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ORIGINAL ARTICLE

Radiation Dose Reduction in Kidney


Stone CT: A Randomized, Facility-Based
Intervention
Christopher L. Moore, MD a , Mythreyi Bhargavan-Chatfield, PhD b, Melissa M. Shaw, BS c,
Karrin Weisenthal, MD d, Mannudeep K. Kalra, MD e

Abstract

Objective: Kidney stones are common, tend to recur, and afflict a young population. Despite evidence and recommendations,
adoption of reduced-radiation dose CT (RDCT) for kidney stone CT (KSCT) is slow. We sought to design and test an intervention to
improve adoption of RDCT protocols for KSCT using a randomized facility-based intervention.
Methods: Facilities contributing at least 40 KSCTs to the American College of Radiology dose index registry (DIR) during calendar
year 2015 were randomized to intervention or control groups. The Dose Optimization for Stone Evaluation intervention included
customized CME modules, personalized consultation, and protocol recommendations for RDCT. Dose length product (DLP) of all
KSCTs was recorded at baseline (2015) and compared with 2017, 2018, and 2019. Change in mean DLP was compared between
facilities that participated (intervened-on), facilities randomized to intervention that did not participate (intervened-off), and control
facilities. Difference-in-difference between intervened-on and control facilities is reported before and after intervention.
Results: Of 314 eligible facilities, 155 were randomized to intervention and 159 to control. There were 25 intervened-on facilities, 71
intervened-off facilities, and 96 control facilities. From 2015 to 2017, there was a drop of 110 mGy ∙ cm (a 16% reduction) in the mean
DLP in the intervened-on group, which was significantly lower compared with the control group (P < .05). The proportion of RDCTs
increased for each year in the intervened-on group relative to the other groups for all 3 years (P < .01).
Discussion: The Dose Optimization for Stone Evaluation intervention resulted in a significant (P < .05) and persistent reduction in
mean radiation doses for engaged facilities performing KSCTs.
Key Words: CT, kidney stone, radiation dose reduction

J Am Coll Radiol 2021;-:---. Copyright ª 2021 American College of Radiology

INTRODUCTION receiving an average of 1.4 to 1.7 CTs per episode


Kidney stones will afflict as many as 1 in 11 people of renal colic [2,4]. CT scanning is thus a relatively
in the United States, and more than half of patients large source of medical radiation in this young
will experience recurrent disease [1-3]. In the United patient population, in which incidence of a first
States, as many of 85% of patients evaluated for symptomatic kidney stone peaks at age 30 in males
renal colic will undergo CT scanning, with patients and age 35 in females [5,6].

a
Chief, Ultrasound Section, Department of Emergency Medicine, Yale Healthcare, grants and personal fees from Caption Health Inc, outside the
University School of Medicine, New Haven, Connecticut. submitted work. Dr Bhargavan-Chatfield reports grants from Agency for
b
Executive Vice President for Quality and Safety, American College of Healthcare Research and Quality, during the conduct of the study. Ms
Radiology, Reston, Virginia. Shaw reports grants from Agency for Healthcare Research and Quality,
c
Yale University School of Medicine, New Haven, Connecticut. during the conduct of the study. Dr Kalra reports grants from Agency for
d
Boston Medical Center, Boston, Massachusetts. Healthcare Research and Quality, during the conduct of the study; grants
e
Massachusetts General Hospital, Boston, Massachusetts. from Siemens Healthineers, grants from Riverain Tech Inc, personal fees
Corresponding author and reprints: Christopher L. Moore MD, Yale from Globus Medical, outside the submitted work. Dr Weisenthal states
University School of Medicine, 464 Congress Avenue Suite 273, New that she has no conflict of interest related to the material discussed in this
Haven, CT 06519; e-mail: Chris.moore@yale.edu. article. Dr Moore, Dr Bhargavan-Chatfield, Ms Shaw, Dr Weisenthal, and
Dr Moore reports grants from Agency for Healthcare Research and Quality, Dr Kalra are nonpartner, non–partnership track employees.
during the conduct of the study; grants and personal fees from Philips

