1.

A patient with a history of recurring attacks of pancreatitis, eruptive xanthomas, and

increased plasma triglyceride levels associated with chylomicrons, most likely has a
deficiency in
A. Lipoprotein lipase
B. HMG-CoA reductase
C. apoB-48
D. apoB-100receptor
2. A 42-year-old man his physical exam reveals xanthelasmas and bilateral tendon
xanthomas. A plasma lipid profile reveals a cholesterol level of 340 mg/dL, with a high
LDL/HDL ratio. What is the cause of deficient for this patient?
A. lethicin cholesterol acyltransferase
B. apoB-100 receptors
C. Fatty acyl-CoA synthetase
D. Cholesterol ester transfer protein
3. Which one is not true about dyslipidemias?
A. It is due to cholesterol increase
B. It is due to elevation of triacylglycerols
C. It is due to decrease of low-density lipoprotein
D. It is due to low high- density lipoprotein
4. One of the following is not correct about type I hyperlipidemia
A. It increases level of VLDL
B. Apo-C II deficiency
C. It increases clearance of chylomicrons
D. It is due to lipoprotein Lipase enzyme deficiency
5. Development of Xanthelesma in the eyelid is most happening due to?
A. Deficiency of LDL receptors region of apoB100
B. Increase in apoE-apoB-rich chylomicron remnants
C. Abnormal conversion of normal VLDL to β-VLDL
D. Complex abnormal lipoprotein metabolism
6. One of the following is not true about management of dyslipidemia?
A. Increase intake of High unsaturated fats
B. Decrease intake of trans-fatty acids
C. Perform regular physical exercise
D. Increase intake of processed food
7. Bassen-Kornzweig syndrome is due to?
A. Increase plasma cholesterol
B. Increase chylomicron
C. Deficiency of apo-B
D. Increase LDL level
8. One of the following is not relate to Tangier’s disease
A. decrease level of HDL
B. defect of apo-A I
C. Decrease triglyceride
D. Mutations of ABCA1 transporter
9. Lipid Storage Diseases is characterized with
A. Defect of Sphingolipids catabolism
B. Increase lipoprotein catabolism
C. Over secretion of lysosome enzymes
D. defect of lipid synthesis
10. A 9-week-old boy, healthy at birth, begins to develop symptoms of ketoacidosis, vomiting,
lethargy, seizures, hypertonia and urine has characteristic odor is
A. Homocystinuria
B. Phenylketonuria
C. Maple syrup
D. Alkaptonuria
11. A child with white-blond hair, blue eyes, and pale complexion due to defect of enzyme of
dihydrobiopeterin reductase considered as
A. Homocystinuria
B. Phenylketonuria
C. Maple syrup
D. Alkaptonuria
12. 55-year-old man with a rare recessive condition is at high risk for deep vein thrombosis and
stroke and has had replacement of ectopic lenses. Which of the following a mutation in the
gene encoding is most likely to cause this disease?
A. Cystathionine β synthase
B. Homocysteine methyltransferase
C. Branched chain a-keto acid dehydrogenase
D. Lysyl oxidase
13. A 56-year-old man with a history of genetic disease undergoes hip replacement surgery
for arthritis. During the operation the surgeon notes a dark pigmentation (ochronosis) in the
man's cartilage. His ochronotic arthritis is most likely caused by oxidation and polymerization of
excess tissue
A. Homogentisic acid
B. Orotic acid
C. Methylmalonic acid
D. Ascorbic acid
14. One of the following amino acid is not the cause of development of autosomal recessive
metabolic disorder Cystinuria
A. Glycine
B. Arginine
C. Ornithine
D. Lysine
15. The precursor for the synthesis of melanin is
A. Tryptophan
B. Arginine
C. Tyrosine
D. Gultamin
16. Which of the following acts as a central molecule when transamination and deamination
occur simultaneously?
A. Aspartate
B. Alanine
C. Oxaloacetate
D. Alpha-ketoglutarate
17. Deamination reactions that are performed by removing of amino group without oxidation is?
A. Hydrolytic deamination
B. Reductive deamination
C. Specific Deamination
D. Transdeamination
18. Oxidative deamination is the conversion of an amino acid to
A. α - keto acid
B. Carboxylic acid plus ammonia
C. Keto acid plus ammonia
D. Carboxylic acid
19. Transamination is the process where
A. α-amino group is removed from the amino acid
B. Carboxyl group is transferred from amino acid
C. Polymerisation of amino acid takes place
D. Carboxylic group is removed by forming keto acid
20. Which one of the following is not related to high concentration of NH3
A. It can decrease the concentration of α-ketoglutarate
B. It can increase glutamine formation
C. It can disturb as neurotransmitter inhibitor
D. It can increase over production of energy