MON TUE WED THR FRI SAT SUN

Subject OOO OOL

LPofonmalalien SHuoie
is defina a tho phase oiLLfanch
deielobht 1 uDhich foanulaiou stdi Chaacteize
Physical chamicoal hroberic of a lwg znolecule in
Onden to develob safe _eftcctive 2 Sfable doccye nbhna
Thee_Studiea_Should tocuc On he Physico chinaica
PaopeHies ot th ned comboundhat Coud affect
dug Penfahmance aud levelntrnout et au efficocous
dosaqe edi
ho Simblet ca th
fhe Poue tahraulaiou nueL
HiaHied mau menoly Confit haB Hwe a
nn.ignifica! batiea tn theCombotnd eleuelcbmaut

Objec-tvel
To etablich u Phugico-chomical Pahamelehd
of anw dhq enity
To_cleteamin ifklntic_ Sabilt
Tetablich i combatibillts_th_camm excihinud
Povictun gight ino houd olu_MOduct Shoufol
be Pmoceyed Stnxod to ensue hai qalify

fMajonAxa ot Pxetommulalicu LSEAMch

) Onganoleptic Chanacte
Bolk_chahac fey
yal|hy Pakymo.nphis
H gho Scopicity
i n Poifde chah acdeigaksn
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 WED THR FRI SAT SUN
MON TUE
O ODLU
Subject

3Solvbily Analystr
foni2alie COntaut Pka
PH Salubiliy 10Eile_
COmmDin 0 efet kSP
Salubili3atio
Pantieu Co- E icieut
Discolotie
u SHabilityAnalysit
Stobility in toy icoldgytohmulatiea
Sol Steuilthy
Solid stale ability
Comh bility
Dy Penformulatfeen mpadauti
Putoumulait Shode EMaGil h ciattt
touudaHou a t quuiolauce bMOide ognlatny
>eiteaaad Coneve aoe in tue dsug
deuelohmat aad
Evaluakic ceH Imbhove Pobllc Safety Ctaudaha
n hauce bMocuct Qulity Pacilitale ahlehe
ai nu echnoloqie
h qoal o h
tohmdlafio iadies ane tn cho(fe
Ho Cchet uom at Ou duq Cbbsteuc evaloale
APhssica 2a0bele and 9.euenaBe a huougb
ndnsiocliuq _ot h malenial iailit cl
uaugds Coudi io eafug m he abiinma dw dlive
Cysiem
Ocnggnoleb Hc Padbedie
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 MON TUE WED THR FRI SAT SUN
Subject

Colouh odountaste, at thu ne_dusgust be

0 COmded

CoDn odoun axte

Pungeut Nctdic
am yellou Sulbhundu
1muity lamd intengr
Shina PMomaHc odou1ley Suectla^telezs
Bulk chana cfenizalioui
A dg_Caudidate at his skeqe ce hajhat
hacall it Solio ohm idtuui Hd aud th
is a G0at_botental tOhe0 folymnnbhd fo enqy
is nhgy
Bolk Pobertie the Solid OmA Such_al
Patuhicle i e balk_dnsiky 2 Sumace masbhal0gy ana
also 1kels chaue_duung PHocCKdewehbnaeud
Cystallinityi-
C a l habie Inlenal Stchosea at dup ca alfect
bolk Physio.chtmicalPoroberle of nlecole
Ctal habit s dsptioCf Culc opb ance_o
CHYSta

nteLna Sthuctu ismolerolaoU1aginud i h i

h colld.
Chamge ih nlenha Sfauckase uCually altun
Coyfalhabif
COnvenkot_of cadum Sal itJ f aid to`um
PoodUce both chauge iíntehna Shhwctord

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 MON TUE ED THR FRI SAT SUN
Subject

Difeund shapel_of Ghystals

Debendinqen indeyal COmbOud i clatitiec aal
DCystalline
Amoubhous

Cuyrtalli ne i Ombound ano chahacdeize bs ubeti

Shacing ot cOnltoeE aBona £m molecule in the
dimuisioaa ua

n_Amou hou om atnm n molerule anen0hmal

placed
Solubili dissalyisn male aru q_MOaiOh tan
ambunphoDs toim han cHyrlallin@ a am0snDhtus 1aSum
ha hghn hhmdunamic hitgy
eg manbhout om_of novo biecin i LOell Qhabeg
lhu a CSallao imeintt in bah chantia,

