Courses Under Management Field

SCHOOL OF BIOTECHNOLOGY,
CHEMICAL & BIOMEDICAL ENGINEERING

Vellore 632 014, Tamil Nadu, India.
Sylla b us & Curric ulum 2008

B.Te c h. Bio te c hno lo g y
Table of Contents
Courses under Engineering field................................................................................................3
Courses under Hum anit ies field .................................................................................................4
Courses under Managem ent Field ............................................................................................4
Courses under Science Field ........................................................................................................5
Proport ion of credit s based on field of specializat ion ..................................................5
COURSES ARRANGED ACCORDI NG TO PROGRAMME COMPONENT ............................. 6
Universit y Core .....................................................................................................................................6
Universit y Elect ives ............................................................................................................................6
Program m e Core ..................................................................................................................................7
Program m e Elect ives ........................................................................................................................8
DETAI LED SYLLABUS..................................................................................................................................... 9
Universit y Core .....................................................................................................................................9
Com prehensive Exam inat ion ........................................................................................................... 9
I nt roduct ion t o Com put ers and Problem Solving .............................................................10
Effect ive English ....................................................................................................................................11
English for Engineers –I ...................................................................................................................13
English for Engineers- I I ..................................................................................................................14
Environm ent al St udies ......................................................................................................................16
Et hics and values ..................................................................................................................................18
Foreign Language .................................................................................................................................19
Modern Physics.......................................................................................................................................20
Mult ivariable calculus and different ial equat ions .............................................................21
Universit y Elect ives ..........................................................................................................................23
Creat ivit y and I nnovat ion in Managem ent ...........................................................................23
Managem ent I nform at ion Syst em .............................................................................................23
Proj ect Form ulat ion: I m plem ent at ion and Cont rol .......................................................23
Self Developm ent .................................................................................................................................23
Tot al Qualit y Managem ent ..............................................................................................................23
Program m e Core ................................................................................................................................24
Analyt ical Techniques in Biot echnology .................................................................................24
Anim al Physiology and Biot echnology .....................................................................................26
Basic Elect rical & Elect ronics Engineering ............................................................................27
Basic Mat hem at ics................................................................................................................................28
BI T102 .........................................................................................................................................................30
Biochem ist ry ............................................................................................................................................30
Bioet hics and I PR..................................................................................................................................32
Bioinform at ics..........................................................................................................................................34
Biophysics ..................................................................................................................................................36
1 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Bioprocess Econom ics and Plant Design ................................................................................37

Bioprocess Engineering .....................................................................................................................38
Biost at ist ics...............................................................................................................................................40
Cancer Biology ........................................................................................................................................42
Cell Biology and Genet ics ................................................................................................................43
Chem ical React ion Engineering and Unit Operat ions ..................................................45
Downst ream Processing ...................................................................................................................45
Engineering Graphics .........................................................................................................................48
Ent repreneurship...................................................................................................................................49
Environm ent al Biot echnology .......................................................................................................50
Food Biot echnology .............................................................................................................................50
Fundam ent als of Behavioural Science ....................................................................................52
Genet ic Engineering and Genom ics ..........................................................................................53
I m m unology and I m m uno- t echnology ...................................................................................55
I ndust rial Biot echnology...................................................................................................................57
I ndust rial Training ................................................................................................................................59
I nt roduct ion t o Life Sciences.........................................................................................................60
Microbiology .............................................................................................................................................61
Molecular Biology ................................................................................................................................63
Nanobiot echnology ..............................................................................................................................65
Organic Chem ist ry ................................................................................................................................66
Pharm aceut ical Biot echnology......................................................................................................68
Plant physiology and biot echnology .........................................................................................69
Principles of Chem ical Engineering ...........................................................................................71
Principles of Managem ent ...............................................................................................................73
Proj ect Work .............................................................................................................................................74
Probabilit y and St at ist ics .................................................................................................................75
Prot ein Engineering and Prot eom ics.........................................................................................76
Workshop Pract ice................................................................................................................................78
PROGRAMME ELECTI VES ..............................................................................................................79
Biobusiness ...............................................................................................................................................79
Biom at erials & Art ificial Organs...................................................................................................80
BioMEMS .....................................................................................................................................................81
Biological Spect roscopy ....................................................................................................................82
Com put er Sim ulat ion and Molecular Modeling ..................................................................83
Developm ent al Biology......................................................................................................................84
I ndust rial Enzym ology .......................................................................................................................85
Medical diagnost ics ..............................................................................................................................86
Met abolic Engineering ........................................................................................................................88
Molecular Modeling and Drug Design ......................................................................................89
St ruct ural Biology .................................................................................................................................90
Tissue Engineering ...............................................................................................................................91

COURSES ARRANGED ACCORDING TO

FIELD OF SPECILIZATION
(Abbreviations: L – Lecture hours; T – tutorial hour one unit is one credit ; P – Practical hour one
unit is half a credit; C – total credits. Field abbreviations: Eng - Engineering; Hum – Humanities;
Sci – Science; Mgmt – Management; Components: PC – Programme Core; PE – Programme
Elective; UC - University Core; UE – University Elective )
Courses under Engineering field
Sl.No. Title L T P C Component
1. Analytical Techniques in Biotechnology 3 0 4 5 PC
2. Animal Physiology and Biotechnology 3 0 0 3 PC
3. Basic Electrical and Electronics Engineering 3 0 2 4 PC
4. Bioinformatics 3 0 2 4 PC
5. Bioprocess Engineering 3 0 4 5 PC
6. Cancer Biology 3 0 0 3 PC
7. Cell Biology and Genetics 3 0 2 4 PC
8. Chemical Reaction Engineering & Unit 3 0 0 3 PC
Operations
9. Comprehension 0 0 0 2 PC
10. Computer Programming and Problem Solving 2 0 2 3 PC
11. Downstream Processing 3 0 4 5 PC
12. Electives I 3 0 0 3 PE
13. Electives II 3 0 0 3 PE
14. Electives III 3 0 0 3 PE
15. Engineering Graphics I 0 0 4 2 PC
16. Environmental Biotechnology 3 0 0 3 PC
17. Food Biotechnology 3 0 0 3 PC
18. Genetic Engineering & Genomics 3 0 4 5 PC
19. Immunology & Immunotechnology 3 0 2 4 PC
20. Industrial Biotechnology 3 0 0 3 PC
21. Industrial Training (4 Weeks) 0 0 0 2 PC
22. Microbiology 3 0 4 5 PC
23. Molecular Biology 3 0 4 5 PC
24. Nanobiotechnology 3 0 0 3 PC
25. Pharmaceutical Biotechnology 3 0 0 3 PC
26. Plant Physiology and Biotechnology 3 0 0 3 PC
27. Principles of Chemical Engineering 3 0 2 4 PC
28. Project Work 0 0 0 20 PC
29. Proteomics & Protein Engineering 3 0 0 3 PC
30. Workshop Practice 0 0 2 1 PC
Total Credits 119

List of electives
1. Biobusiness 3 0 0 3 PE
2. Biomaterials & Artificial Organs 3 0 0 3 PE
3. BioMEMS 3 0 0 3 PE
4. Biological Spectroscopy 3 0 0 3 PE
5. Computer Simulation and Molecular 3 0 0 3 PE
Modeling
6. Developmental Biology 3 0 0 3 PE
7. Industrial Enzymology 3 0 0 3 PE
8. Medical Diagnostics 3 0 0 3 PE
9. Metabolic Engineering 3 0 0 3 PE
10. Molecular Modeling and Drug Design 3 0 0 3 PE
11. Structural Biology 3 0 0 3 PE
12. Tissue Engineering 3 0 0 3 PE
Total (Limited to 9; 6 credits of programme UE
elective and 3 credits university elective)
Total and percent credits from Engg. 115 63.8 %
Courses under Humanities field

1. Effective English* 3 0 0 3 UC
2. English for Engineers I 3 0 0 3 PC
3. English for Engineers II 3 0 0 3 UC
4. Foreign Language 2 0 0 2 UC
5. Environmental Studies 3 0 0 3 UC
6. Fundamentals of Behavioural Science 3 0 0 3 UC
Total and percent of credits from Science 14 7.7 %
* To be undertaken by need based students
Courses under Management Field

Title L T P C Component
1. Bioprocess Economics & Plant Design 2 1 0 3 PC
2. Biobusiness 3 0 0 3 UE
3. Entrepreneurship 3 0 0 3 PC
4. Bioethics & IPR 3 0 0 3 UC
5. Principles of Management 3 0 0 3 PC
6. Project Formulation: Implementation and 3 0 0 3 UE
Control

7. Self Development 3 0 0 3 UE
8. Management Information System 3 0 0 3 UE
9. Creativity and Innovation in Management 3 0 0 3 UE
10. Total Quality Management 3 0 0 3 UE
Total (limited to 12 core + 3 elective ) 15 8.3 %
Courses under Science Field

Title L T P C Component
1. Basic Mathematics 3 1 0 4 PC
2. Biochemistry 4 0 2 5 PC
3. Biophysics 3 0 0 3 PC
4. Introduction to Life Sciences (in lieu of basic 4 0 0 4 PC
maths)
5. Multivariate Calculus and Differential Equations 3 1 0 4 PC
6. Modern Physics 3 0 2 4 PC
7. Organic Chemistry / Engineering Chemistry 2 1 2 4 PC
8. Probability and Statistics 3 1 0 4 PC
9. Biostatistics 3 1 0 4
Total & percentage 32 17.7 %
Total Credits 180
Proportion of credits based on field of specialization

Field Allocated Credits Recommended % Actual %
Engineering 119 64 66.1
Humanities 14 8 7.8
Management 15 8 8.3
Science 32 20 17.8
Total 180 100 100.0

COURSES ARRANGED ACCORDING TO

PROGRAMME COMPONENT
(Field abbreviations: Engg - Engineering; Hum – Humanities; Sci – Science; Mgt – Management)
University Core
Sl. No. Course L T P C Field
1. Comprehension Examination 0 0 0 2 Engg.
2. Computer Programming and Problem Solving 2 0 2 3 Engg.
3. English for Engineers I 3 0 0 3 Hum
4. English for Engineers II 3 0 0 3 Hum
5. Environmental Studies 3 0 0 3 Sci
6. Bioethics and IPR 3 0 0 3 Mgmt.
7. Foreign Language 2 0 0 2 Hum
8. Modern Physics 3 0 2 4 Sci
9. Multivariate Calculus and Differential 3 1 0 4 Sci
Equations
Credits 27
University Electives
Sl.No. Course L T P C Field
1. Project Formulation: Implementation and 3 0 0 3 Mgmt.
Control
2. Self Development 3 0 0 3 Mgmt.
3. Management Information System 3 0 0 3 Mgmt.
4. Creativity and Innovation in Management 3 0 0 3 Mgmt.
5. Total Quality Management 3 0 0 3 Mgmt.
*Total Limited to 6
*With the condition out the total 6 credits of University Elective, 3 credits should be from the field
of Engineering and 3 credits from Management;
Other courses declared as University Elective can also be taken in lieu of the above courses subject
to the above condition.

Programme Core
Sl.No. Course L T P C Field
1. Analytical Techniques in Biotechnology 3 0 4 5 Engg.
2. Animal Physiology and Biotechnology 3 0 0 3 Engg.
3. Basic Electrical and Electronics Engineering 3 0 2 4 Engg.
4. Basic Mathematics 3 1 0 4 Sci
5. Biochemistry 3 1 3 5 Sci
6. Bioethics and IPR 3 0 0 3 Hum
7. Bioinformatics 3 0 2 4 Engg.
8. Biophysics 3 0 0 3 Sci
9. Bioprocess Economics & Plant Design 2 1 0 3 Mgmt.
10. Bioprocess Engineering 3 0 4 5 Engg.
11. Cancer Biology 3 0 0 3 Engg.
12. Cell Biology and Genetics 3 0 3 4 Sci
13. Chemical Reaction Engineering & Unit 3 0 0 3 Engg.
Operations
14. Downstream Processing 3 0 4 5 Engg.
15. Engineering Graphics I 0 0 4 2 Engg.
16. Entrepreneurship 3 0 0 3 Mgmt.
17. Environmental Biotechnology 3 0 0 3 Eng
18. Food Biotechnology 3 0 0 3 Engg.
19. Fundamentals of Behavioural Science 3 0 0 3 Hum
20. Genetic Engineering & Genomics 3 0 4 5 Engg.
21. Immunology & Immunotechnology 3 0 3 4 Engg.
22. Industrial Biotechnology 3 0 0 3 Engg.
23. Industrial Training (4 Weeks) 0 0 0 2 Engg.
24. Introduction to Life Sciences (in lieu of basic 4 0 0 4 Sci.
mathematics)
25. Microbiology 3 0 4 5 Engg.
26. Molecular Biology 3 0 4 5 Engg.
27. Nanobiotechnology 3 0 0 3 Engg.
28. Organic Chemistry 2 1 2 4 Sci.
29. Pharmaceutical Biotechnology 3 0 0 3 Engg.
30. Plant Physiology and Biotechnology 3 0 0 3 Engg.
31. Principles of Chemical Engineering 3 0 2 4 Engg.
32. Principles of Management 3 0 0 3 Mgmt.
33. Probability and Statistics / Biostatistics 3 1 0 4 Sci.
34. Project Work 0 0 0 20 Engg.
35. Protein Engineering & Proteomics 3 0 0 3 Engg.
36. Workshop Practice 0 0 2 1 Engg.
Total 156

Programme Electives

1. Biobusiness 3 0 0 3 Engg.
2. Biomaterials & Artificial Organs 3 0 0 3 Engg.
3. BioMEMS 3 0 0 3 Engg.
4. Biological Spectroscopy 3 0 0 3 Engg.
5. Computer Simulation and Molecular Modeling 3 0 0 3 Engg.
6. Developmental Biology 3 0 0 3 Engg.
7. Industrial Enzymology 3 0 0 3 Engg.
8. Medical Diagnostics 3 0 0 3 Engg.
9. Metabolic Engineering 3 0 0 3 Engg.
10. Molecular Modeling and Drug Design 3 0 0 3 Engg.
11. Structural Biology 3 0 0 3 Engg.
12. Tissue Engineering 3 0 0 3 Engg.
Total (Limited to 9; 6 credits of programme elective and 3 credits from any of university
engineering elective)
Total and percent credits from Engg. 119 66.1 %

DETAILED SYLLABUS
University Core
Comprehensive Examination LTPC: 0 0 0 2

Version No. 1.0.0
Course Prerequisites Completion all program core engineering courses
Objectives: To test the students’ understanding, integration and application
knowledge into viable technology
Expected Outcome: The student will learn to think in holistic view to solve problems by
applying biotechnology.
Text Books Text books as prescribed in the programme core component
References Text books as prescribed in the programme core component
Mode of Evaluation Written Examinations/ viva voce /
Recommended by the Board of Studies on 13th November, 2008
Date of Approval by the Academic Council

L T P C
CSE 101 Introduction to Computers and Problem Solving 2 0 2 3
Version No. 1.0
Course Prerequisites +2 Physics/Chemistry
Objectives To provide an overview of computers and problem solving methods using ‘C’
Language to serve as a foundation for the study of programming languages.
Expected Outcome The student would acquire various problem solving techniques and will be able to
implement them in ‘C’ language.
Unit I Introduction to Computers and Algorithms 6h
Parts of a computer – Overview of operating systems, compilers, interpreters and programming languages.
Algorithms for exchanging the values of two variables, counting, summation of a set of numbers, factorial
computation, sine function computation, generation of the Fibonacci sequence, reversing the digits of an integer,
base conversion and character to number conversion.
Unit II Constructs of C 5h
Lexical elements – Operators - data types – I/O statements – format specifications – control statements –
decision making and looping.
Unit III Arrays 7h
Array handling in C – declaration – single dimensional arrays, two – dimensional arrays, multi-dimensional arrays,
sorting and searching on single and two dimensional arrays. Array order reversal, array counting or
histogramming, finding the maximum number in a set, removal of duplicates from an ordered array, partition an
array, finding the kth smallest element strings: Character array – string handling functions – manipulation on
strings.
Unit IV Functions 6
Prototype – declaration - arguments (formal and actual) – return types – types of functions difference between
built-in and user-defined functions.
Unit V Structures 6
Declarations - nested structures- array of structures - structure to functions - unions- difference between structure
and union
Text Books 1. Alexis Leon and Mathews Leon (2001), Introduction to Information Technology,
Tata McGraw-Hill.
2. R.G. Dromey (2001), How to Solve it by Computer, Prentice Hall of India.
3. Al Kelley and Ira Pohl (1998), A Book on C Programming in C, 4th Edition,
Pearson Education.
Reference Books
Mode of Evaluation Written Examination/ Quiz/ Assignments / Seminar
Recommendation by
Board of Studies on
Date of approval by the 24.05.2007
Academic Council

L T P C
ENG001 Effective English 2 0 0 2
Version No. 1.0
Prerequisites +2
Objectives To help the second language learners to acquire confidence in their basic
writing and speaking onp the campus.
To enable the students to acquire structure and written expressions required
for their profession.
Expected The learners will get the required training in LSRW through the given tasks.
Outcome
Unit 1 10
Speaking a. Introduction and greetings; b. Asking/Offering information;.
c. Requesting/Inviting
Writing a. Making meaningful sentences from the jumbled words
b. Development of basic writing skills applying studied grammatical
structures
c. Hints development
Functional CORRECTIVE GRAMMAR I
Skills Parts of Speech
Unit 2 10
Speaking a. Integrated interrogative and discourse use with targeted vocabulary
and functions.
b. Communicative and decision making activities based on authentic
reading materials
c. Authentic video materials to improve extraction of information form the
given source.
Writing a. Rewriting the given texts following the prompts
b. Instructional writing skills
c. Illustrative and descriptive writing
Functional CORRECTIVE GRAMMAR II
Skills Concord
Unit 3 10
Speaking a. Role-plays in various life like situations
b. Debating to express points of view
c. Project development in groups and pair-work to increase communication
practice
Writing a. Critical appreciation of the given text
b. Narrative written structures to express past events
c. Written communication for task oriented goals
Functional Skills CORRECTIVE GRAMMAR III
Tenses
Text Books A Foundation English course for Undergraduates, Prof. K.A. Jayaseelan,
CIEFL, Hyderabad, 2003
Speak with Confidence, Dianna Booher, TATA McGraw-Hill, 2005.
Strengthen Your English, Bhaskaran & Horsburgh, Oxford University
Press
Reference Books 1. English Vocabulary in Use Advanced, Michael McCarthy and Felicity,

Cambridge University Press, 2003

2. Basic Communication Skills for Technology, Andrea J. Rutherfoord,
Pearson Education Asia.
3. Murphy’s English Grammar with CD, Murphy, Cambridge University
Press.
4. English Skills for Technical Students, WBSCTE with British Council,
Orient Longman
5. Everyday Dialogues in English by Robert J. Dixson, Prentice Hall of
India Ltd, 2006.
6. Spoken English (CIEFL) in 3 volumes with 6 cassettes, OUP.
7. English Pronouncing Dictionary by Daniel Jones, Current Edition
with CD.
8. Language in Use, Adrian Doff and Chris Jones, Cambridge
University Press, 2006.
Mode of Evaluation Writing and Speaking Skills tests, Quizzes,
Assignments, Seminars.
Recommended by the board of studies 25.4.2008
Date of approval by the academic council 16.6.2008

