(ErBOYoulo Experiment No.

18
Pharmacology and Toxicology (0813)

9TubeooT 9aiwqale 0.
4. What is righting reflex? sfh siotai)
CI0 arlt inoit ylue60 07uDeoorg
checked?
5. How the righting reflex is arf
bre
is absent after
administratiön of phenobarbitone?
pno 6. Why ighting refiex (elsmins rno fnemitagxs
7. How phenobarbitone produces
hypnotic effect? "ieioW
phenobarbítone sodium.
duration of action the
8. Write the onset time and
M, shMM 2s 90im orti leds.JS
9. What are CNS stimulants and depressants? ovioad)
and depressant category ori
10. List the five drugs from CNS stimulaht
brns irtgierl erlt ot qu smil s s
srmine srdt iA
pnwst mmoltslq eri rno vtinag lsmins erti qo .noideuo
(Space for answers) eilsa rmt
pnitricen onit svnsedo bns M 1 f vlisonoinsps11al
xelte
cugsohfeb procuce camcoo
Secatives he
sedautives egPhenob cuebi tonedo
Caled as
procuceleepesemblrg
Hypnólla,he dugs ohich
eg$Diq
Called
CaUed a sHyphoues"ee 2epa
to naueal sleep
:9tdsT roitaveedG 0.8
2Belsomresuwo¥exit
Amblen (2olpîcun)
Butiset CButcasbitly4) Dora 5) Fstazola
m 3fioiidEdonar

A dug tha mecuucs ex@tmerct, cans the paent

Sedlatijes n herapeu doses uce anxfoyue aoqent Met

Jascoer dosegprocbuce y NosÍs arit mon erotereitT

Sea atves n

4. he mmedicte s egouininis colled aiighfn Kelex.

eplex.
J9fe (11seaemehunslumie e i ) .290uboT) oiisdors i) ih
.enoitea U.0
When animal s clroppecd roo the hel
TTerES?Toejdese Yd istieiis-se ereie)
Yromfolialy Jestoves the poswe andbehauehe
2atonqyr bre covis be4 bs2u ete ribiwepuib Svi eii 1a
nomalyy 20ijorqy bris zeitsbse to nosos to maineioom sr slhW

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATIONOAO0a AO D3T 0 09A0e STATO TH406 AHAN
nacologyand
andToxicology(0813)
ToXicologv
etBD) veolo Experiment No.18mB

eh.o(Space for answers)

adrninistcuon phenobeu btoneJughaingAelex, e
x becouseolophenoCUBEone to 1Shotosbula dep resstön action
dbse
centsd e Syg um.
on

en o
bawbttone
itone
bauub Na rocuLcesguiR onset ksleep
ph
ohch
ndicaleol b Joss o ughingonelex qnd
e detectecl o9 oyndmadmaieqenoth&
Ae COveN
lgng

Phen obabftal Soclfum has onget CLCtf on 5 minül3

he
he cunq tohich procute stimulatfon CNS0g heul
mulatfhg actton on he CNS Creoulecdaon Ns
stimuulattho

stimuulan eqamphetumine line, heobromune

tohth
duug probluce de pressY6n centsl nervOUS
Sysem
hauingnib?tDry CLcttononthe Cenbeal
nwos suguo depress ardu onoo si onsiereba C
C fo 2i.9riosrt 9rit bnetereoru of

101o
Amphetamineg
) Armod ahul airsmeiupef 0.a
3)tocain
4 Modainid
5 Methy phenicdadt :00 mo noitemotnt 0.3

sneOx9 sil ncl aliama1tupoy arti nweb athi.t

2uls18aq4.

AHARASHTRA STATE BOARD OF TECHNICAL EDUCATION OTAOUG JAHOT 10 ORACE 21A1e

APTH107
 Pharmacology and Toxicology (0813)
Experiment No.19
3. Write the uses of CNS depressant drugs.
Write the therapeutic uses of Chlorpromazine.
5. List the parts of actophotometer.
6. What is the mechanism of action of Chlorpromazine?

7. What is reflex activity?

8. What is locomotor activity of an animal?
9 Which types of drugs infiluence the locomotor activity?
10. Draw a well labeled diagram of actophotometer.

(Space for answers)

Thedugs cohich pro cluCes Cauum olouon

ek Cct o
eclleol as sedatuu eq Pentob eucbitone

diazepan am elonazepam alpra 20 lam

Sw) da 20lam vesta20lam

1 Us ed to eat n s om ni , anxieu

Us ed to troat panic attacks and seizwes.

