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Radiation Dose Reduction in Kidney Stone CT: A Randomized, Facility-Based Intervention
Radiation Dose Reduction in Kidney Stone CT: A Randomized, Facility-Based Intervention
Abstract
Objective: Kidney stones are common, tend to recur, and afflict a young population. Despite evidence and recommendations,
adoption of reduced-radiation dose CT (RDCT) for kidney stone CT (KSCT) is slow. We sought to design and test an intervention to
improve adoption of RDCT protocols for KSCT using a randomized facility-based intervention.
Methods: Facilities contributing at least 40 KSCTs to the American College of Radiology dose index registry (DIR) during calendar
year 2015 were randomized to intervention or control groups. The Dose Optimization for Stone Evaluation intervention included
customized CME modules, personalized consultation, and protocol recommendations for RDCT. Dose length product (DLP) of all
KSCTs was recorded at baseline (2015) and compared with 2017, 2018, and 2019. Change in mean DLP was compared between
facilities that participated (intervened-on), facilities randomized to intervention that did not participate (intervened-off), and control
facilities. Difference-in-difference between intervened-on and control facilities is reported before and after intervention.
Results: Of 314 eligible facilities, 155 were randomized to intervention and 159 to control. There were 25 intervened-on facilities, 71
intervened-off facilities, and 96 control facilities. From 2015 to 2017, there was a drop of 110 mGy ∙ cm (a 16% reduction) in the mean
DLP in the intervened-on group, which was significantly lower compared with the control group (P < .05). The proportion of RDCTs
increased for each year in the intervened-on group relative to the other groups for all 3 years (P < .01).
Discussion: The Dose Optimization for Stone Evaluation intervention resulted in a significant (P < .05) and persistent reduction in
mean radiation doses for engaged facilities performing KSCTs.
Key Words: CT, kidney stone, radiation dose reduction
a
Chief, Ultrasound Section, Department of Emergency Medicine, Yale Healthcare, grants and personal fees from Caption Health Inc, outside the
University School of Medicine, New Haven, Connecticut. submitted work. Dr Bhargavan-Chatfield reports grants from Agency for
b
Executive Vice President for Quality and Safety, American College of Healthcare Research and Quality, during the conduct of the study. Ms
Radiology, Reston, Virginia. Shaw reports grants from Agency for Healthcare Research and Quality,
c
Yale University School of Medicine, New Haven, Connecticut. during the conduct of the study. Dr Kalra reports grants from Agency for
d
Boston Medical Center, Boston, Massachusetts. Healthcare Research and Quality, during the conduct of the study; grants
e
Massachusetts General Hospital, Boston, Massachusetts. from Siemens Healthineers, grants from Riverain Tech Inc, personal fees
Corresponding author and reprints: Christopher L. Moore MD, Yale from Globus Medical, outside the submitted work. Dr Weisenthal states
University School of Medicine, 464 Congress Avenue Suite 273, New that she has no conflict of interest related to the material discussed in this
Haven, CT 06519; e-mail: Chris.moore@yale.edu. article. Dr Moore, Dr Bhargavan-Chatfield, Ms Shaw, Dr Weisenthal, and
Dr Moore reports grants from Agency for Healthcare Research and Quality, Dr Kalra are nonpartner, non–partnership track employees.
during the conduct of the study; grants and personal fees from Philips
Fig 1. Enrollment diagram with exclusions. “Master” facilities refers to IDs associated with facilities that are made up of
multiple “child” facilities (child meaning below master, not pediatric). The master IDs are used to link the child facility IDs
together but do not contain unique data. These were excluded to avoid duplicate counting of results. KSCT ¼ kidney
stone CT.
Demographic and Year All (n ¼ 192) Control (n ¼ 96) Intervened-on (m ¼ 25) Intervened-off (n ¼ 71)
Environment*
Urban 48.1% (91) 43.2% (41) 52.0% (13) 53.6% (37)
Suburban 39.7% (75) 42.1% (40) 44.0% (11) 34.8% (24)
Rural 12.2% (23) 14.7% (14) 4.0% (1) 11.6% (8)
Trauma level
Level I 17.2% (33) 17.7% (17) 8.0% (2) 19.7% (14)
Level II 14.6% (28) 13.5% (13) 8.0% (2) 18.3% (13)
Other 68.2% (131) 68.8% (66) 84.0% (21) 62.0% (44)
Location
Northeast 22.4% (43) 20.8% (20) 20.0% (5) 25.4% (34)
South 25.5% (49) 33.3% (32) 24.0% (6) 15.5% (11)
Midwest 40.6% (78) 34.4% (33) 44.0% (11) 47.9% (34)
West 11.5% (22) 11.5% (11) 12.0% (3) 11.3% (11)
Facility type
Stand-alone 28.1% (54) 33.3% (32) 20.0% (5) 23.9% (17)
Child 71.9% (138) 66.7% (64) 80.0% (20) 76.1% (54)
Note that “child” facilities refers to facilities that are part of a larger group, and “stand-alone” facilities are independent. KSCT ¼ kidney stone CT.
