Drug Name Mechanism of Action Indication/ Contraindication Adverse effect Nursing Responsibilities

Generic Name:  Selectively inhibits the Indication: CNS: Dx:

Celecoxib enzymatic activity of
cyclooxygenace-2 (COX -2), the
Brand Name: enzyme needed to convert
Celebrex arachidonic acid to
prostaglandin. Prostaglandin are
Class: responsible for mediating the
Diaryl-Substituted pyrazole inflammatory response and
derivative causing local vasodilation,
swelling, and pain. Prostaglandin
Therapeutic: also play a role in peripheral
Anlagesic, Anti-inflammatory, pain transmission to the spinal
antirheumatic cord. By inhibiting COX-2
activity and prostaglandin
Pharmacologic: production, this reduces
Cyclooxygenase-2 inhibitor inflammatory symptoms and
relieves pain.
Dosage:
Source: Learning, J, Learning, B.
Route: (2019). Nurse’s Drug Handbook
(8th edition). p220
 To relieve signs and symptoms
of osteoarthritis
 To relieve signs and symptoms
of rheumatoid arthritis
 To relieve signs and symptoms
of juvenile rheumatoid arthritis
 To relieve pain from ankylosing
spondylitis
 To manage acute pain, to treat
primary dysmenorrhea
 Management of acute pain
Contraindication:
 Allergic reaction (such as
anaphylaxis or angioedema) to
aspirin, other NSAIDs, or
sulfonamide derivatives or
history of aspirin-induced nasal
polyps with bronchospasm;
hypersensitivity to celecoxib or
its components; treatment of
pain after coronary artery
bypass graft surgery
Aseptic meningitis, cerebral
hemorrhage, depression, dizziness,
fever, headache, insomnia, ischemic
stroke, stroke, suicidal ideation,
syncope, transient ischemic attack,
vertigo
CV:
Aortic valve incompetence, chest
pain, congestive heart failure, deep
vein thrombosis, fluid retention,
hypertension, MI, palpitation,
peripheral edema or gangrene, sinus
bradycardia, tachycardia,
thrombosis, unstable angina,
vasculitis, hypertrophy
EENT:
a. Check doctors order
b. Assess pain score
c. Assess history of allergies
Tx:
a. Give drug with food, milk
or antacids
b. Do not increase or double
dose; follow exactly as
prescribed and indicated
c. Discontinue drug promptly
if diarrhea. Dark stools.
Hematemesis, ecchymosis,
epistaxis or rash occur and
do not use again. Contact
physician
Edx:
a. Document accordingly
b. Monitor for adverse effect
c. Instruct discontinuation of
medication if adverse effect
occurs