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Hematopoietic Progenitor Cell Colony Forming Unit Assay Report

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QR 6.2-8-18-a DCR No. 1751 Page 1 of 2


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What FTVMUTJOUIF$'
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do the results CFU
in the CFU Assay Report mean to you and your baby?
4HISȩTESTȩCERTIlESȩTHEȩȩPOTENCYȩOFȩTHEȩ(EMATOPOETICȩ3TEMȩ#ELLSȩ(3#S ȩOBTAINEDȩFROMȩTHEȩ@5MBILICALȩ#ORDȩ"LOODȩ5#" ȩ
AFTERȩPROCESSINGȩIT

$IFFERENTIATIONȩ TOȩ MATUREȩ BLOODȩ CELLS ȩ THEȩ PROGENYȩ OFȩ (3#Sȩ WILLȩ GOȩ THROUGHȩ INTERMEDIATEȩ STAGESȩ INLUDINGȩ MULTI
POTENTIALȩPROGENITORSȩANDȩLINEAGE COMMITEDȩPROGENITORS ȩPRIORȩTOȩREACHINGȩMATURITYȩ)NȩVITROȩASSAYSȩAREȩUSEDȩTOȩGAINȩ
INSIGHTȩ INTOȩ THEȩ FREQUENCIESȩ ANDȩ GROWTHȩ PROPERTIESȩ OFȩ HEMATOPOIETICȩ PROGENITORȩ CELLSȩ ATȩ VARIOUSȩ DEVELOPMENTALȩ
STAGESȩ !LTHOUGHȩ (3#Sȩ HAVEȩ THEȩ CAPACITYȩ TOȩ PROLIFERATEȩ ANDȩ DIFFERENTIATEȩ INȩ CULTURE ȩ MOSTȩ CELLSȩ DETECTEDȩ INȩ
HEMATOPOIETICȩCULTUREȩASSAYȩCONSISTȩOFȩHEMATOPOIETICȩPROGENITORSȩWHICHȩHAVEȩLIMITEDȩSELF RENEWALȩCAPACITYȩANDȩSHORTȩ
TERMȩ HEMATOPOIETICȩ POTENTIALȩ 0ROGENITORSȩ DETECTEDȩ INȩ CULTUREȩ ASSAYSȩ CANȩ EITHERȩ BEȩ MULTIPOTENTIALȩ CAPABLEȩ OFȩ
GENERATINGȩPROGENYȩOFȩMULTIPLEȩBLOODȩCELLȩTYPES ȩORȩRESTRICTEDȩTOȩONEȩORȩTWOȩLINEAGESȩERYTHROCYTES ȩGRANULOCYTES ȩ
MONOCYTESMACROPHAGESȩORȩPLATELETS 

-ATUREȩ BLOODȩ CELLSȩ AREȩ SEENȩ TOȩ HAVEȩ LIMITEDȩ LIFEȩ SPANȩ ANDȩ AREȩ CONTINOUSLYȩ REPLACEDȩ BYȩ THEȩ PROLIFERATIONȩ ANDȩ DE
DIFFERENTIAIONȩȩOFȩAȩVERYȩSMALLȩPOPULATIONȩOFȩ@0LURIPOTENTȩ(3#Sȩ4HESEȩCELLSȩAREȩSEENȩPRIMARILYȩINȩTHEȩADULTȩBONEȩMARROW ȩ
BUTȩ Aȩ VERYȩ PRIMITIVEȩ ANDȩ HIGHLYȩ PRODUCTIVEȩ FORMȩ OFȩ THESEȩ AREȩ FOUNDȩ INȩ THEȩ 5MBILICALȩ #ORDȩ "LOODȩ4HESEȩ CELLSȩ AREȩ
PROCESSEDȩANDȩCRYOPRESERVEDȩSOȩTHATȩTHEYȩSUCCESSFULLYȩDIFFERENTIATEȩINTOȩMATUREȩHEMATOPOIETICȩCELLSȩANDȩREPLENISHȩ
THEMSELVESȩBYȩSELF RENEWAL

#ELLȩ DIFFERENTIATIONȩ ALONGȩ THEȩ ERYTHROIDȩ LINEAGEȩ OCCURSȩ OVERȩ Aȩ TWOȩ WEEKȩ SPANȩ INȩ HUMANSȩ 4HEȩ EARLIESTȩ ERYTHROIDȩ
PROGENITOR ȩTHEȩ"&5 %ȩBURSTȩFORMINGȩUNIT ERYTHROID ȩISȩSMALLȩANDȩWITHOUTȩDISTINGUISHINGȩHISTOLOGICȩCHARACTERISTICSȩ
"&5 %SȩEXPRESSȩTHEȩCELLȩSURFACEȩANTIGEN ȩ#$ ȩASȩDOȩALLȩOTHERȩEARLYȩHEMATOPOIETICȩPROGENITORSȩ4HEȩSTAGEȩAFTERȩTHEȩ
"&5 %ȩ ISȩ THEȩ #&5 %ȩ COLONYȩ FORMINGȩ UNIT ERYTHROID ȩ WHICHȩ ISȩ LARGERȩ ANDȩ ISȩ THEȩ STAGEȩ RIGHTȩ BEFOREȩ HEMOGLOBINȩ
PRODUCTIONȩBEGINSȩ)MMATUREȩERYTHROBLASTSȩWHICHȩSTARTȩPRODUCINGȩHEMOGLOBINȩALSOȩSTARTȩCONDENSINGȩTHEIRȩNUCLEUSȩ
-ATUREȩERYTHROBLASTSȩAREȩSMALLERȩWITHȩAȩTIGHTLYȩCOMPACTEDȩNUCLEUSȩWHICHȩISȩEXPELLEDȩASȩTHEȩCELLSȩBECOMEȩRETICULOCYTESȩ
'%--ȩSTANDSȩFORȩGRANULOCYTE ȩERYTHROCYTE ȩMONOCYTE ȩMEGAKARYOCYTE

QR 6.2-8-18-a DCR No. 1751 Page 2 of 2

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