Professional Documents
Culture Documents
How Do You Effectively Evaluate The Elderly For Alcohol Use Disorder?
How Do You Effectively Evaluate The Elderly For Alcohol Use Disorder?
BRIEF ANSWERS
TO SPECIFIC
CLINICAL
QUESTIONS
Q: How do you effectively evaluate
the elderly for alcohol use disorder?
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.
FAGBEMI
cohol use due to changes in the pharmacoki- tial to identifying those who need treatment.
netics and pharmacodynamics of alcohol, re- This should be explored at every opportunity,
sulting in higher blood-alcohol levels. These such as visits for changes in health status or
are related to decreases in body water and medications and after major life events such as
body mass with age, hence a smaller volume of retirement or the loss of a spouse, in addition
distribution, increased sensitivity, and slower to routine health visits.
metabolism. Furthermore, many older adults The National Institute on Alcohol Abuse
tend to have multiple comorbidities such as and Alcoholism (NIAAA) and the Substance
hypertension, other cardiovascular problems, Abuse and Mental Health Service Adminis-
and diabetes that can worsen with chronic al- tration (SAMHSA) recommend that men
cohol use, as well as having drug-drug interac- and women age 65 and older consume no
tions from multiple medications.7,8 more than 1 standard drink per day or 7 stan-
dard drinks per week,12,13 unlike the guidelines
■ UNDERSTANDING THE TYPES OF AUD for adults younger than age 65, which are as
IN OLDER ADULTS follows: for women, no more than 1 standard
drink per day or 7 standard drinks per week;
Older individuals who meet AUD criteria
for men, no more than 2 standard drinks per
can be divided into 2 groups: those who de-
day and not more than 14 standard drinks per
veloped AUD before age 60, and those who
week.12–15 The NIAAA defines “risky use” as
developed it after age 60. Patients with earlier
exceeding the recommended limits of 4 drinks
onset of AUD account for about two-thirds of
per day (56 g/d based on the US standard of 14
the elderly AUD population and have a more
g of ethanol per drink) or 14 drinks per week
severe course of illness. They also tend to be
(196 g/d) for healthy adult men ages 21 to 64,
predominately male and have more alcohol-
or 3 drinks per day or 7 drinks per week (42
related medical and psychiatric comorbidities,
g/d or 98 g/week) for all adult women of any
including being less well-adjusted and having
age and men age 65 or older.16 In addition,
more antisocial traits. Those with later onset
older men should not consume more than 4
of AUD tend to have a milder clinical picture
standard drinks on any day. (A standard drink Older adults
and few medical problems, possibly because of
containing 12 to 14 g of ethanol is equivalent can experience
the shorter exposure to alcohol. These patients
to a 12-oz can of beer, a 5-oz glass of wine, or
also tend to be women, are more affluent, and more problems
about 1.5 oz of 80-proof liquor.)
are likely to have begun alcohol misuse after a
Screening questions should be asked in a with small
stressful event such as the loss of a spouse, job,
confidential setting and in a nonthreatening,
or home, or retirement. Hence, it is necessary
nonjudgmental manner. Note that a patient amounts
to explore these areas when taking the history.
Other risk factors for development of later
may have cognitive impairment that inter- of alcohol
feres with the ability to provide complete and
onset of AUD, apart from personal and fam-
accurate responses during the medical history,
ily history of AUD, include onset of chronic
as well as to self-monitor alcohol intake and
pain, predisposition to affective or anxiety understand feedback from healthcare provid-
disorders, and decreased alcohol metabolism ers.10 This may necessitate involving family
with age.7,9,10 members or friends after discussing permission
with the patient.
■ SCREENING: ASK ABOUT DRINKING Formal screening tools for identifying al-
The United States Preventive Services Task cohol misuse should be used at every oppor-
Force recommends screening adults age 18 tunity as they are brief, easy to recall, and
and older for alcohol misuse and providing highly sensitive and specific. They can be
those engaged in risky or hazardous drinking self-administered by the patient while waiting
(a pattern of drinking that increases the risk of in the doctor’s office and reviewed during the
physical or psychological problems) with brief face-to-face encounter. Commonly used tools
behavioral counseling interventions to reduce include:
alcohol misuse.11 Given the high use of medi- • CAGE (cut-annoyed-guilty-eye), a simple
cal services by the elderly, clinicians are essen- 4-item yes-or-no questionnaire
CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 88 • NUMBER 8 AUGUST 2021 435
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.
ALCOHOL USE DISORDER
TABLE 2
Short Michigan Alcoholism Screening Test—Geriatric Version (SMAST-G)
Please answer yes or no to the following quesƟons:
1. When talking with others, do you ever underestimate how much you drink?
2. After a few drinks, have you sometimes not eaten or been able to skip a meal because you didn’t feel hungry?
3. Does having a few drinks help decrease your shakiness or tremors?
4. Does alcohol sometimes make it hard for you to remember parts of the day or night?
5. Do you usually take a drink to relax or calm your nerves?
6. Do you drink to take your mind off your problems?
7. Have you ever increased your drinking after experiencing a loss in your life?
8. Has a doctor or nurse ever said they were worried or concerned about your drinking?
9. Have you ever made rules to manage your drinking?
10. When you feel lonely, does having a drink help?
Extra question (asked, but not calculated in the final score): Do you drink alcohol and take mood or mind-altering
drugs, including prescription tranquilizers, prescription sleeping pills, prescription pain pills, or any illicit drugs?