*Three facilities did not report.
that tailored intervention is more effective than simple there is little evidence that CT has impacted rates of
auditing [16]. Auditing would also occur in the control and diagnosis, admission, or intervention [4,17,18]. Approaches
intervened-off groups that we followed in our study as part that forego CT and utilize ultrasound first have been shown
of their participation in the DIR. Our results reinforce that to be safe and effective [19]. The vast majority of kidney
tailored intervention is more effective than auditing, and stones will pass spontaneously, and those that are larger
demonstrate that examination-specific tailored education and more likely to require intervention are readily
can be effective. detectable using reduced radiation dose [20,21].
It is the shared responsibility of medical users of Although statistically significant, the reduction in dose
radiation dose or radiation dose-based imaging tests was relatively modest, demonstrating the difficulty in
such as CT to ensure use of as low as reasonably achieving and maintaining substantial change in this area.
achievable radiation doses. This is particularly true for Despite repeated attempts to provide free resources to
an indication such as KSCT, in which there is un- facilitate radiation dose reduction, a minority of facilities
equivocal evidence that RDCT can be employed randomized to intervention opted to participate. Notably,
without adverse effects. KSCT is a particularly attractive these facilities exhibited less radiation dose reduction over
target for radiation dose reduction because high-contrast time when compared with controls, suggesting these facil-
kidney stones can be detected and quantified for stone ities may have overall been less interested or motivated to
burden despite high image noise content and artifacts adjust protocols to decrease radiation dose. There could be
associated with LDCT [7]. several reasons for a reluctance to adopt RDCT recom-
Despite the dramatic increase in use of CT scanning for mendation despite specific recommendations from national
the diagnosis of renal colic over the last several decades, societies and our DOSE initiatives.
Unfortunately, the lack of adoption of RDCT is not year over year at these facilities, the population effect of a
unique to KSCT. A recent study of dose descriptors from 72 modest change is still potentially important [24].
US facilities found that up to 65% (47 of 72) facilities had The measure of radiation dose used in this project is
median doses above the ACR guidelines for RDCT in lung DLP, which is what is consistently reported by facilities to the
cancer screening [22]. Both KSCT and lung cancer screening DIR. DLP is a measure of delivered radiation along the length
share similar imaging attributes of high inherent lesion of the patient and does not take patient size into account. An
contrast between the anticipated lesions (kidney stones or SSDE would be a better measure of absorbed dose [14]. As of
pulmonary nodules) and the background organ parenchyma 2015, in many cases the SSDE was reported in fewer than
that offers fertile basis for RDCT. These observations are half of the CTs (Table 2). Although this did increase to
in stark contrast to multisite, multiyear data on more than three-quarters of CTs by 2019, using SSDE
mammography in the United States that document mean alone would have provided an incomplete picture. It is likely
glandular dose to the breasts well below the compliance that the change in DLP is representative of the change in
limit of 3 mGy for a single craniocaudal view of the breast absorbed dose as long as patient characteristics are relatively
set in the congressionally enacted Mammography Quality constant year over year. The changes in CTDIvol were fairly
Standards Act of 1992, suggesting that legislation rather similar to the changes in DLP (Table 2), although in some
than voluntary participation is likely more effective [23]. cases our protocol suggestions included a shorter scan
Our results were certainly limited by the relatively low length, which could reduce delivered (and absorbed) dose at
response of facilities who were willing to participate, which the same CTDIvol, so we felt that DLP represented the
is likely related to the lack of factors to encourage motivation best measure of radiation to report in this case.
for change. Although we made multiple attempts to contact We are unable to tell if changes in CT protocols affected
facilities via e-mail and telephone, the response rate was low. diagnostic accuracy. However, multiple prior studies
It is also possible we were simply unable to get in touch with (including a meta-analysis) have demonstrated that diag-
personnel who may have been willing to participate. nostic accuracy is maintained even with substantial radiation
Notably, the proportion of academic facilities that partici- dose reduction [7,8,20]. It is very likely that diagnostic
pated was lower than nonacademic (17% of facilities but accuracy is well maintained given the relatively modest
only 8% of participation) for unclear reasons, perhaps effects achieved in this intervention.