Copyright ª 2021 American College of Radiology


1546-1440/21/$36.00 n https://doi.org/10.1016/j.jacr.2021.05.004 1
Visual Abstract

Kidney stones are particularly amenable to detection and METHODS


quantification of stone burden using reduced-radiation dose Facilities and KSCTs
CT (RDCT). Several studies report high sensitivity, speci- The DIR is a national CT radiation dose registry sponsored
ficity, and accuracy for kidney stone detection at substantial by the American College of Radiology. It was launched in
radiation dose reduction without adverse effects on diagnosis 2011, and as of 2014 included 11.9 million CT examinations
or treatment [7,8]. The ACR Appropriateness Criteria contributed by 642 facilities across the United States [13].
recommend the use of RDCT for renal colic evaluation; Basic identifying and demographic information are
however, as of 2013, only about 2% of kidney stone CTs anonymized during automatic submission of radiation dose
(KSCTs) were performed with RDCT protocols [9,10]. descriptors from CT examinations done at participating
RDCT use increased to approximately 8% of KSCTs by facilities to the DIR. Facilities tag their CT examinations to
2016, but it remains well below what is “as low as a corresponding study descriptor, which is mapped to
reasonably achievable” [11,12]. Increased adoption of Radlex Playbook Identifiers that group similar examinations
RDCT protocols will decrease the overall radiation burden together based on test characteristics and body part
associated with KSCT, which often requires repeat scanned. CT dose information includes CT dose index
imaging in relatively young patients. volume (CTDIvol) (in milligrays) and dose length product
We sought to design and test an intervention to improve (DLP) (in milligrays per centimeter) with optional size-
adoption of RDCT protocols for KSCT using a randomized specific dose estimate (SSDE) (in milligrays) [14].
facility-based intervention. Facilities that participated in the Facilities participating in the DIR may contribute
American College of Radiology dose index registry (DIR) independently (stand-alone) or may be part of a system that
were eligible for randomization. Those randomized to includes multiple independently contributing sites. If there
intervention were invited to participate in the Dose Opti- are multiple facilities contributing from a single site, the
mization for Stone Evaluation (DOSE) initiative, a multi- overall site has a master ID that links to each “child” facility
faceted approach that included education on RDCT in the system; these are referred to as master and child
protocols and personalized consultation for dose reduction. facilities. Facilities with multiple imaging locations are
We compared participating facilities to a control group and provided a master ID that links associated facilities together
nonparticipating facilities at baseline and at 1, 2, and 3 years with a child ID to examine data collectively or individually.
after intervention. Facilities could thus be master, child, or stand-alone. The