3) Used to elßue anx fety tension belore Smgeuy
Swguy

ehloy promq2ine s vstd to uat psychoue

PSychote clisordeg
cisordey
Such
Such s schi20phexnfa ayomeinlc cle pTession Ts acut
i Tt is also vsed un acdutu eat nauue
QL
Cnd
and vomittung anxiely bekoe 8Ugey chronec hicupg
aut fnsnèellal prophyia and Symp toms o t e tanus.

SPav eActo photomele

OD
photo ceu
ht9souce u Counlie

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 112

 Toxicology
(0813)
and
macology Experiment No.19

(Space for answers)

Blockage dlopamn He cep tor s esponsfbleor
wColucng th
HeoUclng the posittue signs e psychesis 'and fmpyouing
othex ehauioua the Combfne ekkect to block D
Histamun H, mugtasinic M e cep tors In he vomiLtino
Lenbe s poswlaud To suucuce 'nauuseq Cnd Vomttt

t is an
fnvountauy and neasly Instantaneou
to
movemert Hespons e a
qsünilart A elex fs
made possible by nubal pathoay calledHeex ACS.
wnich Can act o an Tmp use be te that Tmpluse
Jeachs he bTain

8. Ptndmal locaio fn etholog4 any a vasi Ey

methocs thet Cunumal moue LOT On e
place
o anothuySone locomouon mocus u Lnung
summing upin inand ieing
9. Aclministueituon cubused cyugs e nstante methanpetam
heein ethen el in txeases oco mo Atfuit

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

113
 1oXicology
(081 313) Experiment No.200
ana
acology

of convulsions.

List phases
5. observed after the
Write
the
character
injection of Strychnine Sulphate.
6. observed after the injection of diazepam.
7.
Alrite
W the character
acts?
How the diazepam
8.
w r i t e the onset time and recovery for Strychnine Sulphate.

onset time and recovery for the diazepam.

40. Write the

(Space for answers)

A c e t az o l a m i d e Casdbcum a 2epfne Clobazam, clonqzepCu
tho sU2imfclo
Dfqze peum

Tontc- clonic seiztous OT maget epilepsy

seizuxesoT m
Abs en Le
seizuwas Petitmr
ARR Ptondc or

wMy toclonc seizus

H pSoechyBhmia

Pauiinl
Paudial Sel24 1) Simple pavctial seizwes
) Complex Pasdial sei 2wLs

4Erectfon Tail in s shaped stucwe 1s called

as steLub es aul

1) l7odxomal
)Ecu icbreul
3 Tct
4Postictal

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION 119

 Phamacolog
Phamacology and Toxicology (0813) Experiment No.20

(Space for answers) Ti

6 obseued chcua clos 1.0

Ta
-Straubes lail M
Teuky Conuls ions (
Sevei Conuulsions. 2.0

pfq2epeum gonieten G1ABA HeceptOrs

qnd potenttoThe he actton k GA-BA

he 3.0
onset
oactfoo Ys 15 to 30mfnuct
The onset e actfon is 1-5 mi or IV adminfsto
the duraluon
administao
diqzepam peak phaxmgco logfcal e
fs 15 mlo to One houx the HOts
he bfoauailabfTty aP or adminfstratf on
adminnstoocbion
s
90
lo),
a ecct ed adninistrcution.

MAHARASHTRA STATE BOARD OF TECHNICAL

EDUCATION
120 MAHA
 (0813)

1Oxicology Experirnent No.21

and
cology

What a r e analgesics?
five examples of analgesics.
rnent No,21
antipyretics? List five examples of antipyretics.
5

ecautions to be taken about rabbits while

6 Wha

performing the experiment.

re and if sum Write
the
the Pyrogens are removed from the parenteral preparations?
7. methods

ration being Bywhich is controlled in body?

8. H o wt h e t e m p e r a t u r e

9
the other five quality control test, which should be checked before the administration of
Write
10. parenteral preparations.

