Leukemia

Which of the given values represents the minimum percentage of blast cells in
acute leukemia?
• Greater than 20%
Which of the following is NOT seen in bone marrow failure secondary to
leukemia
• Clock-face plasma cells
According to FAB classification, how many subtypes of AML are there?
• 8
Which of the following is responsible for the maturation and release of
eosinophils from the bone marrow?
Interleukin-5

Which of the given interleukin families stimulates the differentiation of

multipotent hematopoietic stem cells into myeloid progenitor cells?
Interleukin-3
Which of the following cytogenetic abnormalities are associated with acute
promyelocytic leukemia?
t(15;17)
Which of the following translocations is associated with acute myeloblastic
leukemia?
t(8;21)
Which of the given values represents the percentage of blast cells in pre-
leukemic conditions, such as AML?
Greater than 10% less than 20%
Which of the following is seen in acute promyelocytic Leukemia-M3
Auer rods
What does the FAB classification categorize M6 as?
Acute erythroid leukemia

Which of the following subtypes corresponds to acute promyelocytic

leukemia?
FAB subtype M3
Which of the following classes of acute myeloid leukemia can be treated with
all-trans retinoic acid?

Acute promyelocytic leukemia

To which of the following body parts is lymphoblastic lymphoma more likely to

metastasize?

Testicles

Which of the given factors is associated with a good prognosis in acute

lymphoblastic leukemia
Precursor B acute lymphoblastic leukemia

Which of the following translocations is associated with chronic myelogenous

leukemia?

t(9;22)
Which of the given enzymes is a product of the BCR-ABL fusion gene?
Tyrosine kinase
Which of the following drugs is used in the treatment of chronic myelogenous
leukemia?
Imatinib
Which of the following is least likely to be associated with chronic lymphoid
leukemia?
Polycythemia vera
Into what kind of aggressive lymphoma is chronic lymphocytic leukemia most
commonly transformed in Richter syndrome?
Diffuse large b-cell lymphoma
Which of the following cells are most often associated with chronic
lymphocytic leukemia?
Smudge cells

Which of the given etiological factors causes increased levels of circulating

red blood cells, independent of erythropoietin production?
Polycythemia vera
Which of the following conditions features a prickly sensation after a hot bath?
Polycythemia vera
Which of the following is NOT associated with secondary polycythemia?
Myeloproliferative disease
Which of the given conditions is NOT caused by polycythemia vera?
Thrombocytopenia
What do you call the type of polycythemia that results from plasma volume
depletion?
Relative polycythemia

Which of the following types of leukemia is most commonly seen in children?

Acute lymphoblastic leukemia
Which of the following types of leukemia has excellent prognosis
Acute lymphoblastic leukemia
What is one of the effects of antimetabolites?
Inhibit DNA replication
Which of the given drugs inhibits post-translational modification?
Etoposide
Which of the following is inhibited by Etoposide?
Topoisomerase II
Which of the following inhibits dihydrofolate reductase?
Methotrexate
Which of the following are inhibited by 5-fluorouracil?
Thymidylate synthase
What is the mechanism of action of 6-mercaptopurine
Decrease in purine synthesis
What is the mechanism of action of Cytarabine?
Inhibits DNA polymerase
Which of the following drugs is cardiotoxic?
Doxorubicin
Which of the following cancer types is best treated with Imatinib?
Chronic myelogenous leukemia
Which of the following drugs causes minimal myelosuppression?
Bleomycin
What is the mechanism of action of Busulfan?
Alkylates DNA
What is the most commonly used glucocorticoid in cancer chemotherapy
Prednisone
Infection with which of the following pathogens is particularly associated with
posttransplant lymphoma?
Epstein–Barr virus
Which of the following tumors is INCORRECTLY matched to the associated
progenitor cells?
Lymphoma - myeloid progenitors

Leukemia –
• lymphoid progenitors
• myeloid progenitors
Lymphoma
• lymphatic system
Myeloma
• plasma cells
A patient presents with large numbers of mature B cells in his serum. Which of
the following is the most likely diagnosis?
• Chronic lymphocytic leukemia
Which of the following best describes paraproteins?
Monoclonal immunoglobulins or immunoglobulin fractions that are produced
by a clonal population of B-cell lineage cells