Cell

Times

Cordlife Introduces

AXP II SYSTEM
®
For Cord Blood Processing

IT IS THE CELL THAT MATTERS

 What is needed for a Successful Transplant?

• HIGH YIELD • INCREASED VIABILITY

Higher recovery of CD34+ (> 97%)[1] & Faster processing time yields higher
MNC ensure increased engraftment & viable cells
success of transplant
• RAPID & CONSISTENT
Higher the viability of cells, better the STEM CELL RECOVERY
chances of successful transplantation Standardized outcomes repeatedly
within a short span of time & without
any chance of human error, ensures
• UNCOMPROMISING SAFETY • COMPREHENSIVE consistent recovery of stem cells for
A cord blood unit which is HES free & AUTOMATION transplant
with low hematocrit (<30% in final Avoids cross-contamination and
storage volume) [1] prevents adverse variation due to human error, thus
effects at the time of transplantation increasing reliability

Automated Stem Cell Processing System

Stem Cell isolation is a critical step in cord blood banking. It affects the number of stem cells that
can be harvested or recovered from the cord blood. Cell recovery rates are critical because a higher
number of stem cells could enhance the success of the transplant or treatment that’s why Cordlife
has upgraded to FDA-cleared[2], cGMP and cGTP compliant [1] AXP® II System. This platform is a safe,
HES free, functionally closed, sterile and automated cord blood processing technology, which uses
optical sensor technology to formulate precision, separation and retention of almost all the target
mononuclear cell population-so you get more stem cells for maximum engraftment and thus better
transplant success.

A comparison of the most commonly-used Cord Blood processing methods[3][4]

Rate of TNC Recovery for AXP vs Other Rate of MNC Recovery for AXP vs Other
Recovery Processing Methods (%) Recovery Processing Methods (%)

100% 100%
90% 90%
**MNCs Recovery
**TNCs Recovery

80% 80%
70% 70%
60% 60%
80.3%

79.9%
96.2%

98.7%
78.0%

80.9%

50% 50%
40% 40%
30% 30%
20% 20%
10% 10%
0% 0%
AXP HESPAN SEPAX (HES) AXP HESPAN SEPAX (HES)
-Data from Cord Blood Registry- -Data from Cord Blood Registry-

Average CD34+ Cell Recovery %/N Average RBC Reduction %/N

98% 88%
97% 86%
% Recoveries

% Recoveries

96% 84%
95% 82%
87.5%
97.3%

94% 80%
93% 78%
81.6%
94.1%

92% 76%
77.1%
92.3%

91% 74%
90% 72%
89% 70%
AXP without HES SEPAX with HES MANUAL AXP without HES SEPAX with HES MANUAL

AXP has higher TNC, MNC and CD34+ recovery compared to other Processing Methods
**TNCs-Total Nucleated Cells | MNCs-Mono Nuclear Cells
References:
1. AXP® II System. Precision cord blood processing, stem cell harvesting, and data tracking. Thermogenesis; 2018.
2. https://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/SubstantiallyEquivalent510kDeviceInformation/ucm627186.htm
3. David T. Harris. Collection, Processing, and Banking of Umbilical Cord Blood Stem Cells for Clinical Use in Transplantation and Regenerative Medicine. LabMedicine 2008 March;Volume 39;3.
4. Christy Kim et al. Meta-analysis of the AXP® and SEPAX® automated cord blood processing systems. CESCA Therapeutics White Paper; 2015.