English for Engineers –I LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites +2
Objectives: To help the second language learners to acquire fluency in spoken and written
English to communicate with clarity and precision in the workplace.
To give the students a perspective to appreciate life in its variables by exposing
them to comprehension texts to enrich their word power.
To enable the students to acquire structure and written expression required for
their profession.
Expected Outcome The learners will get the required training in LSRW through the prescribed texts.
Unit No. 1 Number of hours: 14
Communication Skills Aspects of Communication and Body Language
Textual Comprehension Text 1,2
Structure and Word Magic Tenses, Concord, Tag Question; Word formation
Stylistic Expression Paragraph Writing, cloze test, Informal letter writing and email
Communication Skills Listening and Interpersonal Communication Skills
Structure and Word Magic Voice, Conditionals, Transformation of sentences; Work&Study
Stylistic Expression General Essay, Note Making
Unit No. 3 Cardio respiratory System Number of hours: 14
Communication Skills Speaking and Group Discussion
Structure and Word Magic Answer as Directed; Leisure and lifestyle
Stylistic Expression Reading Comprehension
References English for Professionals, Book 1 Ed., Faculty, English – SSH, VIT.
Communication Skills for Engineers, Sunita Mishra and C.Muralikrishna
VIT Workbook, 2008 (for Semesters I & II) Functional Grammar & Composition by R.
Srinivasan, M.Sahul Hameed.
English Vocabulary in Use Advanced, Michael McCarthy and Felicity,
Cambridge University Press, 2003.
Developing Communication Skills, Krishna Mohan and Meera
Bannerji, Macmillan India Ltd. 1997
Essential English Grammar, Murphy, CUP, 2006.
Language in Use, Adrian Doff and Chris Jones, Cambridge University Press, 2006.
Crystal Clear Communication, Kris Cole, East West Book, 2005.
Mode of Evaluation Writing and Speaking Skills tests, Quizzes, Assignments, Seminars.
Recommended by the 25.4.2008

Board of Studies on
Date of Approval by the 16.6.2008
Academic Council

LTPC: 3 0 0 3
English for Engineers- II
Version No. 2
Course Prerequisites +2
Objectives: 1. To make the students communicate in English for academic and
social purpose.
2. To develop the ability to write assignments in a style that is
appropriate for university study or within a training context.
3. To develop the ability to understand spoken language in both
lecture format, formal and informal conversational styles.
4. To develop the ability to speak on general and specific topics in real
life situations.
Expected Outcome: The learners will get the required training in LSRW through the
prescribed texts.
They will also have a holistic outlook as they go into the world.
Communication Skill Team Talk, Negotiation and Emotional Intelligence
Textual Comprehension Text 1, 2
Structure and Word Magic Error Detection (Errors in Formation of Sentences : Tenses,
Passivity, Conditionals, Synthesis of Sentences, Direct & Indirect Speeches, Degrees of
Comparison, Affirmative & Negative Sentences, Begin with the given word) (- based on workbook)
; Technology
Stylistic Expression Lab Report; Polite Expression; Dialogue Writing; Case Study
Communication Skills Creativity And Leadership skills
Structure and Word Magic Error Detection (errors in use of words : Nouns, Pronouns, Verbs,
Adjectives, Adverbs, Prepositions, Articles, Antonyms / Synonyms, Homonyms, Affixes (from
General Study); Health and Travel
Stylistic Expression Technical Reports, Transcoding, Business Letter Writing, Technical
description.
Communication Skills Mind Mapping and Career Planning (Self-efficacy skills)
Structure and Word Magic Error Detection – contd.; Idioms and Phrasal Verbs
Stylistic Expression Tackling Situations / Argumentative Essays
1. English for Professionals, Book II Ed., Faculty, English – SSH, VIT.
2. Mishra, Sunita & C. Muralikrishna, Communication Skills for Engineers, Pearson Education,
Delhi: 2004.
3. Functional Grammar & Composition: VIT Workbook, 2005 (for
Semesters I & II) by R. Srinivasan, M.A. Sahul Hameed. English Vocabulary in Use Advanced,
Michael McCarthy and Felicity, Cambridge University Press, 2003
4.Developing Communication Skills, Krishna Mohan and Meera
Bannerji, Macmillan India Ltd. 1990
5. Essential English Grammar, Raymond Murphy, Cambridge University Press, 2006.
6. Language in Use, Adrian Doff and Chris Jones, Cambridge University Press, 2006.
7. Corporate Soft skills, Sarvesh Gulati, 2006
8. Effective Communication, John Adair , Macmillan ltd.1997.

Mode of Evaluation Written Tests & Examinations, Quizzes, Assignments, Seminars

.Speaking skills will be tested through assignments
Recommended by the Board of 25.4.2008
Studies on
Academic Council

CHY104 Environmental Studies LTPC: 3 0 0 3

Version No. 1.0
Course Prerequisites +2
Objectives: 1. To make students understand and appreciate the unity of life in all its
forms, the implications of life style on the environment.
2. To give students a basic understanding of the major causes of
environmental degradation on the planet, with specific reference to Indian
situation.
3. To inspire students to find ways in which they can contribute
personally and professionally to prevent and rectify environmental
problems.
Expected Outcome: Students will be able to
1. understand the need for eco balance
2. acquire the knowledge on the methods of pollution prevention
Unit No. 1 Environment & Natural Resources Number of hours: 8
Definition, scope, importance, need for the public - Natural resources: Forest resources – Use,
exploitation, deforestation, construction of multipurpose dams, effect on forests - Water resources:
use of surface and subsurface water; effect of floods, drought, water conflicts - Food resources: Food
problems, advantage and disadvantage of fertilizers & pesticides, effect on environment - Energy
resources: Need to develop renewable energy – Land resources: Land degradation, land slides, soil
erosion, desertification - Case studies
Unit No. 2 Ecology & Bio-diversity Number of hours: 8
Concept of ecosystem - Structure and function of an ecosystem, producers, consumers and
decomposers, energy flow – Ecological succession – Food chains, food webs and ecological
pyramids - Bio diversity: Definition, genetic, species and ecosystem diversity – Bio-geographical
classification of India, hotspots, threats related to habitat loss, poaching of wildlife, man-wildlife
conflicts - Conservation of bio-diversity.
Unit No. 3 Environmental Pollution Number of hours: 8
Definition – Causes, pollution effects and control measures of air, water, soil, marine, noise,
thermal, nuclear hazards - Solid waste management: causes, effects and control measures of urban
and industrial wastes – Pollution measures – Case studies - Disaster management: Floods,
earthquake, cyclone and landslides.
Unit No. 4 Social Issues and the Environment Number of hours: 8
Urban problems related to energy and sustainable development - Water conservation, rain water
harvesting, watershed management, problems related to rehabilitation – case studies - Wasteland
reclamation – Consumerism and waste products - Environment Protection Act, Air, Water,
Wildlife, Forest Conservation Acts, Environmental legislation and public awareness
Unit No. 5 Human Population and the Environment Number of hours: 8
Population growth, variation among nations, population explosion – Family Welfare Programme,
environment and human health - Human rights, value education, HIV/AIDS, women and child
welfare - Role of information technology – Visit to local polluted site / Case studies - Customer
orientation – Retention - QFD – CSM – TQM Models – Case Studies
References 1. Kurien Joseph and R. Nagendran (2004), Essentials of Environmental
Studies, 1st Edition, Pearson Education.
2. Keerthinarayana and Daniel Yesudian (2004), Environmental Science and
Engineering, 1st Edition, Hi-Tech Publications.
3. Erach Bharucha (2005), Text Book of Environmental Studies, Universities
Press (India) Pvt. Ltd.

4. Howard S. Peavy, Donald R. Rowe and George Tchobanoglous (1987),

Environmental Engineering, McGraw-Hill.
5. Metcalf and Eddy (2003), Wastewater Engineering: Treatment and Reuse,
Tata McGraw-Hill.
Mode of Evaluation Written examination / Assignments / Mini project
Recommended by the Board of 25.4.2008
Studies on
Academic Council

Ethics and values LTPC: 3 0 0 3

Syllabus to be approved by the Board of Studies under VIT Business School

Foreign Language LTPC: 2 0 0 2

Syllabus to be approved by the Board of Studies under School of Sciences and Humanities
Foreign Language courses offered are:
ESP101 Basic Spanish LTPC: 2 0 0 2

FRE101 Basic French LTPC: 2 0 0 2

GER101 Basic German LTPC: 2 0 0 2

JAP101 Basic Japanses LTPC: 2 0 0 2


PHY001 Modern Physics LTPC: 3 0 2 4

Version No. 1.0
Course Prerequisites Student must have studies Physics as one the subject in 12th standard or
equivalent level.
Objectives: To enable the students to understand the basics of latest advancement in
Physics namely, Quantum Mechanics, Laser and its applications, Fiber
Optics and its applications, Ultrasonic, Microwaves and Nanotechnology. It
will be the base to understand the concepts involved in all branches of
Engineering and Technology.
Expected Outcome: Students will acquire knowledge about modern physics and the
implementation of the concept of Physics in various technologies.
Unit No. 1 Quantum Physics Number of hours: 10
Dual nature of electron magnetic radiation- de Broglie waves – Compton effect experimental verification-
Heisenberg uncertainty principle – Schrodinger equation- application- particle in a box (ID) –Spectroscopy.
Application of quantum mechanics-Scanning Tunneling Microscope- Atomic Force Microscope problems.
Unit No. 2 Laser Number of hours: 10
Laser characteristics – Einstein’s coefficients – its significance – population inversion – three level – four
level laser – Schawlow and Townes condition – Nd. YAG – He-Ne- Co2 laser – welding, drilling, cutting –
optical disksystems – recording – data readout from optical disks – Holography – Recording and
Reconstruction – Problems.
Unit No. 3 Fiber Optics Number of hours: 8
Light propagation through fibres – Acceptance angle numerical aperture – types of fibres – step index,
graded index – single mode, multimode– dispersion– intermodal, intramodal – application of fibre optics in
communication – source LED – Laser Diode – Detector – PIN photodiode – endoscope – problems.
Unit No. 4 Ultrasonic and Microwaves Number of hours: 8
Properties – generation – Magnetostriction method – Piezo-electric method – detection of ultrasonic –
applications- NDT Characteristic features of micro waves – Te and TM modes – Klystron – Gunn diode –
Applications of microwaves
Unit No. 5 Nano Technology Number of hours: 9
Nanoscale – Nanomaterials – Poperties of Nanomaterialss – Moore’s Law Semiconductor nanoparticles –
Nano Composites – Quantum well – Wire – Dots – Nanolithography – Applications of Nanotechnology –
Aerospace components – sensors – Medicine.
References
1. B.B.Laud, Lasers and Non-Linear Optics, New Ages International 2nd Edition. 2. A. Ghatak,
K.Thyagarajan, Introduction to Fiber Optics, Combridge University Press (2002)
3. William Silfvast, Laser fundamentals, Cambridge University Press ( 2002)
4. Djafar K.Mynbaeu, Fibre Optic Communication Technology, Pearson Education Asia(2004)
5. C. Kittel , Solid State Physics, John Wiley & Sons, Seventh edition ( 2001)
6. K.C Gupta, Micro waves, New Age International Ltd. (2000)
7. Arthur Beiser, Concepts of Modern Physics, 6th edition, Tata-Mc Graw Hill Edition ( 2003).
8. Charles.P.Poole Jr. & Frank J. Owens, Introduction to Nanotechnology – John Wileys & Sons, New Jerey,
2003.
9. Edward L. Wolf, Nano Physics and Nanotechnology – An introduction to Modern Concepts in
Nanoscience – e edition – Wiley VCH verlagambh & Co. Weinheim – 2006.
Mode of Evaluation Written Examinations, Seminar, Assignment, Surprise test,
quizzes, group discussion
Recommended by the Board of Studies on 29.5.2008
Date of Approval by the Academic Council 16.6.2008

L T P C
MAT101 Multivariable calculus and differential equations 3 1 0 4
Version No. 1.0
Prerequisites 10+2 level Mathematics/ Basic Mathematics(MAT )
Objectives This Mathematics course provides requisite and relevant background
necessary to understand the other important engineering mathematics
courses offered for Engineers and Scientists. Three important topics of
applied mathematics, namely the Multiple integrals, Vector Calculus,
Laplace transforms which require knowledge of integration are introduced.
Expected Outcome By the end of the course the students are expected to learn
(i) how to evaluate multiple integrals in Cartesian, Cylindrical and
Spherical geometries.
(ii) the powerful language of Vector calculus with physical
understanding to deal with subjects such as Fluid Dynamics and
Electromagnetic fields.
(iii) to solve ordinary differential equations directly and also use
transform methods where its possible
Unit 1 Multivariable Calculus 9 hours

Functions of two variables-limits and continuity-partial derivatives –total differential–Taylor’s
expansion for two variables–maxima and minima–constrained maxima and minima-Lagrange’s
multiplier method- Jacobians
Unit 2 Multiple Integrals 12 hours
Evaluation of double integrals–change of order of integration– change of variables between
21artesian and polar co-ordinates- evaluation of triple integrals-change of variables between
21artesian and cylindrical and spherical polar co-ordinates-beta and gamma functions–
interrelation-evaluation of multiple integrals using gamma and beta functions-error function-
properties.
Unit 3 Vector Calculus 12 Hours
Scalar and vector valued functions – gradient–physical interpretation-total derivative–directional
derivative-divergence and curl –physical interpretations-vector identities(without proof) – scalar
and vector potentials-line, surface and volume integrals-Green’s, Stoke’s and Gauss divergence
theorems (without proof)-verification and evaluation of vector integrals using them.
Unit 4 Ordinary Differential Equations 12 Hours
Linear higher order ordinary differential equation with constant coefficients– solutions of
homogenous and non homogenous odes- method of undetermined coefficients –method of variation
of parameters – equations reducible to linear equations with constant coefficients
Unit 5 Laplace Transforms 15 hours
Definition-Laplace transforms of functions-properties of Laplace transforms-initial and final values
theorems-inverse transforms-transforms of periodic functions-convolution theorems–step
functions, impulse functions-concept of transfer functions –applications to the solution of
differential equations.
Text Books 1. Erwin Kreyszig, Advanced Engineering Mathematics, 8th Edition., John
Wiley & Sons, (Wiley student Edison) (2004).
2. B. S.Grewal, Higher Engineering Mathematics, 38th Edition. Khanna
Publications, (2005).
Reference Books 1. G.B.Thomas and R.L.Finney, Calculus and analytical geometry, 9th
Edition, Pearson Education, 5th Indian Reprint, (2002).

2. Michale D. Greenberg, Advanced Engineering Mathematics, 2nd Edition,

Pearson Education, First Indian reprint,(2002).
3. Peter V. O’ Neil, Advanced Engineering Mathematics, 5th Edition,
Thomson, Book/Cole. (2003).
Mode of Evaluation Continuous assessment Examination,
Assignments, Tutorial sheets, Class Test, Quiz.

University Electives
Creativity and Innovation in Management LTPC: 3 0 0 3

Management Information System LTPC: 3 0 0 3

Project Formulation: Implementation and Control LTPC: 3 0 0 3

Self Development LTPC: 3 0 0 3

Total Quality Management LTPC: 3 0 0 3


Programme Core
Analytical Techniques in Biotechnology LTPC: 3 0 4 5
Version No. 1.0.0
Prerequisites Modern Physics, Organic Chemistry
Objectives: 1. To learn techniques for analysis of Biotech products
2. To develop methods and validate.
Expected Outcome: Skill in analysis of biotech products and development of new methods and
validation.
Unit No. 1 Lab Practices and Sampling Number of hours: 8
Analytical Lab – record maintenance. Documentation - Standard Operating Procedures- Analytical
Methods and Validations- Laboratory Notebooks - Specifications and Report Sheets - Calibration
and Maintenance Logs. Sampling – methods and techniques –heterogeneity and random sampling -
Qualitative and quantitative analysis: sources of error in experimental results, precision, accuracy,
standard deviation, determinate and indeterminate errors. Sample reduction techniques.
Unit No. 2 Physico-chemical analyses Number of hours: 8
Mass analyses – gravimetric techniques - pH and conductivity meters – principles and components
- Titrimetric and volumetric analyses – Kjeldahl’s method of N estimation –Atomic Emission &
Absorption spectrometers – flame photmeters and atomic absorption spectrophotemeters –
principle and operation. Flow Injection Analyzers.
Unit No. 3 Spectrometry Number of hours: 9
Spectrophotometry; (fluorometry, colorimetry, polarimetry, nephelometry, turbidimetry). The
absorption laws of spectrophotometry. Methods used in single-beam and double - beam
spectrophotometry. Infrared absorption Requirements for infrared absorption - Energy levels in
vibrating and rotating molecules - Equipment: radiation source, monochromators, detectors,
sample cells, Fourier transformation detector systems, Analytical applications, IR spectra
interpretation.
Unit No. 4 Electrophoresis and chromatography Number of hours: 10
Theory of electrophoresis and types of electrophoresis – their principles and applications.
Chromatography, TLC & HPTLC – applications. Gas chromatography, theory, and equipment.
Different detectors and columns used in GC and their application and modes of operation. Liquid
chromatography, detectors, normal phase versus reversed phase chromatography, ion exchange,
gel permeation and supercritical fluid chromatography. Preparative, analytical (narrow bore) and
nano-bore columns applications, method development and validation.
Unit No. 5 Mass Spectrometry and NMR Number of hours: 10
Mass spectrometer components – ionization methods and detectors. Hyphenated methods - theory
of GC/MS and HPLC/MS/MS analysis. Nuclear magnetic resonance (NMR) – chemical shifts,
spin-spin splitting in proton NMR. Important parts of the NMR instrument and their functions
Typical spectra and their interpretation, Application of H1 & C13 NMR in analytical chemistry and
biochemistry.
No. Experiment
1. Maintenance of Lab Notes and Records
2. Collection, storing and transport of soil and liquid samples
3. pH and conductivity estimation
4. N estimation using Kjeldahl’s Analyzer
5. UV-Vis Spectrum of samples
6. Demonstration of IR Spectrophotometer
7. Electrophoretic separation of biological samples
8. Sample separation and purification by column chromatography

9. Demonstration of Gas chromatography

10. Analysis of samples by HPLC
Text Books 1. Nag, A. 2006. Analytical Techniques In Agriculture Biotechnology And
Environmental Engineering. Prentice Hall India, New Delhi.
2. Philopose P.M. 2006. Analytical Biotechnology. Domihant Publishers &
distributors, New Delhi.
References 1. Fifield F.W., 2004. Principles and Practice of Analytical Chemistry. Blackwell,
Scientific Publishers.
2. Lack, C. 2005. Ewing`s analytical instrumentation handbook. Marcel and
Dekker Inc.
Mode of Evaluation Written Exams/ Quiz / Assignments

Animal Physiology and Biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Cell Biology
Objectives: To study the structure, biological coordination, function of organs in animals and
the application of biotechnological procedures for animal improvement.
To provide students with a scientific and technical understanding of animal
biotechnology..
Expected Outcome: All the students are expected to understand and appreciate the various
physiological processes that maintain homeostasis in animals.
Students will better understand the several aspects of animal biotechnology. They
will begin to correlate animal and human health with development of technology.
Unit No. 1 Introduction to Physiology Number of hours: 8
Nutrition, digestion, absorption and assimilation. Respiration - mechanism of gaseous transport. Blood and
Osmoregulation Blood composition and clotting mechanism. Physiology of urinary excretion and
osmoregulation.
Unit No. 2 Neurotransmitters and Nervous system Number of hours: 10
Neurotransmitters, Neurons and nerve impulse, central and peripheral nervous system, Endocrine systems-
various glands and their roles, Thermoregulation, Biological rhythms. Muscles - classifications, contraction
mechanism, Homeostasis and its importance
Unit No. 3 Animal Cell Technology and its applications Number of hours: 11
Cell nutrition, media composition, growth factors, media, substrate, Basic techniques of mammalian cell
culture in vitro, disaggregation of tissue and primary culture, maintenance of cell culture, cell separation,
Scaling-up of animal cell culture, Cell synchronization, cell immobilization techniques, Cryopreservation.
Research, Clinical and Industrial applications of animal cell culture
Unit No. 4 Animal Reproductive Biotechnology Number of hours: 8
Methods of reproduction – artificial insemination, estrous synchronization, super ovulation, embryo transfer
technology, in-vitro fertilization, sperm and embryo sexing. Embryonic Stem cell technology, Micro
manipulation and cloning, Somatic cell cloning
Unit No. 5 Transgenic animals & Transgenic engineering Number of hours: 8
Transgenesis, methods for production of transgenic animals and their application in protein of
pharmaceutical use, in basic understanding the basic organ and tissue specific gene expression in living
body and a animal model for human/ animal diseases
Text Books 1. Moys, 2008. Principles of Animal Physiology. Pearson Education, Delhi.
2. Camepell, N.A. and Reese, J.B. 2008. Biology 7th Edition., Pearson Education, Delhi.
References 1. Tortora, G.J. and S.R. Grabowski, 2002. Principles of Anatomy and Physiology,
Tenth Edition, Wiley Publishers, NY.
2. Solomon et al, (1999). Biology, fifth edition, 1999, Saunders college publishers
3. Bearden, H.B. and Fuquay, J.W. 1997. Applied Animal Reproduction, Prentice Hall
India Ltd., New Delhi.
4. R.I. Freshney. Culture of Animal Cells: A Manual of Basic Technique, 4th Edition
Wiley-VCH
5. Hill, W. Wyse, G.A. and Anderson, M. 2008. Animal Physiology, Second Edition.
Oxford University Press.
Mode of Evaluation Written examination / Assignment / Seminar