2 Journal of the American College of Radiology


Volume - n Number - n Month 2021
term “child” facility has been used by the DIR for some time In parallel with the RadIQ CME modules, facilities
and is maintained in this article but does not refer to were provided with a personalized DOSE consultation
pediatric facilities. Any of the facilities (master, child, or regarding CT protocols for kidney stone. The DOSE team
stand-alone) can see any type of patient. requested information regarding current CT imaging
We defined KSCTs based on study descriptor nomen- equipment and protocols for KSCT at each institution.
clature consistent with stone evaluation (ie, stone, flank Baseline protocols were used to provide detailed recom-
pain, renal colic). Study descriptors associated with multi- mendations for radiation dose reduction as part of a DOSE
phase or contrast-enhanced examinations and study consultation report. The DOSE consultation report con-
descriptors from facilities contributing fewer than 40 KSCT tained two CT protocols specific to the available brand and
examinations were excluded. Facilities that contributed at model of CT scanners used that were developed by a radi-
least 40 KSCTs to the DIR in 2015 were eligible for ologist on the DOSE team (MK, radiologist with more than
randomization to control or intervention groups. 10 years of experience in CT protocol and radiation dose
Recorded dose data included DLP, CTDIvol, and SSDE optimization). The first protocol was intended for undif-
(milligrays), when available, for each of the following years: ferentiated flank pain and had an intermediate radiation
2015, 2017, 2018, and 2019. Facilities that did not have at dose reduction compared with their standard noncontrast
least 20 KSCTs in each year for follow-up (2017, 2018, abdominal-pelvic CT protocol. The second protocol was
2019) were excluded from analysis. intended for follow-up of known KS or high pretest prob-
ability of KS that further reduced radiation exposure.
DOSE Intervention Facilities whose current KSCT examination dose index was
Facilities assigned to intervention were recruited to partici- relatively higher (zDLP > 900 mGy ∙ cm) were offered
pate in the DOSE initiative [15]. An initial e-mail invitation an intermediate LDCT option to optimize KSCT to avoid
to participate directly was sent from the DIR, with DOSE drastic image changes for the comfort of those reading
team initially blinded to facilities for privacy purposes. In and interpreting the CT images.
the initial contact e-mail, facilities were provided After providing the CME and DOSE consultation
information to access online educational modules free of report, facilities were contacted by e-mail to set up a call
charge and invited to visit the DOSE website [15] for about the protocols and to address any concerns or ques-
more information on participation in the project. E-mails tions. Randomized facilities that did not initially respond
were sent to all available persons associated with the were contacted via subsequent e-mails and telephone calls to
facility in the DIR, which could include the facility encourage participation. If facilities did not respond after
administrators, registry administrators, and any users. three e-mails and three telephone calls, they were assumed to
The online educational modules were created collabora- be not interested. Facilities who initially responded but did
tively with radiologists from Massachusetts General Hospital not complete any portion of the intervention were excluded.
through the RadIQ platform (www.radiq.org). The RadIQ Participation was defined as completion of at least one CME
platform allows incorporation of teaching cases using actual module. DOSE participation additionally qualified as a
DICOM images that can be visualized as if looking at images practice quality improvement measure, and any interested
on a hospital PACS system. The first course, entitled “Inter- facilities were supplied an ACR-approved practice quality
pretation of Low Dose Kidney Stone CT,” was geared toward improvement template.
radiologists and included 16 cases for 4.0 hours of CME. The
second course, “Optimizing Scan Protocol and Radiation Dose
in Kidney Stone CT,” was appropriate for both radiologists Statistical Analysis
and CT technicians who may be involved in adjusting CT Statistical analysis was performed in SAS 9.4 (SAS Institute,
protocols. This module offered 19 cases for 4.75 hours of Cary, North Carolina). Mean, SD, median, and 25th and
CME. Both modules were offered free of charge to all 75th percentiles of DLP for all KSCTs were calculated at
personnel at facilities participating in DOSE. baseline and for calendar years 2017, 2018, and 2019.
Facilities who accessed the RadIQ courses or submitted re- Baseline (2015 calendar year data) dose data were collected
quests for more information through the DOSE website or for all facilities and compared with 1, 2, and 3 years after
other response to e-mail were subsequently contacted by a intervention. Median and 25th and 75th percentiles mea-
DOSE team member. The initial contact was facilitated by the sures are used to describe typical performance of the facilities
project director (M.M.S.), who arranged consultation with other by group and year. Statistical difference-in-difference anal-
DOSE team members as appropriate. Participating facilities were ysis used fixed-effect and random-effect model to compare
encouraged to have all CT technologists, medical physicists, and change in mean DLP before and after intervention in the
radiologists in their department complete the RadIQ modules. facilities that were intervened on to the corresponding

