DRUG STUDY

1. Methylprednisole
GENERIC NAME: MECHANISM OF SIDE EFFECTS/ NURSING
Methylprednisole ACTION: ADVERSE EFFECTS: RESPONSIBILITIES
Glucocorticoids are tendon rupture, bone :
BRAND NAME: naturally occurring fractures, avascular Assess for sign
A-Methapred, Depo- hormones that prevent necrosis, heart failure, of renal
Medrol, Medrol or arrhythmia, pulmonary insufficiency•
suppressinflammation edema, optic neuritis, Monitor I&O
and immune responses impaired wound and daily
when administered at healing, weights.
pharmacological doses. immunosuppression, Observe patient
Unbound hypertension, hepatitis, for
glucocorticoids cross weakness, nausea, crackles/rales,
cell membranes and vomiting, diarrhea, steady weight
bind to specific anorexia, gain ordyspnea.
cytoplasmic receptors. THROMBOEMBOLIS Notify health
This binding induces a M, anorexia, PEPTIC care professional
response. Such actions ULCERATION if these
can include: inhibition occur.•Assess
of leukocyte infiltration for changes in
at the site of in- LOC and
flammation, headache during
interference in the therapy
function of mediators (Cerebral
of inflammatory Edema)•PO:
response, and Administer with
suppression of humoral meals to
immune responses minimize GI
DOSAGE: INDICATION: irritation. Avoid
Maximum Dosage/24 hours:  For the treatment of consumption of
Multiple sclerosis: PO - 160 status asthmaticus. grapefruit during
mg/day for 7 days then 64  For asthma therapy• IM:
mg every other day for 1 exacerbation. Shake
mo. Asthma exacerbations:  For the treatment of suspension well
PO 120-180 mg/day in the acute before drawing
divided doses 3-4 times/day respiratory distress up. Do NOT
for 48 hr, then 60-80 mg/day syndrome (ARDS). administer
in 2 divided doses.Most CONTRAINDICATION suspensions
uses: methylprednisolone : IV•Lab Test
succinate: 40-250 mg q 4-6 Preparations containing Considerations:
hr Usual Dosage and benzyl alcohol Monitor serum
Frequency: electrolytes and
 methylprednisolone sodium preservative are glucose. May
succinate 40 mg IV or IM contraindicated in cause hyper-
once daily in the morning infants. Use caution glycemia,
for 5 to 7 days with the 24-mg tablets especially in
marketed as Medrol; persons with
CLASSIFICATION: these contain tartrazine, diabetes. May
Therapeutic: which may cause cause
antiasthmatics, allergic reactions, hypokalemia.
corticosteroids; especially in people Patients on
Pharmacologic: who are allergic to prolonged
corticosteroidsTherape aspirin. Give daily dose therapy should
utic Uses: Suppression before 9 to mimic routinely have
of inflammation and normal peak CBC, serum
modification of the corticosteroid blood electrolytes, and
normal immune re- levels. serum and urine
sponse. Replacement glucose
therapy in adrenal evaluated
insufficiency

2. Gabapentin
GENERIC NAME: MECHANISM OF SIDE EFFECTS/ NURSING
Gabapentin ACTION: ADVERSE RESPONSIBILITIES:
Gabapentin is structurallyEFFECTS: Assessment
BRAND NAME: related to the  An unsteady  History:

Apo-Gabapentin (CAN), neurotransmitter GABA walk Hypersensitivity to

Gen-Gabapentin (CAN), but is neither a GABA  Involuntary gabapentin;
Neurontin agonist nor antagonist. back and forth lactation, pregnancy
Gabapentin-binding sites movements of  Physical: Weight;
have been identified the eyes T; skin color,
throughout the brain  Blurred vision lesions; orientation,
tissues e.g. neocortex and Shaking affect, reflexes; P;
hippocampus. However,  Dizziness R, adventitious
the exact mechanism of  Anxiety or sounds; bowel
action is still unknown. aggressive sounds, normal
behaviors, output
DOSAGE: INDICATION: especially in Interventions
Capsules—100, 300, 400  Adjunctive therapy in children  Give drug with food
mg; tablets—100, 300, 400, the treatment of  Restlessness or to prevent GI upset.
600, 800 mg; oral solution partial seizures with mood changes,  Arrange for
—250 mg/5 mL and without also more consultation with
secondary common in support groups for
CLASSIFICATION:   generalization in children than people with
Antiepileptic adults and children 3– adults epilepsy.
 12 yr with epilepsy  Confusion  WARNING: If
 Orphan drug use: overdose occurs,
Treatment of hemodialysis may
amyotrophic lateral be an option.
sclerosis
 Management of
postherpetic neuralgia
or pain in the area
affected by herpes
zoster after the
disease has been
treated
 Unlabeled uses:
Tremors of MS,
neuropathic pain,
bipolar disorder,
migraine prophylaxis

CONTRAINDICATION:
 Hypersensitivity.
Lactation.