EEE101 Basic Electrical & Electronics Engineering LTPC: 3 0 2 4

Version No. 1.0.0
Prerequisites Knowledge in +2 level physics
Objectives To impart knowledge on the working principles in electrical and electronics
engineering
Expected Outcome The students will gain knowledge in the underlying principle of electrical and
electronic circuits and devices
Unit No. 1 Elementary Circuit Analysis 6 hours
Ohm’s Law, KCL, KVL, Node Voltage Analysis, Mesh Current, Circuits with dependant and controlled
sources, Thevenin’s & Norton’s Equivalent, Maximum Power Transfer and Superposition Theorem, VI
characteristics for capacitors and inductors
Unit No. 2 Analysis of DC & AC Circuits 7 hours: 7
Steady state DC analysis, RL and RC transients in circuits with DC source, Analysis of a second order
circuit with a DC source, RMS values, the use of phasors for constant frequency sinusoidal sources, Steady
State AC analysis of a series circuit, series and parallel combinations of complex impedances, AC power
calculations.
Unit No. 3 Digital Systems 8 hours
Basic Logic Circuit Concepts, Representation of Numerical Data in Binary Form-Combinatorial Logic
Circuits, Synthesis of Logic Circuits, Minimization of Logic Circuits-Sequential Logic Circuits-Computer
Organization, Memory Types, Digital Process Control, Computer Based Instrumentation Systems,
Measurement concepts and sensors, signal conditioning, Analog to Digital Conversion
Unit No. 4 Power semiconductor devices 10 hours
Operating mechanism of power devices including diodes, Zener diode BJTs, MOSFETs, IGBTs,SCRs,
DIAC/TRIACs and GTOs; Equivalent circuits, forward and reverse characteristics, Break down
characteristics, hybrid parameters of these devices, and their applications. - Transistor for SMPS, pulse-
width-modulation (PWM) techniques, and circuit design.
Unit No. 5 Electromechanics 12 h
Magnetic Fields and Circuits, Self and Mutual Inductance, Ideal and Real Transformers, Principles of
Rotating DC Machines, Shunt, Separately Excited and Series Connected DC Motors, Speed Control of DC
Motors, 3-phase Induction Motors, Synchronous Machines and Single Phase Induction Motors, Stepper
Motors and Brushless DC Motors.
Text Books 1. Allan R. Hambley Electrical Engineering-Principles & Applications by, Pearson Education,
First Impression, 2008
2. Basic Electrical Engineering second edition by Kothari D. P and Nagrath I. J., Tata
Mac Graw Hills, 2002,
3. Theory and Problem of Basic Electrical Engineering by Kothari D. P and Nagrath. I. J.
Prentice Hall of India New Delhi – 1998
4. R. A. DeCarlo and Pen-Min Lin, ‘Linear Circuit Analysis’, 2/e, Oxford University Press,
New Delhi, 2001.
5. Batarseh, Power Electronics Circuits, Wiley, 2003
References 1. W. H. Hayt, J.E. Kemmerly and S. M. Durbin, ‘Engineering Circuit Analysis’, 6/e, Tata
McGraw Hill, New Delhi, 2002.
2. A. Ramakalyan, ‘Linear Circuits’, Oxford University Press, New Delhi, 2005.
3. J. Edminister and M. Nahvi, ‘Electric Circuits’, 3/e, Tata McGraw Hill, New Delhi,
2002.
Mode of Evaluation Written Examinations/ Assignments/ Seminars
Recommended by the Board of Studies on

Basic Mathematics LT P C
MAT001
3 1 0 4
Version No. 1.0
Course Prerequisites 10th level Mathematics
Objectives This fundamental course on Basic Mathematics provides requisite and
relevant background necessary to understand the other important
engineering mathematics courses. Further this course is a prerequisite
for the non mathematics students to learn further topics of Engineering
Mathematics.
Expected Outcome By the end of the course the students are expected to
(i) solve a system of equations by matrix method
(ii) know the concept of differentiation, integration and evaluation of
area and volume by integration techniques.
(iii) to explain the concept of ordinary differential equations and have
learnt the method of solving second order differential equations
with constant coefficients.
(iv) understand the concept of analytic geometry and vector algebra.
(v) use the mathematical logic and basic probability for higher studies.
Unit 1 Matrices 9 hours
Matrices - types of matrices - operations on matrices-determinants - adjoint matrix-inverse of a
matrix-solution of a system of linear equations by inversion method–elementary transformations–
rank of a matrix-solution of a system of linear equations by rank method.
Unit 2 Calculus 15 hours
Differentiation of functions of single variable – differentiation techniques- physical interpretations -
differentiation of implicit function – higher order derivatives – Taylor’s series - maxima and
minima for functions of a single variable. Integration-properties-partial fractions-integration
techniques- integration by parts- definite integrals – evaluation of area and volume by integration
Unit 3 Linear Ordinary Differential Equations 12 hours
Differential equations-definition and examples- formation of differential equation- solving
differential equations of first order - solving second order homogenous differential equations with
constant coefficients.
Unit 4 Analytic geometry and Vector Algebra 12 hours
Analytic geometry of three dimensions-direction cosines and direction ratios-plane in space–
straight line in space and sphere . Vectors–operations on vectors-angle between two vectors-
projection of one vector on another vector–equations of plane, line and sphere in vector forms -
shortest distance between two parallel lines- equation of a tangent plane to a sphere. .
Unit 5 Logic and Probability 12 hours
Mathematical logic – propositions – truth table – connectives– tautology- contradiction.
Permutations and combinations – probability – classical approach – addition law-conditional
probability-multiplicative law- Baye’s theorem and applications.
Text Books 1. K.A.Stroud and Dexter J. Booth, Engineering Mathematics, 6th Edition,
Industrial Press Inc.,(2007)
2. B.S.Grewal, Elementary Engineering Mathematics, Khanna
Publications,(2003).
Reference Books 6. Erwin Kreyszig, Advanced Engineering Mathematics, 8th Edition., John
Wiley & Sons, (Wiley student Edison) (2004).
7. B. S.Grewal, Higher Engineering Mathematics, 38th Edition. Khanna
Publications,(2005).

8. Seymour Lipschutz and Marc Lipson, Discrete Mathematics, 2nd Edition,

Tata McGraw-Hill (2005).
9. Seymour Lipschutz and John Schiller, Introduction to Probability and
Statistics , Tata McGraw-Hill (2005).

BIT102 Biochemistry L T P C: 4 0 3 5
Version No. 1.0.1
Course Prerequisites +2 Biology/ Introduction to Life Sciences
Objectives: 1. To impart knowledge on the chemical basis of life
2. To the structure and function of biomolecules .
Expected Outcome: The students after undergoing the course will learn the fundamental
chemical basis of the biomolecules and their function.
Unit No. 1 Foundations of Biochemistry Number of hours: 11
Properties of living system - review on the cellular, chemical, physical, genetic, and evolutionary
background to biochemistry – its relation to other sciences. Properties of water, pH and buffers.
Basic Thermodynamic Concepts - High-Energy Biomolecules.
Unit No. 2 Carbohydrates Number of hours: 14
Monosaccharides, Disaccharides, and Oligosaccharides - types, structure and function – types of
isomers and the basis for classification. Polysaccharides: Homo and hetero polysaccharides
examples (starch, glycogen, cellulose and other plant polymers) structure and function;
Glycoconjugates: glycosaminoglycans, proteoglycans and glycoproteins. Metabolism of
carbohydrates: Glycolysis, TCA cycle, oxidative phosphorylation, gluconeogenesis and pentose
phosphate pathway and their regulation.
Unit No. 3 Amino acids and Proteins Number of hours: 14
Amino Acids: Acid–Base Chemistry of Amino Acids, Classification of Amino Acids, optical activity
and stereochemistry of amino acids. Protein classification – structure and biological function,
reactions of peptides and proteins, introduction to protein structure. Enzyme classification,
mechanism of catalysis and general kinetics (Km, Vmax, Kcat Calculations). Amino acid metabolism
– precursors and routes of amino acid synthesis & urea cycle.
Unit No. 4 Lipids Number of hours: 11
Lipids: Fatty Acids structure, properties and function of: Triacylglycerols, phospholipids,
Glycerophospholipids, Sphingolipids, Waxes, Terpenes, Cholesterol and Steroids. Lipid derivatives.
Biosynthesis of fatty acids & cholesterol – fatty acid degradation and energy generation.
Unit No. 5 Nucleic acids Number of hours: 10
Nucleic acids: structure and function of nucleotides, structure and forms of DNA; types of RNA,
structure and their biological functions. Synthesis and catabolism of purine and pyrimidines.
No. Experiment
1. Laboratory practices in biochemistry
2. Acid-Base titration of amino acids
3. pKa estimation
4. Preparation of buffers
5. Quantitative estimation of reducing sugars
6. Estimation of total sugars
7. Quantitative estimation of amino acids
8. Estimation of proteins
9. Assay of enzymes
10. Estimation of nucleic acids
Text Books 1. Nelson, D.L. and M.M.Cox. 2005. Lehninger’sPrinciples of Biochemistry,
Fourth Edition, WHFreeman, New York.
2. McKee,T. and McKee, J. R. 2002. Biochemistry: the Molecular Basis of Life (3rd
edn.), McGraw-Hill.
References 1. Horton, R. H., Moran, L. A., Ochs, R. S., Rawn, D. J. and Scrimgeour, K. G.
2007. Principles of Biochemistry (4th edn.), Prentice Hall, Upper Saddle River,

New Jersey.
2. Mathews, C. K., van Holde, K. E. and Ahern, K. G. 2000. Biochemistry (3rd edn.),
Addison Wesley Longman, San Francisco.
3. Voet, D.J. Voet, D.G. and Pratt, C.W. 2006. Fundamentals of Biochemistry: Life
at the Molecular Level, 2nd Edition. Wiley, NewYork.
Mode of Evaluation Announced and Unannounced Quizzes,
Assignments/ Seminars and Written Examination
Recommended by the Board of Studies on 21st May, 2008/ 13th November, 2008

Bioethics and IPR LTPC: 3 0 0 3

Version No. 1.0.0
Course Prerequisites +2 level Physics/Chemistry/Biology
Objectives This course seeks to identify and explore salient ethical, legal, and policy
issues and possible solutions associated with developments in
biotechnology. It also provides knowledge on biosafety and intellectual
property rights.
Expected Outcome Students will gain familiarity with some of the important ethical issues
that arise as a result of advances in biotechnology and changes in biotech
policy. Students will follow biosafety measures in future research works
and gain knowledge on patenting his or her research finding.
Unit No. 1 Introduction to Bioethics Hours: 10
Definition and scope of ethics, bioethics and business ethics, purpose, ideology and methodology,
regulation, public evaluation of science and technology, unethical contexts for ethical questions:
what is right and what are wrong, human subject protections, environmental ethics:
anthropocentrism, biocentrism, ecocentrism, ecofeminism, deep ecology, pluralism,
communitarianism, land ethics, environmental health, environmental racism, environmental policy
and law, epidemics: ethical implications and case studies (Tropical moist forest degradation, DDT
and control of malaria, Pros and cons of nuclear power etc.,)
Unit No. 2 Ethical Issues Hours: 10
GM crops, patenting of genes for agricultural biotechnology, world food crisis, biofuels,
environment and biodiversity conservation, in vitro fertilization, embryo research, sex selection,
surrogacy, genetic selection and enhancement, prenatal screening and gene therapy , patenting
human genes, cloning of animals and humans, tissue engineering and transplantation, euthanasia
and related issues, animal experimentation in biomedical research and genetically modified
microbes. (8 classes)
Unit No. 3 Biosafety Hours: 10
Guidelines, principles, risk criteria for establishing ascending levels of containment, agent
summary statements, biosecurity, biological risk assessment, laboratory and animal biosafety level
criteria. Status, safety and ecological assessment of drugs, vaccines, feeds, foods and food products
produced by genetically modified microorganisms, plants and animals. (9 lectures)
Unit No. 4 IPR Hours: 10
History of Intellectual property rights in India, intellectual property, protection of IPR: Trade
secret, Patent, Copyright, PVP, mask work protection, trademarks, cyber squatting, international
harmonization of patent laws, WTO, TRIPs, India and TRIPs, protection of biotechnological
inventions, patenting of genes, DNA sequences and genetic resources, patenting life forms, broad
patents in biotechnology, biotechnology industry and patents, the patent imbroglio, PBR, policy on
seed development and GEAC. (9 lectures)
Unit No. 5 Patents Hours: 5
Choice of IPR protection, foreign patent protection, ownership and transfer of patent rights,
employment contracts, management of IPR, benefits and problems from IPR, IPR and developing
countries, ICBD, Indian response to IPR upheaval.
Text Books 1. Arthur W. Galston and Christiana Z. Peppard. 2005. Expanding horizons in
bioethics. Springer, The Netherlands.
2. Casey Chosewood, L and Deborah E. Wilson. 2007. Biosafety in
Microbiological and Biomedical Laboratories. 5th edition. U. S. Government
Printing Office, Washington.
3. Singh B.D. 1993. Plant breeding: Principles and methods. Kalyani publishers,

New Delhi.
References 1. Howard B. Rockman. 2004. Intellectual property law for engineers and
scientists. John Wiley & Sons, Inc., Hoboken, New Jersey.
2. Stephen G. Post.2004. Encyclopedia of Bioethics, 3rd edition. The Gale
Group, Inc. USA.
3. John A. Thomas and Laurie A. Myers. 1993. Biotechnology and safety
assessment. Elsevier. Raven Press Ltd., New York.
4. John Bryant, Linda Baggott la Velle and John Searle. 2002. Bioethics for
scientists. John Wiley & Sons Ltd., West Sussex.

Bioinformatics LTPC: 3 0 2 4
Version No. 1.0.0
Course Prerequisites Biochemistry
Objectives: To provide a detailed knowledge on the basics of bioinformatics for
biotechnologists. To apply bioinformatics methods in various fields
of biotechnology.
Expected Outcome: Acquire a good knowledge on identification of novel gene function.
Visualize and analyze protein structure and gene expression data
Unit No. 1 Databases Number of hours: 9
Introduction to Bioinformatics. Biological information resources. Genome sequence acquisition and
analysis, Retrieval of biological data. Data acquisition, databases, structure and annotation. Data
mining and data characteristics.
Unit No. 2 Sequence Alignment and Database searches Number of hours: 9
Database searches and Sequence Alignment. Pair wise and multiple sequence alignment. Methods
of local and global alignment. Dynamic programming, Scoring matix, PAM, searching sequence
databases by sequence similarity-BLAST and FASTA.
Unit No. 3 Phylogeny Analysis Number of hours: 9
Phylogenetics, Molecular Phylogeny and evolutionary analysis. ClustalW, MSA, Dendrogram,
Maximum likelihood, Maximum Parsimony, convergent and parallel evolution, Bootstrapping,
Jackknifing. Phylograms.
Unit No. 4 Structural bioinformatics Number of hours: 9
Structural bioinformatics, analysis for protein structure, Predicting protein structure and function
from Sequence. Homology modeling. Microarray Data analysis- proteomic data analysis.
Visualization of molecular structures.
Unit No. 5 Applications of Bioinformatics Number of hours: 9
Scope of bioinformatics. Bioinformatics in the Pharmaceutical Industry- Structure-Based Rational
Drug Design and discovery. Chemi-informatics in Biology
No. Experiment
1. Operating systems, Internet browsers and File Editors
2. Biological databases
3. File formats of biological databases – Analysis and Interconversion
4. Retrieval of sequences from biological databases – BLAST and FASTA
5. Pairwise Alignment of sequences
6. Multiple sequence alignment
7. Phylogenetic analyses
8. Gene prediction
9. Prediction of secondary structures of protein
10. Protein structure Visualization (Rasmol, Deepview, Cn3D)
11. Submission of sequences to databases
Text Books 1. Attwood, T. and P.S. David. 2006. Introduction to Bioinformatics. Pearson
Education Ltd., New York.
2. Baxevanis, A.D., and Ouellette, B.F.F. (eds) 2006. Bioinformatics A Practical
Guide to Analysis of Genes and Proteins. 3rd Edition, John Wiley and Sons, New
York.
References 1. Attwood T.K. and Higgs, P.G. 2005. Bioinformatics and molecular evolution.
Blackwell Publishers, London.
2. Lesk, A.M. 2002. Introduction to Bioinformatics. Oxford University Press.
Mode of Evaluation Written examinations/ Seminar/ Quiz

/Assignments

L T P C
BIT102 Biophysics 3 0 0 3
Version No. 1.0.1
Prerequisites BIT101
Objectives: To expose the students to the field of Biophysics and let them know the
background concepts involved in biology to enrich their knowledge. The
student can develop a clear idea about Molecular bonding, their interactions
in drug designing, bioluminescence and the different types of radiation
detectors, their application to human body for diagnostic and therapeutic
purposes.
Expected Students are able to understand the conformational aspects of protein and the
Outcome: biological macromolecules. They will also have clear about the biological
effects of radiations and can identify the applications of physics in biology.
Unit No. 1 Molecular Biophysics 9 hours
Introduction to the principles of biophysics, intra and inter molecular forces, chemical bonds,
effect of bonding of reactivity, bond length, bond angle, dipole moment, electrostatic
interactions and hydrogen bonding interactions, Van der waals forces and hydrophobic
interactions, Ramachandran plot, Eulerian angle of rotation.
Unit No. 2 Techniques for the study of biological 10 hours
structure and function:
Size and shape of macromolecules, macromolecular diffusion, ultra-centrifugation, X-ray
crystallography – determination of molecular structures, X-ray fiber diffraction, electron
microscopy, neutron scattering and light scattering.
Unit No. 3 Photobiology 9 hours
Dual nature of light, characteristics of electromagnetic radiation, energy states, light driven
electron flow, chloroplasts, chlorophylls and light, light harvesting luminescence complexes,
light emission, phosphorescence, fluorescence and bioluminescence.
Unit No. 4 Radiation Biology 8 hours
Radiation in biology, radiation decay, units of radiation, detection measurements of
radioactivity – ionization chamber, GM counter, scintillation counters and labeling
techniques, nuclear electronics.
Unit No. 5 Imaging Techniques 9 hours
Rectilinear scanner, Gamma camera, Positron emission tomography, Intensity Modulated
Radiation Therapy, Magnetic resonance imaging.
Books 1. Cantor and Schimmel, Biophysical Chemistry, W. H. Freema & Co., (1985).
2. Lehninger, Nelson and Cox, Principles of biochemistry, Macmillan Publishers
(2000).
3. Daniel M, Basic Biophysics for Biologists, (1998).
4. D.Velmurugan, Elementary Crystallography, MJP Publishers, Chennai (2008).
5. K. Thayalan, Basic Radiological Physics, Jaypee Brothers Medical Publishers,
New Delhi (2005).
6. R.S. Khandpur, Handbook of Biomedical Instrumentation, TMH Publishers,
New Delhi (2001)
Mode of Evaluation Written examination, assignment, seminar and spot test.

