancer cells
2. Computed tomography (CT), X-rays and Magnetic Resonance Imaging (MRI) are
very useful to detect cancers of the internal organs.
3. Antibodies against cancer-specific antigens are also used for detection of certain
cancers.
4. Techniques of molecular biology can be applied to detect genes in individuals with
inherited susceptibility to certain cancers and such individuals can be advised to
avoid exposure to particular carcinogens to which they are susceptible (e.g. tobacco
smoke in the case of lung cancer).
Treatment of cancer
1) Surgery
Surgical removal of tumour mass is one of the easiest approaches in the
treatment of cancer. But it is not applicable in all types of cancer.
2) Radiation therapy
Treatment of cancer with radiations like X-rays, gamma rays or electron beams is
called radiation therapy. In this method tumour cells are irradiated lethally, taking
proper care of the normal tissues surrounding the tumour mass.
3) Chemotherapy
Treatment of cancer with anticancer drugs to kill cancer cells is known as
chemotherapy. Majority of drugs have side effects like hair loss, anaemia etc.
Most cancers are treated by combination of surgery, radiotherapy
and chemotherapy. Tumour cells are not detected and destroyed by immune system. So
the patients are given substances called alpha interferon which activates their immune
system and help in destroying the tumour.