(Spacefor answers)
procdue metabo'sm micro-03garisms
A
Ogern
s s o clated wHh Ccuuiex o l e l c
Chemfeal
ogen

cohlch . usvalyH poysachaulode bc may be peptide

PyRLOgens edsobstan ce ass odcted with

poysacchcuufde,
noletule tohYch usUaly
caeedex

e sbll. produau mst be

suil. AU produdi
mus t
AU pToducu
pTodust

Au Pgenuc con teumnatuon.

than no ma
Jumprau
The o Crease in bo oly
coled Pyexfq

by q cenbu In
cene
Aegulatad
JAegulaltd
JumpTqie
Normal body
bocly
chich
tohich is e s r o n s i ble
o balane

hupothclamus heat
prodluction.
pro
cuctidn. bedy
body
he and
hêat

To heat loss
oss olrswcbance In his
eluoeen
beuoe en theu J
When
ulses
mprauue
thoun ostolle
hupo t h l a m u s
CISSocictd
associct oofHh
elteue
the paun
pcun
Lohfch
o hich
The dug analgesfc dutgs
cculleed Nal oxore
oxare
m ammclon Meperiolne
Meperlolne, Nal
codone,
oxy codone,
exCod
eine Metha cdone,
127

TECHNICAL
EDUCATION
BOARD OF
STATE
MAHARASHTRA

126
 Pnarmacolog
Phamacology and Toxicology (0813) Experiment No.21

(Space for answers)

1.0
uohfch ooex the e levated body temp
he elbuugs
Canti-pye couugs
prolin
/U coulled a

q - Pcace tam el 2.0

) he ethe theumomelbe sheud be ept bou

bulb 3.0

4-5 Cm aboue h e Swee Ce o

i ) Pieces o pumice stone should
be added to toci
to tDcl
beore heating q vofd burm pipg

De pyo genaüon xekou to to amoval o Pogtn

8
9.Ox Intunal body emp Jeguleuua by A Pastt
Otue br auh called e hypoth & amus The hypothalar
checks o cuwunt temp. arnd COmp cuR oRih
t o h the
rmal
norma Jtem prolu e
e o the hypothal amus
about
34'T ou mp.
makes sue hat th
ou mp

that he
b ocy genexcdlsand mafnctalns heat

) stile Test
) Pyogtn Tests
3) Leakex Test

4) Padticulte mAte Tesung

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

128 MA

wwww
 a n d Toxicology( 0 8 1 3 )

nMcoOYaNd7 Experiment No.22

(CNS stimulanttdepressant) effect.
xperiment No,22
11.0 Questions
Write a n s w e r s t o
o Q.... Q... Q.... Q... (Questions to be allotted by
subject teacher
What is conditio avoidance response

What
nditioned avoidance response?
is uncond

Name t h e five antipsychoti drugs.

2.
3.

Schizophrenia?

What is
4. avoidance of response?
trained for
mice

5.
Howthe
the action of chlorpromazine in mice?
6 What is
W
tranquillizers?
are
What
7.
Listthe
five examples of drugs used as tranquillizers or Narcoleptics?
8.
drugs?
tual conduct of 9.
What are
psychoactive

antipsychotic drugs?
What are
10.

(Space for answers)

noxroUS stmuuus by22ex Hesp onse
esp onse
i.e. scape o
ole training
climbing elecbuic shock
(i.e sm
d.) training
Drugs choti u
the animal in
Arniip sy ) Mallo peuidot
Chlor clfa2e pTOXite T opea 2ing
chlovo proma zine
Y Trwtodel.

A dfsodei that aku q peson 's abil

l urnd behau pleouy
think

auuofd
Cuwofd
shoek
eleJvuc shoek
elebuc by mecuns
mecun

uauned To
we condiboning pTOCecuu
p TOCeslu
s.Mice Conclibfoning
ual passfue
ngle

doses 1 rmg/
to 6ma/
to S kg mpairs
Rg fmpair
zine dn m.ated
decrecse
chloy prema
BeAs and fnduees

mobor dcbíuiuy
b ooly 136

EDUCATION
TECHNICAL

BOARD OF
MAHARASHTRA
STATE

134
 7ame

Experiment No 22
Phamacology and Toxicology (0813)

(Space for answers)

1.0
alo d own
he duugs procucs cohfch
C cLll ed
tolthout p rocucing hypnosis
2.0
Tan quf Ui2 brs

1) Stfmuulanith 3 . 0

S euDt o nin
novepIne phine

Tfoy c antide pressant

Sooium o xybatte

substantes hact ohen k

ohen Taken
.Psgchoa ctfue cugs aul

adminfse d 9n to ones sysum e c t mehtal

PrO Cessee .
eq- PerCepti on, Con scYousness
fon
Contfon

moo d 8 emotions

Lo.Anrupsychouesa0 knoor neuroleplcg

Psychotropfc meolication pimailyUSed o

Oanao
psychoais, pindipaly Tn schi20phrenig but lalso
lo1

Aange o ofhe Pschotic aisordd.

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

36