Date of Approval by the Academic Council on

Bioprocess Economics and Plant Design LTPC: 2 1 0 3

Version No. 1.0.0
Prerequisites Bioprocess Engineering
Objectives: To Provide an Understanding of the concepts of process design; to provide
design methods for specific plant items; to develop skills in process flow
sheeting.
Expected Outcome: i) Students should be able to apply their chemical and process
engineering knowledge to the design of a process plant.
ii) Students should be able to determine the feasibility of a process for
chemical and material manufacture
iii) Work individually or as a team on process and equipment design
iv) Assess the economic/profitability of a process
v) Design a safe and environmentally acceptable process
Unit No. 1 Process Design Development Number of hours: 12
Technical feasibility survey, process development, flow diagrams, equipment design and
specifications. GMP - classes and guidelines for pharmaceutical and food industry.
Unit No. 2 General design Consideration Number of hours: 13
Environmental, safety and Health considerations, Marketability of the product, availability of
technology, raw materials, equipments, human resources, land and utilities, site characteristics,
government regulations and other legal restrictions, community factors and other factors affecting
investment and production costs
Unit No. 3 Cost Estimation Number of hours: 10
Capital investments – fixed capital investments including land, building, equipments and utilities,
installation costs (including equipments, instrumentation, piping, electrical installation and other
utilities), working capital investments. Manufacturing costs – Direct production costs(including
raw materials, human resources, maintenance and repair, operating supplies, power and other
utilities, royalties, etc.)
Unit No. 4 Plant overheads and depreciation Number of hours: 10
Administration, safety and other auxiliary services, paryroll overheads, warehouse and storage
facilities. Depreciation , determination of depreciation – types and methods
Unit No. 5 Profitability Analysis Number of hours: 10
Profitability Analysis – return on original investment, interest rate of return, accounting for
uncertainty and variations and future developments. Optimization techniques – Linear and
Dynamics programming, Optimization strategies
Text Books Peters and Timmerhaus, 1989. Plant design and Economics for Chemical
Engineers, McGraw Hill 4th Edition.
References Rudd and Watson, 1987. Strategy of Process Engineering, Wiley.
Mode of Evaluation Written Examination, Assignments and Seminar
Recommended by the Board of 13th November, 2008
Studies on
Date of Approval by the Academic
Council

Bioprocess Engineering LTPC: 3 0 4 5

Version No. 1.0.0
Course Prerequisites Chemical Reaction Engineering
Objectives: 1. Apply knowledge of heat and mass transfer to bioreactor design
and scale-up
2. Understand the need for and methods of bioreactor
instrumentation and control
3. To develop mathematical models for bioprocesses.
4. To understand and analyze non-ideal behavior in bioreactors
Expected Outcome:
Unit No. 1 Bioreactors Number of hours: 10
Reactor engineering types of bioreactors, modes of operation of bioreactors – continuous stirred
tank reactor, stirred tank reactor with recycle, Batch reactor, stirred tank reactors in series.
Reactors for plant cells and animal cells. Immobilized reactors.
Unit No. 2 Transport Operations in bioreactors Number of hours: 10
Gas liquid transport in cells – transfer resistances – mass transfer coefficients – oxygen transfer
and determination oxygen transfer coefficients – sterilization criteria – design – air sterilization –
equipment for air sterilization
Unit No. 3 Monitoring of Bioprocesses Number of hours: 10
Main parameters to be monitored in fermenters – On-line data analysis for measurement of
important physicochemical and biochemical parameters; Methods of on-line and off-line biomass
estimation; Flow injection analysis for measurement of substrates, products and other metabolites;
State and parameter estimation techniques for biochemical processes; Computer-based data
acquisition.
Unit No. 4 Models for growth and product formation Number of hours: 9
Simple unstructured kinetic models for microbial growth, Monod model, Growth of filamentous
organisms. Growth associated (primary) and non-growth associated (secondary) product formation
kinetics, Leudeking-Piret models, substrate and product inhibition on cell growth and product
formation. Introduction to Structured Models for growth and product formation. Model simulation
using MATLAB-SIMULINK package
Unit No. 5 Process Technology for bioproducts Number of hours: 6
Process technology used in production of alcohols, organic acds, enzymes, pharmaceutical products,
fine chemicals flow sheet – process description of modern processes
No. Experiment
1. Growth kinetics
2. Product formation kinetics
3. Media optimization – individual factors
4. Media optimization – Placket and Burman
5. Estimation of mass transfer coefficient
6. Estimation of thermal death kinetics
7. Fermenter components and operation
8. Cultivation of microbes in fermenter
9. MATLAB commands and syntax
10. Using MATLAB for simulation
Text Books 1. Shuler And Kargi, Bioprocess Engineering, Prentice Hall,1992
2. Pauline Doran , " Bioprocess Engineering Calculation", Blackwell Scientific
Publications
References 1.Bhatt B. I and S.M. Vora Stoichiometry Tata McGraw Hill, 4th Edition, 2004.


Date of Approval by Academic Council

BIT LTPC: 3 1 0 4
Biostatistics
Version No. 1.0.0
Course Prerequisites MAT001 & BIT001
Objectives: 1. To expose the students about the role of statistics in biological
sciences and engineering
2. To enable the students to design, analyze, present and interpret
research data .
Expected Outcome: Ability to design experiments, sampling variables, analyze the
biological data, interpret and present the results in meaningful way.
Unit No. 1 Descriptive methods and Measures of Number of hours: 9
central tendency
Frequency Distribution, Measures of dispersion - Frequency Distributions, Diagrams and
Characteristics of a Frequency Distribution. Arithmetic Mean, Median, Mode, Position of
Averages, Selection of the Appropriate Measure of Central Tendency, Geometric Mean, Harmonic
Mean and Percentile. Range, Interquartile Range, mean Deviation, Variance and Standard
Deviation and Alternative Method of Calculating Standard Deviation. Tabular and Graphical
Presentation of Data: Line Graphs, Bar Charts, Histograms, Stem-and-Leaf Plots Dot Plots,
Scatter Plots.
Unit No. 2 Probability and Life Tables Number of hours: 9
Probability Definition, Rules for Calculating Probabilities, De nitions from Epidemiology, Bayes’
Theorem, Binomial, Normal and Poisson Distributions, Probability in Sampling, Sampling without
Replacement, Estimating Probabilities by Simulation, Probability and the Life Table.
Unit No. 3 Sampling and Experimental Design Number of hours: 9
Sampling and Sample Designs, Significance of Probability Sampling methods. Designed
Experiments - Blocking and Extraneous Variables. Variations in Study Designs: Crossover Design,
Case Control Design, Cohort Study Design. Completely Randomized Design, Factorial Designs
and Latin Square Designs. Designing clinical trials - Single- and Double-Blind Experiments.
Unit No. 4 Data analysis and interpretation Number of hours: 9
Tests of hypothesis, Non-parametric tests, Goodness of fit, tests of significance, comparison of
means, chi-square test, analysis of variance, analysis of survival data. Use of Excel, SPSS and
Statistical Application packages.
Unit No. 5 Correlation and Regression Number of hours: 9
Simple correlation and linear regressions. Multiple correlations and non-linear regression analysis.
Response Surface Methodology: Introduction - First-Order Designs and Analysis - Second-Order
Designs and Analysis - Properties of Second-Order Designs: CCDs, Box–Behnken Design.
Text Books 1. Sundar Rao P.S.S. and Richard ,J. (2003) An Introduction to Biostatistics – A
manual for students in Health Sciences – 3rd Edition, Prentice-Hall of India
Private Limited, New Delhi.
2. Le, C.T. Introductory Biostatistics. 2003. Wiley-Interscience
References 1. Daniel , W.W. Biostatistics : A Foundation for Analysis in the Health

Sciences – IV Edition.Mathews, C. K., van Holde, K. E. and Ahern, K. G.
(1999) Biochemistry (3rd edn.), Addison Wesley Longman, San Francisco.
2. Forthofer, R.N. Lee, E.S. and Hernandez, M. 2007. Biostatistics: A Guide to
Design, Analysis, and Discovery. Elsevier Ltd., Amsterdam. p. 502.
Mode of Announced and Unannounced Quizzes, Assignments/ Seminars and Written

Evaluation Examination,

Recommended 9th April 2009

by the Board of
Studies on
Date of 24th April 2009
Approval by
the Academic
Council

Cancer Biology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Molecular Biology and Animal Physiology and Biotechnology
Objectives: To provide an overview of the developing areas of oncology and create an
awareness for stem cell technology
Expected Outcome This basic course content will update their knowledge in the focused areas
of cancer and stem cell biology
Unit No. 1 Cell cycle control Hours: 9
Genetic pathways that protect cells from uncontrolled growth and genes: tumor suppressor genes,
oncogene and activation mechanisms, oncoviruses. Pathways that regulate tumor initiation and/or
its progression. Cell cycle control genes; the role of tumor suppressors in the cell cycle;
Unit No. 2 Genetics of cancer and Carcinogenesis Hours: 9
Apoptosis: Apoptosis- signal transduction pathways of apoptosis and signaling molecules; defective
apoptotic pathways leading to cancer
Unit No. 3 Genomic Stability and Tissue Specificity Hours: 9
Types of genomic instability: instability of short, repetitive sequences due to loss of DNA
mismatches repair and dysfunction of telomeres; tissue Specificity and Cells of origin- mouse
models of cancer.
Unit No. 4 Metastasis and Cell-Cell Interactions Hours: 9
Recent approaches to identify key factors controlling metastasis; Angiogenesis- relationship
between blood vessel formation, tumor growth, and metastasis.
Unit No. 5 Cancer therapeutics and diagnostics Hours: 9
Industrial Implications: Potential anti-cancer therapies that target the visualization process; the
process of differentiation and cancer therapies that work by inducing differentiation of tumor cells;
tumor stem cells-clinical implications; current methods of cancer screening, development new
diagnostic tests, and other innovations for the future.
Text Books 1. The Molecular Biology of Cancer ( 2006) . Michael khan, Stella Pelengaris,
Blackwell Publishing Limited.
2. An Introduction to Cellular and Molecular Biology of cancer ( 1991) . Oxford
Medical Publications.
References 1. Stem Cell Research (2000) . J M Humber and R. F Almeder.

Cell Biology and Genetics LTPC: 3 0 3 4

Version No. 1.0.0
Course Prerequisites: School Biology/ BIT001
Objectives: 1. To impart knowledge on the structure and function of prokaryotic
and eukaryotic cells
2. To teach students on the fundamental aspects of genetics and
introduce them to its applications
Expected Outcome: Students will gain knowledge on
• Cell and its activities
• Qualitative and Quantitative genetics and its applications
Unit No. 1 Cell structure and function Number of hours: 9
Cytoskeleton, biomembranes (phospholipid bilayer, integral proteins and glycolipids) and sub cellular
organization of eukaryotic cells (nucleus, mitochondria, chloroplasts, endoplasmic reticulum, golgi
vesicles, peroxisomes, lysosomes, vacuoles and cytosol) – life cycle of cells/cell division (mitosis and
meiosis)and regulation of cell cycle (regulated protein phosphorylation and degradation control passage
through the cell cycle: heterodimeric protein kinases – cyclins, cdks, mitogens)
Unit No. 2 Transport across cell membranes Number of hours: 8
Diffusion of small molecules across phospholipid bilayers, membrane transport proteins, uniporter-
catalyzed transport, intracellular ion environment and membrane electric potential, active
transport by ATP-powered pumps, co transport by symporters and antiporters, transport across
epithelia, osmosis, water channels, and the regulation of cell volume
Unit No. 3 Cell signaling, motility and integration Number of hours: 10
Hormones and receptors, autocrine, paracrine and endocrine models of action, signal transduction
(signal amplification models, cyclic AMP, role of inositol phosphates as messengers, biosynthesis of
inositol triphosphates, role of cyclic GMP, G proteins and calcium ion flux, phosphorylation of
proteins kinases) – cell motility (microfilaments, microtubules and intermediate filaments) -
integrating cells into tissues (cell-cell adhesion and communication, cell-matrix adhesion, collagen:
the fibrous proteins of the matrix, noncollagen components of the extra cellular matrix and the
dynamic plant cell wall)
Unit No. 4 Mechanisms of inheritance Number of hours: 10
Mendelian laws, Gene interactions, multiple alleles, linkage, crossing over, chromosomal theory of
heredity and chromosomal mapping, sex determination and sex linked inheritance, extra
chromosomal inheritance, chromosomal aberrations, mutation, recombination, transformation,
transduction, conjugation and sexduction. Quantitative inheritance, inbreeding, probability and
Chi-square test
Unit No. 5 Evolution and genetic applications Number of hours: 8
Hardy-Weinberg equilibrium. Speciation. Polyploidy. Evolution. Eugenics and euthenics. Genetic
diseases. Genes and cancer. Genetic counseling. Genotoxicity testing. Gene therapy.
No. Experiment
1. Study of plant cell morphology
2. Study of animal cell morphology
3. Cell fractionation
4. Osmosis - Effect of solute concentration on onion cells
5. Enumeration of RBC & WBC
6. Study of mitosis in onion root tips
7. Study of meiosis in Rheo discolor
8. Study of barr bodies in buccal epithelial cells
9. Study of polytene chromosomes from Chironomous larvae

10. Identification of inheritance pattern based on offspring data

Text Books 1. Lodish H. et. al., 2004. Molecular Cell Biology, 5th Edition, W.H. Freeman & Co.
2. Gardner, E.J., Simmons, M.J., and Snustad. D.P. 2005. Principles of genetics. 8th
edition. Wiley India, Nice Printing press, New Delhi.
3. Agarwal V.K., and Verma, P.S. 2004. Genetics. Sultan Chand & co. New Delhi.
References 1. Raul., C.R., Jaime, C.S. and Stansfield, W.D. 2004. Theory And Problems Of
Molecular And Cell Biology. Tata mcgraw hill publ. Company, New Delhi.
2. Geoffrey M. Cooper. 2000. The Cell: A Molecular Approach. 2nd Edition.
Sinauer Associates, Inc.
3. Lewin, B. 2004. Genes VIII. Pearson Education Inc.
Mode of Evaluation Written examinations/Assignments/Seminars/ Quiz
Date of Recommendation by BOS 13th November, 2008

Chemical Reaction Engineering and Unit LTPC: 3 0 0 3

Operations
Version No. 1.0.0
Prerequisites Organic Chemistry/ Multivariable calculus
Objectives: The course aims to develop skills of the students in area of reactor design
and unit operations.
Expected Outcome: The students can analyze kinetic data and obtain rate laws and understand
the behavior of different reactor types when they are used individually.
The students would learn chemical kinetics, various types of reactors, heat
exchangers and drying and how they function.
This will help the students to take up PG courses in Bioprocess,
Biochemical Engineering and also the project work
Unit No. 1 Basic of Kinetics Number of hours: 10
Introduction, Kinetics of homogeneous reactions: Concentration dependent term of rate equation,
Temperature dependent term of rate equation. Interpretation of batch reactor data, constant
volume batch reactor, integral method of analysis of data for reversible and irreversible reactions,
differential method for partial and complete analysis of the rate equation-integral method of
analysis for reactions of different orders in a variable volume batch reactor
Unit No. 2 Reactor Design Number of hours: 9
Introduction to reactor design, Single ideal reactors, Batch reactor, plug flow reactor and mixed
flow reactor for single reactions. Design equation for batch reactor, plug flow reactor and mixed
flow reactor for single reactions.
Unit No. 3 Flow behaviour of Reactors Number of hours: 9
Non-ideal flow, Residence time distribution studies, C, E, F and I curves, conversion calculation
directly from tracer studies. Models for non-ideal flow.
Unit No. 4 Heat Exchanger Number of hours: 8
Introduction, classification, performance and application of types of heat exchanger, Different
methods of heat exchange, Estimation of heat exchange area.
Unit No. 5 Evaporation and drying Number of hours: 9
Introduction, classification, Theory of drying, drying rate, drying of biological material, drying
equipments, conventional and freeze drying
Text Books 1. O. Levenspiel, Chemical Reaction Engineering, 3rd Edition, John Wiley,
1999.
2. W.L. Mc Cabe & J.C. Smith, “Unit Operations in Chemical Engineering” V
Edition, McGraw Hill International Edition, 2001.
References 1. Fogler H.S. Elements of Chemical Reaction Engineering, Prentice Hall India,
2001.
2. J.M. Smith, Chemical Engineering Kinetics, McGraw Hill International
Editions, 2001.
3. GeanKoplis C.J. Transport Processes and Unit Operations, Prentice Hall
India, 2002
Downstream Processing LTPC: 3 0 4 5

Version No. 1.0.0
Prerequisites Bioprocess Engineering, Chemical Reaction Engineering

Objectives: To provide an overview of the fundamentals of downstream processing for

biotechnological processes through the study of primary separation and
recovery processes like cell disruption methods, centrifugation and
filtration., to understand enrichment operations like precipitation methods,
extraction etc., to understand processes for product resolution and
fractionation
Expected Outcome: Students will be able to understand the basic principles governing each of
the listed unit operations. Discuss the practical uses of the separation
techniques in relevant areas of commercial applications.
Unit No. 1 Role of Downstream Processing in Number of hours: 9
Biotechnology
Role and importance of downstream processing in biotechnological processes, Economics of
downstream processing in Biotechnology, characteristics of biological mixtures
Unit No. 2 Primary Separation and Recovery Processes Number of hours: 9
Cell disruption methods for intracellular products: Mechanical and Chemical methods, Removal of
insolubles: flocculation and sedimentation, centrifugation and filtration methods.
Unit No. 3 Enrichment Operations Number of hours: 9
Precipitation methods (with salts, organic solvents and polymers). Extractive separations: Solvent
extraction, Aqueous two phase extraction, Riverse micelle extraction, supercriticial extraction.
Membrane-based separations: Porous and dense membrane separations, Dialysis, Reverse osmosis,
Ultrafiltration, Electrodialysis, Pervaporation, Gas permeation, Liquid membranes.
Unit No. 4 Product resolution Number of hours: 9
Chromatographic principles: distribution coefficients, retention parameters, qualitative and
quantitative aspects of chromatography, column efficiency, selectivity and resolution, Gel
permeation chromatography, Ion exchange chromatography, Reverse Phase chromatography,
Adsorption., hydrophobic interaction Affinity chromatography.
Unit No. 5 Product Polishing Number of hours: 9
Crystallization, Drying and product formulation, Lyophilization.
No. Experiment
1. Cell separation
2. Cell lysis
3. Separation of metabolites
4. Precipitation proteins
5. Aquesous phase extraction
6. Reverse micelle extraction
7. Dialysis
8. Size Exclusion Chromatography
9. Ion Exchange Chromatography
10. Lyophilization
Text Books 1.BIOTOL Series, Product recovery in Bioprocess Technology, VCH, 1995.
2.BIOTOL series. Techniques used in bioproduct analysis. Butterworth-
Heinemann
References 1. S.N.Mukhopadhyay, Process Biotechnology fundamentals.
2. Robert K Scopes, Protein purification. Principles and practice. 3rd Edition.
3.Simon Roe, Protein purification techniques, A Practical Approach. (2nd
Edition).
4. Reed G., and Rehm H.J., 1993. Biotechnology: bioprocessing. Wiley – VCH,
New York.



