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Honbun-3928 06
Honbun-3928 06
1.1 Introduction
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Chapter 1
biomedical engineering. These gills enhanced the oxygen transfer from water to
air and provided high oxygen partial pressure in air, which was suitable for
human respiration. This thesis would be a step toward the realization of artificial
gills and the fulfillment of the dream of swimming under water.
3
General introduction
The artificial gill is a device that transfers oxygen from water to underwater
divers. Hence, the artificial gill is designed based on human respiration and
oxygen concentration in seawater. The oxygen consumption rate in humans
determines the required oxygen transfer rate from water to air, and the oxygen
concentration in seawater determines the required flow rate of seawater and the
driving force for oxygen transfer. The conditions for designing the artificial gill
are described in this section.
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Chapter 1
(a) (b)
Fig. 1.1 Oxygen (a) and carbon dioxide (b) concentrations in seawater
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General introduction
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Chapter 1
Fig. 1.2 Partial pressure profiles of oxygen and Fig. 1.3 Artificial gills using capillary
carbon dioxide in membrane-type artificial gills tubes composed of silicone rubber [5]
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General introduction
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Chapter 1
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General introduction
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Chapter 1
Fig. 1.7 Artificial gill with the circulation of an RBC suspension [20]
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General introduction
A fish can exchange gases effectively by the indirect contact of blood with
water in its gills. A comparison of respiration in fishes and humans is shown in
Table 1.1. For example, water contains a small amount of oxygen as compared
to air, and the oxygen diffusion rate in water is smaller than that in air. It would
be useful to elucidate the mechanism of a fish gill for developing an efficient
artificial gill.
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Chapter 1
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General introduction
The Controlled Ecological Life Support System (CELSS) has been studied
for its application to space exploration. It is an ecological system in which
several creatures coexist in a closed system such as a space station. An artificial
gill system was used to exchange respiratory gases between the algae cultivation
tank and animal habitation space. As shown in Fig. 1.9, oxygen is produced by
photosynthesis in cultivated algae and is supplied to the animal habitation space
through an artificial gill module. In contrast, the expired carbon dioxide from an
animal is transferred to the algae cultivation tank, and carbon dioxide is used in
photosynthesis by the algae.
Bowman and Thomae [25,26] were successful in sustaining a mouse for 66
days in a closed chamber. Oxygen that was produced due to photosynthesis in
the algae was supplied from the algae cultivation chamber through a gas
permeable membrane. Mastumoto et al. designed a water-water CELSS in order
to culture fish [26-28]. They demonstrated that it was possible to exchange
dissolved oxygen and carbon dioxide between the aqueous phases in algae
cultivation and fish habitation tanks in opposite directions by the contact of
these phases in an artificial gill module.
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Chapter 1
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General introduction
Thus, various hollow fiber modules were designed to disrupt the blood side
resistance. A blood oxygenator for blood flowing into coiled hollow fibers (Fig.
1.11) [47-56] and for blood flowing outside the hollow fibers (Fig. 1.12) [57-71]
was developed to enhance the oxygen transfer. After several attempts, some
researchers demonstrated that a hollow fiber module in which the hollow fibers
are perpendicular to blood flow exhibit a high gas exchange performance
[72-77]. Currently, almost all membrane oxygenators use this hollow fiber
arrangement. In an artificial gill, a fluid, such as seawater or oxygen carrier
solution, flowing outside and perpendicular to the hollow fibers may enhance
oxygen transfer to or from the outer hollow fibers. The theory of designing a
blood oxygenator may be useful to optimize the hollow fiber arrangement in the
artificial gill.
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Chapter 1
Fig. 1.11 Blood oxygenator for blood flowing Fig. 1.12 Blood oxygenator for blood flowing
into coiled hollow fibers [49] outside hollow fibers [47]
On the other hand, the hollow fiber modules for other purposes, such as
absorption, separation, and pervaporation, have been extensively studied for
their high mass transfer performance and low cost [79-86]. These modules were
designed to enhance mass transfer and reduce the operating energy. The
methodology of designing such modules would also be useful to design the gas
exchange module in the artificial gill.
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General introduction
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Chapter 1
PFC
emulsion
Hemoglobin vesicle
Modified Recombinant
hemoglobin hemoglobin
Fig. 1.13 Blood substitutes [87,102]
On the other hand, PFCs have attracted considerable attention for their
oxygen-dissolving capacity after Clark and Gollan demonstrated that mice can
breathe in PFCs, as shown in Fig. 1.14. PFCs are highly fluorinated organic
compounds that are chemically and biologically inert and display high solubility
in oxygen and other respiratory gases [106]. Several researchers have developed
the emulsified PFC as a blood substitute because it is immiscible in water. They
have several advantages such as low cost of production, long shelf stability, and
no risk of infection. However, the oxygen transport capacity is inadequate as
compared to other blood substitutes such as hemoglobin vesicles, as shown in
Fig. 1.15.
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General introduction
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Chapter 1
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General introduction
Fig. 1.18 Cobalt Schiff bass oxygen carrier as a Fig. 1.19 Cobalt porphyrin
fixed carrier in an oxygen enriching membrane complex as a fixed carrier in an
[131] oxygen enriching membrane [141]
Next, metal porphyrins, which have a structure similar to that of the oxygen
binding site of hemoglobin, were used as fixed oxygen carriers (Fig. 1.19).
Nishide et al. have performed a detailed study on fixed cobalt porphyrin
complex carriers [131-142]. They reported that oxygen sorption and desorption
to and from the fixed carrier complexes in their membranes are very rapid and
reversible resembling the form of the Langmuir isotherm. The oxygen
permeability was enhanced by a decrease in the upstream oxygen pressure,
P(O2), and the oxygen transport was analyzed by dual mode transport. The
permselectivity P(O2)/P(N2) reported was greater than 10. Using in situ UV-VIS
spectroscopy, they showed that in order to enhance the facilitated transport of
oxygen in the membrane, the complexes formed should posses both strong
oxygen-binding affinity and fast oxygen dissociation kinetics.
These oxygen carriers are also useful oxygen absorbents. In fact, CoS was
used as an oxygen absorbent for the artificial gill and CELSS. These studies
provide a hint to develop a more efficient oxygen carrier solution for the
artificial gill.
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Chapter 1
References
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General introduction
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General introduction
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Chapter 1
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