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PAPER NAME : 2011

1) Which of the following targeted drug delivery system is a tiny bubble like structure having

resemblance with cell membraneA) Nanoparticles

B) Liposomes

C) Niosomes

D) Dendrimers

Correct Answer is B

2) Select the IR sample

A) Ethylene

B) 3-hexene

C) Bromine gas

D) None of these

Correct Answer is D

3) The hydrolytic product of digitalis s glycoside

A) Purpurea glycoside

B) digitoxigenin

C) Both

D) None of these

Correct Answer is B

4) Select the suitable match for distinguishing character of Indian Senna over Egyptian Seena

A) Long, 3 subsidiary cells,Asymmetric base, less broken edges, tinnevellian glycoside containing leaf

B) Short, 3 subsidiary cells, Asymmetric base, less broken edges, tinnevellian glycoside containing lea

C) Long, 3 subsidiary cells, Symmetric base, More broken edges, Naphthalene glycoside containing leaf

D) Long, 3 subsidiary cells, Symmetric base, less broken edges, tinnevellian glycoside containing leaf

Correct Answer is D
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5) Calculate the maximum UV wavelength for 3-heptene-2-one.

A) 205nm

B) 210nm

C) 215nm

D) None of these

Correct Answer is C

6) (1 cyclohexene-1-yl-)-1,5 dimethyl barbituric acid is an IUPAC nomenclature of

A) Phenobarbital

B) Mephobarbital

C) Secobarbital

D) Hexobarbital

Correct Answer is D

7) Drug interaction of Erythromycin and Cisapride is due to enzyme.

A) CYP2D6

B) CYP3A4/5

C) CYP2E1

D) CYP1A1/2

Correct Answer is B

8) Therapeutic Drug monitoring is required in all except.

A) Loading dose

B) Maintenance dose

C) Poisioning

D) Hit & run drugs

Correct Answer is D

9) What may be the reason for Hyperchromic shift?

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A) Decrease in solvent polarity

B) Attachment of Auxochromes

C) Both

D) None of these

Correct Answer is C

10) (Beta) elimination results when

A) Two groups lost from adjacent atoms

B) Two groups lost from same atom

C) Two groups lost and three membered ring formed

D) Only one group is lost.

Correct Answer is A

11) A 60 years old worker is found to have sign and symptoms of plumbism and Calcium gluconate is

administered i.v. to control pain; he is suffering from

A) Acute Lead poisoning

B) Chronic Lead poisoning

C) Chronic Mercury poisoning

D) Chronic Cadmium poisoning

Correct Answer is B

12) A person encountered arrhythmia after myocardial infraction he was prescribed a high dose of

lidocaine to control the arrhythmia; the use of high dose is termed as

A) Maintanance dose

B) Therapeutic drug monitoring

C) Loading dose

D) Toxic dose

Correct Answer is C
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13) DSC curve is& .

A) Temperature(x) V/s Heat Flow (y)

B) Heat Flow (x) V/s Temperature(y)

C) Differential temperature(x) V/s Time (y)

D) Time (x) V/s Differential temperature(x)

Correct Answer is A

14) Which one of the following is a neuromodulator

A) Cl - ion

B) Neuropeptide Y

C) CO2

D) Dopamine

Correct Answer is C

15) The term spiro in polycyclic compound denotes:

A) Ring attachment at one point

B) Ring attachment at two point

C) Ring attachment at three point

D) Ring attachment at multiple point

Correct Answer is A

16) Foetal hydantoin syndrome is caused by

A) Phenytoin

B) Primidone

C) Gabapentin

D) Phenobarbitone

Correct Answer is A

17) Which one is five membered one heteroatom compound found in tobacco smoke:
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A) Pyrolline

B) Pyridine

C) Furan

D) None of above

Correct Answer is A

18) Hormone released from pineal gland which play a role in entraining

A) Inhibin

B) Melatonin

C) Liothyronine

D) Equilin

Correct Answer is B

19) Which of the following opioids do not contain Phenanthrene group in its chemical structure:

A) Codeine

B) Morphine

C) Papavarine

D) Thebaine

Correct Answer is C

20) Which is a drug of choice in febrile convulsion

A) Diazepam

B) Gabapentin

C) Ethosuximide

D) Levetiracetam

Correct Answer is A

21) Halogen Dance mechanism is shown by:

A) Furan
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B) Pyridine

C) Thiophene

D) Aziridines

Correct Answer is C

22) Which is a drug of choice in febrile convulsion

A) Diazepam

B) Gabapentin

C) Ethosuximide

D) Levetiracetam

Correct Answer is A

23) In nomenclature of steroid Beta term is used to denote:

A) Alkyl group attachment on steroid ring

B) Replacement of alkyl group from steroid reing

C) Substitution of steroid nucleus with dotted lines

D) Substitution of steroid nucleus with solid lines

Correct Answer is D

24) A diabetic patient is undergoing surgery he was given general anaesthesia and prescribed one of the

following as preanaesthetic. Choose the correct one:

A) Insulin

B) Glucose

C) Frusamide

D) Dichlorthiozide

Correct Answer is A

25) Calculate the NMR peaks of 2,methyl-2-pentene.

A) 5
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B) 4

C) 6

D) 3

Correct Answer is A

26) Attachment of amino group to above compound 2,methyl-2-pentene will results in&

A) 6 peaks, downfield & deshielding

B) 5 peaks, upfield & shielding

C) 7 peaks, downfield & deshielding

D) None of these

Correct Answer is A

27) ALOIN BP is&

A) 75% hydrous barbaloin

B) 70% anhydrous barbaloin

C) 70% hydrous Emodin

D) 70% hydrous x-barbaloin

Correct Answer is B

28) Purpurian glycoside B gives on Hydrolysis& .

A) Digitoxin + Glucose

B) Digitoxigenin + 3 Digitoxose

C) Both

D) None of these

Correct Answer is D

29) IR range for N-H stretching&

A) 3640 cm-1

B) 3423 cm-1
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C) 326cm-1

D) 2456cm-1

Correct Answer is B

30) Select the best suited analytical technique for 2%w/v & 20%w/v suspension of Aspirin.

A) Nephlometry & Turbidimetry respectively

B) Turbidimetry & Nephlometry respectively

C) Any from Nephlometry &Turbidimetry

D) Nephlometry & Turbidimetry are not suitable for suspensions

Correct Answer is A

31) Select the right statement for cardeneolides cardiac glycosides.

A) Biosynthesised from pregelonone

B) Present in Squill

C) Contain six membered lactone ring

D) Both a & b

Correct Answer is A

32) Following statement is true for E2 elimination

A) Two groups depart simantaneosly

B) Follow second order kinetics

C) Groups departs one by one

D) A and B

Correct Answer is D

33) The branch of science dealing with medicolegal aspects of chemicals is

A) Descriptive Toxicology

B) Regulatory Toxicology

C) Mechanistic Toxicology
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D) Forensic Toxicology

Correct Answer is D

34) What will be configuration of 1 bromo 1-chloroethane?

A) (S) 1-bromo 1-chloroethane

B) (R)1-bromo 1- chloroethane

C) (RS)1-bromo 1- chloroethane

D) None of the above

Correct Answer is A

35) Combination of neuroleptic and opoids to produce analgesia with or without loss of consiousness is

termed as

A) Central analgesia

B) Central analgesia

C) Neurolept analgesia

D) Neuroleptic

Correct Answer is C

36) In E, Z system of nomenclature cis-cis 2, 4 hexadiene will be known as

A) E, E Hexadiene

B) Z, Z Hexadiene

C) E, Z Hexadiene

D) Z, E Hexadiene

Correct Answer is B

37) New drug delivery system used for delivery of drug s.c. without using a needle; instead a high

velocity jet of drug solution is projected using a gun like implement is

A) Dermojet delivery system

B) Microjet delivery system

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C) Sialistic delivery system

D) Scarring delivery system

Correct Answer is A

38) 1-bromo-1, 2-dichloro ethene has the confirmation?