Engineering Graphics LTPC: 0 0 4 2

Version No. 1.0.0
Prerequisites +2 Physics/10th Geometry
Objectives: 1. To create an awareness and emphasize the need for Engineering
Graphics in all the branches of engineering
2. To follow basic drawing standards and conventions.
3. To develop skills in three-dimensional visualization of engineering
component.
4. To develop an understanding OFID and 3D drawings using the Solid
works software
Expected Outcome: On completion of this course, .the students will be able to:
1. Prepare drawings as per standards (BIS).
2. Solve specific geometrical problems in plane geometry involving lines,
plane figures and special curves.
3. Produce orthographic projection of engineering components working
from pictorial drawings. 4. Prepare 2D Drawings using the Solid works
software.
No. Experiment
1. Introduction to Engineering Graphics
2. Geometrical Construction
3. Conics and Special Curves
4. Free hand Sketching
5. Dimensioning Principles
6. Orthographic Projection
7. Projection of Points
8. lines and solids in Simple position
9. Detailed Views of Simple 3D Objects
Text Books K.V. Natarajan (2003), Engineering Drawing and Graphics, Classic Prints
References 1. N.D. Bhatt (1998), Engineering Drawing, Charotar Publishing House.
2. K.L. Narayana and P. Kannaiah (2000), Engineering Graphics, Scitech
Publications.
3. Bureau of Indian Standards (2003), Engineering Drawing Practice for School
and Colleges - SP46:2003.
4. CAD Manual prepared by VIT Staff

Entrepreneurship LTPC: 3 0 0 3

Environmental Biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Organic Chemistry and Environmental Studies
Objectives: To expose the students to the biotechnological component in waste and
waste water treatment
Expected Outcome: Understanding the biological treatment processes and development of
suitable technologies
Unit No. 1 Solid Waste Management Number of hours: 8
Municipal solids wastes – characterization, treatment and disposal technologies. Landfills,
composting, electricity generation. Xenobiotic compounds, recalcitrance. hazardous wastes -
biodegradation of Xenobiotics . Biological detoxification.
Unit No. 2 Bioremediation Number of hours: 9
Introduction, constraints and priorities of Bioremediation, Biostimulation of Naturally occurring
microbial activities, Bioaugmentation, in situ, ex situ, intrinsic & engineered bioremediation, Solid
phase bioremediation - land farming, prepared beds, soil piles, Phytoremediation. Composting,
Bioventing & Biosparging
Unit No. 3 Waste water treatment Number of hours: 9
Liquid phase bioremediation - suspended bioreactors, fixed biofilm reactors. Aerated Processes
Activated Sludge (Suspended Growth), Aerated Lagoons, Waste Stabilization, Trickling Filter
(Attached Growth) Rotating Biological Contactors (RB Packed Beds) - Anaerobic Digestion
(Treatment) – removal of nitrogen and phosphorus.
Unit No. 4 Industrial applications Number of hours: 9
Pulp and paper industries – biopulping, biobleaching, waste water treatment. Treatment of leather
and tannery waste water, Mining and Metal biotechnology – with special reference to Copper &
Iron. Microbial transformation, accumulation and concentration of metals, metal leaching,
extraction and future prospects.
Unit No. 5 Gas purification and biofuels Number of hours: 10
Microbial aspects Process engineering for waste gas purification: Biofilters, Bioscrubbers,
Biotrickling filters and membrane procedures. Commercial application of biological waste gas
purification. Microorganisms and energy requirements of mankind; Production of non-conventional
fuels - Methane (Biogas), Hydrogen, Alcohols and algal hydrocarbons, Use of microorganisms in
augmentation of petroleum recovery.
Text Books 1. Jördening, H.-J. and J. Winter. (2005). Environmental Biotechnology. Wiley-Vch
Verlag GmbH & Co. KGaA, Weinheim.
2. Chatterjee, A.K. 2005. Introduction to Environmental Biotechnology. Prentice-
Hall of India, NewDelhi
References 1. Evans, G.M. and J.C. Furlong. 2003. Environmental Biotechnology: Theory and
Application, John Wiley & Sons, Ontorio, Canada. P.302.
2. Rehm, I. and Reed. 1998. Biotechnology A comprehensive treatise. VCH
Publications Berlin.
3. Rajendran and Gunasekaran, P. 2004. Bioremediation. MJP Publishers, Chennai.
Food Biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Course Prerequisites Biochemistry, Microbiology

Objectives: The purpose of this unit is to familiarize the students with basic science of
food biotechnology. The course offer an integrated approach to food
preservation methods, fermentation/food production technology and food
quality and hygiene aspects
Expected Outcome: 1. Students should be able to use their knowledge on Biotechnology to the
science of food.
2. Understand the basic food preservation methods and appreciate role of
biotechnology in preserving food.
3. Discuss the various biotechnological means of improving the food process
technology and be able to understand the biotechnological basis for
processing foods.
4. Design a Quality assurance and control system for specific food industry
type.
Unit No. 1 Introduction to Food Biotechnology Number of hours: 8
The potentiality of food trade, the difference between the Food science and Technology and Food
Biotechnology, The biotechnological methods used in food technology. Microorganisms in food –
primary and secondary sources of microorganisms in food – extrinsic and intrinsic parameters for
microbial growth. Spoilage of food, factor supporting growth and development of microbes in
foods, meat, milk, vegetables.
Unit No. 2 Food Products Number of hours: 10
Single cell protein -yeast, mushroom. Fermentation and Fermented foods from Dairy, Cereal
Grains, Fruits and Vegetables, Meat and sea foods. Preserved foods. Alcoholic and Non-alcoholic
beverages.
Unit No. 3 Food Preservation technology Number of hours: 9
Food preservation by Chemical additives, Modified atmosphere, Drying, Thermal and Low
temperature preservation, sonication and Irradiation. Technology of canning, dehydration,
ultrafiltration, sterilization, irradiation etc.
Unit No. 4 Technology for improved process Number of hours: 8
Nutraceuticals, Probiotics, prebiotics and synbiotics. Enzyme in bakery and cereal products,
Enzymes in fat/oil industries, Protease in cheese making and beverage production, Food additives.
Utilization of food waste for production of value added products
Unit No. 5 Food quality assurance and control Number of hours: 10
Analysis of food, Indicators of Food Microbial Quality and Safety. Indicators of Product Quality,
Indicators of Food Safety, Hazard Analysis Critical Control Point System - Microbiological
Criteria food safety management system for food industry.
Text Books 1. Jay, J.M. 2000. Modern Food Microbiology. Aspen Publishers, Maryland.
References 2. Gutiérrez-López , G.F. and Barbosa-Cánovas, G.V. 2003. Food Science and
Food Biotechnology . CRC Press
3.Tucker, G.S. 2008. Food Biodeterioration and Preservation. Blackwell
Publishers.

Fundamentals of Behavioural Science LTPC: 3 0 0 3

Version No. 1.2.0
Prerequisites BIT001/ + 2 Biology
Objectives: Enable the students to understand social behaviour and adapt to work
environment
Expected Outcome: 4. To enable the students to comprehend the behaviour of individuals and
societal groups affecting their lives.
5. To appreciate the inter – disciplinary approach to solving problems.
6. To learn the behavioural aspects of working in a group.
Unit No. 1 Introduction to behavioural Sciences Hours: 5
Definition, Scope and relevance (Definition, Interdisciplinary approach), Overview of research
tools (Experimental and non-experimental approaches).
Unit No. 2 Biological Foundations Hours: 9
Nervous system and behaviour (Basics of nervous and endocrine systems); Types and function of
neurotransmitters; Heredity and behaviour; Chronobiological relevance to behaviour
Unit No. 3 Psychological Foundations Hours: 16
Sensory process (Vision, auditory, touch, taste, vestibular and kinesthesis); Perception; Cognition
(Concepts, language and thought, problem solving and decision – making); Intelligence (
Characteristics, assessment, role of creativity); Learning and memory (Principles, types and
effective methods); Individual development across the life span; Psychological disorders ( Types –
moods, anxiety, depression, suicide); Overview of therapies.
Unit No. 4 Foundations of Individual Behaviour Hours: 8
Motivation ( Principles, types); Emotions, stress and health (Psychological and Physiological
factors and responses); Personality ( Characteristics, types); Personal ethics
Unit No. 5 Foundations of Group Behaviour Hours: 7
Social concepts; social perceptions; social influences; social relationships; dynamic interplay of
culture and society.
Text & 7. Edward E. smith et. al., 2003. Atkinson and Hilgard’s Introduction to
Reference Psychology. 14th Ed. Thomas Learning publications. p674.
Books 8. Clifford T. Morgan et. al., 1993. Introduction to psychology. Tata Mc Graw
Hill. p666.
9. Robert A. Baron 2006. Psychology. 5th edition Prentice Hall of India Pvt,
Ltd. P617.
10. Richard J.Gerring and Philip G. Zimbardo. 2006. Psychology and life.
Pearson Education p.630.
Recommended by the Board of Studies on 8th April, 2009

Genetic Engineering and Genomics LTPC: 3 0 4 5

Version No. 1.0.0
Prerequisites Molecular Biology & Bioinformatics
Objectives: To equip the students with the basics and applications of genomics and
proteomics
Expected Outcome: To make the students
•realize the importance of genomic studies
•understand the techniques involved in the analysis of genomics
•utilize the genomic patterns in industries, medicinal diagnostics and
treatment
Unit No. 1 Concepts and Tools in Genetic Engineering Number of hours: 9
Restriction endo-nucleases- types, restriction, cleavage patterns, ligation, modification of DNA
ends, creating recombinant DNA molecules. Vectors – properties of a good vector and host, cloning
and expression vectors, plasmid vector construction, bacteriophage (λ, filamentous phage), yeast
cloning vectors, phasmid, phagemid, cosmid, YAC, BAC, transposons, vectors for animals and
plants, Methods of restriction mapping, reverse transcriptase function, mechanisms of restriction
digestion and ligation.
Unit No. 2 Recombinant DNA Technology Number of hours: 9
Elementary concept of Recombinant DNA technology- method of creating recombinant DNA
molecules, host expression systems – Expression of recombinant proteins in microorganism, plants
and animals. safety guidelines of creating recombinant DNA research. PCR types and applications.
.Molecular characterization & DNA finger printing techniques
Unit No. 3 Genomic Libraries Number of hours: 9
Construction of genomic and cDNA libraries & EST. Methods of nucleic acid sequencing, Physical
map of the genome, methods of constructing genome maps, sequencing whole genomes, genomic
variations. Probe and primer design methods. Molecular marker technology – RAPD, RFLP,
AFLP, SSR.
Unit No. 4 Basics of Genomics Number of hours: 9
Organization and structure of genomes, Genome size, Sequence complexity, introns and exons,
Genome Mapping and strategies for construction of genome. Gene and Genomic databases –
retrival and anlysis tools. Human Genome Project, Genomes of other organisms, Genome structure
in viruses and prokaryotes.
Unit No. 5 Genome Analysis Number of hours: 9
Genome annotation, traditional routes of gene identification, detecting open-reading frames,
Identifying the function of a new gene, gene expression and microarray analysis. Gene ontology,
comparative genomics, determining gene function by sequence comparison, software programs for
finding genes.
No. Title of the Experiment
1. Preparation of plasmid DNA from bacteria
2. Restriction digestion and restriction mapping
3. Vector construction
4. Transformation & expression of gene in host cells
5. Detection of genes in hosts
6. PCR and molecular characterization
7. Microarray data analysis
8. Genomic sites in web and retrieval
9. ORF finding
10. Gene and genome annotation

Text Books 1. Khanum, A. and I.A. Khan. 2004. Fundamentals of Gene genomics and Genetic
Engineering. Ukaaz publications Hyderabad
2. Sahai, S. 1999. Genomics and Proteomics. Functional and Computational
Aspects. Plenum Publication.
References 1. S.B.Primrose and R.M. Twyman. 2006. Principles of Genome analysis and
Genomics. 7th edition. Blackwell Publishing.

Immunology and Immuno-technology LTPC: 3 0 3 4

Version No. 1.0.0
Course Prerequisites Biochemistry, Animal Physiology and Biotechnology
Objectives: To introduce the concept of immune response in a mammalian host
thereby emphasize their significance in innovation in developing
therapeutic modalities for immunological disorders of humans, to orient
the students to the biology of the immune system
Expected Outcome: The course outlines the basis of immune responses. Also it describes the
effector molecules that mediate the functions, the major signaling
pathways of activation of cells of the immune system, the abnormal
responses that result in disease
Unit No. 1 Immune system Number of hours: 8
An overview of the immunology – Cells and tissues of the immune system- Haematopoiesis: Origin
and differentiation of Lymphocytes and phagocytic cells- receptors and signals that control
lymphocyte lineage commitment. Immunogens and antigens, Innate and acquired immunity.
Elements of Immunity – B lymphocytes and thymus derived (T) Lymphocytes.
Unit No. 2 Humoral and Cellular Immunity Number of hours: 9
Immunoglobulins - Classes and subclasses, organization and expression of immnunoglobulin genes.
immunoglobulin gene rearrangement –antibody diversity –Clonal theory: B cell memory and
immune response. Classification of thymus derived (T) Lymphocytes, apoptosis, T cell receptor
gene rearrangement, antigen presenting cells. Macrophages, Langerhan’s cells, dendritic cells,
mechanism of phagocytosis, molecular structure and assembly of MHC molecules, Classes of MHC
– MHC/HLA genetic loci , antigen processing and presentation.
Unit No. 3 Immunity to infection and Hypersensitivity Number of hours: 9
Reactions
An overview of immune response to infections, complement systems, Hypersensitivity reactions,
case studies with remedial measures; cytokines, Immunological tolerance- role of cytokines and
regulatory and immunosuppressive T cells- role of B cells in oral tolerance- T cell tolerance-
idiotype and anti-idiotype network theory
Unit No. 5 Immunology of tumors, autoimmunity and Number of hours: 9
transplantation
Transplantation: Types, immunological mechanisms of graft rejection- immunological strategies to
prevent graft rejection-role of immunosuppressive drugs. Autoimmunity: HLA alleles and disease
susceptibility- an overview of the immunopathogenic mechanisms of autoimmunity -therapeutic
approaches. Tumors: Immune response to tumors-types of tumor antigens- immunological
approaches to tumor regression.
Unit No. 5 Immunotechnology Number of hours: 9
Hybridoma technology - Production and purification of monoclonal antibodies and their application
in clinical Diagnosis. Antibody engineering: definition; applications. Immuno diffusion & immuno
electrophoresis,ELISA, ELISpot, Immuno fluorescence. Application of Antibodies: Western
Blotting; Flow Cytometry; Antibody Arrays; Immunostaining; Immunoblotting; Immunoassay;
Immunoaffinity Chromatography; Catalytic Antibodies and phage display.
No. Experiment
1. Complement mediated lysis of sheep RBC coated with amboceptor (antisheep RBC
antibody)
2. Immunodiffusion – single radial diffusion
3. Immunodiffusion – double diffusion
4. Latex Agglutination test

5. VIDAL tube agglutination test

6. Quantitative precipitin assay
7. Immuno-electrophoresis & Immunoblotting
8. Immunostaining
9. Antibody labeling with enzymes
10. ELISA
Text Books 1. Goldsby. R.A, Kindt.T.J, Kuby J and Osborne BA Immunology, 5th Eds. W.H.
Freeman Pubn. 2002.
2. Abbas K A, Litchman A. H. Cellular and Molecular Immunology. 5th Edn., W. B.
Saunders Co. 2005.
References 1. Roitt I.M., Brostoff. J, Male. D.K. Immunology, 5th B. K. & Cdr eds, Garland
Pub Ltd. 2001.
2. C. A. Janeway Jr, P. Travers. Immunobiology, 4th Ed. (or later).
3. R.M. Coleman, M.F. Lombard, R.E.Sichard. Fundamental Immunology, 2nd Ed
(or later)

Industrial Biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Microbiology
Objectives: To provide a detailed knowledge on various biofermentation technologies,
production of different metabolites and factors influencing the industrial
production of metabolites such as alcohol, amino acids, antibiotics, enzymes,
biopolymers, etc
Expected Outcome: The students will
Have brief idea about the upstream and downstream process for various
products in biotech industries.
Be able to apply this knowledge to design processes for the microbial
production of various primary and secondary metabolites and also certain
specialty bio-products for various industrial sectors.
Have an overall view of the processes involved in the biological treatment
of industrial wastes.
Unit No. 1 Introduction to Industrial Bioprocess Number of hours: 8
Overview of Industrial fermentation processes and products; Process Flow-Sheeting; a brief survey
of organisms, processes, products, and screening of organisms. Fermentation – aerobic and
anaerobic fermentation processes. Solid state fermentations.
Unit No. 2 Metabolic Stoichiometry Number of hours: 8
Stoichiometry of Cell growth and product formation, elemental balances, degrees of reduction of
substrate and biomass, available electron balances, yield coefficients of biomass and product
formation, maintenance coefficients ; oxygen consumption and heat evolution in aerobic cultures.
Unit No. 3 Raw Material for Fermentation Process Number of hours: 12
Raw Materials, Media Design and Sterilization: Criteria for good medium, medium requirements
for fermentation processes, carbon, nitrogen, minerals, vitamins and other complex nutrients,
oxygen requirements, medium formulation of optimal growth and product formation, examples of
simple and complex media, design of various commercial media for industrial fermentations -
medium optimization methods. Sterilization : Thermal death kinetics of microorganisms, batch and
continuous heat, sterilization of liquid media, filter sterilization of liquid media & air.
Unit No. 4 Production of Primary and Secondary Metabolites Number of hours: 10
A brief outline of processes for the production of some commercially important organic acids (citric
acid, acetic acid); amino acids (glutamic acid, lysine); and solvents and alcohols (buteniodiol &
ethanol); Enzymes for Laundry Detergents, Automated Dishwashing, Production of Textiles, Pulp
& Paper Industry, Starch & Food. Enzymes as additives to animal feed, enzymes for production of
bioethanol and enzymes in organic syntheses).
Unit No. 5 Strain Development Number of hours: 7
Selection and genetic screening of industrial organisms and products, Techniques of strain
improvement – selection, screening and mutation, recombinant techniques and selection of hosts
and vectors for recombinant protein production. Modification of pathway of production by
environment and genetic factors.
Text Books 1. Stanbury, P.F., Whitaker, A. and S.J.Hall. 1995. Principles of Fermentation
Technology. Butterworth Heinmann. Oxford.
References 1. Shuler, M. and F. Kargi. 2002. Bioprocess Engineering. Prentice Hall (I) Ltd., N.
Delhi.
2. Ulber, R. and Sell, D. 2007. White Biotechnology. Springer & Verlog, Berlin.
3. Colin Ratledge, Bjorn Kristiansen, Basic Biotechnology, Cambridge University

Press, 2001.
3. Rehm, H,G- and Reed, I. 1993. Biotechnology. 2nd Edition Vol.1-12. VCH
Verlagsgesellschaft mbH, Weinheim, Germany.
4. World Wide Web and Current Peer Reviewd Journals
Mode of Evaluation Written examination/Assignment/Seminar

Industrial Training LTPC: 0 0 0 2

Version No. 1.0.0
Course Prerequisites
Objectives: To expose the students to the industrial environment for experiential
learning
Expected Outcome: The exposure will prepare the students to observe and analyze
industry problems and will sow the seeds for successful entrepreneur.
Text Books Relevant to the industry visited
References Relevant to the industry visited
Mode of Evaluation After the end of 4 weeks training, the student’s
diary, project report will be evaluated and the
knowledge acquired will be tested as written test
or viva voce.

BIT 101 Introduction to Life Sciences LTPC: 4 0 0 4

Version No. 1.0.0
Course Prerequisites +2 physics and chemistry
Objectives: To understand the general concepts of life sciences connected to
biotechnology
Expected Outcome: The students after undergoing the course will learn the concepts in
biology and lay the foundation to understand further concepts and
techniques in biotechnology.
Unit No. 1 Life and taxonomy Number of hours: 10
The Science of Biology, Characteristics of Life, Levels of Organization, The Significance of Biology,
Consequences of Not Understanding Biological Principles Future Directions in Biology.
Classification of organisms –kingdoms of Life – basis for different classification schemes – plants,
animals and microorganisms – tools in modern taxonomy.
Unit No. 2 Cells Number of hours: 10
The Cell Theory, Cell Membranes, Diffusion, Dialysis and Osmosis, Controlled
Methods of Transporting Molecules, Cell Size, Organelles Composed of Membranes,
The Endoplasmic Reticulum, The Golgi Apparatus, The Nuclear Membrane, Energy Converters –
Nonmembranous Organelles: Ribosomes, Microtubules, Microfilaments and Intermediate
Filaments, Centrioles, Cilia and Flagella Inclusions, Nuclear Components – Major Cell Types: The
Prokaryotic Cell Structure. The Eukaryotic Cell Structure – Cell organization, tissues and organs.
Cell division – mitosis and meiosis.
Unit No. 3 Plants & Microbes Number of hours: 14
Microbial world – viruses, bacteria, fungi and algae – typical morphology and significance.
Plant Cell division and cell walls, Growth and differentiation, Herbaceous stems and roots, Woody
plants, Leaves- Respiration, Photosynthetic pathways, Photosynthesis & transpiration Hormones,
Signals and sensors, Seed to plant, Flowering to senescence.
Unit No. 4 Animals and human Number of hours: 15
Structure and organization of animal cells – introduction to human digestive, circulatory, nervous,
excretory, reproductive and defensive mechanisms.
Unit No. 5 Genetics Number of hours: 11
Heredity – Mendel’s laws – units of heredity – chromosomes, genes organization – karyotyping,
pedigree analysis – genetic engineering tools – transgenic technology – applications and ethics in
biotechnology
Text Books Plus 2 / CBSE Biology Series
References Campbell,N.A. Reece,J.B., and Simon, E.J. 2007. Essential Biology with
Physiology (2nd Edition). Campbell Biology Websites Series.
Assignments/ Seminars and Written Examination
Recommended by the Board of Studies on June, 2008.

