REVITAL HEALTHCARE (EPZ) LTD.

T I T L E : SOP FOR CLEANING AND OPERATION OF MEMBRANE FILTRATION

UNIT.

PROCEDURE NO.: ISSUE DATE: EFFECTIVE DATE: NEXT REVIEW DATE:

RHEL/QA/SOP/218 01/09/2021 01/09/2021 01/09/2023

REVISION NO.:00

CLEANING AND OPERATION OF

THE MEMBRANE FILTRATION UNIT
PROCEDURE.

APPROVED BY: SIGN & DATE

Nandni Parmar
(Quality control-Microbiologist)
(Prepared By)

Kevin Mochama
(Quality Control Manager)
(Reviewed By)

Nancy Mwangi
(Ass. Quality Assurance Manager)
(Reviewed By)

Vikrant Chowgule
( Head Quality )
( Approved By )

P a g e 1 of 4
 REVITAL HEALTHCARE (EPZ) LTD.
T I T L E : SOP FOR CLEANING AND OPERATION OF MEMBRANE FILTRATION
UNIT.

PROCEDURE NO.: ISSUE DATE: EFFECTIVE DATE: NEXT REVIEW DATE:

RHEL/QA/SOP/218 01/09/2021 01/09/2021 01/09/2023

REVISION NO.:00

REVISION HISTORY
Revision No. Revised Page(s) Description Date
00 00 Original issue 01/09/2021

P a g e 2 of 4
 REVITAL HEALTHCARE (EPZ) LTD.
T I T L E : SOP FOR CLEANING AND OPERATION OF MEMBRANE FILTRATION
UNIT.

PROCEDURE NO.: ISSUE DATE: EFFECTIVE DATE: NEXT REVIEW DATE:

RHEL/QA/SOP/218 01/09/2021 01/09/2021 01/09/2023

REVISION NO.:00

PURPOSE:
To lay down a procedure for cleaning and operating of the membrane filtration unit.

SCOPE:
This SOP is applicable to the Microbiologists operating the membrane filtration unit.

RESPONSIBILITIES:
The membrane filtration unit operator follows the procedure for cleaning and operating the membrane
filtration unit.

ACCOUNTABILITY:
QC & QA Head shall be accountable for implementation of this SOP.

PROCEDURE
Installation :
 The MultiVac manifold can be connected with a vacuum pump for the filtration. It is always
recommended to install a waste bottle between the manifold and vacuum pump to prevent water
from flowing into the vacuum pump.
 The direction of the outlet of MultiVac manifold is interchangeable. You can disassemble the
outlet by hand or tool to change the direction into your desired position.
 The adjustable vent valve design can avoid “Water Hammer” and help to drain residual liquid
out of the tube.

Operation :
 Make sure all valves are off before use, rotate the valves counterclockwise to up position for
filtration.
 If water hammer effect happens during filtration, adjust the vent valve until smooth.
 After filtration, turn the vent valve counter-clockwise to draw out the remaining liquid if
necessary.

P a g e 3 of 4
 REVITAL HEALTHCARE (EPZ) LTD.
T I T L E : SOP FOR CLEANING AND OPERATION OF MEMBRANE FILTRATION
UNIT.

PROCEDURE NO.: ISSUE DATE: EFFECTIVE DATE: NEXT REVIEW DATE:

RHEL/QA/SOP/218 01/09/2021 01/09/2021 01/09/2023

REVISION NO.:00

 Tighten fixing screw with L-Type hex key (2mm) to prevent support base from rotation.

Maintenance :
 Suck in pure water to clean the tubing after every use.
 MultiVac manifold and waste bottle are autoclavable, thus, after every use they should be
sterilized by use of an autoclave.

REFERENCE:
User Manual.

ABBREVIATIONS:

QC- Quality Control.

QA- Quality Assurance.

SOP- Standard Operating Procedure.

P a g e 4 of 4