Journal of the American College of Radiology 3


Moore et al n Radiation Dose Reduction in Kidney Stone CT
change in control facilities. The difference-in-difference randomized to intervention, 38 initially responded,
comparisons of the facility means were used to determine although only 25 actually engaged in the intervention
if there was a significant difference between facilities that (completed at least one CME module). For the final
were intervened on compared with those that did not analysis, there were 96 control facilities and 96 test
participate and the control group, and if these changes facilities including 25 that participated in the intervention
persisted over time. In an effort to minimize statistical (“intervened-on”) and 71 that did not participate despite
overtesting in presence of identical trends among CTDIvol repeated attempts to include them (“intervened-off”).
and DLP across different facilities (and because SSDE was Facility demographics and number of KSCT per year are
incompletely reported), we limit our results to DLP as it is summarized in Table 1.
the most commonly reported dose descriptor in prior Ultimately, there were 32 dual protocols (one for
publications on RDCT use for KSCT protocols [12]. baseline or initial KSCT and the other for follow-up KSCT)
Distribution of examinations by DLP categories are developed for the four major manufacturers: Siemens (15),
reported for all years in the analysis. Percent of examinations GE (11), Philips (3), Toshiba (3). The distribution of ma-
with DLP below 400 is used as an indicator of RDCTs; chines was based on whatever equipment and models were
generalized mixed modeling was used to assess significance available at each site, and could be reused at different sites
of the difference-in-difference in this measure. that had the same equipment. These protocols are available
on the DOSE website [15].
Overall, there were 422,039 KSCTs across 4 years from
Institutional Review Board the 192 facilities included in the analysis. Overall mean and
As a quality improvement project involving anonymized
median DLP, CTDIvol, SSDE, and proportion of exami-
data this project was exempt from institutional review board
nations stratified by DLP is shown in Table 1. Baseline
approval.
mean DLP (SD) in 2015 was 691 (202) mGy ∙ cm in
the control group, 689 (297) mGy ∙ cm in the
RESULTS intervened-on group, and 663 (223) mGy ∙ cm in the
Out of 161,293 study descriptors in the DIR, there were intervened-off group. From 2015 to 2017, the mean DLP in
481 study descriptors consistent with KSCT that mapped to the intervened-on group dropped 110 mGy ∙ cm (a 16%
41 Radlex Playbook Identifiers. From 1,512 active reduction; Fig. 2). Regression analyses adjusting for facility
facilities in the DIR, there were 380 facilities contributing random effects showed the decrease in DLP between 2015
at least 40 KSCTs in calendar year 2015 (baseline). There and 2017 using a difference-in-difference comparison was
were 314 child and stand-alone facilities, of which 155 significantly different for the intervened-on group than for
facilities were randomized to intervention and 159 were the control group (P < .05). Figure 2 shows the persistence
in the control group (Fig. 1). Of the 155 facilities of dose reduction in each group over subsequent years.

Fig 1. Enrollment diagram with exclusions. “Master” facilities refers to IDs associated with facilities that are made up of
multiple “child” facilities (child meaning below master, not pediatric). The master IDs are used to link the child facility IDs
together but do not contain unique data. These were excluded to avoid duplicate counting of results. KSCT ¼ kidney
stone CT.

4 Journal of the American College of Radiology


Volume - n Number - n Month 2021
The proportion of studies that could be considered reduced was significant (P < .05) in facilities that participated in the
dose (DLP < 400 mGy ∙ cm) increased in the “intervened-on” DOSE intervention when compared both with the control
group from 22% in 2015 to 33% in 2017 and 36% in 2019 group and facilities that opted not to participate, and the
(Figure 3), a higher proportion than in the other groups. The radiation dose reduction persisted over 3 years of observa-
change in the intervened-on group over time is significantly tion. Although mean facility DLP in the control group did
different from the control group in 2017, 2018, and 2019 drift down over time, the drop in the intervened-on group
relative to 2015 (P < .01 for all three comparisons). occurred more quickly and drifted up only slightly over
time, remaining lower in 2019 than either other group, even
though it started higher than the group that declined
DISCUSSION intervention. This suggests that sustainable radiation dose
To our knowledge, this is the first intervention performed at reduction through education is feasible and can promote
a national facility level to measure the effects of an inter- sustainable change.
vention to reduce CT radiation dose specific to kidney stone We are aware of one other initiative at the facility level
imaging. The mean reduction in radiation dose for KSCTs for a broad array of CT scanning applications that showed