Microbiology LTPC: 3 0 4 5
Version No. 1.0.0
Course Prerequisites: BIT101
Objectives: To impart knowledge and skill in isolation, identification, mass
multiplication and handling and controlling of microorganisms in
labs and industries.
Expected Outcome: After the completion of the course the student will be able to isolate,
identify, grow microorganism, control their growth to prevent
infection and dispose them safely.
Unit No. 1 Tools in Microbiology Number of hours: 8
History and development of Microbiology- Microscopy – different types of microscopes &
micrometry; staining techniques, pure culture techniques, microbial nutrition and role of major,
minor elements and types of media, enrichment, isolation, purification, maintenance and
preservation of cultures. Preparation of media and cultivation of microorganisms
Unit No. 2 Morphology and Taxonomy Number of hours: 10
Classification of microorganisms –prokaryotes and eukaryotes – bacteria types and cell components
– bacterial classification schemes and identification methods. Fungal classification and key
identification characters. Algal characteristics, groups, and classification. Viruses – types,
classification and characters. Sources of microorganisms - Microbial Type Collection Centres in
India and abroad.
Unit No. 3 Metabolism Number of hours: 10
Respiratory metabolisms of microorganism – aerobic and anaerobic paths of energy production.
Nutrition modes – autotrophy, heterotrophy, & lithotrophy. Fermentative pathways – organisms,
substrates, intermediates and end products. Storage polymers and excretory metabolism.
Membrane transport – nutrient uptake and protein secretion in bacteria.
Unit No. 4 Microbial growth Number of hours: 8
Microbial Growth: definition, cell division in microbes, factors affecting growth, techniques for
measurements of growth and enumeration, Batch culture, continuous culture and synchronous
growth; growth phases and growth curves - Chemostat, Turbidostat. Filamentous growth and
measurement. Control of growth, principles, physical and chemical agents and their mode of action
and application
Unit No. 5 Applied Microbiology Number of hours: 9
Microorganisms as human pathogens – role of bacteria, fungi and viruses in human diseases -
Detection methods. Aquatic microorganisms – water testing and biological analysis – algal blooms
and eutrophication. Soil microorganisms their role in biogeochemical cycles – beneficial
interactions with plants, animals and humans.
No. Experiments
1. Light microscopy and components of microscope
2. Morphology of bacteria, fungi and algae
3. Simple & Differential staining and Gram’s staining
4. Micrometry
5. Preparation and sterilization of medium and glassware
6. Purification of microorganisms by serial dilution and pour plate technique
7. Streak plate technique and single spore isolation
8. Biochemical tests for identification of microorganisms
9. Antibiotic profiling of microorganisms
10. Growth of microorganism under shake flaks culture
Text Books 1. Pelczar MJ, Chan ECS and Krieg NR. 2005. Microbiology, Tata McGraw Hill

Edition, New Delhi, India.

2. Black ,2004 . Text book of Microbiology. Freeman Publishers
References 1. Atlas RM, 2003. Principles of Microbiology (2nd Edition), Dubuque Wm.C.
Brown.
2. Talaro K, Talaro A, Pelczar, C. and Reid, 2003. Foundation in Microbiology,
WC Brown Publishers.
3. Madigan MT, Martinko JM, Parker J. 2002. Brock Biology of Microorganisms
(8th eds), Prentice-Hall.
4. Glazer AN, Nikaido H. 2003. Microbial Biotechnology: Fundamentals of
Applied Microbiology, WH Freeman.

Molecular Biology LTPC: 3 0 4 5

Version No. 1.0.0
Prerequisites Biochemistry & Cell Biology
Objectives: To serve as an eye opener to the field of molecular cell biology.
To learn how nucleic acids, DNA and RNA carry and transfer genetic
information from one generation to the next and translate this coded
information into active proteins.
Expected Outcome: On reading the course students will gain knowledge on the synthesis,
function of nucleic acids and gene regulation
Unit No. 1 Genome organization Number of hours: 8
Prokaryotic (bacteria, viruses and yeast) and eukaryotic (Plant and Animal) genome, plasmids,
episomes and transposons.
Unit No. 2 Chromosomes Number of hours: 8
Chromosome: Morphology, models, histone and non histone proteins, karyotype, ideotype, special
chromosomes, sequence organization of DNA, functions.
Unit No. 3 Genetic material Number of hours: 10
DNA/RNA as genetic material, C-value paradox , Chargaff’s rule, DNA double helix, different
forms of DNA, DNA replication, mutation, repair, recombination, RNA structure, synthesis and
processing of t RNA and r RNA genes.
Unit No. 4 Gene transcription and translation Number of hours: 10
Gene transcription and translation in prokaryotes and eukaryotes - genetic code, post
transcriptional and translational modifications (processing of eukaryotic m RNA, signal mediated
transport through nuclear pore complexes, targeting of mitochondrial, chloroplast and peroxisomal
proteins, translocation of secretory proteins across the ER membrane, protein glycosylation in the
ER and golgi complex and protein sorting)
Unit No. 5 Gene structure and expression Number of hours: 9
Structure of gene, gene families, gene expression, promoters, introns, exons, psuedogenes –
regulation of gene expression in prokaryotes and eukaryotes (lac operon, trp operon and human
gene expression)
No. Experiment
1. Isolation and analysis of microbial genomic DNA
2. Isolation and analysis of plant genomic DNA
3. Isolation and analysis of human genomic DNA from blood cells
4. Isolation and analysis of RNA from prokaryotic and eukaryotic cells
5. Isolation of Yeast genomic DNA
6. Quantification of DNA and RNA
7. PCR
8. Growth vs DNA concentration
9. Separation of proteins by SDS PAGE
10. Western blotting
Text Books 1. Nelson,D.N. and Michal M.C. 2007. Lehninger. Principles of Biochemistry. W.H.
Freeman publications.
2. Gardner, E.J., Simmons, M.J., and Snustad. D.P. 2005. Principles of genetics. 8th
edition. Wiley India, Nice Printing press, New Delhi
3. James D. Watson et al.,2004. Molecular biology of the gene. Pearson education
Inc.
References 1. Benjamin Lewin. 2004. Genes VIII. Pearson Education, Inc.
2. Geoffrey M. Cooper. 2000. The Cell: A Molecular Approach. 2nd Edition. Sinauer

Associates, Inc.
3. Lodish H. et. al., 2004. Molecular Cell Biology, 5th Edition, W.H. Freeman & Co.
4. Joseph Sambrook. 2001. Molecular Cloning: A Laboratory Manual. 3rd edition,
CSHL press.
Assignments/ Seminars and Written
Examination

Nanobiotechnology LTPC: 3 0 0 3
Version No. 1.2.0
Prerequisites Knowledge on biochemistry, biophysics and molecular biology
Objectives: To make the students learn the basics of nanotechnology.
Understand the various methods in the synthesis / preparation of
nanoparticles.
Get exposed to potential applications of nanobiotechnology.
Expected Outcome: At the end of the course the student should be able to suggest a suitable
technique(s) to characterize a given nanoparticle. Appreciate the potential
uses of nanobiotechnology. Design a nanobioparticle for specific application.
Unit No. 1 Introduction to nanotechnology and Number of hours: 9
Interphase systems
Biocompatible inorganic devices, Lab-on-a-chip devices, Microcontact printing of proteins, Cell
nanostructure interactions, Defined networks of neuronal cells in vitro
Unit No. 2 Nanoanalytics Number of hours: 9
Lumuniscent quantum dots for biological labeling, Nanoparticle molecular labels, Force
spectroscopy, Biofunctionalized Nanoparticles for surface enhanced Raman scattering and Surface
plasmon resonance
Unit No. 3 DNA-based nanostructures Number of hours: 9
DNA-Protein nanostructures, DNA-templated electronics, Biomimetic fabrication of DNA-based
metallic nanowires and networks, Mineralization in Nanostructured Biocompartments: Biomimetic
ferritins for high-density data storage, DNA-gold nanoparticle conjugates, DNA nanostructrures
for mechanics and computing: Nonlinear thinking with life’s central molecule; Nanoparticles as
non-viral transfection agen
Unit No. 4 Protein based nanostructures Number of hours: 8
Engineering nanopores, Genetic approaches to programmed assembly, Microbial nanoparticle
production, Magnetosomes: Nanoscale Magnetic Iron Minerals in Bacteria, Polymer
nanocontainers, Nanoparticle-biomaterial hybrid systems for Bioelectronic Devices and Circuitry
Unit No. 5 Application of nanobioparticles Number of hours: 10
Bacteriorhodopsin and its potential in technical applications, Biological activities of nanoparticles,
interactions with cells, biomolecules, immune system, Reducing and eliminating nanotoxicity and
ecotoxicology
Text Books 1. CM Niemeyer and CA Mirkin. 2004. Nanobiotechnology: Concepts,
applications and perspectives. Wiley-VCH Verlag GmbH & Co., (A).
2. M Kohler and W Fritzsche. 2004. Nanotechnology: An introduction to
nanostructuring techniques. Wiley-VCH Verlag GmbH & Co.,
References 1. Bhusan. 2004. Handbook of nanotechnology. Springer-Verlag.
2. PM Ajayan, LS Schadler and PV Braun. 2003. Nanocomposite science and
technology. Wiley - VCH Verlag, GmbH & Co.,
3. Yuliang Zhao and Hari Singh Nalwa. 2007. Nanotoxicology. American
Scientific Publishers.
Recommended by the Board of Studies on 8th April, 2009

CHY103 Organic Chemistry LTPC: 3 0 2 4

Version No. 1.0.0
Course Prerequisites Chemistry at 12th Standard or equivalent level.
Objectives: To introduce principles of bioorganic chemistry.
Expected Outcome: To lay foundation for usage of bioorganic chemistry in different areas.
Expected Outcomes At the end of the course, students will
•be familiar with the fundamentals of electronic effects and their utility in
understanding biological reactions.
• acquire knowledge in the stereochemistry, chirality, prochirality and its
application in biological aspects.
•acquire knowledge in the nomenclature, synthesis of crown ethers and
how the crown ethers forming the basis for templates and bio-models.
Unit No. 1 Electronic effects in Organic Chemistry Hours: 9
Electronic effects: Inductive effect, resonance effect, hyper conjugative effects, field effects,
hydrogen bonding, steric inhibition of resonance - electromeric effect - London forces -
Applications of all these effects to simple molecule such as alcohols- amines, carboxylic acids and
ketones with special reference towards biological applications.
Unit No. 2 Introductory stereochemistry to Bio-organic Hours: 9
Chemistry
Stereochemistry: Chirality -prochiral- R, S notation for simple chiral molecules (up to six chiral
carbon atoms) - stereo electronic requirements for the reactions - stereoselectivity and
stereospecificity - asymmetric induction.
Unit No. 3 Prochirality and Prostereoisomerism Hours: 9
Homotopic ligands and faces - heterotopic ligands and faces - diaseterotopic ligands and faces -
nomenclature of stereoheterotopic ligands and faces - biological stereospecificity - manifestation of
biological stereoselectivity in Krebs cycle - biological stereoselectivity by enzyme dehydrogenase
and glycerolkinase.
Unit No. 4 Phase Transfer catalysts Hours: 9
Introduction – definition – mechanism - types of phase transfer catalysts and reactions -
preparation of phase transfer catalysts: Quaternary salts, exchange of anions on the quaternary
salts, applications of PTC in organic synthesis. Macrocyclic ethers as PTC.
Unit No. 5 Crown ethers and Cryptands Hours: 9
Introduction: Nomenclature - synthesis of crown ethers, aza-crown ethers and cryptands (upto 18-
crown- 6) - template effects - nature of donor sites. Application of crown ethers towards biomodels.
No. Name of the experiment
1. Identification of aromaticity, nature and saturation
2. Aldehydes
3. Ketones
4. Aliphatic diamides
5. Aromatic amines
6. Aromatic amides
7. Aromatic carboxylic acids,
8. Dicarboxylic acids
9. Carbohydrates
10. Esters
Text Books 1. I.L. Finar (2000), Orgainc Chemistry, Vol. II, ELBS.
2. H. Dugas (2003), Bio-organic Chemistry - A Chemical Approach to Enzyme
Action, Springer.

3. V.K. Ahluwalia and Renu Agarwal (2002), Organic Synthesis – Special

Techniques, Narosa Publishing House.
4. S.M. Khopkar (2003), Analytical Chemistry of Macrocyclic and
Supramolecular Compounds, Narosa Publishing House.
References
Mode of Evaluation Written examinations, seminar, assignment,
surprise tests, quizzes, group discussions.

Pharmaceutical Biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Biochemistry and Animal Physiology and Biotechnology
Objectives: To create an awareness on pharmacology and biotechnology based
pharmaceutical products
To promote the applications of biotechnology to the thrust areas of
healthcare industry
Expected Outcome: Biotechnology undergraduate students will gain enough knowledge to take
up pharmaceutical biotechnology as a research career to develop newer
products
To provide manpower to the biotechnology based pharmaceutical
companies, clinical trial industries
Prepares students to aspire as consultants in KPO healthcare industry
Unit No. 1 General pharmacology Number of hours: 7
Introduction - Development of Drugs, Pharmacokinetics and pharmacodynamics, routes of drug
administration –Bioavailability curve, Drug receptor interaction, adverse drug reaction,
prescription.
Unit No. 2 Pharmacology Number of hours: 10
Mechanism of action of local and general Anesthetics, opioid analgesics and antagonists, NSAIDs,
antihistamines, pharmacotherapy of hypertension, electrolytes, diuretics, pharmacotherapy of peptic
ulcer.
Unit No. 3 Formulating Biotech drugs Number of hours: 10
Pharmacokinetics and pharmacodynamics of peptide and protein drugs, Microbial decontamination,
excipients used in biotech products, self life of protein based drugs, routes of administration and
absorption enhancement in protein drugs, controlled and site specific delivery of protein drugs
Unit No. 4 Biotech drugs Number of hours: 11
Pharmacotherapy using Cytokines, interleukins and interferon-gama, insulin and insulin analogs in
diabetes treatment. Growth hormone, Modern vaccines -subunit vaccines, r-DNA vaccines,
Development of antibody based drug therapy, monoclonal antibody, murine antibody, chimeric
antibody, humanized antibody.
Unit No. 5 Clinical trials Number of hours: 7
Clinical Trials & Regulations - Clinical Trials – Design, double blind studies, placebo effects, FDA
regulations (General) and Indian Drug regulations- highlights.
Text Books 1. Pharmacology and pharmacotherapeutics, R.S.Satoskar, 20th edition2007
References 1. Pharmaceutical biotechnology, Daan J A Crommelin and Robert D Sindelar
second edition2002.

Plant physiology and biotechnology LTPC: 3 0 0 3

Version No. 1.0.0
Course Prerequisites BIT101
Objectives: To provide a thorough understanding of the different physiological
mechanisms operating in plants
To provide knowledge on tissue culture methods
To provide knowledge of different biotechnology tools that help to
study as well as modify plants suited to our needs
Expected Outcome: Students will gain knowledge on
Physiological mechanisms of plants – Micropropagation techniques of
plants – molecular marker technology - plant transformation, transgenic
plants.
Unit No. 1 Mineral nutrition, photosynthesis and respiration Number of hours: 9
Mineral nutrition, essential elements, role and deficiency symptoms, Photosynthesis, chloroplasts,
principles of light absorption, photosystem I and II, photophosphorylation, light and dark
reactions, C3, C4 and CAM pathways, Respiration, glycolysis, Krebs cycle, pentose phosphate
pathway.
Unit No. 2 Plant growth and development Number of hours: 9
Flowering, photoperiodism, Long day and short day plants, Dormancy, Phytohormones, auxins,
gibberellins, cytokinins, ethylene and abscissic acid, Stress physiology, Biotic stress (microbes and
insects) Abiotic stress (water stress, high temperature stress, acidic and alkaline soils)
Unit No. 3 Plant tissue culture and plant transformation Number of hours: 9
Plasticity and Totipotency, The culture environment, Plant culture media, Plant growth
regulators, Culture types (callus, cell suspension cultures, protoplasts, root cultures, shoottip and
meristem culture, embryo culture and Microspore culture), Plant regeneration (Somatic
embryogenesis and Organogenesis). Direct (Particle bombardment, PEG mediated transformation,
electroporation, Silicon carbide fibre) and indirect gene transformation (Agrobacterium mediated
plant transformation).
Unit No. 4 Transgenic plants Number of hours: 9
Manipulation for herbicide resistance, development of stress tolerance (cold tolerance, drought
resistance, salt tolerance, pest tolerance, pathogen tolerance, etc), Improvement of Quality traits
(delayed ripening of fruits, increasing vitamin content), Molecular pharming (Vaccines, bioplastics
etc.,)
Unit No. 5 Marker technology Number of hours: 9
Molecular markers, single locus and multilocus markers, Isozymes, RAPD, ISSR, AFLP, SSR,
genetic diversity, fingerprinting, linkage mapping, map based cloning, analysis of complex traits,
marker assisted selection for biotic and abiotic stresses.
Text Books 1. Adrian Slater, NW Scott, MR Fowler, Plant Biotechnology: The Genetic
Manipulation of Plants, Oxford University Press.
2. Frank. B. Salisbury and Cleon. W. Ross, Plant Physiology, Fourth Edition, 1992,
Wardworth publishers.
References 1. Gerard.J. Tortora, Sandra. R. Grabowski, Principles of Anatomy and
Physiology, Tenth Edition, 2002, Wiley Publishers.
2. Mantal S.H., Mathews J.A., Mickee R.A., Principles of Plant Biotechnology. An
Introduction of Genetic Engineering in Plants, Blackwell Scientific Publication,
1985.
3. Dodds J.H., Plant Genetic Engineering, Cambridge University Press, 1985.


Examination

Principles of Chemical Engineering LTPC: 3 0 2 4

Version No. 1.0.0
Prerequisites MAT101
Objectives: Introduction of the fundamentals of the energy balances and their role in
chemical processes
Development of skills of the students in the area of Chemical engineering
with emphasis in thermodynamics, fluid mechanics
Expected Outcome: Convert quantities from one set of units to another quickly and accurately.
At the end of the course, the students would have gained knowledge in
solving material and energy balance equations for single-unit and multiple-
unit processes and processes with recycle and bypass, principles of fluid
mechanics.
The course will help them to understand certain subjects of engineering
offered in this programme
Unit No. 1 Introduction Number of hours: 10
Dimensions and system of units, Fundamental quantities, Derived quantities and conversions-
Basic chemical engineering calculations, Atomic, molecular and equivalent weights, molar concepts,
concentration units for pure components, vapor pressures, moles, mixtures and solution, Molarity,
normality and partial pressures, laws of chemical combination, definition of stoichiometry,
composition of mixtures and solutions, weight fraction, mole fraction, volumetric composition,
partial pressures, density and specific gravity. Ideal gas law, ideal mixtures and solution, Dalton’s
Law of Additive pressures, Amagot’s Law of Additive volumes.
Unit No. 2 Material Balance Number of hours: 9
Law of conservation of mass, meaning of material balance and its applications, process flow sheet,
drawing material balance on non reacting steady system, recycling, bypassing, material balance on
steady state reacting systems with recycling and bypassing.
Unit No. 3 Energy Balance Number of hours: 9
Law conservation of Energy, meaning of Energy balance and its importance inputs of energy
balance, specific heat and sensible heat, Latent heat and heats of transition, sublimation, enthalpy of
solutions, chemical reactions, conversion, yield, standard heats of reaction, Hess Law, Kirchoff’s
Law.
Unit No. 4 Dimensional Analysis Number of hours: 8
Introduction, derived quantities, homogeneity, methods of dimensional analysis, Rayleighs method,
Buckingham theorem, procedure for solving problems by Buckingham theorem, similarities
Unit No. 5 Momentum Transport Number of hours: 9
Fluid head and manometry, fluid types, nature of flow, basic equation of fluid flow, transportation
and metering of fluids, pipe, fittings and valves, fluid moving machinery, measurement of flowing
fluids.
No. Experiment
1. Characteristics of centrifugal pump.
2. Characteristics of gear pump.
3. Characteristics test of self priming Pump.
4. Flow through Venture Meter.
5. Flow through Orifice Meter.
6. Fluid flow through fluidized bed.
7. Plate and frame filter press.
8. Batch and sedimentation.
9. Leaf filter.

