DOSAGE,

NAME OF ROUTE AND INDICATION MECHANISM OF DRUG-TO-DRUG ADVERSE NURSING

DRUG FREQUENCY ACTION INTERACTION EFFECTS RESPONSIBILITY

Adults Cefalexin is a Cephalexin bin As with other beta-lactam CNS: dizziness, Assessment & Drug
Generic semisynthetic drugs, renal excretion of headache, fatigue,
cephalosporin ds to and cephalexin is inhibited by Effects
Name
1–4 g/day in antibiotic for oral inactivates probenecid. agitation, confusion,
administration. hallucinations. Determine
cephalexin divided penicillin- In a single study of 12 
GI: pseudomembran
doses; 250 Cefalexin is indicated
binding
healthy subjects given
ous
history of
Brand Name in the treatment of the single 500 mg doses of
mg PO q 6 following infections proteins cefalexin and metformin, colitis,nausea,  vomiti hypersensitivi
Keflex
hr usual due to susceptible
(PBPs) locate
plasma metformin Cmax ng, diarrhea, gastritis ty reactions
micro organisms: and AUC increased by
dose. d on the inner an average of 34% and , glossitis, dyspepsia, to
Respiratory tract abdominal pain, anal
Therapeutic 24%, respectively, and cephalosporin
Classificatio
infections membrane of metformin renal pruritus, tenesmus,
 s and
the bacterial clearance decreased by oral candidiasis.
n Otitis media
an average of 14%. No penicillin and
Skin and soft tissue cell wall. PBPs side-effects were GU: genital pruritus
antibiotic infections reported in the 12 healthy and candidiasis, history of
are enzymes subjects in this study. No vaginitis, interstitial other drug
Bone and joint involved in the information is available
nephritis.
infections about the interaction of allergies
terminal cefalexin and metformin Hematologic: neutro
Genito urinary tract before
infections, including stages of following multiple dose penia, eosinophilia, t
administration. The hrombocytopenia. therapy is
acute prostatitis assembling clinical significance of
Musculoskeletal: arth initiated.
Dental infections the bacterial this study is unclear,
particularly as no cases ritis, arthralgia, joint  Lab tests:
. cell wall and in of “lactic acidosis” have pain. Evaluate
reshaping the been reported in
Skin: maculopapular
association with renal and
cell wall during concomitant metformin and erythematous
rash, urticaria. hepatic
growth and and cefalexin treatment.
Other: hypersensitivit function
division.. Hypokalaemia has been
described in patient y reactions (serum periodically
taking cytotoxic drugs for sickness, anaphylaxi
leukaemia when they
in patients
s)..
were given gentamicin receiving
and cephalexin.
prolonged
 therapy.
 Monitor for
manifestation
s of
hypersensitivi
ty (see Signs
& Symptoms,
Appendix F).
Discontinue
drug and
report their
appearance
promptly.

Patient & Family

Education

 Take
medication
for the full
course of
therapy as
directed by
physician.
 Keep
physician
informed if
adverse
reactions
 appear.
 Be alert to
S&S of
superinfectio
ns (see
Appendix F).
These
symptoms
should be
reported
promptly and
appropriate
therapy
instituted.
 Do not breast
feed while
taking this
drug.

MEDICATION
TICKET