A) (E)-1-bromo-1, 2 dichloro ethene

B) (Z)-1-bromo-1, 2 dichloro ethene

C) (E, Z)-1-bromo-1, 2 dichloro ethene

D) (Z, E)-1-bromo-1, 2 dichloro ethene

Correct Answer is B

39) Which one of the following is drug of choice in methanol poisoning

A) Fomepizole

B) Naltrexonel

C) Disulfiram

D) Acamprostate

Correct Answer is A

40) Syn & anti Confirmation are Shown by

A) Acids

B) Oxims

C) Ketones

D) Alkenesand alkgenes

Correct Answer is B

41) Zonisamide; a antiseizure drug act via

A) T- type Ca ion Channel

B) L- type Ca ion Channel

C) N- type Ca ion Channel

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D) Voltage gated Na ion Channel

Correct Answer is A

42) E1 mecanism involves

A) Formation of carbocation only

B) Formation of carbocation followed by loss of proton

C) formation of anion followed by loss of proton

D) formation of anion followed by less of proton

Correct Answer is C

43) Digitalis contains&

A) Digitoxose,a 2,6 dideoxy hexose

B) Digitoxose,a 2,4 dideoxy pentose

C) Digitoxose, a 2,5 dioxy hexose

D) Digitoxose,a 2,6 dideoxy heptose

Correct Answer is A

44) Calculate the theoretical molar absorptivity constant for 1000 ml. Aq. solution containing 122 gm of

Benzoic acid if it shows UV extinction coefficient of 0.50 at 246nm.

A) 0.05 units

B) 0.50 units

C) 5.00 units

D) None of these

Correct Answer is B

45) Calculate the specific absorptivity constant for above question.

A) 0.04 units

B) 0.004 units

C) 0.40 units
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D) None of these

Correct Answer is A

46) What will be the maximum UV wavelength on attachment of a phenyl group at 5 position for the

above compound?

A) 254nm

B) 249nm

C) 253nm

D) None of these

Correct Answer is A

47) Which of the following is targeted Drug delivery System:

A) Osmotic Pumps

B) Transdermal Patches

C) Niosomes

D) Suppositories

Correct Answer is C

48) Ipecacuanha root contain

A) Cephaelin, a Tryptophen derived alkaloids

B) Cephaelin, a Tetrahydroisoqinoline derived alkaloids

C) Cephaelin & Emetine, a Tetrahydroisoqinoline derived alkaloids

D) Cephaelin & Emetine, a Tryptophen derived alkaloids

Correct Answer is B

49) Under Microbial assay I.P. the final pH of the culture media is maintained

A) Before Sterilization

B) After Sterilization

C) Anytime & not related with sterlisation

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D) No need to adjust the final pH

Correct Answer is A

50) Candida albicans can be detected using

A) Manotoox test

B) Canadian tube formation test

C) Germ tube formation test

D) Tuberculin test

Correct Answer is C

51) Strength of dry granule is due to

A) Surface tension and Capillary forces

B) Fusion and recrystallization

C) Vanderwaal forces

D) Electrostatic forces and frictional forces

Correct Answer is B

52) Zonisamide; a antiseizure drug act via

A) L- type Ca++ Channel

B) T- type Ca++ Channel

C) Voltage gated Na++ Channel

D) N- type Ca++ Channel

Correct Answer is D

53) The ability to regenerate a whole Plant is known as

A) Transgensis

B) Self promotion

C) Ontogenesis

D) Totipotency
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Correct Answer is D

54) Is a neuromodulator& ?

A) Cl - ion

B) CO2

C) Dopamine

D) Neuropeptide Y

Correct Answer is B

55) Select the most suitable Sterilization technique for tetanus vaccine.

A) Dry heat

B) Moist heat

C) Gaseous

D) Filtration

Correct Answer is D

56) Material which is not used as glidant or flow promoter -

A) Aerosil

B) Cab-o-sil

C) Syloid

D) Avicel

Correct Answer is D

57) Select the best distinguishing microscopical character for European belladonna over Alianthus.

A) Microsphenoidal Sandy crystals of Ca-Oxallate

B) Wavy epidermis with striated cutical

C) Both a & b

D) None of these

Correct Answer is A
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58) Cartridge filters contains& ..

A) One prefilter & one actual filter made up of polyethylene

B) One prefilter & one actual filter made up of polypropylene

C) One prefilter made up of polypropylene

D) Two actual filter made up of polypropylene

Correct Answer is B

59) Working principle of Ball mill is based on& .