Potumo:nbhitm
i he ahilik of the Comboumd to_cykalline
_moe thanCue Cu EIA4_ Cursallino cheaeeL
ith_clilferut Indna atice.
Dfeht culfalliag tonms ao called_Polybaa.hmbhiSn,

Polymanbho ot too ube

Enahoteohic c_
2) Mond thobic
The boly mon h_ hich Can be chauyedL
titm Onl
Anm_n mBhn bu vau ng-lemb 0h Rhusn
L calleda nalio taobic
e Sulbhuawww.remixeducation.in
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 Subject MON TUE WED THR FRI SAT SUN
UULUUDU
Ou_bolyalyu mobhos hichi astable at
PauMu s Called a all femb
e mbadtobic_balsmanbhus
lycens Cfeole_

Poly mnbhou diii f10m each_ ofh

tnhei Phy sical ooheube such ai uh uesbeet

1Soluhility
2 nelting_beint
Denuty
Handn
sComy iouchahactenkhic
Ca Chlon0m honi ca exisE h_ A.B Ctannd
e hex B iohm imoL Stable_E mot b Jufaable
Pnalyical mehod fouh the chahacteizalion af solld
tam
Hot Sta l mich01 Coby
3 huma Analyair
XRaysRauy_ditfractio
nfnaud (1R) Shectna cehy
6Pr0hn_magneli esonauce (MR)_
NUleQN_ma9nuhc ejonance NMR)
BScamning electaronmictos.ceby CSEM)

ygoScobiclky
Many cn Soh.SteamcP_PaHcolash c0aleh Seluble alt
ONm_ a teadentyÎ cd Sah atmngbhsuic
Mois o,no
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 Subject
MON TUE WED THR FRI SAT SUN
DOOOOO
thAbmosbhei
PXposUno md hUmidittempSOhiace aoa
tho machnitm o i acuo DiS
ubtak e HTO

hdequo aiHy qhoscoot cik

cla4i Licd Inth

dightly HygnaScobi ci- Mse i

eight i 0-27
aud <2% /u
HyaoScobic se in tneight 2 0-2 7 ullw ad
15 olo
ery Hs amosobici C in weiqht is2 15 W/
Delia ueLcet Suif icie
ade f adco.hbed to
tA0I a Soloiey

Hyluscojaicty is teted by
Sambles exbosec ho moStuo
Ex ayed to coudholleo
JIlaHive humiclity envitonma o

Moiston ublake mOnit oinc at_ditterut time

Pinl
Analyhcamhod hich i Dsed a
(nNavimel
Ka ischih ithabio
1a c Omahqhaphy

ParuHicle Sige)
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 Subject MON TUE WED THR FRI SAT
SUN
| farictesi3e is han acdenized uiug thue
Vey_C0O Coan fenmd
moolehatoaly Co fias vehy ftn
laricle_size can inElueatt veuiety af
factn imbandaut-
Dissolufiou ae u) Pentnabili
2)
3
Sushendability 5)lack of qitinus
tdm sthebutiou

Method tp Detemins Panlicle sizei

Steviug Su-_ISOu)_
MiCHO Scolby 0 2 H- oo u).
Sedimesdakon mae methed 200 u)
Light ehengu_diLfhacHa o - 500 )
Laieh halo qnabhs 4 -60 u
Powclun tlouw barabenhie
Pouldun lau BMobenHej Can be gftected by chan4e in
Palicle S13eShapt 8 dnsty
The tloLO probenHie cdebend opon fallouaiug

FonLe of PaichHeum
oheio blu Ou parHcle n anethuy
Finr PaHcle bn.ceM_bonh ilo by ling Vaid Shacee
blu angenPau-lclels CoLSiug Packing2 dhs iticakio
o Palicles
By vsiq gliduat use can allen th fow barohenh e
tgTalC
DeBenminatioywww.remixeducation.in
of Pouzlun flo paobeki
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 Subject
MON TUE WED THR FRISAT, SUN
OOODOO0
B A diteminiuq Pngle o Rebase
9 a t e ngle otubaye indfcade_Pro
Shoulo be e llou
han 30 2 can be ddenmhad
bytollouniug fquaiou
Tan h
Angle of a
htht af bile

Angle of ebos e ybe otPlo

in_clg
C25
EAelleLt
25-30
ond
20-yHo
Pakable
vOy_pro
iMethecA o cdiktamiul augl_oÉ_uLhole
S+eli aMle t tubose
ixed-nhtl mf thecl
kinrlc dyhoamic melhed
Rot-aling cylindn malhoo
ng boXmfthod