Table 1. Facility demographics and KSCT examinations performed by year

Demographic and Year All (n ¼ 192) Control (n ¼ 96) Intervened-on (m ¼ 25) Intervened-off (n ¼ 71)

Environment*
Urban 48.1% (91) 43.2% (41) 52.0% (13) 53.6% (37)
Suburban 39.7% (75) 42.1% (40) 44.0% (11) 34.8% (24)
Rural 12.2% (23) 14.7% (14) 4.0% (1) 11.6% (8)

Academic 17% (34) 16.7% (16) 8.0% (2) 22.5% (16)

Trauma level
Level I 17.2% (33) 17.7% (17) 8.0% (2) 19.7% (14)
Level II 14.6% (28) 13.5% (13) 8.0% (2) 18.3% (13)
Other 68.2% (131) 68.8% (66) 84.0% (21) 62.0% (44)

Location
Northeast 22.4% (43) 20.8% (20) 20.0% (5) 25.4% (34)
South 25.5% (49) 33.3% (32) 24.0% (6) 15.5% (11)
Midwest 40.6% (78) 34.4% (33) 44.0% (11) 47.9% (34)
West 11.5% (22) 11.5% (11) 12.0% (3) 11.3% (11)

Facility type
Stand-alone 28.1% (54) 33.3% (32) 20.0% (5) 23.9% (17)
Child 71.9% (138) 66.7% (64) 80.0% (20) 76.1% (54)

KSCT examinations per year mean (SD)


Year
2015 519 (567) 514 (515) 602 (689) 497 (593)
2017 584 (676) 573 (647) 617 (711) 586 (709)
2018 550 (596) 547 (602) 692 (811) 505 (492)
2019 545 (660) 568 (742) 695 (852) 461 (418)

KSCT examinations per year median (interquartile range)


Year
2015 393 (119,687) 405 (119,706) 277 (611,143) 384 (133,677)
2017 361 (127,782) 371 (130,724) 500 (78,961) 354 (166,908)
2018 333 (146,779) 331 (149,723) 425 (56,1217) 332 (177,768)
2019 311 (127,793) 362 (127,784) 242 (52,1249) 278 (160,674)

Note that “child” facilities refers to facilities that are part of a larger group, and “stand-alone” facilities are independent. KSCT ¼ kidney stone CT.
*Three facilities did not report.

Journal of the American College of Radiology 5


Moore et al n Radiation Dose Reduction in Kidney Stone CT
Fig 2. Change in mean facility dose length product in mGy ∙ cm by group.

that tailored intervention is more effective than simple there is little evidence that CT has impacted rates of
auditing [16]. Auditing would also occur in the control and diagnosis, admission, or intervention [4,17,18]. Approaches
intervened-off groups that we followed in our study as part that forego CT and utilize ultrasound first have been shown
of their participation in the DIR. Our results reinforce that to be safe and effective [19]. The vast majority of kidney
tailored intervention is more effective than auditing, and stones will pass spontaneously, and those that are larger
demonstrate that examination-specific tailored education and more likely to require intervention are readily
can be effective. detectable using reduced radiation dose [20,21].
It is the shared responsibility of medical users of Although statistically significant, the reduction in dose
radiation dose or radiation dose-based imaging tests was relatively modest, demonstrating the difficulty in
such as CT to ensure use of as low as reasonably achieving and maintaining substantial change in this area.
achievable radiation doses. This is particularly true for Despite repeated attempts to provide free resources to
an indication such as KSCT, in which there is un- facilitate radiation dose reduction, a minority of facilities
equivocal evidence that RDCT can be employed randomized to intervention opted to participate. Notably,
without adverse effects. KSCT is a particularly attractive these facilities exhibited less radiation dose reduction over
target for radiation dose reduction because high-contrast time when compared with controls, suggesting these facil-
kidney stones can be detected and quantified for stone ities may have overall been less interested or motivated to
burden despite high image noise content and artifacts adjust protocols to decrease radiation dose. There could be
associated with LDCT [7]. several reasons for a reluctance to adopt RDCT recom-
Despite the dramatic increase in use of CT scanning for mendation despite specific recommendations from national
the diagnosis of renal colic over the last several decades, societies and our DOSE initiatives.