A) Impact & Attrition

B) Cutting & Impact

C) Cutting only

D) Attrition only

Correct Answer is A

60) Hausner s ratio having value in between 4 10 shows that the material is

A) Easy Flowing

B) Free flowing

C) Very cohesive

D) Cohesive

Correct Answer is A

61) Which of the following is not match for Endotoxin

A) Water soluble

B) Metabolites

C) Clostridium

D) None of these

Correct Answer is D

62) The blade used to remove excess granulation and direct it to turrets....
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A) Sweep off blade

B) Wipe off blade

C) Both of the above

D) None of these

Correct Answer is B

63) Select the best couple of microbes & antibiotic, for microbial assay& .

A) M. luteus: Polymyxin B & Staphylococcus aureus: Erythromycin

B) M. luteus: Erythromycin & Staphylococcus aureus: Doxycyclin

C) Bacillus stubtilis: Kanamycin& Staphylococcus aureus: Erythromycin

D) M. luteus: Doxycyclin & Bacillus stubtilis: Kanamycin

Correct Answer is B

64) Under PTC profound effects on the morphology of the tissues that grow from the initial explant is

very much deppends Upon& .

A) Sterlising agent

B) Whole culture media content

C) Nitrogen source

D) None of these

Correct Answer is C

65) Select the filter equipment using In penicillin production to separate the extract from mycelium.

A) Sweetland filter

B) Rotary drum filter

C) Membrane filter

D) Metafilter

Correct Answer is B

66) The form of Lactose which do not undergo Maillard reaction is

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A) Spray dried lactose

B) Spray dried & Hydrous lactose

C) Anhydrous. Lactose

D) All of the above

Correct Answer is A

67) Combination of neuroleptic and opoids to produce analgesia with or without loss of consiousness is

termed as....

A) Neurolept analgesia

B) Neuraxial

C) Central analgesia

D) Neuroleptic

Correct Answer is A

68) Attachment of amino group to 2-methyl, 2-pentene will results in&

A) 5 peaks, upfield & shielding

B) 6 peaks, downfield & deshielding

C) 7 peaks, downfield & deshielding

D) None of these

Correct Answer is B

69) Select the best suited statement for caffine.

A) True Alkaloid & Terpenoidal derivative

B) Pseudo Alkaloid & Purine derivative

C) Pseudo Alkaloid & Steroidal derivative

D) None of these

Correct Answer is B
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70) Under Microbial assay I.P. the final pH of the culture media is maintained& .

A) After Sterilization

B) Before Sterilization

C) Anytime & not related with sterlisation

D) No need to adjust the final pH

Correct Answer is A

71) According to BPC 1998 standardization of Rauwolfia is based on& .

A) Precipitation

B) Flourscence

C) Optical rotation

D) Color reaction

Correct Answer is D

72) Belladona herb can be best distinguished from the above adulterants using the characters of&

A) Epidermis & Flowers

B) Epidermis & hairs

C) Epidermis & Shape of leaf

D) All of these

Correct Answer is B

73) Select Tryptophen derived alkaloids& .

A) Emetine, Quinidine, Strychine, Atropine

B) Reserpine, Quinidine, Strychine, Ajmaline

C) Emetine, Cephaelin, Quinidine, Strychine

D) All of these

Correct Answer is B

74) Nux vomica contains strychnine, which is derived from& .

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A) Purine

B) Tryptophen

C) Lysine

D) Phenylalanine

Correct Answer is B

75) Tautomerism involves& .

A) movement of only proton

B) movement of only bonding electrons

C) movement of a proton and electrons

D) movement of a proton and the shifting of bonding electrons

Correct Answer is D

76) The reaction mechanism of Keto-enol isomerism forms an intermediate, which is known as& .

A) Enolate Anion

B) Enolate Cation

C) Both a & b

D) None of these

Correct Answer is B

77) IUPAC nomenclature of diazepam is

A) 7-Choloro- 1,3 dihydo-1methyl -5-phenyl-2H-1-4-benzodiazepine-2-one

B) 7-Nitro 1,3 dihydo-5 phenyl-2H-1-4-benzodiazepine-2-one

C) 7-Choloro- 1,3 dihydo-3 -Hydroxy-5-phenyl-2H-1-4-benzodiazepine-2-one

D) 7-Choloro- 1,3 dihydo-3 - Hydroxy-5(2-chloro-)phenyl-2H-1-4-benzodiazepine-2-one

Correct Answer is A

78) Which of the anticonvulsant drug under goes Knoevanagel condensation.

