New Product Pipeline

S. Company (Indication)
No. Name Compound Therapeutic class Mechanism Area Under Investigation Phase

Astra
1 Zeneca Saxagliptin Antidiabetes DPP-4 inhibitor Type 2 Diabetes Launched

Saxagliptin+Metformin Antidiabetes DPP-4 inhibitor + biguanide FDC Type 2 Diabetes Launched

Dapagliflozin Antidiabetes SGLT2 inhibitor Type 2 Diabetes III
SGLT2 inhibitor +
Dapagliflozin+metformin Antidiabetes biguanide FDC Type 2 Diabetes III
Aspirin + Proton pump inhibitor + Low dose aspirin associated
Esomeprazole magnesium Gastrointestinal Low dose aspirin FDC peptic ulcer III

EGFR tyrosine(epidermal Non-small cell lung

Gefitinib Oncology(Anticancer) growth factor receptor's) cancer(NSCLC) Launched
Ticagrelor Cardiovascular ADP receptor antagonist Arterial thrombosis III
Rosuvastatin + Fenofibric acidCardiovascular Statin + Fibrate FDC Dyslipidaemia III

Signs and symptoms of OA,

Naproxen + Esomeprazole Pain management and GITNaproxen + PPI RA and AS Launched

VEGFR/EGFR tyrosine kinase inhibitor

with RET Medullary thyroid cancer -
Vandetanib Oncology(Anticancer) kinase activity orphan III
Cediranib  Oncology(Anticancer) VEGFR tyrosine kinase inhibitor CRC (Colorectal cancer) III
Castrate resistant
Zibotentan Oncology(Anticancer) Endothelin A receptor antagonist prostate cancer III
Ceftaroline Anti-infective Affinity to penicillin - binding proteins Pneumonia/skin infections III
Lesogaberan Gastrointestinal GABAB agonist GERD II
Olaparib Oncology(Anticancer) PARP inhibitor BRCA breast cancer II
 Pfizer +
2 Wyeth
Breast Cancer Combo
Bosutinib Oncology(Anticancer) Tyrosine kinase inhibitor Therapy II

Transplant Rejection,
Inflammation / Inflammatory Bowel Disease,
Ophthalmology Psoriasis, Dry Eye, Ankylosing
Tasocitinib / Gastrointestinal Kinase inhibitors Spondylitis, Psoriatic Arthritis II
Peyronie's Disease
Xiaflex Inflammation (Biologic) II
Vabicaserin Neuroscience  Selective 5-HT2C receptor full agonist Schizophrenia II
Thiophene sulfonamide γ-secretase
Begacestat Neuroscience inhibitor  Alzheimer’s Disease II
Onchocerciasis
Moxidectin Anti-infective (River Blindness) III

Zithromax(Azithromycin)/
Chloroquine Anti-infective 5-OS Ribosome Inhibitor Malaria III
Axitinib Oncology(Anticancer) VEGF Tyrosine Kinase Inhibitor Renal Cell Carcinoma III
Neratinib Oncology(Anticancer) Pan-HER inhibitor Breast Cancer III
Sunitinib Oncology(Anticancer) Multiple Tyrosine Kinase Inhibitor Breast Cancer Launched
Cardiovascular & Acute Coronary Syndrome/
Apixaban Metabolic Diseases Factor Xa Inhibitor Atrial Fibrillation III
Latrepirdine Neuroscience MpTp Modulator Alzheimer’s Dementia III
Sitaxentan Cardiovascular Endothelin A Receptor Antagonist Pulmonary Hypertension III

Cardiovascular,
Metabolic & Selective Estrogen Receptor
Lasofoxifene Endo Diseases Modulator Osteoporosis Treatment III
Skin and Skin Structure
Dalbavancin Anti-infective Cell Wall Synthesis Inhibitor Infections III
3 BMS
Inhibits VEGFR2, a tyrosine kinase
Brivanib Oncology(Anticancer) receptor  Metastatic melanoma II
Dapagliflozin Antidiabetes SGLT2 inhibitor Type 2 Diabetes III

Cardiovascular & Acute Coronary Syndrome/

Apixaban Metabolic Diseases Factor Xa Inhibitor Atrial Fibrillation III

Philadelphia chromosome-
positive lymphoblastic
Dasatinib Oncology(Anticancer) Tyrosine kinases inhibitor leukemia Launched

locally advanced breast

Ixabepilone Oncology(Anticancer) It acts to stabilize microtubules cancer Launched