6 Journal of the American College of Radiology


Volume - n Number - n Month 2021
Fig 3. Proportion of reduced-radiation dose kidney stone CTs (DLP < 400 mGy∙ cm) each year by group. DLP ¼ dose length
product.

Unfortunately, the lack of adoption of RDCT is not year over year at these facilities, the population effect of a
unique to KSCT. A recent study of dose descriptors from 72 modest change is still potentially important [24].
US facilities found that up to 65% (47 of 72) facilities had The measure of radiation dose used in this project is
median doses above the ACR guidelines for RDCT in lung DLP, which is what is consistently reported by facilities to the
cancer screening [22]. Both KSCT and lung cancer screening DIR. DLP is a measure of delivered radiation along the length
share similar imaging attributes of high inherent lesion of the patient and does not take patient size into account. An
contrast between the anticipated lesions (kidney stones or SSDE would be a better measure of absorbed dose [14]. As of
pulmonary nodules) and the background organ parenchyma 2015, in many cases the SSDE was reported in fewer than
that offers fertile basis for RDCT. These observations are half of the CTs (Table 2). Although this did increase to
in stark contrast to multisite, multiyear data on more than three-quarters of CTs by 2019, using SSDE
mammography in the United States that document mean alone would have provided an incomplete picture. It is likely
glandular dose to the breasts well below the compliance that the change in DLP is representative of the change in
limit of 3 mGy for a single craniocaudal view of the breast absorbed dose as long as patient characteristics are relatively
set in the congressionally enacted Mammography Quality constant year over year. The changes in CTDIvol were fairly
Standards Act of 1992, suggesting that legislation rather similar to the changes in DLP (Table 2), although in some
than voluntary participation is likely more effective [23]. cases our protocol suggestions included a shorter scan
Our results were certainly limited by the relatively low length, which could reduce delivered (and absorbed) dose at
response of facilities who were willing to participate, which the same CTDIvol, so we felt that DLP represented the
is likely related to the lack of factors to encourage motivation best measure of radiation to report in this case.
for change. Although we made multiple attempts to contact We are unable to tell if changes in CT protocols affected
facilities via e-mail and telephone, the response rate was low. diagnostic accuracy. However, multiple prior studies
It is also possible we were simply unable to get in touch with (including a meta-analysis) have demonstrated that diag-
personnel who may have been willing to participate. nostic accuracy is maintained even with substantial radiation
Notably, the proportion of academic facilities that partici- dose reduction [7,8,20]. It is very likely that diagnostic
pated was lower than nonacademic (17% of facilities but accuracy is well maintained given the relatively modest
only 8% of participation) for unclear reasons, perhaps effects achieved in this intervention.
because they felt they had more resources to do this on their As CT imaging equipment and algorithms improve,
own or had other priorities. Although we counted a facility there is a move toward radiation dose reduction over time
as having participated if they completed at least one CME even without intervention, as seen particularly in the control
module, it is likely that change was more impacted by group that received no attempt at intervention. All facilities
facilities who completed the full intervention. However, in our study were already participating in the ACR DIR
although the absolute reductions in radiation dose in our initiative, which does provide feedback and may help facil-
study were modest, given the number of KSCTs performed ities adjust their protocols to be more in line with other