10. Shell and tube heat exchanger

Text Books 1.Bhatt B. I and S.M. Vora Stoichiometry Tata McGraw Hill, 4th Edition, 2004.
2.McCabe RL & J.C Smith “Unit operations of Chemical Engineering” McGraw
Hill International Editions, 2001.
References 1.Himmelblau D.M., Basic Principles and Calculations in Chemical Engineering,
Prentice Hall, 2003
2.White F.M, Fluid Mechanics, Fourth Edition, McGraw Hill Inc.,1999

Principles of Management LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Nil
Objectives to inculcate the students about fundamentals of Management
Expected Outcome Convert quantities from one set of units to another quickly and accurately.
At the end of the course, the students would have gained knowledge in
solving material and energy balance equations for single-unit and multiple-
unit processes and processes with recycle and bypass, principles of fluid
mechanics.
The course will help them to understand certain subjects of engineering
offered in this programme.

Project Work LTPC: 0 0 0 20
A research project to be undertaken in a reputed institute or in VIT for a period of one semester.
Mode of Evaluation 0th, mid and final reviews/ Dissertation/ viva voce

L T P C
MAT104 Probability and Statistics
3 1 0 4
Version No. 1.0
Course Prerequisites Multivariable Calculus and Differential Equations (MAT101)
Objectives This course is intended to provide a comprehensive introduction to the
probability models and statistical methods most likely to be encountered
and used by students in their careers in engineering and the natural
sciences.
Expected Outcome By the end of the course the students are expected to
(i) to identify the probability distribution for a given data.
(ii) use the model with the parameters of the data for analyzing samples.
Unit 1 Probability 10 hours
Introduction–sample spaces and events, axioms and properties of probability – conditional
probability – Baye’s theorem and its applications.
Unit 2 Random Variables 11 hours
Random variable – distributions and density functions - mathematical expectation – moment
generating function – characteristic function – Binomial, Poisson, Normal, Gamma and
Exponential distributions
Unit 3 Joint Probability Distribution and 15 hours
Random Samples
Random vectors-joint distribution and joint density functions – conditional distribution and density
functions–Co-variance-correlation–statistics and their distributions–distribution of the sample
mean.
Unit 4 Inference Based on Single Sample 12 hours
Confidence interval – population mean and proportion–variance and standard deviation–hypotheses
and tests procedures-tests about a population mean and proportion – p-values.
Unit 5 Inference Based on Two Sample 12 hours
Z-tests–confidence interval for a difference between two population mean – two sample t-test and
confidence interval–analysis of paired data – inferences concerning a difference between two
population proportion and variances.
Text Books Jay L. Devore, Probability and Statistics, Thomson Duxbury, Singapore,
2002.
References 1. Irwin Miller and John Freund, Probability and Statistics for
Engineers, 7th Edition, Prentice Hall (2004).
2. R E Walpole, RH Myers, S.L. Myers and Kye, probability and statistics for
engineers and scientists, Prentice Hall, 7th Edition (2002).
Mode of Evaluation Continuous assessment Examination,
Assignments, Tutorial sheets, Class Test, Quiz.

Protein Engineering and Proteomics LTPC: 3 0 0 3

Version No. 1.0.0
• To make the student familiarize with the basics, concepts and

Prerequisites Biochemistry, Molecular biology and Genetic Engineering
Objectives:
application of protein engineering and proteomics
Expected Outcome: • Explain the principles involved in the maintenance of protein structure
• Analyze the given protein structure and predict the sites to be
engineered for altering/introducing a specific property
• Apply the concepts of proteomics for novel applications
Unit No. 1 Chemical Properties and Evolution of Proteins Number of hours: 12
Amino acid structure and properties- Detection of the sizes of proteins – covalent structures in
proteins – overview of chemical and biosynthesis of proteins – topogenesis – post translational
covalent modification of polypeptide chains. Evolutionary divergence – Reconstructing evolution
from contemporary sequences – gene rearrangements and the evolution of protein complexity –
genetics to probe protein structure – physical nature of non-covalent interaction – interaction(s)
with solvent – hydrophobic interaction – intramolecular interactions – degradation of proteins.
Unit No. 2 Conformation of Proteins No. hours: 10
Overview of the levels of structures in globular proteins – Ramachandran plot – X-ray and NMR
measurements for the determination of three dimensional structures of proteins – theoretical
structure prediction methods – flexibility and stability of protein structure – mechanism of protein
folding – physical and chemical properties of soluble and membrane proteins
Unit No. 3 Rational Engineering and Design of proteins No. hours: 11
Introduction to protein engineering – site directed and random mutagenesis – stability
enhancement – bacteriophage display libraries – design of metalloproteins – engineering
therapeutic antibodies – enhanced recovery and folding of recombinant proteins using fusion
protein strategies – protein engineering for affinity purification – biosensor and vaccine
development
Unit No. 4 Proteomics No. hours: 12
Analytical protein and peptide separations – protein digestion techniques – MS for protein and
peptide analysis – protein identification by peptide mass finger printing – tandem mass and coupled
techniques. Application of proteomics: mining proteomes – protein expression profiling – protein-
protein interactions – mapping protein modifications.
Text Books 1. Creighton TE (2002) Proteins: Structure and Molecular Properties, WH
Freeman and Company. (Modules 1 & 2)
2. Cleland JL & Craik CS (Ed) (1996) Protein Engineering Principles and Practice,
John Wiley & Sons. (Module 3)
3. Lilia Alberghina (2003) Protein Engineering in Industrial Biotechnology,
Harward academic Publishers. (Module 3)
4. Daniel C Liebler (2002) Introduction to Proteomics, Humana Press. (Module 4)
References 3. David Whitford (2005) Proteins: Structure and function, John Wiley and Sons.
4. Mahmoud Hamdan & Pier Giorgio Righetti (2005) Proteomics Today, John
Wiley & Sons.
5. Reiner Westermeir and Tom Naven (2002) Proteomics in Practice: A
Laboratory manual of Proteome Analysis, Wiley VCH.
5. Alian Bernot (2004) Genome Transcriptome and Proteome Analysis, John Wiley
and Sons.


MEE102 Workshop Practice LTPC: 0 0 2 1

Version No. 1.0.0
Prerequisites
Objectives: • To train the students in metal joining processes like welding, soldering,
etc
• To impart skill in fabricating simple components using sheet metal.
• To cultivate safety aspects in handling of tools and equipment
Expected Outcome: On completion of the course, students will be able to do:
• Welding and soldering operations.
• Fabrication of simple sheet metal parts
No. Experiment
1. Introduction of BI standards and reading of welding drawings.
2. Butt Joint
3. Lap Joint
4. TIG Welding
5. MIG Welding
6. Making of Cube
7. Making of Cone using development of surface.
8. Making of control panel using development of surface
9. Soldering and desoldering of Resistor in PCB
10. Soldering and desoldering of IC in PCB
11. Soldering and desoldering of Capacitor in PCB
12. Demonstration of all BOSCH TOOLS
Text Books Workshop Manual prepared by VIT Staff
References

PROGRAMME ELECTIVES
Biobusiness LTPC: 3 0 0 3
Version No. 1.0.0
Course Prerequisites General understanding of biotechnology concepts
Objectives: This inter-disciplinary course is designed to enable students to develop
an effective conceptual framework for addressing BioBusiness related
opportunities and challenges.
Expected Outcome: Issues and concerns relating of importance to BioBusiness in such areas
as public policy, human capital needs, investment and financing
(including venture capital), innovation and knowledge management,
intellectual property management, intrapreneurship entrepreneurship
development, regulatory affairs, marketing, brand management, best
practices, bioethics and so on will brought to students’ attention.
Unit No. 1 Understanding BioBusiness Number of hours: 9
Introduction to BioBusiness, Fundamentals of Biotech for BioBusiness, New versus Old
BioBusiness, Wealth Creation in BioBusiness: The Role of Innovation
Unit No. 2 BioBusiness Trends and Opportunity Areas Number of hours: 9
Healthcare, the BioMedical Sciences, Agriculture and Agribiotechnology, The Environment and
Environmental Biotechnology, Industrial Life Sciences and Biotechnology, Where Things Stand: A
Quick Survey of Regional and Global Strengths and Capabilities
Unit No. 3 Issues and Challenges in BioBusiness Number of hours: 9
Creating World Class Corporations and Biotech Clusters, Moral, Ethical and Social Concerns and
Opportunities, Intellectual Property, Technology Licensing and Branding Concerns and
Opportunities, Policy and Regulatory Concerns and Opportunities, Human Resource Concerns and
Opportunities, Financing Concerns and Opportunities.
Unit No. 4 Making Things Happen Number of hours: 9
Public Policy Opportunities, Entrepreneurial Opportunities, Investment and Investment
Management Opportunities Open Discussion and Course Review.
Group Project Presentation: Case studies of different industries and their strategic planning
Text Books Shahi, G. BioBusiness in Asia: How Asian Countries Can Capitalize on the Life
Science Revolution. Pearson Prentice Hall. 2004.
References 1. Cynthia Robbins-Roth From Alchemy to IPO: The Business of Biotechnology,
HarperCollins, 2001.
2. Gurinder S Shahi BioBusiness: A Strategic Perspective Global BioBusiness
Books. 2005
3. Newspapers and magazines as The Economist, Newsweek, Business Week,
Financial Times, the New York Times, The Wall Street Journal and so on

Biomaterials & Artificial Organs LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Animal or Human Physiology
Objectives: The purpose of this course is to acquaint each student with the field of
material science, bio materials that are used in medical devices or in
contact with biological systems and artificial organs
Expected Outcome: A thorough knowledge on the classes of biomaterials and artificial organs
is emphasized
History of Biomaterials, General Properties of Bio–materials, Classes of materials used in medicine.
Definition Bio–materials, Bio–medical devices, Bio– functionality, Bio–compatibility, Properties of
Bio-materials, Bulk properties, Surface properties, characterization of biomaterials
Unit No. 2 Metallic Bio-materials Number of hours: 10
Stainless steel, Titanium, Alloys, Dental metals. Bio-Ceramics: Bio – inert ceramics, Bio – active
ceramics, Biodegradable ceramics, Alumina, Zirconia, Hydroxy Apatite. Polymeric Bio-materials:
Types of polymers, Sterilisation, Structure – Bio- compatibility relationship, Stability, Examples of
polymers used in medicine. Composite Bio-materials: Fibres composites, Particulate composites,
Examples. Nanobio- materials: Properties, preparation, characterisation, applications. Bio-material
Toxicology: Requirement, Test for bio- compatibility,
Unit No. 3 Artificial Organs - I Number of hours: 8
Substitutive medicine, Biomaterial Concentration, Outlook for Organ Replacement, Design
Consideration, Evaluation of Artificial Organs.
Unit No. 4 Artificial Organs - II Number of hours: 8
Design of Artificial heart, History of Artificial Heart, Types of Valve Prostheses, Mechanical
Circulatory Assistance, Two Main Categories, Intra- Aortic Balloon Pump, Percutaneous Cardio-
Pulmonary Bypass. Comparison of Artificial Lungs and Natural Lungs, Coupling of Oxygen &
Carbon-di-oxide Exchange, Shear Induced Transport, Augmentation and Devices for Improved
Gas Transport.
Renal Transplantation, Mass Transfer in Dialysis, Membranes, Hemofiltration, Adequacy of
Dialysis, Peritoneal Dialysis Equipment. Insulin Therapy, Therapeutic options in Diabetes, Insulin
Administration System, Insulin Production System. Plasmapheresis, Blood Substitutes,
Hemodilution, Classification, Characterisation of Substitutes. Liver Support Systems, Global Liver
Function Replacement, Hybrid Liver function Replacement
Text Books 1. ‘Biomaterials, Artificial Organs and Tissue Engineering’ by Larry L.Hench
and Julian R.Jones
2. “Artificial Organs” by Gerald E.Miller Morgan & Claypool Publishers
References 1. J.B.Park, Bio-materials: An introduction , Plenum Press, 1979
2. B.D.Ratner, A.S.Hoffman, F.J.Schoen and J.E.Lemons,eds., Biomaterials
Science: An introduction to Materials in Medicine, Academic Press, 1996
3. Nanofabrication towards biomedical applications – Challa. SSR.Kumar,
Josef Homer, Carola Leuschner, Wiley –VCH Publications, 2005

BioMEMS LTPC: 3 0 0 3
Version No. 1.0.0
Prerequisites Physics & Basic Electrical & Electronics
Objectives: To expose the students to the application of Micro/ nano fabrications and
applications in biology
Expected Outcome: This course will provide the student with underlying concepts behind
fabrication of micro and nano electro mechanical system for health care
applications, which includes implantable sensor, micropipette electrode and
many more
Unit No. 1 Introduction to MEMS Number of hours: 8
What is MEMS? Historical Background- Smart materials and structures-Microsystems and their
advantages-Materials used- Technology involved in MEMS. General applications in aerospace,
automotive industry and health care. Market size and world scenario
Unit No. 2 Micro machining technology Number of hours: 9
Lithography- etching- Ion implantation- wafer bonding- Integrated processing- Bulk micro
machining- surface micro machining- coating technology and CVD-LIGA process
Unit No. 3 Principles of Microsystems Number of hours: 8
General principles- Microsensors – Pressure sensors- Actuators- Electrostatic forces- Piezoelectric
crystals – Intelligent materials and structures
Unit No. 4 MEMS application in medicine Number of hours: 9
Special features / requirements for medical applications. Current scenario of MEMS for health care.
Drug delivery systems and MEMS. Application models – Blood pressure sensors – Biochip – Micro
needles- Microelectrodes- Neural prosthesis and catheter end sensors
Unit No. 5 Biomedical Nanotechnology Number of hours: 9
Nanotechnology and biomedicine- Medical applications of Nanotechnology- Drug synthesis and
delivery- Nanobiomedicine and diagnostic – Nanofabrication methods – Nanomaterials in human
body- Toxicity in nanomaterials
Text Books 1. Fundamentals of Microfabrication by Marc Madar ( CRC Press ).
References 1. The MEMS Handbook – Cal-el-Hala.
2. MEMS & Microsystem, Design and manufacture by Tai-Ran Hsu , McGraw
Hill.
3. Biomedical Nanotechnology – Neelina Malsch

Biological Spectroscopy LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Physics/ Organic Chemistry/ Biochemistry
Objectives •Get familiarized with the various spectroscopic tools for biomolecular
characterization.
•Learn the basic instrumentation of the various spectrometers.
•Understand the utility / limitations of various spectroscopic techniques.
Expected Outcome •Differentiate the various spectroscopic techniques in terms of
instrumentation and application.
•Derive maximum possible information from a given spectrum.
•Choose the spectroscopic technique that suits the application
Unit No. 1 Introduction to spectroscopy Number of hours:
Interaction of radiation with matter, basic definitions and equations, types of electromagnetic
radiation, interparticle forces and energies, energy levels, population of energy levels, scattering,
absorption and emission.
Unit No. 2 Infrared spectroscopy Number of hours: 9
Measurement of infrared spectrum, physical basis of infrared spectra, infrared of polyatomic
molecules, biological examples, secondary structure of proteins, Second derivative spectra, ATR-
FTIR and its biological applications, FTIR microscopy.
Unit No. 3 UV-visible, Circular dichroism and Number of hours: 9
fluorescence spectroscopy
Electronic energy levels, electronic transitions, selection rules, properties associated with the
transition dipole moment and interaction between them,, absorption range of biological
chromophores, introduction to CD spectra and its applications to proteins, Fluorescence
spectroscopy, Biological fluorophores, Fluorescence probes, RET, FRET, emission spectroscopy
for the characterization of biomolecules
Unit No. 4 Nuclear magnetic resonance Number of hours: 9
Magnetization, measurement, spectral parameters in NMR, spin-spin coupling, T1 and T2
relaxation times, Nuclear overhausser effect, application of NMR in biology, multidimensional
NMR spectroscopy, NMR spectral assignment of small molecules, application to ligand binding.
Unit No. 5 Mass spectrometry Number of hours: 9
Types MALDI-TOF, and ESI: General principles and instrumentation, determining molecular
weights of biomolecules; Identification of biomolecules, sequencing by mass spectrometry; probing
three dimensional structure of biomolecules.
Text Books 1. Campbell, I.D. and R.A.Dwek. Biological spectroscopy, Benjamin Cummins &
company, 1986.
References 1. P.W. Atkins. Physical Chemistry. Oxford IV Edition, 1990.

Computer Simulation and Molecular LTPC: 3 0 0 3

Modeling
Version No. 1.0.0
Course Prerequisites Bioinformatics
Objectives: Application to key biological problems such as protein folding, protein
structure prediction and structure-based design, and in how, by
combining experimental and theoretical approaches, very large biological
systems can be studied at the molecular level. structure refinement using
experimental data and theoretical methods.
Expected Outcome: At the end of the course the student should be able to understand protein
folding, protein structure prediction and structure-based design of
different organisms.
Unit No. 1 Introduction to simulation Number of hours: 9
Advantages and Disadvantages of simulation, areas of application, systems and system
environment, components of system, Discrete and continuous systems, Model of a system, types of
models, Discrete-event system simulation, Steps in a simulation study. Simulation Examples,
Concepts in DES, Programming languages for DESS: FORTRAN, GASP, SIMSCRIPT, GPSS,
SLAM.
Unit No. 2 Statistical models in simulation Number of hours: 9
Useful statistical models, discrete distributions, continuous distributions, process, empirical
distributions. queuing models: characteristics of queuing systems, queuing notation, Transient and
steady state behavior of Queues, long run measures of performance of queuing systems, Markovan
models, Steady state behaviour of finite population models.
Unit No. 3 Inventory systems Number of hours: 9
Measures of effectiveness, inventory policies, deterministic systems, probabilistic systems,
simulation in inventory analysis. Random Number Generation: Properties of random numbers,
Generation of pseudorandom numbers, Techniques for generating random number, Random
Variant Generation, Inverse transform technique, Direct transformation for the normal distribution
Acceptance- Rejection Technique.
Unit No. 4 Input Data analysis Number of hours: 9
Data collection, Identifying the distribution, Parameter estimation, Goodness-of-fit tests, Bwariato
data. Verification and validation of simulation models: Model building, verification of simulation
models, calibration and validation of models.
Unit No. 5 Output analysis for a single model Number of hours: 9
Stochastic nature of Oil data, types of simulations with respect to OIP analysis, Measures of
performance and their estimation, OIP analysis for terminating simulations, OIP analysis for
steady-state simualtions. Comparison and evaluation of alternative system designs: Comparison of
two and several system designs.
Text Books Jerry Banks, John S.Carson, Discrete -Event System Simulation, Prentice Hall
of India.
References Karian, Z.A and Dvdewicz E.J., Modern Statistical Systems and GPSS
simulation, Freeman, 1991.
Mode of Evaluation Announced and Unannounced Quizzes, Assignments/ Seminars and
Written Examination.
Recommended by the Board of Studies on 13th November 2008

Developmental Biology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Biology/ Biochemistry
Objectives: To understand the principles of developmental biology and examine model
systems with emphasis on classical and modern experiments.
Expected Outcome: The student will have an appreciation of the history and modern
developments in developmental biology.
Unit No. 1 Principles Hours: 9
Developmental biology: The anatomical tradition - Life cycles and the evolution of developmental
patterns - Genes and development: Techniques and ethical issues - Cell-cell communication in
development.
Unit No. 2 Early embryonic development Hours: 9
Fertilization: Beginning a new organism - Patterning in C. elegans and slime molds,
Morphogenesis, Cell differentiation, Organogenesis, Tissue growth, Aging and senescence.
Unit No. 3 Drosophila and amphibians Hours:
Early development in selected invertebrates - axis specification in Drosophila - Early development
and axis formation in amphibian.
Unit No. 4 Fish, birds, and mammals Hours: 10
The early development of vertebrates: Fish, birds, and mammals. Maternal effect mutations in
zebrafish- Neurulation in zebrafish - Retinoic acid in anterior–posterior axis specification in
chordates - Ciliary movements and left–right axis specification in vertebrates - Role of Cerberus
in chick head formation - Mesoderm specification and migration in chick gastrulae - FGF and cell
fate in chick and mammalian epiblasts - Induction of pluripotency in mammalian inner cell mass
blastomeres - Homeotic transformation in mammals due to total Hox paralog knockouts -
Controversy over blastocyst polarity in mammals - Folate receptors and teratogens affecting
neurulation
Unit No. 5 Later embryonic development Hours: 9
The central nervous system and the epidermis - Neural crest cells and axonal specificity -
Paraxial and intermediate mesoderm - Lateral plate mesoderm and endoderm - Development of the
tetrapod limb - Sex determination - Metamorphosis, regeneration, and aging.
Text Books 1. Twyman. R.M. 2001. Instant Notes in Developmental Biology, Viva
Publishers.
2. Gilbert, S.F. 2006. Developmental Biology, Eighth Edition. Sineur
Associates, NY.
References 1. L. Wolpert Principles of development, Oxford University Press. 1998
2. Y.K.Paraher Developmental Biology. 1998.