A) paramethadione
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B) Phenytoin

C) Phensuximide

D) Primidone

Correct Answer is C

79) In above question (B) is& .

A) Droperidol

B) Chlorprothixene

C) Prochloroperazine

D) Chloropromazine

Correct Answer is D

80) Is formerly known as Vagusstoff

A) Noradrenaline

B) Neuropeptide Y

C) Acetylcholine

D) Adrenaline

Correct Answer is C

81) Causes Docking and Fusion of synaptic vesicles

A) Tetrodotoxinb

B) Saxitoxin

C) Neuropeptide Y

D) Syntaxin

Correct Answer is D

82) Which of the following contains more solid content:

A) Water for Injection (WFI)

B) Sterile water for Injection (SWFI)

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C) Both contains equal solid content

D) There is no solid content permitted in WFI and SWFI

Correct Answer is B

83) Is a example of bradykinin antagonist

A) Icatibant

B) Enalaprilat

C) Telmisartan

D) Kininase I

Correct Answer is A

84) A case of brassy cough occur while using captopril, it is due to breakdown of

A) Angiotensin III

B) Subsatance P

C) Neuropeptide Y

D) Degradation of captopril

Correct Answer is B

85) A parenteral preparation of Vitamin K may be stabilized with:

A) Sorbitol

B) EDTA

C) Lecithin

D) Thiomersal

Correct Answer is C

86) A patient under disopyramide treatment shows sign of dry mouth, constipation, urinary retention,

blurred vision. The symptoms are due to

A) Anticholinergic activity

B) Cholinergic activity
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C) Arrhythmia potentiation

D) Local anesthetic effect

Correct Answer is A

87) Ringing in ear, deafness, vertigo are signs in patients suffering from cinchonism which is side effect

of

A) Procainamide

B) Quinidine

C) Digitoxin

D) Cinnamic acid

Correct Answer is B

88) Which of the following is not a tonicity modifier used in parenterals

A) Sodium chloride

B) Dextrose

C) Glycerin

D) All are tonicity modifiers used in parenterals

Correct Answer is C

89) Amrinone; an inodilator acts via

A) Increasing cAMP

B) Decreasing cAMP

C) Increasing Na/K/ATPase

D) Decreasing Na/K/ATPase

Correct Answer is A

90) Chemically pyrogens are lipid substances containing a carrier molecule, which may be:

A) A polysaccharide

B) A metal
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C) A Nucleic acid

D) All of above

Correct Answer is A

91) The preferred route for total parenteral nutrition is:

A) Intramuscular

B) Intravenous

C) Subcutanious

D) Intraperitoneal

Correct Answer is B

92) Torsades de pointes causes

A) Triggered arrhythmia

B) Sick sinus

C) Atrial fibrillation

D) Reentrant arrhythmia

Correct Answer is A

93) Heteroreceptors which causes enhanced NA release

A) Dopaminergic

B) Nicotinic

C) Serotonergic

D) Muscarinic

Correct Answer is B

94) A patient was concurrently administered drug A & B (NSAID), which results in adverse

hemorrhagic reaction. The drug A is& .

A) Warfarin: Synthetic coumarin derivative

B) Cynocobalamine: Water soluble vitamin

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C) Warfarin: Natural coumarin derivative

D) Digoxin: Cardiac glycoside

Correct Answer is A

95) Sodium Chloride infusion IP contains which of the following preservatives

A) Thiomersal

B) PMN

C) PMA

D) None of the above

Correct Answer is D

96) Usually Intravenous injections are given through which of the following vein:

A) Subclavian

B) Internal juglar

C) median cubital vein

D) Femoral

Correct Answer is C

97) Vanishing creams are

A) An Emulsion

B) Solution

C) Suspension

D) Lotion

Correct Answer is A

98) Which form of a drug is more absorable

A) Unionized form

B) Inonized form

C) Both
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D) Complex form

Correct Answer is A

99) Shedule p deals with

A) Life periode

B) Documentation

C) GMP

D) GLP

Correct Answer is A

100) Shedule M deals with

A) Life periode

B) Documentation

C) GMP

D) GLP

Correct Answer is C