Journal of the American College of Radiology 7


Moore et al n Radiation Dose Reduction in Kidney Stone CT
8

Table 2. Detailed CT radiation dose results by group and year

Characteristic or Category 2015 % 2017 % 2018 % 2019 %

Control (n ¼ 96)
DLP (in mGy ∙ cm)
No. of CT examinations with information 49,330 54,995 52,481 54,543
Mean (SD) 691 (202) 662 (205) 642 (207) 649 (221)
Median (IQR) 712 (551,814) 645 (519,791) 640 (501,793) 612 (515,797)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 2,385 4.8 3,729 6.8 3,478 6.6 3,577 6.6
200-399 4,329 8.8 6,111 11.1 6,206 11.8 6,956 12.8
300-399 5,883 11.9 7,517 13.7 7,585 14.5 8,125 14.9
400-499 5,867 11.9 6,750 12.3 6,906 13.2 7,062 12.9
500-599 5,526 11.2 6,025 11.0 5,870 11.2 5,995 11.0
600-699 4,846 9.8 5,254 9.6 4,875 9.3 4,853 8.9
700-799 4,086 8.3 4,166 7.6 3,987 7.6 3,892 7.1
800-899 3,244 6.6 3,422 6.2 3,148 6.0 3,342 6.1
900-999 2,893 5.9 2,983 5.4 2,604 5.0 2,639 4.8
1,000 10,271 20.8 9,038 16.4 7,822 14.9 8,102 14.9
Dose (CTDIvol) in mGy
No. of CT examinations with information 49,330 54,995 52,481 54,543
Mean (SD) 14.3 (4.2) 13.4 (4.2) 13.1 (4.4) 13.1 (4.6)
Median (IQR) 14.3 (11.2,17.3) 13.2 (10.5,16.2) 13.1 (10.3,15.9) 12.0 (10.3,15.9)
Journal of the American College of Radiology

SSDE in (mGy)
No. of CT examinations with information 26,411 32,955 32,334 35,122
% of total CT examinations with SSDE 54 60 62 64
Mean (SD) 15.4 (4.9) 13.6 (4.2) 13.1 (5.0) 13.4 (5.0)
Volume - n Number - n Month 2021

Median (IQR) 15.3 (11.8,18.3) 13.6 (9.8,15.8) 13.6 (9.8,15.8) 13.2 (10.1,15.6)

Intervened-on (n ¼ 25)
DLP (in mGy ∙ cm)
No. of CT examinations with information 15,053 15,433 17,304 17,368
Mean (SD) 689 (297) 582 (176) 585 (171) 593 (168)
Median (IQR) 678 (534,731) 569 (508,714) 583 (519,673) 583 (509,692)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 700 4.7 1,076 7.0 942 5.4 905 5.2
200-399 1,188 7.9 1,820 11.8 2,269 13.1 2,417 13.9
300-399 1,464 9.7 2,219 14.4 2,749 15.9 2,848 16.4
Moore et al n Radiation Dose Reduction in Kidney Stone CT
Journal of the American College of Radiology

400-499 1,970 13.1 2,294 14.9 2,558 14.8 2,573 14.8


500-599 1,950 13.0 1,897 12.3 2,038 11.8 1,958 11.3
600-699 1,793 11.9 1,418 9.2 1,545 8.9 1,442 8.3
700-799 1,247 8.3 1,137 7.4 1,244 7.2 1,139 6.6
800-899 1,280 8.5 904 5.9 988 5.7 990 5.7
900-999 1,057 7.0 771 5.0 778 4.5 807 4.6
1,000 2,404 16.0 1,897 12.3 2,193 12.7 2,289 13.2
Dose (CTDIvol) in mGy
No. of CT examinations with information 15,053 15,433 17,304 17,368
Mean (SD) 14.3 (5.8) 12.0 (3.4) 11.9 (3.2) 12.0 (3.2)
Median (IQR) 13.1 (12.0,15.2) 12.1 (10.1,14.6) 12.1 (9.9,13.9) 12.1 (9.9,13.9)
SSDE (in mGy)
No. of CT examinations with information 6,142 8,969 12,926 13,017
% of total CT examinations with SSDE 41 58 75 75
Mean (SD) 14.7 (5.7) 12.4 (2.9) 12.2 (3.0) 12.6 (3.0)
Median (IQR) 13.5 (12.0,17.0) 12.2 (10.7,14.9) 12.4 (11.0,17.7) 14.3 (11.0,17.7)

