Barbiturates and benzodiazepines are commonly used sedative and hypnotic drugs. Barbiturates work by enhancing GABA activity at GABA-A receptors, while benzodiazepines bind to a separate site on GABA-A receptors to produce similar sedative effects. 'Z drugs' like zolpidem are non-benzodiazepine hypnotics that have advantages over benzodiazepines like less daytime drowsiness. Sedative and hypnotic drugs can disrupt normal sleep architecture by decreasing sleep onset latency, suppressing REM sleep, and reducing overall sleep time.
Barbiturates and benzodiazepines are commonly used sedative and hypnotic drugs. Barbiturates work by enhancing GABA activity at GABA-A receptors, while benzodiazepines bind to a separate site on GABA-A receptors to produce similar sedative effects. 'Z drugs' like zolpidem are non-benzodiazepine hypnotics that have advantages over benzodiazepines like less daytime drowsiness. Sedative and hypnotic drugs can disrupt normal sleep architecture by decreasing sleep onset latency, suppressing REM sleep, and reducing overall sleep time.
Barbiturates and benzodiazepines are commonly used sedative and hypnotic drugs. Barbiturates work by enhancing GABA activity at GABA-A receptors, while benzodiazepines bind to a separate site on GABA-A receptors to produce similar sedative effects. 'Z drugs' like zolpidem are non-benzodiazepine hypnotics that have advantages over benzodiazepines like less daytime drowsiness. Sedative and hypnotic drugs can disrupt normal sleep architecture by decreasing sleep onset latency, suppressing REM sleep, and reducing overall sleep time.
1. Enumerate Barbiturates. Which Barbiturates are used now-a-days in your hospital?
2. Mechanism of action (in 2-3 lines). What is the difference between MOA of Barbiturates and Benzodiazepines? 3. Classify Benzodiazepines (based on their uses) 4. Examples of BZD receptor antagonist & Inverse agonist 5. What are the disadvantages of Barbiturates compared to Benzodiazepines? 6. What is ‘Z’ drug? / Enumerate few non-Benzodiazepine hypnotic drugs. What are their advantages over Benzodiazepines? 7. Enumerate few drugs, which act on BZD receptor apart from Barbiturates and Benzodiazepines. 8. How Sedative & Hypnotics affect sleep architecture?