Scoring: 1 point for each “yes” answer, and total the responses. A score of 2 or more points indicates an alcohol problem,
and a brief intervention should be conducted.
Adapted from reference 17.
• AUDIT (Alcohol Use Disorder Identi- defined as mild for the presence of 2 to 3 symp-
Hypertension, fication Test), with good sensitivity and toms, moderate for 4 to 5 symptoms, or severe
cardiovascular specificity, or its shorter version AUDIT-C for 6 or more symptoms.
disease, and questionnaire, which is good at identifying Assessment and diagnosis provide data
those with hazardous drinking for a comprehensive and effective treatment
diabetes can • MAST-G (Michigan Alcohol Screening plan, a process called SBIRT (screening, brief
worsen with Test–Geriatric Version) and its shorter intervention, and referral to treatment). Plans
version (SMAST-G), shown in Table 2.17 range from simple brief intervention in the
chronic alcohol MAST-G and SMAST-G were designed clinic to admission to a medically managed
use for older patients who drink less and are bet- facility. After discharge, older patients with
ter than the CAGE tool at identifying older AUD need to participate in alcohol treatment
adults with AUD.18 Using more than 1 screen- programs with a focus specific to the elderly
ing tool can provide more data on alcohol that incorporates both pharmacologic treat-
quantity consumed, alcohol use patterns, and ment and nonpharmacologic treatments, and
alcohol-related consequences, which may to participate in support groups such as Alco-
help identify AUD in older patients across holics Anonymous. Other treatment options
a wide range of demographic characteristics. are cognitive behavior therapy and motiva-
SAMHSA has published a compilation of tional interviewing techniques and admission
these instruments.19 to a therapeutic community.
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.
FAGBEMI
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.
ALCOHOL USE DISORDER
principle of “start low, go slow” and should been found to reduce alcohol consumption
be closely monitored for early detection of and increase abstinence rates.27 It is renally ex-
adverse effects such as cognitive impairment, creted unmetabolized; thus, before prescribing
hypotension, and falls.5 it, the patient’s renal function should be deter-
mined, as renal dysfunction is not uncommon
Naltrexone in the elderly. Acamprosate is most effective
Studies have shown that pharmacotherapy at maintaining abstinence in patients who are
such as naltrexone, which is thought to block not currently drinking alcohol.27,28
the endogenous opioid system contribution to
alcohol priming effects, can be an important Disulfiram
ally in preventing relapse when used in con- The evidence is inconsistent on the efficacy of
junction with behavioral interventions and disulfiram, the only alcohol-sensitizing medi-
treatments.26 The oral dose approved by the cation FDA-approved to treat AUD in the
US Food and Drug Administration (FDA) is elderly. It decreases alcohol consumption by
50 mg daily, but it can be initiated at 25 mg/ irreversibly binding with the enzyme aldehyde
day with a 25-mg/day increase as often as dehydrogenase, hence causing a disulfiram-
weekly, to a maximum of 150 mg/day, using ethanol reaction. Daily dosage ranges from
desire-to-drink and other patient symptoms as 250 mg to 500 mg.
a measure of relative risk of relapse to heavy Factors that make disulfiram a less suit-
drinking. able choice for many older patients with AUD
Compared with placebo, naltrexone has include problems with adherence and serious
been found to be well tolerated, with no sig- adverse effects (drowsiness, optic neuritis,
nificant differences in frequency of self-report- peripheral neuropathy, hepatotoxicity). It is
ed adverse effects or in liver enzyme values. contraindicated in patients with history of sei-
But treatment has resulted in reduced craving zure, psychosis, or cerebrovascular accident,
for alcohol, as well as in fewer drinking days and in those not willing to achieve complete
and relapse events.26 abstinence.5,28
Long-acting naltrexone, available as a
380-mg dose given every 4 weeks as a deep ■ THE BOTTOM LINE
intramuscular gluteal injection, is an alterna- AUD is a significant problem in the elderly,
tive, especially if patients do not adhere to the and as this segment of the population contin-
daily oral regimen. Avoid long-acting naltrex- ues to grow, we can expect to see more elderly
one in patients taking opioids and in those patients with AUD. Fortunately, studies have
with elevated levels of liver enzymes. shown that elderly patients with AUD have
very good outcomes when it is diagnosed and
Acamprosate treatment is initiated, especially with age-
Another medication useful in AUD reha- specific care and programming. It behooves
bilitation is acamprosate, an amino acid de- clinicians to be knowledgeable about the pre-
rivative that fosters gamma-aminobutyric acid sentations, screening, and assessment of AUD
neurotransmission. It seems to interact with in the elderly, with the goal of timely inter-
glutamate at the N-methyl-d-aspartate recep- ventions and referral to appropriate care. ■
tor, although its exact mechanism is unclear.
It is an alternative and has an FDA-approved ■ DISCLOSURES
dosing of 1,998 mg/day, usually administered The authors report no relevant financial relationships which, in the context
as two 333-mg capsules 3 times a day. It has of their contributions, could be perceived as a potential conflict of interest.
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.
FAGBEMI
Downloaded from www.ccjm.org on December 21, 2021. For personal use only. All other uses require permission.