because they felt they had more resources to do this on their As CT imaging equipment and algorithms improve,
own or had other priorities. Although we counted a facility there is a move toward radiation dose reduction over time
as having participated if they completed at least one CME even without intervention, as seen particularly in the control
module, it is likely that change was more impacted by group that received no attempt at intervention. All facilities
facilities who completed the full intervention. However, in our study were already participating in the ACR DIR
although the absolute reductions in radiation dose in our initiative, which does provide feedback and may help facil-
study were modest, given the number of KSCTs performed ities adjust their protocols to be more in line with other
Control (n ¼ 96)
DLP (in mGy ∙ cm)
No. of CT examinations with information 49,330 54,995 52,481 54,543
Mean (SD) 691 (202) 662 (205) 642 (207) 649 (221)
Median (IQR) 712 (551,814) 645 (519,791) 640 (501,793) 612 (515,797)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 2,385 4.8 3,729 6.8 3,478 6.6 3,577 6.6
200-399 4,329 8.8 6,111 11.1 6,206 11.8 6,956 12.8
300-399 5,883 11.9 7,517 13.7 7,585 14.5 8,125 14.9
400-499 5,867 11.9 6,750 12.3 6,906 13.2 7,062 12.9
500-599 5,526 11.2 6,025 11.0 5,870 11.2 5,995 11.0
600-699 4,846 9.8 5,254 9.6 4,875 9.3 4,853 8.9
700-799 4,086 8.3 4,166 7.6 3,987 7.6 3,892 7.1
800-899 3,244 6.6 3,422 6.2 3,148 6.0 3,342 6.1
900-999 2,893 5.9 2,983 5.4 2,604 5.0 2,639 4.8
1,000 10,271 20.8 9,038 16.4 7,822 14.9 8,102 14.9
Dose (CTDIvol) in mGy
No. of CT examinations with information 49,330 54,995 52,481 54,543
Mean (SD) 14.3 (4.2) 13.4 (4.2) 13.1 (4.4) 13.1 (4.6)
Median (IQR) 14.3 (11.2,17.3) 13.2 (10.5,16.2) 13.1 (10.3,15.9) 12.0 (10.3,15.9)
Journal of the American College of Radiology
SSDE in (mGy)
No. of CT examinations with information 26,411 32,955 32,334 35,122
% of total CT examinations with SSDE 54 60 62 64
Mean (SD) 15.4 (4.9) 13.6 (4.2) 13.1 (5.0) 13.4 (5.0)
Volume - n Number - n Month 2021
Median (IQR) 15.3 (11.8,18.3) 13.6 (9.8,15.8) 13.6 (9.8,15.8) 13.2 (10.1,15.6)
Intervened-on (n ¼ 25)
DLP (in mGy ∙ cm)
No. of CT examinations with information 15,053 15,433 17,304 17,368
Mean (SD) 689 (297) 582 (176) 585 (171) 593 (168)
Median (IQR) 678 (534,731) 569 (508,714) 583 (519,673) 583 (509,692)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 700 4.7 1,076 7.0 942 5.4 905 5.2
200-399 1,188 7.9 1,820 11.8 2,269 13.1 2,417 13.9
300-399 1,464 9.7 2,219 14.4 2,749 15.9 2,848 16.4
Moore et al n Radiation Dose Reduction in Kidney Stone CT
Journal of the American College of Radiology
Intervened-off (n¼71)
DLP (in mGy ∙ cm)
No. of CT examinations with information 35,275 41,611 35,890 32,756
Mean (SD) 663 (223) 654 (216) 646 (222) 649 (222)
Median (IQR) 648(507,821) 658 (494,781) 637 (478,794) 649 (489,786)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 2,042 5.8 2,709 6.5 2,248 6.3 1,847 5.6
200-399 3,798 10.8 3,937 9.5 3,643 10.2 3,256 9.9
300-399 4,177 11.8 4,386 10.5 4,158 11.6 4,373 13.4
400-499 4,353 12.3 4,923 11.8 4,489 12.5 4,347 13.3
500-599 3,797 10.8 4,561 11.0 4,274 11.9 3,910 11.9
600-699 3,282 9.3 4,119 9.9 3,339 9.3 3,029 9.2
700-799 2,569 7.3 3,193 7.7 2,608 7.3 2,327 7.1
800-899 2,221 6.3 2,617 6.3 2,033 5.7 1,752 5.3
900-999 1,890 5.4 2,253 5.4 1,749 4.9 1,610 4.9
1,000 7,146 20.3 8,913 21.4 7,349 20.5 6,305 19.2
Dose (CTDIvol) in mGy
No. of CT examinations with information 35,275 41,611 35,890 32,756
Mean (SD) 13.8 (4.5) 13.5 (4.3) 13.3 (4.4) 13.4 (4.6)
Median (IQR) 13.2 (10.8,17.1) 13.6 (10.0,16.7) 13.6 (9.4,15.5) 13.6 (9.5,16.0)
SSDE (in mGy)
(continued)
9
institutions that are achieving lower radiation doses for
%
similar studies. It is likely that if our results were compared
with institutions that do not participate in the DIR, the
differences would be even greater. However, as this study
13.8 (9.8,16.8)
demonstrates, with appropriate education and attention to
13.8 (4.8)
27,138
83
website [15,25,26].
13.7 (10.3,16.0)
TAKE-HOME POINTS
13.6 (4.3)
29,129
2018
81
84
ACKNOWLEDGMENTS
This study was funded by the Agency for Healthcare
Research and Quality, R18HS023778. This research was
supported by the American College of Radiology’s National
%
60
REFERENCES
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and treatment of recurrent kidney stones. CMAJ 2002;166:213-8.
2. Scales CD, Smith AC, Hanley JM, Saigal CS. Prevalence of kidney
stones in the United States. Eur Urol 2012;62:160-5.
No. of CT examinations with information
% of total CT examinations with SSDE