Bioinformatics

Prof. M. Michael Gromiha

Department of Biotechnology
Indian Institute of Technology, Madras

Lecture - 2b
Sequence based Parameters

Sequence based parameters

AT and GC contents

Sequence based parameters by word size of 2 and 3

For example, with word size of two, the dinucleotide composition can be calculated and
the values of the property (e.g. hydrogen bond in this case) can be assigned using
dinucleotide parameters.

Structure based properties

We can also calculate the Young’s modulus of DNA by the given formula.

Algorithm to calculate base-stacking energy

Flexibility calculation