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Lecture 5 Neuronal Signaling BIO161 Wolf S22
Lecture 5 Neuronal Signaling BIO161 Wolf S22
Lecture 5 Neuronal Signaling BIO161 Wolf S22
Structure of a Neuron
5
Neurons
• Neurons are neurons. Nerves are neurons+glia.
Glial Cells
Fig. 6.6
7
Glial Cells of the CNS
1. Astrocytes: support cells, control extracellular
environment of neurons
PNS
Glial
Myelination
CNS
Fig. 6-2 10
Best Known Roles for Glia
• Structural support
• Metabolic homeostasis
– Glutamate recycling
– Oxygen & glucose supply
– Ionic balance
12
Affect
Effect
Fig. 6.4
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Relative #
10
200,000
15
Synapses
Neurovasculature
Blood-brain barrier
fMRI based on local [O2]
19
membrane potential
Basic Principles of Electricity
By convention, extracellular is
0 Volts
Range: -5 to -100 mV
23
24
26
Equilibrium Potential
The membrane potential when flux due to
ion concentration difference equals flux
due to charge difference.