Merck +
Schering-
4 Plough
Anacetrapib Cardiovascular CETP inhibitor Atherosclerosis III
Osteoporosis and 
Odanacatib Oncology(Anticancer) Inhibitor of cathepsin K bone metastasis III
Selective antagonist at theadenosine
Preladenant  A2A receptor Parkinson’s Disease, II
lonafarnib Oncology(Anticancer) Farnesyl-OH-transferase inhibitor  Progeria II
Betrixaban Cardiovascular Factor Xa inhibitor Thrombosis II
ER Niacin+laropiprant Cardiovascular Atherosclerosis III
Laropiprant+Niacin+SimvastatCardiovascular Atherosclerosis III
Sitagliptlin+Pioglitazone Antidiabetes DPP-4 inhibitor+Thiazolidinedione Type 2 Diabetes III
Tafluprost Ophthalmologicals  Prostaglandin analogue  Glaucoma III
Acute lymphoblastic
Acadesine Cardiovascular AMP-activated protein kinase activator leukemia III
Calcitonin gene-related peptide
Telcagepant Neuroscience receptor (CRLR) antagonist  Migraine III
 Neuromuscular
Sugammadex Selective relaxant binding agent blockade reversal III
Inhibitor of the mammalian target of
Ridaforolimus Oncology(Anticancer) rapamycin Bone Sarcoma III
Inhibition of protein, DNA, and RNA 
Daptomycin Anti-infective synthesis Staph Infection III
Vorapaxar Cardiovascular Thrombin receptor antagonist Thrombosis III
Sitagliptin + Simvastatin Cardiovascular DPP-4 inhibitor+Statin Type 2 Diabetes III

Inhibits the absorption of cholesterol+

Ezetimibe + Atorvastatin Cardiovascular Statin Atherosclerosis III

Indiscriminately blocking various ionic Under

Vernakalant Cardiovascular channels Atrial Fibrillation Review
Under
Nomegestrol Harmonal   Contraception Review
Schizophrenia, Under
Asenapine  Neuroscience Serotonin 5-HT1A antagonist Bipolar Disorder Review

Abbott +
5 Solvay

Positive inotropic effect by increasing
calcium sensitivity of myocytes by binding Under
Levosimendan Cardiovascular to cardiac troponin C Congestive heart failure Review
 Partial agonist at neural nicotinic
acetylcholine
Pozanicline Neuroscience receptors ADHD  II
Quinolone antibiotic that inhibits
Olamufloxacin Anti-infective DNA gyrase Bacterial infection III
Navitoclax Oncology(Anticancer) Small-cell lung cancer   II
5-formyl derivative of tetrahydrofolic Adjuvant used in cancer 
Leucovorin Oncology(Anticancer) acid chemotherapy  III
Inhibits members of the vascular
Linifanib Oncology(Anticancer) endothelial growth factor Hepatocellular carcinoma  II
 Veliparib Oncology(Anticancer) Polymerase inhibitor Breast cancer
Pardoprunox Neuroscience  D2 and D3 receptor partial agonist  Depression and anxiety III
 Bifeprunox Neuroscience Potent D2 receptor antagonists  Schizophrenia III

6 GSK Cardiovascular disease (also

COPD
Iosmapimod Cardiovascular p38 kinase inhibitor , pain & depression)  II
Threatened pre-term
Retosiban Cardiovascular Oxytocin antagonist labour  II
Rilapladib Cardiovascular Lp-PLA2 inhibitor Atherosclerosis  II
Darapladib Cardiovascular Lp-PLA2 inhibitor Atherosclerosis  II
Fondaparinux Sodium Cardiovascular Synthetic factor Xa inhibitor Acute coronary syndrome Launched
Sitamaquine Anti-infective 8-aminoquinoline Visceral leishmaniasis  II
Tafenoquine Anti-infective 8-aminoquinoline Plasmodium vivaxmalaria  II
Firategrast Neuroscience Dual alpha4 integrin antagonist (VLA4) Multiple sclerosis  II
Migraine
Voltage-gated calcium channel prophylaxis/Neuropathic
Gabapentin enacarbil Neuroscience modulator pain  II
Almorexant Neuroscience Orexin antagonist Insomnia III
Retigabine Neuroscience Neuronal potassium channel opener Epilepsy – partial seizures Submitted

