mmol) SEY Y (20ml) BML. YAH S JEYZY (DIFDMAP ERTS.) (4 0ag) = M2, SECO SOFRINLEE L te. IR a tlc cre ASE bY coke (1.0 Onl) FHA, PEA THLE L AS. FIBRILS RAIS 7 77 LCE i, HUE MCL RES VAN 7A hF DPE (POUR A: AP 7—“W=9 2 LIED SL. WT ST LOMA y MERE ET MEE Figen L. BaLILA YY 1 3 Omg URS 19%) SAE te (0019) wp: 165-1665 IRGBr.cxr!) 1715, 1653 (0.0.2.0) SHNMR(CDCL,) & = 8.10(d, JET. 8H, 2H, Ar H), 7.76(bs, 2H, Ari), 7.62(t,J=7. tz, 1H, ArH), 7.52 (n, 3H, ActD , 7. 40(n, 6H, Art) .7.29 (0 1H, ArH), 7.0864, 48, 8llz, HC." =Ni), 6.26(8, 1H, CoH) .6.20(bt, J99, (liz, H.C; 9H), 5.85(dd, J=8.8,2. lz, 1H, Co -H) 5.65 (G,J°7-1ilz, 1H, Cy-HD, 5.48 (4,555. 1H 1H,C,” “HD 4.95 (6.58.38, 1H, C5-HD, 4.42 (b8, C,H), 4.2900, 8.54 ZAM, Coo“H) 4.17 (dB, MHz, 1H,Cop-H), 4.224.120 2H), 3.77 (a, d56, 62 1H, CoH) 2.42.63 (bs, 8H), 2,38(8, 3H, Cy-OAe) ,2.23(S, 3H, -Olc) .2.10-1.35(0, 1 OH), 1.89(bs. 3H. Cjo-Me), 1.66(8, 3H, CroMe) 1.341 08¢8, 2H), 1.22(s.3H), 1.12(s,3#). (0.0.21) Mass (SIMS) : 1048 (MH). (0022) Sem2 20 = ( (ABRUY SERIE HILRAAS Y) PRA) FRY OBA: (1) A-ERY ERY YY AREY (920m, Anmol) £71) IWHEEFY (1250 mg, 1 2amol) 2i(LXFL > (40a) & YRFVTSY (2. 55ml, 20nml) 2 YxFT SJEV YY (100mg) SIZ, BTA TBE Lie, BENGE BREE FRAN L,I St WP IRIITE (Parad WA) (CL OWL. HPATLOM Atty MMe SHUT, LHVTA FIUKG 2 Ong (MES 2%) BH. COLAF IVR (6.0 Omg, Qmmol ) 21 UE ABRILT bY 7 Zea (2m) ez, HC 2 4 BREE L 7. RIGHERIE 1 NAMIE (2ul) SIZ A, MEE Fm Le RIEL ALIVE ITE (5 0%XT JW FAA) CE ORL BT STL Bo2iky hEPeSbEC, A-ENUT ER UY PARANA TERS O Ong (IES 2%) BAF Re (2) PRIM (26 Ong, 0. Sumo) EA-ER YEP Sy AAR A (24 Bag, 0. Omol) SCH.C 1, (2Om1) (CRML. 77 AFL SK (LIFDCC emer.) (12 Ang, 0. Gnwol) {DMAP (30mg) SMA SiC HmEO-110865 6 2BHRIMEEL TE. RGR OREE SEL. A TRICO RIERA bY ACHE (1.0 Ol) Sim PIAA CH LT, AVES ATES 7 Dray CGH REE Panel L | TNE 3% WP ARES IIB (POA: API—W=9 1) ELOWRL. BHP STL CRA y hime Gb UC RRIE PRMML . HELGA] 4 Ons CLE 42%) & 4, £00.23) mp : 133-1350 IR(Br.cwr) £1711, 1655 £00.24} SH-NMR(CDCI,) H), 7.76(d, 5511.3, 2H, ArH) 7. 63-7. 31 (a, 11H, Arf) , 6.96(bs.1H.C,” “MD, 6.2848, 1H, Cy“) .6.23(b, 558.5) He, 1H,C,y-H), 5.95¢bred, 25. 8Hz, 1H," -H),5.67(0. 382. 1H. CW), 5.54(bs, 1,2"), 4.9604, ZAM, CoH) 4. T0(8,2H-Cle-), 4.43 (bs, 1H, ID, 4.3 0(d, J=8. 28, 1H, Cz o-H) 4. 194d, J=8.OHlz, 1H, CoH. 4 184.150, 2H), 3.80(d, 7.12, 1H, Co-H) ,2.95-2.03 (a.10H), 2.41 (s.3H.C,-Ole), 2.224, 3H.C, 9-Le). 1.9 8-1.52(n, 8H), 1.92(8,3H.C,o-Me), 1.6768, 3H, C:9-M ).1.5041. 3500, 2), 1.2265,38), 1.1265, 38). (0.0.25) Mass (SINS) : 1106(MHH)* (0026) sites 2) — (4 (AER ERY) THU) PRY WOE: (1) 4- ERY YJ ERUYY (3. 38, 20m) 1) EA-FOETHFY PTY y REFVEAFY (5. Og, 26nml) SYXFIAWAT SK (50 ml) (VERE TK A (33. Ome) AMZ, GACT ZOFWEEEL re BIGUERRE MUEE Pie]. REL UAL OV ESF 7H (1 0% POET Deb XI IAW) EL OWL. WETS TLC Zalty MHS ab ET, THLIAFIUKA. Be (MES 5%) BR. LOTAF ME (3g, 100mm OL) 12 AORBRILY bY 298K C1 Tal) AMZ SEUET 4 SRHRIEEL 7c. BUGREYEIC | HDEMERRINTE (1 Lal) Sin tote, SUE ideal Ler YASWIALKA IIE (SO%WXI JF. cb) CLO RRL . HHESS TLC RK y bill BEBDET. A— (AER IER YY) TF JR2. 3 UES 5%) 2H, (2) 9RY—W (10008, O. 1 Lmml) ea (AER ZTERU YY) TIME (10728, 0. 4awl) SCH;C 1; (201) HHL, DOC (87ng, 0. Anmol) EDMAP (1 Oag) #2 HCO OBFRIKESEL 72. RUGS MOTRIN A 2 Le. SiR RE RUBEREASR I by Lot (1:0 Ol) EMAL, 7 TRILL CHL Te ARE OARS PROT Meh, VEE FRAIL. PRT AEWI ODA DIE (POA | APN