Avilamycin

CHEMICAL NAME: Avilamycin

Chickens
1. FDA Status: No feed mill license required.
Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed
veterinarian. Animal feed bearing or containing this Veterinary Feed Directive (VFD) drug
shall be fed to animals only by or upon a lawful veterinary feed directive issued by a licensed
veterinarian in the course of the veterinarian’s professional practice. Feed continuously as the
sole ration for 21 consecutive days.
CAUTION: To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin
on or before 18 days of age. The safety of Avilamycin has not been established in chickens
intended for breeding purposes. Avilamycin has not been demonstrated to be effective in
broiler chickens showing clinical signs of necrotic enteritis prior to the start of medication.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Chickens (broilers) Avilamycin 13.6-40.9 g/ton of Type C For the prevention of mortality caused by
medicated feed (15-45 ppm) as necrotic enteritis associated with
sole ration for 21 consecutive days. Clostridium perfringens in broiler chickens.
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COMBINATIONS ALLOWED
2. FDA Status: No feed mill license required.
Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed
veterinarian. Animal feed bearing or containing this Veterinary Feed Directive (VFD) drug
shall be fed to animals only by or upon a lawful veterinary feed directive issued by a licensed
veterinarian in the course of the veterinarian’s professional practice. Feed continuously as the
sole ration for 21 consecutive days.
CAUTION: To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on
or before 18 days of age. The safety of Avilamycin has not been established in chickens in-
tended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler
chickens showing clinical signs of necrotic enteritis prior to the start of medication. Do not
allow horses, other equines, mature turkeys or guinea fowl access to formulations containing
Monensin. Ingestion of Monensin by these species has been fatal. In the absence of coccidio-
sis, the use of Monensin with no withdrawal period may limit feed intake resulting in reduced
weight gains. Monensin must be thoroughly mixed in feed before use. Do not feed Monensin
undiluted.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Chickens (broilers) Avilamycin 13.6-40.9 g/ton of Type C For the prevention of mortality caused by
and medicated feed (15-45 ppm) as necrotic enteritis associated with
sole ration for 21 consecutive days. Clostridium perfringens in broiler chickens.
Monensin 90-110 g/ton As an aid in the prevention of coccidiosis
caused by Eimeria necatrix, Eimeria tenella,
Eimeria acervulina, Eimeria brunetti, Eimeria
mivati and Eimeria maxima.
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2021 Feed Additive Compendium | Additive Listings 137

Avilamycin (Continued)
3. FDA Status: No feed mill license required.
Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed
veterinarian. Animal feed bearing or containing this Veterinary Feed Directive (VFD) drug
shall be fed to animals only by or upon a lawful veterinary feed directive issued by a licensed
veterinarian in the course of the veterinarian’s professional practice. Feed continuously as the
sole ration for 21 consecutive days. Do not allow adult turkeys, horses or other equines access
to Narasin formulations. Ingestion of Narasin by these species has been fatal.
CAUTION: To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on
or before 18 days of age. The safety of Avilamycin has not been established in chickens in-
tended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler
chickens showing clinical signs of necrotic enteritis prior to the start of medication.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Chickens (broilers) Avilamycin 13.6-40.9 g/ton of Type C For the prevention of mortality caused by
and medicated feed as sole necrotic enteritis associated with
ration for 21 consecutive days. Clostridium perfringens in broiler chickens.
Narasin 54-90 g/ton For the prevention of coccidiosis
caused by Eimeria necatrix, Eimeria tenella,
Eimeria acervulina, Eimeria brunetti,
Eimeria mivati and Eimeria maxima for
broiler chickens.
LIMITATIONS FOR USE: Feed as sole ration for 21 consecutive days to chickens that are at risk of developing,
but not yet showing clinical signs of necrotic enteritis assoicated with Clostridium perfringens for broiler chickens.
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4. FDA Status: No feed mill license required.

Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed veterinar-
ian. Animal feed bearing or containing this Veterinary Feed Directive (VFD) drug shall be fed
to animals only by or upon a lawful veterinary feed directive issued by a licensed veterinarian
in the course of the veterinarian’s professional practice. Feed continuously as the sole ration
for 21 consecutive days. Do not allow adult turkeys, horses or other equines access to Narasin
formulations. Ingestion of Narasin by these species has been fatal. Do not feed to chickens
producing eggs for human consumption.
CAUTION: To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on
or before 18 days of age. The safety of Avilamycin has not been established in chickens in-
tended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler
chickens showing clinical signs of necrotic enteritis prior to the start of medication.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Chickens (broilers) Avilamycin 13.6-40.9 g/ton of Type C For the prevention of mortality caused by
and medicated feed as sole ration necrotic enteritis associated with
for 21 consecutive days. Clostridium perfringens in broiler chickens.
Narasin/Nicarbazin 54-90 g/ton of the combination For the prevention of coccidiosis
caused by Eimeria necatrix, Eimeria tenella,
Eimeria acervulina, Eimeria brunetti,
Eimeria mivati and Eimeria maxima for
broiler chickens.
LIMITATIONS FOR USE: Feed as sole ration for 21 consecutive days to chickens that are at risk of developing,
but not yet showing clinical signs of necrotic enteritis assoicated with Clostridium perfringens for broiler chickens.
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138 Additive Listings | 2021 Feed Additive Compendium

5. FDA Status: No feed mill license required.
Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed veterinar-
ian. Animal feed bearing or containing this Veterinary Feed Directive (VFD) drug shall be fed to
animals only by or upon a lawful veterinary feed directive issued by a licensed veterinarian in
the course of the veterinarian’s professional practice. Feed continuously as the sole ration for
21 consecutive days. Do not feed to laying hens producing eggs for human consumption. Not
approved for use with pellet binders. May be fatal if accidentally fed to adult turkeys or horses.
CAUTION: To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on
or before 18 days of age. The safety of Avilamycin has not been established in chickens in-
tended for breeding purposes. Avilamycin has not been demonstrated to be effective in broiler
chickens showing clinical signs of necrotic enteritis prior to the start of medication.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Chickens (broilers) Avilamycin 13.6-40.9 g/ton For the prevention of mortality caused by
and necrotic enteritis associated with
Clostridium perfringens in broiler chickens.
Salinomycin 40-60 g/ton For the prevention of coccidiosis
caused by Eimeria tenella, Eimeria necatrix
Eimeria acervulina, Eimeria maxima,
Eimeria brunetti and Eimeria mivati.
___________________________________________________________________________________________________________________________

Swine
6. FDA Status: No feed mill license required.
Veterinary feed directive (VFD) drug. VFD expiration date must not exceed 90 days from the
time of issuance. VFDs for Avilamycin shall not be refilled.
Regulation §558.68
LIMITATIONS FOR USE: Federal law limits this drug to use under the professional supervision of a licensed
veterinarian. Animal feed bearing or containing this veterinary feed directive drug shall be fed
to animals only by or upon a lawful veterinary feed directive issued by a licensed veterinarian
in the course of the veterinarian’s professional practice. Feed continuously as the sole ration
for 21 consecutive days. The veterinarian may direct feeding for up to a total of 42 consecutive
days based on the clinical assessment.
ANIMAL DRUG USE LEVEL INDICATIONS FOR USE
Swine (weaned pigs Avilamycin 73 g/ton of Type C medicated For the reduction in incidence and overall
less than 14 weeks feed (80 ppm) as sole ration severity of diarrhea in the presence of
of age) for 21 consecutive days. pathogenic Escherichia coli in groups of
weaned pigs.
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PRODUCT INFORMATION
Avilamycin
Trade Name: Inteprity Type A Medicated Article, Elanco US Inc., Greenfield, Ind. 46140; Package: 25-kg. (55.12-lb.) bag;
Concentration: Each pound contains 45.4 g Avilamycin; Expiration Date: Package carries; Manufacturing Suggestions: See label.

Trade Name: Kavault Type A Medicated Article, Elanco US Inc., Greenfield, Ind. 46140; Package: 25-lb. bag; Concentration: Each
pound contains 90.7 g Avilamycin; Expiration Date: Package carries; Manufacturing Suggestions: See label.
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2021 Feed Additive Compendium | Additive Listings 139