Mesenchymal-epithelial transition factor

(C-met) Papillary renal cell carcinoma
Foretinib Oncology(Anticancer) kinase inhibitor and other cancers  II
Related
Eltrombopag Oncology(Anticancer) Thrombopoietin receptor agonist thrombocytopaenia  II
Head & neck
Lapatinib Oncology(Anticancer) Her2 and EGFR dual kinase inhibitor squamous cell carcinoma  II
Breast cancer,
Pazopanib Oncology(Anticancer) Her2 and EGFR dual kinase inhibitor adjuvant therapy  II
Long-acting beta2 agonist +
Vilanterol + Fluticasone Respiratory glucocorticoid agonist Asthma  II
Iosmapimod Respiratory p38 kinase inhibitor COPD  II
7 J&J
Abiraterone Oncology(Anticancer) Inhibiting CYP17A1  Prostate cancer III
 Inhibitor of subtype 2 sodium-glucose
Canagliflozin Antidiabetes transport protein Type 2 Diabetes III
Serdemetan Oncology(Anticancer) Novel inhibitor of vascular maturation  II
Tipifarnib Oncology(Anticancer)  Farnesyltransferase inhibitor Acute myeloid leukemia III
Metaglidasen Antidiabetes Potential best-in-class insulin sensitizer Type 2 Diabetes III

8 Novartis
Inhibits one or more of the histone
Panobinostat Oncology(Anticancer) deacetylase enzymes Hodgkin‘slymphoma III
Novel multireceptor ligand
Pasireotide Oncology(Anticancer) somatostatin analog  Cushing’s disease III
Direct renin inhibitor + Calcium channel
Aliskiren + Amlodipine + blocker III
Hydrochlorothiazide Cardiovascular + Thiazide diuretic Hypertension completed
Myeloproliferative
 Ruxolitinib Oncology(Anticancer) JAK2 inhibitor neoplasms, psoriasi  II
Norepinephrine-dopamine
Agomelatine Neuroscience disinhibitor  Depression III

Prostate cancer and HER2-

negative
Vadimezan Oncology(Anticancer) Tumor-vascular disrupting agent metastatic breast cancer III
Omadacycline Anti-infective cSSSI III
Elinogrel Cardiovascular P2Y12 protein inhibitor Thrombosis  II
Dovitinib Oncology(Anticancer) Inhibits its phosphorylation Solid tumors  II
Ultra long acting beta-adrenoceptor
Indacaterol+ Mometasone Respiratory agonist+ glucocorticoid steroid COPD Launched
Kidney & heart transpl.
Sotrastaurin Immunosuppressive Protein kinase C inhibitor rejection

9 Eli lilly
Diabetic peripheral
Ruboxistaurin Neuroscience Inhibitor of protein kinase C-beta retinopathy III
 Antidepressant, anxiolytic,
and working memory-
Pruvanserin Neuroscience Selective 5-HT2A receptor antagonist enhancing effects  II
Semagacestat Neuroscience Blocks the enzyme γ-secretase  Alzheimer's disease  II
Long-acting glucagon-like peptide-1
Dulaglutide Antidiabetes (GLP-1) analog Type II diabetes  II

Vertebral fractures and

breast cancer in
Arzoxifene Oncology(Anticancer) Potent estrogen antagonist postmenopausal women III
Enzastaurin Oncology(Anticancer) PKCβ-selective inhibitor Non-Hodgkin's Lymphoma III
Gataparsen  Oncology(Anticancer) Lung cancer III

10 Bayer
Acute decompensated
Cinaciguat Cardiovascular Soluble guanylate cyclase activater heart failure  II
Stimulator of soluble guanylate
Riociguat Cardiovascular cyclase   Pulmonary hypertension  III
Sagopilone Oncology(Anticancer)  Inhibits breast cancer bone metastasis Prostate cancer  II
Regorafenib Oncology(Anticancer) Multi-kinase inhibitor   Multiple tumor   II
Active direct inhibitor of coagulation  III(USA)
Rivaroxaban Antithrombotic agents Factor Xa  Venous thromboembolism Launched
Prostate cancer and
Alpharadin Oncology(Anticancer) breast cancer III
Florbetaben Neuroscience Novel positron emission tomography Alzheimer's Disease III

Sanofi-
11 Avintis
Glucagon-like peptide 1 (GLP-1)
Lixisenatide Antidiabetes receptor agonist Type 2 Diabetes III
 Iniparib Oncology(Anticancer)  PARP inhibitors Breast Cancer III
Ombrabulin Oncology(Anticancer) Inhibiting tubulin polymerization Non small cell lung cancer III
Alvocidib Oncology(Anticancer) Cyclin-dependent kinase inhibitor Chronic lymphocytic leukemia III
 Non-ST-elevation acute
Otamixaban Cardiovascular Inhibitor of Factor Xa coronary syndromes  III
Immunomodulatory drug inhibiting
Teriflunomide Neuroscience pyrimidine Rheumatoid arthritis III
Cabazitaxel Oncology(Anticancer) Tubulin inhibitor  Prostate cancer III
1st line Colorectal
Aflibercept Oncology(Anticancer) VEGF-Trap Cancer (combo) III
Celivarone Cardiovascular Ventricular Arrhythmia  II
Nerispirdine Neuroscience K+/Na+ channel blocker Multiple Sclerosis  II
Ferroquine Novel antimalarial drug Malaria  II
Prednisporin FDC prednisolone/ cyclosporine Allergic Conjunctivis  II
Selectively blocks coagulation
Idraparinux Cardiovascular factor Xa  Thromboembolism  III
Octaparine Cardiovascular Factor Xa Inhibitors  Thromboembolism  III