Intervened-off (n¼71)
DLP (in mGy ∙ cm)
No. of CT examinations with information 35,275 41,611 35,890 32,756
Mean (SD) 663 (223) 654 (216) 646 (222) 649 (222)
Median (IQR) 648(507,821) 658 (494,781) 637 (478,794) 649 (489,786)
No. of CT examinations in DLP ranges (mGy ∙ cm)
<200 2,042 5.8 2,709 6.5 2,248 6.3 1,847 5.6
200-399 3,798 10.8 3,937 9.5 3,643 10.2 3,256 9.9
300-399 4,177 11.8 4,386 10.5 4,158 11.6 4,373 13.4
400-499 4,353 12.3 4,923 11.8 4,489 12.5 4,347 13.3
500-599 3,797 10.8 4,561 11.0 4,274 11.9 3,910 11.9
600-699 3,282 9.3 4,119 9.9 3,339 9.3 3,029 9.2
700-799 2,569 7.3 3,193 7.7 2,608 7.3 2,327 7.1
800-899 2,221 6.3 2,617 6.3 2,033 5.7 1,752 5.3
900-999 1,890 5.4 2,253 5.4 1,749 4.9 1,610 4.9
1,000 7,146 20.3 8,913 21.4 7,349 20.5 6,305 19.2
Dose (CTDIvol) in mGy
No. of CT examinations with information 35,275 41,611 35,890 32,756
Mean (SD) 13.8 (4.5) 13.5 (4.3) 13.3 (4.4) 13.4 (4.6)
Median (IQR) 13.2 (10.8,17.1) 13.6 (10.0,16.7) 13.6 (9.4,15.5) 13.6 (9.5,16.0)
SSDE (in mGy)
(continued)
9
institutions that are achieving lower radiation doses for

%
similar studies. It is likely that if our results were compared
with institutions that do not participate in the DIR, the
differences would be even greater. However, as this study

13.8 (9.8,16.8)
demonstrates, with appropriate education and attention to
13.8 (4.8)
27,138

protocols, this reduction can be enhanced and maintained.


2019

83

The DOSE initiative for radiation dose reduction in KSCT


has developed and maintained resources that may be useful
to facilities interested in optimizing their protocols for CT
in kidney stone. These include the two CME modules on
RadIQ and the CT scanning protocols on the DOSE
%

website [15,25,26].
13.7 (10.3,16.0)

TAKE-HOME POINTS
13.6 (4.3)
29,129
2018

81

- This analysis included 422,039 KSCTs from 192


facilities during 2015, 2017, 2018, and 2019.
- This randomized, controlled intervention achieved a
substantial reduction of 110 mGy ∙ cm in mean DLP
CTDIvol ¼ CT dose index volume; DLP ¼ dose length product; IQR ¼ interquartile range; SSDE ¼ size-specific dose estimate.
%

for KSCTs done by participating facilities compared


with control facilities.
- The proportion of reduced dose CTs increased in
13.6 (11.4,16.8)

participating facilities for all years postintervention.


13.8 (4.5)
35,010
2017

84

ACKNOWLEDGMENTS
This study was funded by the Agency for Healthcare
Research and Quality, R18HS023778. This research was
supported by the American College of Radiology’s National
%

Radiology Data Registry (NRDR). The authors thank ACR


staff for assistance in preparation of the data and acknowl-
edge guidance and input by the NRDR steering committee
14.3 (11.0,17.7)
14.6 (5.3)

for this analysis.


21,226
2015

60

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Journal of the American College of Radiology 11


Moore et al n Radiation Dose Reduction in Kidney Stone CT

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