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Capotril
Capotril
id1=10&id2=1 &id4=3
CAPOTRIL
Composition
Each tablet contains:
Captopril 25 or 50 mg
Indications
Hypertension
CAPOTRIL is indicated for the treatment of hypertension in adults and children.
It may be used alone or in combination with other antihypertensive agents, especially thiazide - type diuretics. The blood
pressure lowering effect of CAPOTRIL and thiazides are additive.
Heart failure CAPOTRIL is indicated for the treatment of heart failure. In such patients it is recommended that
CAPOTRIL be administered together with a diuretic.
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reached, further increases in dosage should be delayed to determine if a satisfactory response occurs.
Twice daily dosage has been used.
A maximum daily dose of 150 mg should not be exceeded.
Children
The usual dose is 0.1 - 0.5 mg/kg every 8 - 12 hrs and can be increased if necessary to a maximum daily dose of 4
mg/kg.
Precautions
Patients with renal disease, particularly those with bilateral renal artery stenosis, may develop increases in BUN and
serum creatinine after reduction of blood pressure with CAPOTRIL.
CAPOTRIL dosage reduction, discontinuation of diuretic, or both has been required in such patients. For these patients, it
may not be possible to normalize blood pressure and maintain adequate renal perfusion. During long - term treatment
some patients with heart failure have experienced a reduction in renal function that usually stabilized at the reduced level.
A few patients have developed angioedema of the face, mucous membranes of the mouth, and the extremities which is
reversible upon discontinuation of the drug. Laryngeal oedema and anaphylaxis have also been reported.
CAPOTRIL, as with any drug that reduces vascular resistance, should be used only with extreme caution in patients with
aortic stenosis because of the potentially harmful consequences of reduced coronary perfusion secondary to the reduced
blood pressure.
CAPOTRIL, as other ACE inhibitors, can cause fetal and neonatal morbidity and mortality when administered to pregnant
women.
When pregnancy is detected, discontinue the drug as soon as possible.
Small amounts of CAPOTRIL are excreted in human breast milk. Therefore, breast-feeding should be avoided.
In patients undergoing major surgery or during anaesthesia, CAPOTRIL may cause hypotension which can be corrected
by volume expansion.
Drug Interactions
NSAIDs may reduce the effectiveness of CAPOTRIL.
If given with a diuretic (preferably thiazide - type), the dose of either agent is necessary to be reduced.
With K+ supplements, as serum K + level may be increased.
With other antihypertensive agents, as the hypotensive effect may be pronounced.
Contra_indications
A history of previous hypersensitivity to CAPOTRIL, bilateral renal artery stenosis and neutropenia, pregnancy, lactation.
Side effects
Headache, rash, dizziness, fatigue, malaise, taste alteration, gastric upset or diarrhoea and cough, hyperkalaemia,
hyponatraemia.
Presentation
CAPOTRIL 25 mg Tablets : Box of 2 blisters of 10 scored tablets each.
CAPOTRIL 50 mg Tablets : Box of 2 blisters of 10 scored tablets each.
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