12 Takeda
Alogliptin Antidiabetes DPP-4 inhibitor class Type 2 Diabetes III
Cetilistat Metabolic Inhibitingpancreatic lipase  Obesity III
Azilsartan Cardiovascular  Angiotensin II receptor antagonist Hypertension III
Motesanib Oncology(Anticancer) Potent inhibitor of VEGFR1 lung cancer III
Tandutinib Oncology(Anticancer) Inhibitor of FLT3 kinase  Prostate Cancer  III
Diabetic peripheral
Ruboxistaurin Neuroscience  Inhibitor of protein kinase C-beta retinopathy III

Boehringer
13 Ingelheim
Stroke Prevention in
Dabigatran etexilate  Cardiovascular atrial fibrillation  III

Hypoactive
sexual desire
disorder (HSDD)
Flibanserin  Neuroscience 5-HT1A receptor agonist in pre-menopausal women III
Linagliptin Antidiabetes DPP-IV antagonist Type 2 Diabetes III
Non-small cell
Vargatef Oncology(Anticancer) Angiogenesis inhibition lung cancer (NSCLC) III
 Selective Calcitonin Gene-Related
Olcegepant Neuroscience Peptide (CGRP) antagonist  Acute Migraine III

Daiichi
14 Sankyo
AF/Stroke Prevention,
Edoxaban Cardiovascular Factor Xa inhibitor VTE/DVT,PE III

Amlodipine besylate +
Hydrochlorothiazide + Calcium channel blocker + Thhiazide +
Olmesartan  Cardiovascular Angiotensin 2 antagonist Hypertension Launched

15 Eisai
Perampanel Neuroscience Selective antagonist for the AMPA  Parkinson's disease III
Ranirestat Neuroscience Aldose reductase inhibitor. Diabetic Neuropathy III
Launched
Eslicarbazepine Neuroscience  Blocks voltage-gated sodium channels Epilepsy europe
Mitiglinide Antidiabetes  ATP-sensitive K(+) K(ATP) channels Type 2 Diabetes Launched
Iguratimod Anti-inflammatory  Immunomodulatory actions Rheumatoid arthritis  II
Eribulin Oncology(Anticancer) Inhibitor of microtubule dynamics Breast cancer III
Indislam Oncology(Anticancer) Cancer  II
Irofulven Oncology(Anticancer) Prostate cance  II
Eritoran TLR4 antagonist  Sepsis III
16 UCB
 Binding to the ubiquitous synaptic
 Brivaracetam Neuroscience vesicle protein SV2 Partial seizures III
17 Astellas
Vernakalant Cardiovascular Atrial fibrillation  II
 Mirabegron Urological Novel selective β3-AR agonis OAB( Over active bladder) III
Acotiamide Gastrointestinal Acetylcholinesterase inhibitor  Functional dyspepsia III
18 Alcon
Cilomilast Opthalmological  Phosphodiesterase-4 inhibitor Dry eye  II
Aganocide Opthalmological Eye infection  II

19 Allergan
Androgen Tear Opthalmological Ocular Surface Disease III
Diquafosol Opthalmological P2Y2 Receptor Dry eye disease  III
Apaziquone Oncology(Anticancer) Bladder cancer III

20 Forest lab
Serotonin-norepinephrine reuptake
Levomilnacipran Neuroscience inhibitor Depression III

Tinnitus, Alzheimer's disease,
drug addiction and as
Neramexane Neuroscience NMDA antagonist an analgesic. III
Cariprazine Neuroscience D2 and D3 antagonism Bipolar depression III
Radiprodil Neuroscience NMDA NR2B antagonist Neuropathic pain  II
Potent antagonism of human
Aclidinium bromide Respiratory system muscarinic receptors COPD III
Aclidinium + Formoterol Respiratory system COPD III
Ceftaroline Anti-infective Affinity to penicillin - binding proteins Pneumonia/skin infections III
Linaclotide acetate Gestrointestinal Constipation, IBS  II
Oglemilast Respiratory system PDE4 inhibitor Asthma/COPD  II
Dutogliptin Antidiabetes DPP-4 inhibitor Type 2 Diabetes III
21 Teva
Laquinimod Neuroscience Multiple sclerosis III

Epilepsy, malignant g
Noncompetitive antagonist of the  liomas and amyotrophic
Talampanel Neuroscience AMPA receptor lateral sclerosis (ALS)  II