AIA-PACK Series

Immunoassay Reagents

Clinical Testing Solutions with Consistency, Stability and Harmony

Tosoh’s ST AIA-PACK Test Menu of immunoassays

utilizes our proprietary Unit Dose Test Cup technology
and is free from biotin interference.

Not all immunoassays are the same. Using the right

immunoassay gives you confidence in the results
you deliver. Choose wisely. Choose Tosoh.

TOSOH BIOSCIENCE
www.tosohbioscience.us
 Unit Dose Test Cup Technology Aluminum
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The AIA-PACK technology utilizes a patented concept by Tosoh based

on individual test cups, each containing lyophilized and ready-to-use
reagents that require no pre-mixing, no pre-measuring, and no on-board
refrigeration. One test, one cup ensures minimal reagent waste leading to 3/4”
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both increased efficiency and cost savings. Load the cup and press start. Top Seal

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The entire immunoassay reaction

takes place in the test cup, from
the pipetting of the sample, the
antigen-antibody reaction, up to
the signal detection. This ensures:
n Consistency
Breaking Addition 10 minute Wash step Addition of
of the of sample incubation with magnetic substrate and n Stability
aluminum separation fluorescence
top-seal detection
n Harmony

Analyte capture
Sandwich assay: The analyte is isolated with a
Analyte capture

capture and signaling antibody. The contained reaction

with 10-minute incubation ensures a rapid assay
format with results in 18 minutes.
Both our sandwich and competitive immunoassays
are biotin-streptavidin free with minimal risk from
biotin interference.

Signal generation
The alkaline phosphate-labeled signaling antibody
Signal Generation

hydrolyzes the substrate, 4-Methyl Umbelliferyl

Phosphate (4MUP) to a fluorescent product.
Signal detection
The fluorescence signal is measured in a unique
biochromatic kinetic measurement that achieves
high signal to noise ratio, ensuring high analytical
and functional sensitivity for all assays.
 AIA-PACK Series: Immunoassay Reagents

Consistency
The Unit Dose Test Cup technology ensures no transfer of reagents, no pre-mixing and no pre-measuring,
minimizing the introduction of analytical errors while maximizing on performance specifications. Together,
this yields reliable diagnostic results allowing for accurate clinical decisions and customized patient care.
AIA-PACK assays have excellent CVs across the entire test menu.

Precision of the AIA-PACK Immunoassay Menu

9
8.2
8
7 6.4
5.8 5.9 5.7 5.9
6 5.4 5.6 5.6 5.5 5.6
5.3
4.8 5 5.2
4.7 4.7
Method: Precision of
5 4.4 4.6
the AIA-PACK as
%CV

4 4.1 4.1 4.2

4 3.6 3.4 3.5 3.3
3.2
2.7
3.1 measured by th
3 2.6
variation obtained
2
from the use of the
1
Multi Analyte Control
0
Level 2 on the AIA

LH
TSH

FSH

HGH
Troponin

DHEA-S
CA27.29

25-OH Vitamin D
T4

TT3

FT3

iPTH
Prolactin

IgE
Ferritin

Cortisol
Folate
PSA

Testosterone
Insulin

CKMB

Vitamin B12
AFP

CEA

β-2 Microglobulin
β-HCG
Myoglobin

Estradiol (E2)
C-Peptide

Progesterone
FT4

system

Tumor Diabetes Thyroid Cardiac Anemia T9:BC<5O;7U9 Kidney Metabolic Others

Wide dynamic range High analytical sensitivity Rapid results

n Save time and cost by reducing re-runs for n Accurate & precise analyte n 10 minute incubation times ensure
out of range results measurements quick turnaround times suitable for
n Estradiol range 25 pg/nL- 3000 pg/mL n bHCG 0.5 mIU/mL intraoperative testing such as iPTH,
suitable for IVF applications n Troponin 0.06 ng/mL Troponin etc.

Stability
12.8
Cost of calibration over 90 days

n Lyophilized reagents allow long shelf life

n Up to 90 days calibration stability for most assays
n One test, one cup: Use only what you need
Cut costs of
calibration by
6.4
up to 12.8 times
Zero using Tosoh
reagents
Waste 3.2

Together, this translates to cost savings due to

reduced calibration frequency and time, reagent 7 days 14 days 28 days 90 days
use and reagent waste.
Others Tosoh
Calibration stability period
 AIA-PACK Series: Immunoassay Reagents

Harmony
The AIA-PACK assays are a universal reagent and are interchangeable
within our entire portfolio of automated immunoassay analyzers suitable
for labs of all sizes, from small POLs to large reference labs.

FSH Correlation Test (mIU/mL)

200

150
AIA-900

100

50

R2 = 0.999

0
0 50 100 150 200
AIA-2000

Interchangeable results between all Tosoh AIA systems is

ideal for all lab settings:
n Satellite labs
n Backup instrumentation
n Intra-operative testing

Choose Wisely. Choose Tosoh.

No Biotin
Interference No Biotin
Interference

Accurate & precise Specific & sensitive TP 205

Correlation with gold [%] Aluminum
Biotin-free
standard methods immunoassays
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No Biotin
0.0 15.0
0.0

No Biotin
Interference
Interference
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No Biotin
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1.0 Aluminum
TP 205 [%]

Interference
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Extensive test menu Up to 90 day calibration 10 min incubation Automated workflows

1.0 Aluminum
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TP 205 [%]
[min]

0.0
1.5

NoNoBiotin
Biotin stability 1.0
times Aluminum
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0.0

Interference
Interference 1.5
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0.5
[min]

1.0

TP 205

For more information, call 1.800.248.6764

[%] Aluminum

TP 205 0.0 15.0 Top Seal

[%] 1.5
0.0 15.0
Aluminum
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0.0
0.0

Tosoh products are for Prescription use only as In-Vitro Diagnostics

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TOSOH BIOSCIENCE
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www.tosohbioscience.us
“Tosoh Bioscience”, “AIA-PACK” and “AIA” are the registered trademarks of Tosoh Corporation
Part # AIA-MENU-0001 Rev. 01/0719