CAN I LIVE WITHOUT A CORPUS CALLOSUM

Introduction 50
● Corpus callosum is the thick bundle which acts as the connector of left and right side
lobes of the brain.
● Band of nerve fibre present deep inside the brain
● This presentation is going to illustrate the anatomy along with physiology of corpus
callosum.
This report has illustrated the importance of corpus callosum and analysis based on life
without this particular part.
Anatomy of Corpus Callosum
● The corpus callosum is a huge bundle of more than 200 million myelinated nerve
fibres that connects the two hemispheres of the brain and allows communication
between them.
● Individual nerve lines that link different sections of the hemispheres make up the
corpus callosum (Blaauw & Meiners, 2020).
● The four parts of corpus callosum are rostrum and genu and trunk or body as well as
splenium
The corpus callosum links homolog and heterotopic areas in both hemispheres and is the
primary white matter route connecting the two cerebral hemispheres.
Physiology of Corpus Callosum
● One of the most striking characteristics of brain evolution is the improvement of the
corpus callosum in Eutherian animals.
● The controlling and sensations on the opposite sections of body are controlled by
either side of the brain (Allouh et al. 2020).
● As a result, muscular coordination and sophisticated information processing need the
cooperation of each sides of brain and the corpus callosum plays the role of connector
for two hemispheres (Oran et al. 2021).
● Corpus callosum is observed at the middle of the brain and measures around 10
centimeters in length and shaped as letter C.
Corpus callosum links the left as well as right lobes of the brain, each of which are referred to
as a hemisphere. The link permits data to go back and forth between the two parts.
Can I live without a Corpus Callosum
● Few children are observed to be born without the corpus callosum which has led to an
illness known as agenesis.
 ● Between 12 to 16 weeks completion of conception, and around the conclusion of the
first trimester of pregnancy, the corpus callosum develops in the brain (Bayram et al.
2021).
● Lack of this particular aspect can lead to loss of own skills and power
Living without Corpus callosum is next to impossible as the body action remains unstable
and action of the body becomes zero.
Essentiality of corpus callosum knowledge in future profession
● Developmental problems of the corpus callosum can occur alone, affecting solely the
corpus callosum, or as part of a syndrome with additional brain abnormalities ( Bartha‐
Doering et al. 2021).
● Its purpose is to integrate information from both sides of the brain, allowing the brain
to process sensory and motor information more efficiently, as well as execute
complicated activities like communication.
● Callosal dysgenesis is a structural alteration in the way the brain is wired from the
earliest stages of brain development and it impacts the individual throughout their
lives.
Thus, the study of corpus callosum is highly prudential in building strong analysis of current
medical science as corpus callosum is one of the essential parts of the brain as well as the
body.
Annotated Bibliography

Citation Summary

The article has developed a literature-based account of

development, anatomy, and function of corpus callosum.
Besides that the article has specified the perspective
effect on splenium and its contemporary impacts. This
article has succeeded to develop a well perceived analysis
of embryological development and anatomy as well as
function and more things in detail.

Cortical physiology is characterised by interhemispheric

connection between homotopic regions, which is thought
to arise through the corpus callosum. However, it is
uncertain how behavioural situations impact
 interhemispheric correlations and corpus callosum
activity. Based on that the article has developed laminar
extracellular and intracellular recordings on mice based
on which the analysis has been drawn.

The most common commissural abnormality of the brain

is agenesis of the corpus callosum (ACC). It is still a
significant cause of pregnancy termination linked to the
central nervous system (CNS). The study's goal is to offer
a comprehensive evaluation of foetuses with full ACC
diagnoses, as well as postnatal neurodevelopmental
outcomes.

Although the precise role of the corpus callosum (CC) in

language network architecture is unknown, two opposing
theories have been proposed: suppression of homotopic
regions to enable separate hemispheric functioning vs
integration of information from both hemispheres. With
the first research of language network connection in
conjunction with volume measurements, the study
intended to add to this topic.

The goal of this study was to see how age and gender
affected morphometric measurements of the corpus
callosum in a Middle Eastern Arab population in order to
collect reference data and make racial comparisons with
measures from other ethnicities.

Conclusion
● Corpus callosum is important as it ensures communication between both sides of the
brain through providing signals to each other.
● Coordination of the brain is highly dependent on Corpus Callosum that meets the
signals being provided to the brain itself.
● Hence, living without corpus callosum is next to paralysis and without it the
motorable activities do not take place.
Reference List
Allouh, M. Z., Al Barbarawi, M. M., Ali, H. A., Mustafa, A. G., & Alomari, S. O. (2020).
Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs:
Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder. Frontiers in Systems
Neuroscience, 14, 30. https://www.frontiersin.org/articles/10.3389/fnsys.2020.00030/full
Bartha‐Doering, L., Kollndorfer, K., Schwartz, E., Fischmeister, F. P. S., Alexopoulos, J., Langs,
G., ... & Seidl, R. (2021). The role of the corpus callosum in language network connectivity in
children. Developmental science, 24(2), e13031.
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/desc.13031
Bayram, A. K., Kütük, M. S., Doganay, S., Özgün, M. T., Gümüş, H., Başbuğ, M., ... & Per, H.
(2020). An analysis of 109 fetuses with prenatal diagnosis of complete agenesis of corpus
callosum. Neurological Sciences, 41(6), 1521-1529. https://www.researchgate.net/profile/Hueseyin-
Per/publication/338761635_An_analysis_of_109_fetuses_with_prenatal_diagnosis_of_complete_age
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prenatal-diagnosis-of-complete-agenesis-of-corpus-callosum.pdf
Blaauw, J., & Meiners, L. C. (2020). The splenium of the corpus callosum: embryology, anatomy,
function and imaging with pathophysiological hypothesis. Neuroradiology, 62(5), 563-585.
https://link.springer.com/article/10.1007/s00234-019-02357-z
Oran, Y., Katz, Y., Sokoletsky, M., Malina, K. C. K., & Lampl, I. (2021). Reduction of corpus
callosum activity during whisking leads to interhemispheric decorrelation. Nature
communications, 12(1), 1-14. https://www.nature.com/articles/s41467-021-24310-6