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 Subject
JL
DeBeiminalion ot_boudh lo Puoberhei
measuomaut o fulousing Pouol by CompLibilt
Also knous Qa Cah indir

CARRS indtx( ) Taphed olnsiy- Pouned Deushy

TapbedDensiy D
simble tayt 3 Pobula_mehod oF Pudictting
Poulthtfo ChahactenisHics
Detehmination of Pousd floud pesh Ente
Cans ind ex Tube ofHou
5-IS Excelleut
12 6
8- 21 tainoPossible_
23-3 PoD
33-38 Vey GD
4d
extebmsdy Poo
Solubily Shodie
Solotion_bhate equiibuiLm ith Colid_bhaseatq Steada
Hem Cmd uku
Deiesvnintu amtlt_t dhug d'ssolued amaunt at odbug
aveilable fon absonPfion
3SoluhilHy oducdisn cahlee oua l Cetaia coudito
tnhanemouit Ochohai ca siability
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PoLndDet3
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0 Subject MON TUE WER THR FRL SA SUN

Pmoducliot of Sostainccd elees Poluct

Desciptive e Pants_oE solye-ct oq Lied

fo Pant of Solote

e Soloble
eot Soluble o m 1to. lo
Soluble EHomlo to 3o
Spaungly_soluhle o m 30to 10
Sfghhy Soluble
vey Slghty Solvble
Parhcally in Solble lo0 00 Cud l,ues

The
h equillhsdua Solobilky hat ed on the Pha
Solubili tecnique boposed by hi bchi COhha
methoc

Dsug disbened So lueut i a closed atlaint

aqftaled aia_Condlaut fempvsinq Shakehs
Samble of theSUy ano thduaul a tunctia
im

Cla bied byceudui itgadin aad adyed by HPLC

HPLC
Uv n ett

LPka dueminaho
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 Subject

Pka L the clissocialio Concta-of a dwq

Pka
Ihe Un-icnized_dnug IS 1ibid lublefhus Pemale
thMoughlibid mfm btan
he tOnized Substaute is libid Ih SDluble heno toa
Pto thea tota
mêna Ho s Solue
Degsue of ionizahea oleheud n P

Htndfntey-Hauelbl aih equakie

o acidic COmod4
p Pka U 10ARed
lonized
lcaized o PHPka _
o CPH- Pka
onbatic_ccmpounol
PH P Ka t
h louized

Detenmind b Uy sbetnscobyPoicwtioneloic
tnimti method ata
lkkaio

Sol uhfli3aHm
Solvbilizaion dhned as the Spoowtn eou Pautaqe
t Padaly de Hable sebhleSoluBe
molec uleg
Soluibn Ot a thtmocynamicall intn
Solufiby is TOUmAd
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 Subject MON TUE WED THR FRI SAT SUN
OOOOOO
i h e Dioces c by tWhich abharoc Solubilit,-
o a_0thmuise Sbaunqly
Substence
Intfaed byhe Pnene o SUtActat
micelle

Micellea hehe machnirm Involvesthe Panobak,

ot Suntace acive aqeud anm
COlloida a99L qalesknoun oy micee
Whon SUMiactaut ane added to the auid at
loD Con hty lend to u f t qt h Qi
liuid Inieiüce
On fusthun additiou of Sutac-lath
becomecomble ely_cccobied amdexcey niehiace
molecule
Ooo.nced into liquid
A ehy high cou Sutactant_mdlecole
bulk of liuid beqin to the
fom mirellyaaad hi
Con is knouaa RITICAL mirelle
Con CMC
eneal methdo sing th Salobilikyi
Additton ct (OSolvet
PH change method
Redvction i PaLicle Si3
Temb Chaug e methad
HydiotMaby
Additidn otSunactaud
Dielectical (onla.
(omblexaHaa
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3 Subject MON TUE WED THR FRI SAT SUN
UUUUUU

Panitiom (o-efficient|
A DHLOmtc dwq libohy!Iicity e t
abilitsto C0.s ho CP_membsaue

Pala COqamil

Distibutien coe iciout

ON Acidsi loq1 Dlcg lo9lh C[+lo PH- Pea
baic loq1o D to o P-loglo (+0 Pka-PH)

h iocnal 0aken Suctena i uidely at(ebted to

exblain thuPhenomeua.
BuceelmemhiQnt byteno l , Penleno Sustem
5lpDcl Brain bursi Chalahofoam cyclo hiraane
Detemined by SHAKE flask_methood

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