Industrial Enzymology LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Biochemistry/ Industrial Biotechnology
Objectives: The ultimate objective of this course is that students should be able to use
enzymes at industrial process and should be able to either implement a new
enzymatic step or modifying an existing one.
Expected Outcome:
Unit No. 1 Introduction to enzymology Hours: 9
Introduction to enzymology – enzyme types and sources – selection of processing enzymes –
review of enzyme activity and kinetics – determination of constants – evaluation of analytical pH
and temperature curves – the optima concept – physical factors affecting optima – effect of chemical
substances – stability of enzymes.
Unit No. 2 Brewing and fruit industries Hours: 9
Brewing industry: Process of malting, mashing and brewing, use of exogenous enzymes and
process improvement by use of novel enzymes – commercial enzymes used in baking and brewing
industry. Process and enzymes involved in wine production. Process involved in fruit juice
production – cell wall degrading enzymes in the production of fruit juices with specific reference to
apple, mango, guava, banana, lemon and grape fruit.
Unit No. 3 Baking and cheese industries Hours: 9
Baking industry: Dough production process, action of additives and processing aids, amylases and
proteinases, practical interpretation of enzyme performance (farinograph, extensograph,
alveograph), relation between wheat grade and enzyme utility. Cheese and Whey: Process involved
in cheese manufacture, Milk coagulating enzymes, ripening of cheese and control of bitterness in
cheese, enzymes (lipase, lysozyme, lactase, catalase) used in cheese manufacture and proceessing of
whey. Enzymes (aminopeptidases) involved in debittering of protein hydroxylates. Enzyme
modified cheese (ENC) – Altering flavors using enzymes (lipoxygenase and hydrogen peroxide
lyase).
Unit No. 4 Other industries Hours: 9
Textile industry: Desizing process, process of preparing desizing liquors, desizing amylases.
Starch industry: process involved in starch hydrolysis – gelatinization, liquefication, dextrinization,
saccharification, isomerization. Leather industry: leather processing steps – curing, soaking,
dehairing, dewooling, bating, tanning. Animal feeds: enzyme supplementation of animal feeds –
selection of enzymes for feed applications.
Unit No. 5 Altering enzyme performance and Hours: 9
regulatory considerations
Modification of industrial enzyme function: factors affecting performance, hydrolysis product
considerations, deactivation considerations, yield considerations, hydrolysate character
considerations, medical and dietary considerations, taste considerations. Safety evaluation of
enzymes – specification of purity – toxicological considerations, regulatory aspects and regulatory
assessments – safe handling of enzymes legislative constraints – methods of legistative control –
enzymes and environmental pollution
Text Books Industrial Enzymology. Eds. Godfrey and West, Macmillan Press Ltd. 2nd
Edition1996
References Recent review articles in peer review journals
Mode of Evaluation Written Examinations/ Assignments/ Seminars/
Quiz

LTPC: 3 0 0 3
Medical diagnostics
Version No. 1.0.0
Prerequisites Microbiology/ Immunology
Objectives: Graduate course is designed to review state-of-the-art information in the
diagnosis and management of important infectious disease problems in
current medical practice. This course focuses on advances in infectious
diseases and their diagnosis to direct patient care
Expected Outcome: This course provides an in-depth and up-to-date synthesis of major
advances in the field of clinical Infectious Diseases and its diagnosis.
Students will:
• Learn the latest strategies for the prevention, recognition, diagnosis,
and treatment of important syndromes in Infectious Diseases
• Be able to establish a differential diagnosis and initiate an
appropriate diagnostic evaluation for the major infectious disease-related
problems in clinical practice
Unit No. 1 Introduction to infection Number of hours: 9
Pathogens and pathogenecity; Koch’s postulates; Host-parasite interactions; components of
microbial pathogenecity; Overview of infectious diseases of different systems (Respiratory;
Gastrointestinal; Uro-genital, Lymphatic & Circulatory etc.); overview of emerging and re-
emerging infectious diseases and epidemiology; infectious diseases as bioweapon; major infectious
diseases of our country
Unit No. 2 Infection & Immunity Number of hours: 9
Role of immunology in infectious diseases; vaccine and infectious diseases; role of antibiotics to
control infectious diseases and resistance mechanisms; regulatory genes for establishing infections
and host susceptibility; Immunotechnological application-slide & tube agglutination; ELISAs;
lymphocyte proliferative assay; ELISPOT; immuno-chemistry and fluorescent microscopy;FACS.
Unit No. 3 Diagnostics Number of hours: 9
Introduction to Medical Microbiology; collection of samples (sputum, stool, eye, wounds, CSF);
microscopy; transportation of samples; culture (nutrient agar, MacConkey agar, blood agar, EMB
agar, chocolate agar, HE agar etc.) and biochemical identification (bile esculin medium, triple sugar
iron agar, lysine iron agar, MIO medium, Simmon's citrate medium, etc.) ; enzyme assay (Catalase,
Oxidase, Coagulase etc.), antibiotic sensitivity testing and reporting; Common anaerobic infections
and laboratory identification of the causative agents; Automation and rapid methods in
microbiology; Quality control in microbiology.
Introduction to human physiology & instrumental Diagnosis: Measurement of Physiological
Events; Clinical Evaluation of Renal Function; x-ray. Biochemistry: Venipuncture; Glucose
Tolerance Test; Fast Hemoglobin and Glycohemoglobin; Clinical Nutrition; Cholesterol and
Triglycerides; Urea/creatinine Assays (clinical evaluation of renal function); Regulation of Blood
Glucose Levels in Normal and Diabetic patient;
Unit No. 5 Diagnosis of infectious diseases Number of hours: 9
Molecular biology tools: PCR and non-PCR based diagnosis; Application of RFLP, AFLP, RAPD,
Ribotyping, PFGE. Understanding of molecular epidemiology of recent infectious disease (eg.,
SARS)
Text 1. Connie Mahon and George Manuselis, Textbook of Diagnostic Microbiology,
Books Saunders Co. 2nd Eds. 2000.
2. Estridge, Reynolds and Walters. Basic Medical Laboratory Techniques, Delmar
Learning, 4th eds.

References 1. Forbes, Sahm and Weissfeld, C.V Bailey and Scott's Diagnostic Microbiology.
Mosby Co., 11th Eds., 2002.
2. Koneman, Allen, Janda, Schreckenberger and Winn, Lippincott. Color Atlas and
Textbook of Diagnostic Microbiology. 5th Eds. 1997.
3. I Edward Alcamo, Jones and Barlett, Foundations in Microbiology, 2001.
4. Margarett A. Bartelt, F.A. Davis. Diagnostic Bacteriology, A Study Guide. 2000.
5.Patrick R. Murray, Ellen Jo Baron, Michael A. Pfaller, Fred C. Tenover, Robert H.
Manual of Clinical Microbiology. Yolken. ASM Press. 2006.
http://www.kcom.edu/faculty/chamberlain/website/lectures/syllabi3.htm

Metabolic Engineering LTPC: 2 1 0 3

Version No. 1.0.0
Course Prerequisites Biochemistry
Objectives: To make the students
Get familiarized with the various metabolic pathways.
Learn the basic methods for flux analysis in metabolic pathways.
Understand the utility / limitations of pathway manipulations
• Identify the metabolic pathway that would yield the required

Expected Outcome: At the end of the course the student should be able to
• Understand the importance of flux analysis for pathway

metabolite.
manipulations.
Choose the appropriate method for specific metabolite production
Unit No. 1 Introduction to Metabolic engineering : Number of hours: 9
Overview of cellular metabolism, active and passive transport, fueling reactions, biosynthetic
reactions, polymerization reactions, growth energetics, stoichiometry of cellular reactions, reaction
rates, dynamic mass balances, yield coefficients and linear rate equations
Unit No. 2 Regulation of metabolic pathways and Number of hours: 9
manipulations
Regulation of enzyme activity, regulation of enzyme concentration, global control regulation,
regulation of metabolic networks
Unit No. 3 Metabolic flux analysis Number of hours: 9
Overdetermined and underdetermined systems, sensitivity analysis, direct flux determination,
enumeration of metabolite isotopomers, carbon metabolite balances, applications of metabolic flux
analysis
Unit No. 4 Metabolic control analysis Number of hours: 9
Fundamentals of metabolic control analysis, determination of flux control coefficients, MCA
analysis of structure of metabolic networks, relationships among group and individual control
coefficients
Unit No. 5 Applications of Metabolic Engineering Number of hours: 9
Application in pharmaceuticals, chemical bioprocess, food technology, agriculture,
environmental bioremediation and biomass conversion.
Text Books 1.Gregory N. Stephanopoulos, Aristos A. Aristidou, Jens Neilson. Metabolic
engineering: Principles and methodologies. San Diego, Academic Press, 1998.
References 1. Voit, EO., Computational analysis of biochemical systems, Cambridge
university press, 2000.
2. Relevant articles in the Web and recent review articles in peer reviewed
scientific journals

Molecular Modeling and Drug Design LTPC: 3 0 0 3

Version No. 1.0.0
Prerequisites Bioinformatics
Objectives: To impart knowledge in computational chemistry especially of molecular
mechanics, semiempirical, and ab initio methods.
Expected Outcome: At the end of the course the student should be able to understand molecular
mechanics, semiempirical, and particularly ab initio approaches
Unit No. 1 Introduction and Review of Quantum Chemistry No, hours: 9
Introduction to computational chemistry, Operators, commutators, Dirac notation, linear vector
spaces, Postulates, Analytically soluble problems (particle in a box, etc.) Variation and perturbation
methods
Unit No. 2 Molecular Quantum Mechanics No. hours: 9
Born-Oppenheimer Approximation, Force Field methods (Molecular Mechanics) Molecular
dynamics, Electronic structure of atoms, Electronic structure of diatomics Group theory and
molecular point groups, Electronic structure of polyatomics Hartree-Fock theory,
Unit No. 3 Analysis and Properties No hours: 9
Geometry optimization, Vibrational frequencies: symmetry analysis, harmonic vs. fundamental
frequencies, zero-point vibrational energies (ZPVE's), Hessian index, distinguishing minima from
transition states, Intrinsic reaction coordinate (IRC) analysis, Electrostatics: dipole moment,
polarizability, hyperpolarizability Transition state theory, statistical mechanics, and
thermodynamic properties
Unit No. 4 Computation of Electronic Structure: No hour: 9
Hartree-Fock method and various notations for one- and two-electron integrals , Basis sets - Semi-
empirical methods, Intro to electron correlation methods, Dynamical correlation and configuration
interaction (CI)
Unit No. 5 Electronic Structure methods Number of hours: 9
Many-body perturbation theory (MBPT), Coupled, cluster methods (CC) , Density functional
theory (DFT) , Valence-bond theory (VB) , Extrapolation methods (G2, G3, CBS, focal-point
analysis).Nondynamical correlation and multi-configurational self-consistent-field (MCSCF) ,
Comparing the performance of electronic structure theories
Text Books 1. F. Jensen, Introduction to Computational Chemistry, (Wiley, New York,
1999).
2. A. Szabo and N. S. Ostlund, Modern Quantum Chemistry, Introduction to
Advanced Electronic Structure Theory, 1st ed., revised (Dover, 1989).
References 1. D. A. McQuarrie, Quantum Chemistry (University Science Books, Mill
Valley, CA, 1983)..
2. I. N. Levine, Quantum Chemistry, 4th ed. (Prentice Hall, Englewood
Cliffs, NJ, 1991).

Structural Biology LTPC: 2 1 0 3

Version No. 1.0.0
Prerequisites Biochemistry
Objectives: Problem-based course is designed to train molecularly oriented students
in the field of structural biology.
Expected Outcome: On completion of the course, the student will be
Able to analyze the data on biomacromolecules from different analytical
techniques
Elucidate the structure / conformation of biomacromolecules from using
relevant techniques
Overview of the spectroscopic techniques and biomolecular structure – Electromagnetic radiation –
interaction with matter – usefulness in the evaluation of structure of biomolecules. Review of the
structure of biomacromolecules.
Unit No. 2 X-ray Diffraction Number of hours: 8
Overview, crystallization, diffraction theory, phase problem, patterson functions and maps,
molecular replacement, multiwavelength anomalous diffraction and crystallographic statistics,
model building and refinement, quality and validation of structure
Unit No. 3 Nuclear Magnetic Resonance Number of hours: 10
Nuclear magnetic resonance: overview and practical aspects, nuclear spin and coupling interactions,
measurement and multidimensional experiment (2D, 3D and 4D), homonuclear and heteronuclear
experiments, determination of protein and nucleic acid structures, solid-state and high resolution
NMR, dynamics (T1 and T2 analysis).
Unit No. 4 Circular Dichroism and Fluorescence Number of hours: 10
Optical spectroscopy: Circular dichroism – molecular chirality, structural transitions of
macromolecules, interpretation of spectral data, introductory aspects of UV-CD, VCD and MCD.
Fluorescence – theory, application to structural analysis, ligand binding and stability, measurement of
individual fluorescent cells.
Unit No. 5 Other Analytical Techniques Number of hours: 10
Application of other analytical techniques to probe structure of biomacromolecules: (includes basic
principle and application) Mass spectrometry, surface Plasmon resonance, Microscopy, Gel filtration,
Isothermal titration Calorimetry, neutron scattering, infrared spectroscopy
Text Book Tinoco, Ignacio, Jr., Sauer, Kenneth, Wang, James C., & Puglisi, Joseph D. (2001)
Physical Chemistry: Principles and Applications in Biological Sciences, 4th ed. Prentice Hall
References 1. Rhodes, Gale (2006) Crystallography Made Crystal Clear, 3rd Ed., Academic Press
2. Chapman, J. R. Ed. (2000) Mass Spectrometry of Proteins and Peptides, Humana Press
3. Cavanagh, J., Fairbrother, W.J., Palmer III, A.G. and Skelton, N. J. (1996) Protein
NMR Spectroscopy: Principles and Practice, Academic Press
Examination.

LTPC: 2 1 0 3
Tissue Engineering
Version No. 1.0
Course Prerequisites Must have studied basic biology concepts.
Objectives: Role of stem cell technology in biology.
Use of Biomaterials used in Tissue Engineering.
Significance of scaffold design in fabrication of different
biological tissues.
Expected Outcome: Impart knowledge in tissue characterization methods and their
clinical Implementation
Unit No. 1 Historical perspective of tissue Number of hours: 9
engineering
Historical perspective of tissue engineering industry and products; Cell and Tissue Biology:
Introduction to basic biology concepts: cells, biochemistry. Introduction to tissue development
and organization.
Unit No. 2 Cell sources Number of hours: 9
Cell sources, culture conditions, three dimensional interactions, cell reprogramming, Stem cells
(embryonic), Stem cells (adult), Extracellular matrix. Stem cells and its applications
Unit No. 3 Scaffolds for Tissue engineering Number of hours: 9
Classification of scaffold materials, criteria for ideal scaffold, polymer scaffold, bioactive ceramic
scaffold, bioactive glass scaffold, composites scaffold, control of architecture
Unit No. 4 Drug and growth factor delivery Number of hours: 9
Introduction to growth factors, Polymer scaffold delivery systems, Polymer hydrogel delivery
systems, Polymer microsphere technology. Immunochemical techniques and their applications:
immuno histochemistry, immuno cytochemistry, immuno fluorescence, western blotting, ELISA,
FACs, immuno electron microscopy
Unit No. 5 Engineering Methods and Design and Number of hours:9
Clinical Implementation
Tissue Biomechanics, Scaffold design and fabrication, Tissue Engineering of Skin, Bone,
Cartilage, Neurons, Cardiovascular Tissue Engineering, Musculoskeletal system
(tendon/ligament/muscle) and Adipose Tissue.
References 1. Biomaterials, artificial organs and Tissue engineering, Larry L. Hench,
Julian.R Jones, Wood head publishing Ltd, 2005.
2. Principle of Tissue Engineering, Robert P.Lanza, Robert Langer William
L.Chick. Academic Press, 2004.
3 Tissue Engineering, by Palsson and Bhatia (eds.), Published by Pearson
Prentice Hall, 2004.
Mode of Continuous Assessment (Written Exam) and Assignment -50%
Evaluation Term End Examination (Written Exam) -50%
Recommended by the Board of Studies on th
13 November, 2008

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SCHOOL OF BIOTECHNOLOGY,

CHEMICAL & BIOMEDICAL ENGINEERING

Sylla b us & Curric ulum 2008

1 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Bioprocess Econom ics and Plant Design ................................................................................37

2 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

COURSES ARRANGED ACCORDING TO

3 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Courses under Humanities field

Courses under Management Field

4 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Courses under Science Field

Proportion of credits based on field of specialization

5 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

COURSES ARRANGED ACCORDING TO

6 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

7 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Sl.No. Title L T P C Component

8 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Comprehensive Examination LTPC: 0 0 0 2

9 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

10 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

11 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Cambridge University Press, 2003

Date of approval by the academic council 16.6.2008

12 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

English for Engineers –I LTPC: 3 0 0 3

Recommended by the 25.4.2008

13 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

14 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Mode of Evaluation Written Tests & Examinations, Quizzes, Assignments, Seminars

15 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

CHY104 Environmental Studies LTPC: 3 0 0 3

16 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

4. Howard S. Peavy, Donald R. Rowe and George Tchobanoglous (1987),

17 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Ethics and values LTPC: 3 0 0 3

18 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Foreign Language LTPC: 2 0 0 2

Foreign Language courses offered are:

ESP101 Basic Spanish LTPC: 2 0 0 2

FRE101 Basic French LTPC: 2 0 0 2

GER101 Basic German LTPC: 2 0 0 2

JAP101 Basic Japanses LTPC: 2 0 0 2

19 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

PHY001 Modern Physics LTPC: 3 0 2 4

20 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Unit 1 Multivariable Calculus 9 hours

21 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

2. Michale D. Greenberg, Advanced Engineering Mathematics, 2nd Edition,

22 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Creativity and Innovation in Management LTPC: 3 0 0 3

Management Information System LTPC: 3 0 0 3

Project Formulation: Implementation and Control LTPC: 3 0 0 3

Self Development LTPC: 3 0 0 3

Total Quality Management LTPC: 3 0 0 3

23 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

24 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

9. Demonstration of Gas chromatography

25 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

Animal Physiology and Biotechnology LTPC: 3 0 0 3

26 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008

EEE101 Basic Electrical & Electronics Engineering LTPC: 3 0 2 4

27 | B.Tech. Biotech syllabus to be approved by the Board of Studies, SBCBE on 08.04.2008